Full List of Publications

Selected Publications

Vlachavas EI, Voutetakis K, Kosmidou V, Tsikalakis S, Roditis S, Pateas K, Kim R, Pagel K, Wolf S, Warsow G, Dimitrakopoulou-Strauss A, Zografos GN, Pintzas A, Betge J, Papadodima O, and Wiemann S. Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer. Mol Oncol, (2025). PMID: https://www.ncbi.nlm.nih.gov/pubmed/39876058

Sumer OE, Schelzig K, Jung J, Li X, Moros J, Schwarzmuller L, Sen E, Karolus S, Worner A, de Melo Costa VR, Nataraj NB, Vlachavas EI, Gerhauser C, Muller-Decker K, Helm D, Yarden Y, Michels BE, and Korner C. Selective arm-usage of pre-miR-1307 dysregulates angiogenesis and affects breast cancer aggressiveness. BMC Biol 23, 25 (2025). PMID: https://www.ncbi.nlm.nih.gov/pubmed/39849498

Radke J, Ishaque N, Koll R, Gu Z, Schumann E, Sieverling L, Uhrig S, Hubschmann D, Toprak UH, Lopez C, Hostench XP, Borgoni S, Juraeva D, Pritsch F, Paramasivam N, Balasubramanian GP, Schlesner M, Sahay S, Weniger M, Pehl D, Radbruch H, Osterloh A, Korfel A, Misch M, Onken J, Faust K, Vajkoczy P, Moskopp D, Wang Y, Jodicke A, Trumper L, Anagnostopoulos I, Lenze D, Kuppers R, Hummel M, Schmitt CA, Wiestler OD, Wolf S, Unterberg A, Eils R, Herold-Mende C, Brors B, Consortium IM-S, Siebert R, Wiemann S, and Heppner FL. The genomic and transcriptional landscape of primary central nervous system lymphoma. Nat Commun 13, 2558 (2022). PMID: https://www.ncbi.nlm.nih.gov/pubmed/35538064

Wahjudi LW, Bernhardt S, Abnaof K, Horak P, Kreutzfeldt S, Heining C, Borgoni S, Becki C, Berg D, Richter D, Hutter B, Uhrig S, Pfutze K, Leichsenring J, Glimm H, Brors B, von Kalle C, Stenzinger A, Korf U, Frohling S, and Wiemann S. Integrating proteomics into precision oncology. Int J Cancer 148, 1438-1451 (2021). PMID: https://www.ncbi.nlm.nih.gov/pubmed/32949162

Maia A, Gu Z, Koch A, Berdiel-Acer M, Will R, Schlesner M, and Wiemann S. IFNbeta1 secreted by breast cancer cells undergoing chemotherapy reprograms stromal fibroblasts to support tumour growth after treatment. Mol Oncol 15, 1308-1329 (2021). PMID: https://www.ncbi.nlm.nih.gov/pubmed/33476079

Ibing S, Michels BE, Mosdzien M, Meyer HR, Feuerbach L, and Korner C. On the impact of batch effect correction in TCGA isomiR expression data. NAR Cancer 3, zcab007 (2021). PMID: https://www.ncbi.nlm.nih.gov/pubmed/34316700

Berdiel-Acer M, Maia A, Hristova Z, Borgoni S, Vetter M, Burmester S, Becki C, Michels B, Abnaof K, Binenbaum I, Bethmann D, Chatziioannou A, Hasmann M, Thomssen C, Espinet E, and Wiemann S. Stromal NRG1 in luminal breast cancer defines pro-fibrotic and migratory cancer-associated fibroblasts. Oncogene 40, 2651-2666 (2021). PMID: https://www.ncbi.nlm.nih.gov/pubmed/33692466

Haller F, Bieg M, Will R, Korner C, Weichenhan D, Bott A, Ishaque N, Lutsik P, Moskalev EA, Mueller SK, Bahr M, Woerner A, Kaiser B, Scherl C, Haderlein M, Kleinheinz K, Fietkau R, Iro H, Eils R, Hartmann A, Plass C, Wiemann S, and Agaimy A. Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands. Nature Communications 10, 368 (2019). PMID: https://www.ncbi.nlm.nih.gov/pubmed/30664630

