We integrate single-cell (epi)genomics with advanced fluorescence microscopy methods to understand how chromatin organization and nuclear architecture govern gene regulation and telomere maintenance. Our work combines the imaging-based analysis of cellular phenotypes in their endogenous tissue context with molecular multi-omics profiles that include transcriptome, chromatin accessibility, surface proteins, and immune cell receptors.
This interdisciplinary approach connects genome organization to functional outcomes, revealing how a disrupted nuclear architecture drives aberrant cell states in cancer. We test the mechanisms identified in cell model systems through targeted perturbations, such as light-controlled epigenetic editing. This integrated methodology helps us understand tumor heterogeneity, therapy resistance mechanisms, and the unlimited proliferation potential of cancer cells in both blood cancers and solid tumors.
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