MARIErad and ISE: Radiosensitivity

The aim of this subproject is to identify genetic markers that influence occurrence of late toxicity after radiotherapy and prognosis in breast cancer patients.

Radiotherapy leads to an increased formation of reactive molecules ("oxidative stress"). Cells have developed several defence mechanisms to cope with oxidative stress and its damaging effects, e.g. DNA repair systems or antioxidant enzymes that eliminate harmful molecules.

Enzyme activity can be altered by single nucleotide polymorphisms (SNPs), for example. Genetic markers in genes that are related to oxidative stress may modify the ability to protect against oxidative damage.

Thus, variants in those genes might influence the efficacy of cancer treatment and therefore modify survival time as well as long-term side effects after radiotherapy.

For this aim the patients of the MARIEplus Study and the ISE study are included.

Cooperations: The project is conducted in collaboration with the unit of DNA repair and Epigenomics (P. Schmezer and O. Popanda).

Funding: Dietmar Hopp Stiftung (#PW1062)

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