Wiemann S, Pennacchio C, Hu Y, Hunter P, Harbers M, Amiet A, Bethel G, Busse M, Carninci P, Diekhans M, Dunham I, Hao T, Harper JW, Hayashizaki Y, Heil O, Hennig S, Hotz-Wagenblatt A, Jang W, Jöcker A, Kawai J, Koenig C, Korn B, Lambert C, LaBeau A, Lu S, Maurer J, Moore T, Ohara O, Park J, Rolfs A, Selehi-Ashtiani K, Seiler C, Simmons B, van Brabant Smith A, Steel J, Wagner L, Weaver T, Wellenreuther R, Yan S, Vidal M, Gerhard DS, LaBaer J, Temple G, and Hill DE. The ORFeome Collaboration: a genome-scale human ORF-clone resource. Nat Methods 13, 191-192 (2016). PMID: https://www.ncbi.nlm.nih.gov/pubmed/26914201

Keklikoglou I, Hosaka K, Bender C, Bott A, Koerner C, Mitra D, Will R, Woerner A, Muenstermann E, Wilhelm H, Cao Y, and Wiemann S. MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and KRAS genes. Oncogene 34, 4867-4878 (2015). PMID: https://www.ncbi.nlm.nih.gov/pubmed/25500542

Korner C, Keklikoglou I, Bender C, Worner A, Munstermann E, and Wiemann S. MicroRNA-31 sensitizes human breast cells to apoptosis by direct targeting of protein kinase C epsilon (PKCepsilon). J Biol Chem 288, 8750-8761 (2013). PMID: https://www.ncbi.nlm.nih.gov/pubmed/23364795

Keklikoglou I, Koerner C, Schmidt C, Zhang JD, Heckmann D, Shavinskaya A, Allgayer H, Guckel B, Fehm T, Schneeweiss A, Sahin O, Wiemann S, and Tschulena U. MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-kappaB and TGF-beta signaling pathways. Oncogene 31, 4150-4163 (2012). PMID: https://www.ncbi.nlm.nih.gov/pubmed/22158050

Taylor CF, Field D, Sansone SA, Aerts J, Apweiler R, Ashburner M, Ball CA, Binz PA, Bogue M, Booth T, Brazma A, Brinkman RR, Michael Clark A, Deutsch EW, Fiehn O, Fostel J, Ghazal P, Gibson F, Gray T, Grimes G, Hancock JM, Hardy NW, Hermjakob H, Julian RK, Jr., Kane M, Kettner C, Kinsinger C, Kolker E, Kuiper M, Le Novere N, Leebens-Mack J, Lewis SE, Lord P, Mallon AM, Marthandan N, Masuya H, McNally R, Mehrle A, Morrison N, Orchard S, Quackenbush J, Reecy JM, Robertson DG, Rocca-Serra P, Rodriguez H, Rosenfelder H, Santoyo-Lopez J, Scheuermann RH, Schober D, Smith B, Snape J, Stoeckert CJ, Jr., Tipton K, Sterk P, Untergasser A, Vandesompele J, and Wiemann S. Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project. Nat Biotechnol 26, 889-896 (2008). PMID: https://www.ncbi.nlm.nih.gov/pubmed/18688244

Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sultmann H, and Poustka A. From ORFeome to biology: a functional genomics pipeline. Genome Res 14, 2136-2144 (2004). PMID: https://www.ncbi.nlm.nih.gov/pubmed/15489336

Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, and Poustka A. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Res 11, 422-435 (2001). PMID: https://www.ncbi.nlm.nih.gov/pubmed/11230166

Smahi A, Courtois G, Vabres P, Yamaoka S, Heuertz S, Munnich A, Israel A, Heiss NS, Klauck SM, Kioschis P, Wiemann S, Poustka A, Esposito T, Bardaro T, Gianfrancesco F, Ciccodicola A, D'Urso M, Woffendin H, Jakins T, Donnai D, Stewart H, Kenwrick SJ, Aradhya S, Yamagata T, Levy M, Lewis RA, and Nelson DL. Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium. Nature 405, 466-472 (2000). PMID: https://www.ncbi.nlm.nih.gov/pubmed/10839543

Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, and Wiemann S. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. EMBO Rep 1, 287-292 (2000). PMID: https://www.ncbi.nlm.nih.gov/pubmed/11256614

Heiss NS, Knight SW, Vulliamy TJ, Klauck SM, Wiemann S, Mason PJ, Poustka A, and Dokal I. X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions. Nature Genet 19, 32-38 (1998). PMID: https://www.ncbi.nlm.nih.gov/pubmed/9590285

Mollenhauer J, Wiemann S, Scheurlen W, Korn B, Hayashi Y, Wilgenbus KK, von Deimling A, and Poustka A. DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours. Nature Genet 17, 32-39 (1997). PMID: https://www.ncbi.nlm.nih.gov/pubmed/9288095

