Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .

Essential

These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.
Statistics

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external video platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name Youtube
Purpose External media

The MARIE Study

MARIE is a large population-based case-controls study conducted between 2002 and 2005 to identify potential risk factors for the development of breast cancer after menopause. "MARIE" is an acronym for Mammary carcinoma risik factor Investigation. Almost all incident patients from the Rhine-Neckar-Karlsruhe and Hamburg regions aged between 50 and 74 years were interviewed personally. As a comparison group, women of the same age without breast cancer from the same cities and counties were randomly selected and interviewed in-person in order to compare them with the patients. All participants were also asked to provide a blood sample for molecular and genetic investigations.

Objectives

The main objective of MARIE was to identify modifiable risk factors for the development of postmenopausal breast cancer and thus to find approaches to reduce the risk of breast cancer. To do this, we examined the influence of the following factors:

  • Menopausal hormone therapy
  • Factors related to pregnancy, childbirth and menstruation
  • Lifestyle habits such as physical activity, diet, smoking and alcohol consumption
  • Pre-existing illness
  • Genetic variants

Results

  • Full-term pregnancies protect against breast cancer. Especially, if they occur at a younger age.
  • Breastfeeding is also a protective factor.
  • Taking hormones to relieve menopausal symptoms increases the risk of developing breast cancer. This is particularly true with continuous estrogen-progesterone combination therapy. If used for more than 5 years, the risk of breast cancer is almost twice as high as that of women who are not taking hormones.
  • The MARIE Study confirms physical activity as a protective factor.
  • There was no increased risk of breast cancer in relation to smoking and passive smoking.

A more detailed description of the results can be found in the study report, and further details are available in the scientific publications.

to top
powered by webEdition CMS