MARIE study

MARIE is a large population-based case-control study, conducted between 2002 and 2005 in two study regions in Germany: the Rhine-Neckar-Karlsruhe region and the city and state of Hamburg. The objective was to identify potential risk factors for the development of breast cancer after menopause. MARIE is an acronym for Mammary carcinoma Risk factor Investigation. Patients between 50 and 74 years old and diagnosed with a first primary invasive or in situ breast cancer between 2001 and 2005 in the study region and unaffected control persons matched to the patients by age and study region were recruited and interviewed for the case-control comparison.
For further information (in German only):

Objectives

The main objective of MARIE is to identify modifiable risk factors for postmenopausal breast cancer. We investigate the effect of the following factors in relation to breast cancer risk:

  • Hormone replacement therapy
  • Lifestyle factors, such as nutrition, smoking and physical activity
  • Genetic factors

Collaborations

  • Universitätsklinikum Hamburg-Eppendorf, PD Dr. D. Flesch-Janys (Institut für Medizinische Biometrie und Epidemiologie), Prof.(em) Dr. W. Braendle und Prof. Dr. F. Jänicke (Klinik und Poliklinik für Gynäkologie)
  • Hamburgisches Krebsregister, Behörde für Umwelt und Gesundheit, Dr. S. Hentschel
  • Albertinen Pathologie Hamburg, Prof. Dr. Th. Löning
  • Universität Heidelberg, Prof. Dr. A. Schneeweiss (Frauenklinik)
  • Deutsches Krebsforschungszentrum, Abteilung Toxikologie und Krebsrisikofaktoren, DKFZ Arbeitsgruppe Genetische Toxikologie und DNA-Reparatur, Dr. Peter Schmezer und PD Dr. Odilia Popanda
  • Krebsregister Rheinland-Pfalz, Prof. Dr. M. Blettner und Dr. K. Emrich
  • Krebsregister Baden-Württemberg, Deutsches Krebsforschungszentrum Abteilung Epidemiologie von Krebserkrankungen, Prof. Dr. N. Becker
  • Universität Heidelberg, Pathologisches Institut, Prof. Dr. H.P. Sinn
  • MARIE-GENICA consortium
  • Breast Cancer Association Consortium  BCAC

Funding

Deutsche Krebshilfe e.V. (2002-2005)

Projects

  • Hormone replacement therapy
  • Vitamin D
  • Phytoestrogen intake
  • Physical activity
  • Alcohol intake and smoking
  • Genetic factors

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