Preprints

Abad N, Glas I, Hong C, Pageaud Y, Hutter B, Brors B, Körner C, and Feuerbach L. Identifying, Prioritizing, and Visualizing Functional Promoter SNVs with the Recurrence-agnostic REMIND-Cancer Pipeline and pSNV Hunter. bioRxiv (2024) DOI:10.1101/2024.09.10.612212

Abad N, Glas I, Hong C, Small A, Pageaud Y, Maia A, Weichenhan D, Plass C, Hutter B, Brors B, Körner C, and Feuerbach L. The promoter mutation paucity as part of the dark matter of the cancer genome. submitted (2025) und bioRxiv (2024) DOI:10.1101/2024.06.03.597231

2025

2024

Gedik ME, Saatci O, Oberholtzer N, Uner M, Akbulut-Caliskan O, Cetin M, Aras M, Ibis K, Caliskan B, Banoglu E, Wiemann S, Uner A, Aksoy S, Mehrotra S and Sahin O: Targeting TACC3 induces immunogenic cell death and enhances T-DM1 response in HER2-positive breast cancer. Cancer Res 2024, Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/38319231

Loghmani SB, Zitzow E, Schwarzmuller L, Humboldt Y, Eisenberg P, Kreikemeyer B, Veith N, Kummer U and Fiedler T: Comparing genome-scale metabolic models of the non-resistant Enterococcus faecalis ATCC 19433 and the multi-resistant Enterococcus faecalis V583. J Biotechnol 2024, 392 109-17. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/38996920

Montero-Vergara J, Plachetta K, Kinch L, Bernhardt S, Kashyap K, Levine B, Thukral L, Vetter M, Thomssen C, Wiemann S, Pena-Llopis S, Jendrossek V and Vega-Rubin-de-Celis S: GRB2 is a BECN1 interacting protein that regulates autophagy. Cell Death Dis 2024, 15 (1):14. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/38182563

Obacz J, Archambeau J, Lafont E, Nivet M, Martin S, Aubry M, Voutetakis K, Pineau R, Boniface R, Sicari D, Pelizzari-Raymundo D, Ghukasyan G, McGrath E, Vlachavas EI, Le Gallo M, Le Reste PJ, Barroso K, Fainsod-Levi T, Obiedat A, Granot Z, Tirosh B, Samal J, Pandit A, Négroni L, Soriano N, Monnier A, Mosser J, Chatziioannou A, Quillien V, Chevet E and Avril T: IRE1 endoribonuclease signaling promotes myeloid cell infiltration in glioblastoma. Neuro Oncol 2024, 26 (5):858-71. Pubmed: https://pubmed.ncbi.nlm.nih.gov/38153426

Rafi AM, Nogina D, Penzar D, Lee D, Lee D, Kim N, Kim S, Kim D, Shin Y, Kwak IY, Meshcheryakov G, Lando A, Zinkevich A, Kim BC, Lee J, Kang T, Vaishnav ED, Yadollahpour P, Kim S, Albrecht J, Regev A, Gong W, Kulakovskiy IV, Meyer P and de Boer CG: A community effort to optimize sequence-based deep learning models of gene regulation. Nat Biotechnol 2024, Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/39394483

Rivas-Delgado A, Lopez C, Clot G, Nadeu F, Grau M, Frigola G, Bosch-Schips J, Radke J, Ishaque N, Alcoceba M, Tapia G, Luizaga L, Barcena C, Kelleher N, Villamor N, Baumann T, Muntanola A, Sancho-Cia JM, Garcia-Sancho AM, Gonzalez-Barca E, Matutes E, Brito JA, Karube K, Salaverria I, Enjuanes A, Wiemann S, Heppner FL, Siebert R, Climent F, Campo E, Gine E, Lopez-Guillermo A and Bea S: Testicular large B-cell lymphoma is genetically similar to PCNSL and distinct from nodal DLBCL. Hemasphere 2024, 8 (10):e70024. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/39380845

Schlieben LD, Carta MG, Moskalev EA, Stohr R, Metzler M, Besendorfer M, Meidenbauer N, Semrau S, Janka R, Grutzmann R, Wiemann S, Hartmann A, Agaimy A, Haller F and Ferrazzi F: Machine Learning-Supported Diagnosis of Small Blue Round Cell Sarcomas Using Targeted RNA Sequencing. J Mol Diagn 2024, Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/38395409

2023

Ben-Yaakov H, Meshel T, Pasmanik-Chor M, Korner C and Ben-Baruch A: A Tumor Microenvironment-Driven Network Regulated by STAT3 and p65 Negatively Controls the Enrichment of Cancer Stem Cells in Human HR+/HER2- Breast Cancer. Cancers (Basel) 2023, 15 (8): Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/37190183

Beumers L, Vlachavas EI, Borgoni S, Schwarzmuller L, Penso-Dolfin L, Michels BE, Sofyali E, Burmester S, Heiss D, Wilhelm H, Yarden Y, Helm D, Will R, Goncalves A and Wiemann S: Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets. NPJ Breast Cancer 2023, 9 (1):97. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/38042915

Kontogianni G, Voutetakis K, Piroti G, Kypreou K, Stefanaki I, Vlachavas EI, Pilalis E, Stratigos A, Chatziioannou A and Papadodima O: A Comprehensive Analysis of Cutaneous Melanoma Patients in Greece Based on Multi-Omic Data. Cancers (Basel) 2023, 15 (3): Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/36765773

Ricordel C, Chaillot L, Vlachavas EI, Logotheti M, Jouannic A, Desvallees T, Lecuyer G, Aubry M, Kontogianni G, Mastrokalou C, Jouan F, Jarry U, Corre R, Le Guen Y, Guillaudeux T, Lena H, Chatziioannou A and Pedeux R: Genomic characteristics and clinical significance of CD56+ circulating tumor cells in small cell lung cancer. Sci Rep 2023, 13 (1):3626. Pubmed: https://pubmed.ncbi.nlm.nih.gov/36869231

2022

Chakraborty S, Andrieux G, Kastl P, Adlung L, Altamura S, Boehm ME, Schwarzmuller LE, Abdullah Y, Wagner MC, Helm B, Grone HJ, Lehmann WD, Boerries M, Busch H, Muckenthaler MU, Schilling M and Klingmuller U: Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo. Cell Rep 2022, 40 (12):111360. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/36130519

Kemmer S, Berdiel-Acer M, Reinz E, Sonntag J, Tarade N, Bernhardt S, Fehling-Kaschek M, Hasmann M, Korf U, Wiemann S and Timmer J: Disentangling ERBB Signaling in Breast Cancer Subtypes-A Model-Based Analysis. Cancers 2022, 14 (10):2379. Pubmed: https://pubmed.ncbi.nlm.nih.gov/35625984

Li X, Michels BE, Tosun OE, Jung J, Kappes J, Ibing S, Nataraj NB, Sahay S, Schneider M, Worner A, Becki C, Ishaque N, Feuerbach L, Hessling B, Helm D, Will R, Yarden Y, Muller-Decker K, Wiemann S and Korner C: 5'isomiR-183-5p|+2 elicits tumor suppressor activity in a negative feedback loop with E2F1. J Exp Clin Cancer Res 2022, 41 (1):190. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/35655310

Menck K, Wlochowitz D, Wachter A, Conradi LC, Wolff A, Scheel AH, Korf U, Wiemann S, Schildhaus HU, Bohnenberger H, Wingender E, Pukrop T, Homayounfar K, Beissbarth T and Bleckmann A: High-Throughput Profiling of Colorectal Cancer Liver Metastases Reveals Intra- and Inter-Patient Heterogeneity in the EGFR and WNT Pathways Associated with Clinical Outcome. Cancers (Basel) 2022, 14 (9): Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/35565214

Noronha A, Belugali Nataraj N, Lee JS, Zhitomirsky B, Oren Y, Oster S, Lindzen M, Mukherjee S, Will R, Ghosh S, Simoni-Nieves A, Verma A, Chatterjee R, Borgoni S, Robinson W, Sinha S, Brandis A, Kerr DL, Wu W, Sekar A, Giri S, Chung Y, Drago-Garcia D, Danysh BP, Lauriola M, Fiorentino M, Ardizzoni A, Oren M, Blakely CM, Ezike J, Wiemann S, Parida L, Bivona TG, Aqeilan RI, Brugge JS, Regev A, Getz G, Ruppin E and Yarden Y: AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer. Cancer Discov 2022, 12 (11):2666-83. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/35895872

Radke J, Ishaque N, Koll R, Gu Z, Schumann E, Sieverling L, Uhrig S, Hubschmann D, Toprak UH, Lopez C, Hostench XP, Borgoni S, Juraeva D, Pritsch F, Paramasivam N, Balasubramanian GP, Schlesner M, Sahay S, Weniger M, Pehl D, Radbruch H, Osterloh A, Korfel A, Misch M, Onken J, Faust K, Vajkoczy P, Moskopp D, Wang Y, Jodicke A, Trumper L, Anagnostopoulos I, Lenze D, Kuppers R, Hummel M, Schmitt CA, Wiestler OD, Wolf S, Unterberg A, Eils R, Herold-Mende C, Brors B, Consortium IM-S, Siebert R, Wiemann S and Heppner FL: The genomic and transcriptional landscape of primary central nervous system lymphoma. Nat Commun 2022, 13 (1):2558. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/35538064

Will R, Bauer K, Kudla M, Montero-Vergara J, Wiemann S, Jendrossek V, Pena-Llopis S and Vega-Rubin-de-Celis S: A Dual HiBiT-GFP-LC3 Lentiviral Reporter for Autophagy Flux Assessment. Methods Mol Biol 2022, 2445 75-98. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/34972987

2021

Berdiel-Acer M, Maia A, Hristova Z, Borgoni S, Vetter M, Burmester S, Becki C, Michels B, Abnaof K, Binenbaum I, Bethmann D, Chatziioannou A, Hasmann M, Thomssen C, Espinet E and Wiemann S: Stromal NRG1 in luminal breast cancer defines pro-fibrotic and migratory cancer-associated fibroblasts. Oncogene 2021, 40(15):2651-2666. Pubmed: https://pubmed.ncbi.nlm.nih.gov/33692466/

Bieg M, Moskalev EA, Will R, Hebele S, Schwarzbach M, Schmeck S, Hohenberger P, Jakob J, Kasper B, Gaiser T, Ströbel P, Wardelmann E, Kontny U, Braunschweig T, Sirbu H, Grützmann R, Meidenbauer N, Ishaque N, Eils R, Wiemann S, Hartmann A, Agaimy A, Fritchie K, Giannini C and Haller F: Gene expression in Solitary Fibrous Tumors (SFTs) correlates with anatomical localization and NAB2-STAT6 gene fusion variants. Am J Pathol 2021, 191(4):602-617. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/33497701

de Koning L, Bernhardt S, Macleod KG, Ouine B, Cartier A, Sibut V, Carragher NO, Korf U, Serrels B and Byron A: Multicenter reverse-phase protein array data integration. bioRxiv 2021, 2021.08.31.458377. Pubmed:

Giacomelli C, Jung J, Wachter A, Ibing S, Will R, Uhlmann S, Mannsperger H, Sahin Ö, Yarden Y, Beißbarth T, Korf U, Körner C and Wiemann S: Coordinated regulation of WNT/β-catenin, c-Met, and Integrin signalling pathways by miR-193b controls triple negative breast cancer metastatic traits. BMC Cancer 2021, 21(1):1296. Pubmed: https://pubmed.ncbi.nlm.nih.gov/34863149

Haga Y, Marrocco I, Noronha A, Uribe ML, Nataraj NB, Sekar A, Drago-Garcia D, Borgoni S, Lindzen M, Giri S, Wiemann S, Tsutsumi Y and Yarden Y: Host-dependent Phenotypic Resistance to EGFR Tyrosine Kinase Inhibitors. Cancer Res 2021, 81(14):3862-3875. Pubmed: https://pubmed.ncbi.nlm.nih.gov/33941614/

Haller F, Schlieben LD, Ferrazzi F, Michal M, Stöhr R, Moskalev EA, Bieg M, Bovée J, Ströbel P, Ishaque N, Grützmann R, Meidenbauer N, Eils R, Wiemann S, Hartmann A, Michal M and Agaimy A: Lipomatous solitary fibrous tumors harbor rare NAB2-STAT6 fusion variants and show upregulation of the gene Peroxisome Proliferator Activated Receptor Gamma (PPARG) encoding for a regulator of adipocyte differentiation. Am J Pathol 2021, 191(7):1314-1324. Pubmed: https://pubmed.ncbi.nlm.nih.gov/33887215/

Ibing S, Michels BE, Mosdzien M, Meyer HR, Feuerbach L and Korner C: On the impact of batch effect correction in TCGA isomiR expression data. NAR Cancer 2021, 3 (1):zcab007.. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/34316700

Kaminska K, Akrap N, Staaf J, Alves CL, Ehinger A, Ebbesson A, Hedenfalk I, Beumers L, Veerla S, Harbst K, Ehmsen S, Borgquist S, Borg A, Perez-Fidalgo A, Ditzel HJ, Bosch A and Honeth G: Distinct mechanisms of resistance to fulvestrant treatment dictate level of ER independence and selective response to CDK inhibitors in metastatic breast cancer. Breast Cancer Res 2021, 23(1):26. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/33602273

Koralli P, Tsikalakis S, Goulielmaki M, Arelaki S, Müller J, Nega AD, Herbst F, Ball CR, Gregoriou VG, Dimitrakopoulou-Strauss A, Wiemann S and Chochos CL: Rational design of aqueous conjugated polymer nanoparticles as potential theranostic agents of breast cancer. Materials Chemistry Frontiers 2021, 5(13):4950. DOI https://doi.org/10.1039/D1QM00479D

Maia A, Gu Z, Koch A, Berdiel-Acer M, Will R, Schlesner M and Wiemann S: IFNbeta1 secreted by breast cancer cells undergoing chemotherapy reprograms stromal fibroblasts to support tumour growth after treatment. Mol Oncol 2021, 15(5):1308-1329. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/33476079

Maia A, and Wiemann S: Cancer-associated fibroblasts: implications for cancer therapy. Cancers (Basel) 2021, 13, 3526. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/34298736

Menck K, Heinrichs S, Wlochowitz D, Sitte M, Noeding H, Janshoff A, Treiber H, Ruhwedel T, Schatlo B, von der Brelie C, Wiemann S, Pukrop T, Beißbarth T, Binder C and Bleckmann A: WNT11/ROR2 signaling is associated with tumor invasion and poor survival in breast cancer. J Exp Clin Cancer Res 2021, 40 (1):395. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/34911552

Mitra D, Vega-Rubin-de-Celis S, Royla N, Bernhardt S, Wilhelm H, Tarade N, Poschet G, Buettner M, Binenbaum I, Borgoni S, Vetter M, Kantelhardt EJ, Thomssen C, Chatziioannou A, Hell R, Kempa S, Muller-Decker K and Wiemann S: Abrogating GPT2 in triple-negative breast cancer inhibits tumor growth and promotes autophagy. Int J Cancer 2021, 148 (8):1993-2009. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/33368291

Vlachavas EI: Simple. Variant Ranking Annotation CAncer Score. R-package available in GitHub https://github.com/Jasonmbg/Simple.-Variant-Ranking-Annotation-CAncer-Score

Vlachavas EI, Bohn J, Ückert F and Nürnberg S: A Detailed Catalogue of Multi-Omics Methodologies for Identification of Putative Biomarkers and Causal Molecular Networks in Translational Cancer Research. Int J Mol Sci 2021, 22 (6):2822. Pubmed: https://www.mdpi.com/1422-0067/22/6/2822

Wahjudi LW, Bernhardt S, Abnaof K, Horak P, Kreutzfeldt S, Heining C, Borgoni S, Becki C, Berg D, Richter D, Hutter B, Uhrig S, Pfutze K, Leichsenring J, Glimm H, Brors B, von Kalle C, Stenzinger A, Korf U, Frohling S and Wiemann S: Integrating proteomics into precision oncology. Int J Cancer 2021, 148 (6):1438-51. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/32949162

2020

Borgoni S, Sofyalı E, Soleimani M, Wilhelm H, Müller-Decker K, Will R, Noronha A, Verschure PJ, Yarden Y, Magnani L, van Kampen AHC, Moerland PD and Wiemann S: Time-resolved profiling reveals ATF3 as a novel mediator of endocrine resistance in breast cancer. Cancers (Basel) 2020, 12 (10) Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/33050633

Byron A, Bernhardt S, Ouine B, Cartier A, Macleod KG, Carragher NO, Sibut V, Korf U, Serrels B and de Koning L: Integrative analysis of multi-platform reverse-phase protein array data for the pharmacodynamic assessment of response to targeted therapies. Sci Rep 2020, 10 (1):21985. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/33319783

Dadiani M, Necula D, Kahana-Edwin S, Oren N, Baram T, Marin I, Morzaev-Sulzbach D, Pavlovski A, Balint-Lahat N, Anafi L, Wiemann S, Korner C, Gal-Yam EN, Avivi C, Kaufman B, Barshack I and Ben-Baruch A: TNFR2+ TILs are significantly associated with improved survival in triple-negative breast cancer patients. Cancer Immunol Immunother 2020, 69 (7):1315-26. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/32198536

Haller F, Moskalev EA, Kuck S, Bieg M, Winkelmann C, Muller SK, Ihrler S, Markl B, Eils R, Wiemann S, Iro H, Hartmann A and Agaimy A: Nuclear NR4A2 (Nurr1) Immunostaining is a Novel Marker for Acinic Cell Carcinoma of the Salivary Glands Lacking the Classic NR4A3 (NOR-1) Upregulation. Am J Surg Pathol 2020, Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/32341238

Hentrich T, Koch A, Weber N, Kilzheimer A, Maia A, Burkhardt S, Rall K, Casadei N, Kohlbacher O, Riess O, Schulze-Hentrich JM and Brucker SY: The Endometrial Transcription Landscape of MRKH Syndrome. Front Cell Dev Biol 2020, 8 572281. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/33072755

Lin BD, Colas F, Nijman IJ, Medic J, Brands W, Parr JR, van Eijk KR, Klauck SM, Chiocchetti AG, Freitag CM, Maestrini E, Bacchelli E, Coon H, Vicente A, Oliveira G, Pagnamenta AT, Gallagher L, Ennis S, Anney R, Bourgeron T, Luykx JJ and Vorstman J: The role of rare compound heterozygous events in autism spectrum disorder. Transl Psychiatry 2020, 10 (1):204. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/32572023

López-Cortés A, Paz YMC, Guerrero S, Jaramillo-Koupermann G, León Cáceres Á, Intriago-Baldeón DP, García-Cárdenas JM, Guevara-Ramírez P, Armendáriz-Castillo I, Leone PE, Quiñones LA, Cayún JP and Soria NW: Pharmacogenomics, biomarker network, and allele frequencies in colorectal cancer. Pharmacogenomics J 2020, 20 (1):136-58. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/31616044

Soleimani Dodaran M, Borgoni S, Sofyali E, Verschure PJ, Wiemann S, Moerland PD, and van Kampen AHC. Candidate methylation sites associated with endocrine therapy resistance in ER+/HER2- breast cancer. BMC Cancer 2020, 20, 676. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/32684154

Yousaf A, Waltes R, Haslinger D, Klauck SM, Duketis E, Sachse M, Voran A, Biscaldi M, Schulte-Rüther M, Cichon S, Nöthen M, Ackermann J, Koch I, Freitag CM and Chiocchetti AG: Quantitative genome-wide association study of six phenotypic subdomains identifies novel genome-wide significant variants in autism spectrum disorder. Transl Psychiatry 2020, 10 (1):215. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/32624584

2019

Bernhardt S, Tonsing C, Mitra D, Erdem N, Muller-Decker K, Korf U, Kreutz C, Timmer J and Wiemann S: Functional Proteomics of Breast Cancer Metabolism Identifies GLUL as Responder during Hypoxic Adaptation. J Proteome Res 2019, 18 (3):1352-62. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/30609375

Giotti B, Chen SH, Barnett MW, Regan T, Ly T, Wiemann S, Hume DA and Freeman TC: Assembly of a parts list of the human mitotic cell cycle machinery. J Mol Cell Biol 2019, 11 (8):703-18. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/30452682

Grove J, Ripke S, Als TD, Mattheisen M, Walters RK, Won H, Pallesen J, Agerbo E, Andreassen OA, Anney R, Awashti S, Belliveau R, Bettella F, Buxbaum JD, Bybjerg-Grauholm J, Baekvad-Hansen M, Cerrato F, Chambert K, Christensen JH, Churchhouse C, Dellenvall K, Demontis D, De Rubeis S, Devlin B, Djurovic S, Dumont AL, Goldstein JI, Hansen CS, Hauberg ME, Hollegaard MV, Hope S, Howrigan DP, Huang H, Hultman CM, Klei L, Maller J, Martin J, Martin AR, Moran JL, Nyegaard M, Naerland T, Palmer DS, Palotie A, Pedersen CB, Pedersen MG, dPoterba T, Poulsen JB, Pourcain BS, Qvist P, Rehnstrom K, Reichenberg A, Reichert J, Robinson EB, Roeder K, Roussos P, Saemundsen E, Sandin S, Satterstrom FK, Davey Smith G, Stefansson H, Steinberg S, Stevens CR, Sullivan PF, Turley P, Walters GB, Xu X, Autism Spectrum Disorder Working Group of the Psychiatric Genomics C, Bupgen, Major Depressive Disorder Working Group of the Psychiatric Genomics C, andMe Research T, Stefansson K, Geschwind DH, Nordentoft M, Hougaard DM, Werge T, Mors O, Mortensen PB, Neale BM, Daly MJ and Borglum AD: Identification of common genetic risk variants for autism spectrum disorder. Nat Genet 2019, 51 (3):431-44. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/30804558

Guillen Diaz-Maroto N, Sanz-Pamplona R, Berdiel-Acer M, Cimas FJ, Garcia E, Goncalves-Ribeiro S, Albert N, Garcia-Vicien G, Capella G, Moreno V, Salazar R, Villanueva A and Mollevi DG: Noncanonical TGFbeta Pathway Relieves the Blockade of IL1beta/TGFbeta-Mediated Crosstalk between Tumor and Stroma: TGFBR1 and TAK1 Inhibition in Colorectal Cancer. Clin Cancer Res 2019, 25 (14):4466-79. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/30979739

Haller F, Bieg M, Will R, Korner C, Weichenhan D, Bott A, Ishaque N, Lutsik P, Moskalev EA, Mueller SK, Bahr M, Woerner A, Kaiser B, Scherl C, Haderlein M, Kleinheinz K, Fietkau R, Iro H, Eils R, Hartmann A, Plass C, Wiemann S and Agaimy A: Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands. Nat Commun 2019, 10 (1):368. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/30664630

Haller F, Skalova A, Ihrler S, Markl B, Bieg M, Moskalev EA, Erber R, Blank S, Winkelmann C, Hebele S, Baneckova M, Wiemann S, Muller S, Zenk J, Eils R, Iro H, Hartmann A and Agaimy A: Nuclear NR4A3 Immunostaining Is a Specific and Sensitive Novel Marker for Acinic Cell Carcinoma of the Salivary Glands. Am J Surg Pathol 2019, 43 (9):1264-72. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/31094928

Liubomirski Y, Lerrer S, Meshel T, Morein D, Rubinstein-Achiasaf L, Sprinzak D, Wiemann S, Korner C, Ehrlich M and Ben-Baruch A: Notch-Mediated Tumor-Stroma-Inflammation Networks Promote Invasive Properties and CXCL8 Expression in Triple-Negative Breast Cancer. Front Immunol 2019, 10 804. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/31105691

Liubomirski Y, Lerrer S, Meshel T, Rubinstein-Achiasaf L, Morein D, Wiemann S, Korner C and Ben-Baruch A: Tumor-Stroma-Inflammation Networks Promote Pro-metastatic Chemokines and Aggressiveness Characteristics in Triple-Negative Breast Cancer. Front Immunol 2019, 10 757. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/31031757

Lopez-Cortes A, Paz YMC, Guerrero S, Jaramillo-Koupermann G, Leon Caceres A, Intriago-Baldeon DP, Garcia-Cardenas JM, Guevara-Ramirez P, Armendariz-Castillo I, Leone PE, Quinones LA, Cayun JP and Soria NW: Pharmacogenomics, biomarker network, and allele frequencies in colorectal cancer. Pharmacogenomics J 2019, Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/31616044

Sitte M, Menck K, Wachter A, Reinz E, Korf U, Wiemann S, Bleckmann A and Beissbarth T: Reconstruction of Different Modes of WNT Dependent Protein Networks from Time Series Protein Quantification. Stud Health Technol Inform 2019, 267 175-80. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/31483270

2018

Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nothen MM, Rossor M, Lupton MK, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis JC, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee SJ, De Jager PL, Geschwind DH, Riemenschneider M, Riedel-Heller S, Rotter JI, Ransmayr G, Hyman BT, Cruchaga C, Alegret M, Winsvold B, Palta P, Farh KH, Cuenca-Leon E, Furlotte N, Kurth T, Ligthart L, Terwindt GM, Freilinger T, Ran C, Gordon SD, Borck G, Adams HHH, Lehtimaki T, Wedenoja J, Buring JE, Schurks M, Hrafnsdottir M, Hottenga JJ, Penninx B, Artto V, Kaunisto M, Vepsalainen S, Martin NG, Montgomery GW, Kurki MI, Hamalainen E, Huang H, Huang J, Sandor C, Webber C, Muller-Myhsok B, Schreiber S, Salomaa V, Loehrer E, Gobel H, Macaya A, Pozo-Rosich P, Hansen T, Werge T, Kaprio J, Metspalu A, Kubisch C, Ferrari MD, Belin AC, van den Maagdenberg A, Zwart JA, Boomsma D, Eriksson N, Olesen J, Chasman DI, Nyholt DR, Avbersek A, Baum L, Berkovic S, Bradfield J, Buono R, Catarino CB, Cossette P, De Jonghe P, Depondt C, Dlugos D, Ferraro TN, French J, Hjalgrim H, Jamnadas-Khoda J, Kalviainen R, Kunz WS, Lerche H, Leu C, Lindhout D, Lo W, Lowenstein D, McCormack M, Moller RS, Molloy A, Ng PW, Oliver K, Privitera M, Radtke R, Ruppert AK, Sander T, Schachter S, Schankin C, Scheffer I, Schoch S, Sisodiya SM, Smith P, Sperling M, Striano P, Surges R, Thomas GN, Visscher F, Whelan CD, Zara F, Heinzen EL, Marson A, Becker F, Stroink H, Zimprich F, Gasser T, Gibbs R, Heutink P, Martinez M, Morris HR, Sharma M, Ryten M, Mok KY, Pulit S, Bevan S, Holliday E, Attia J, Battey T, Boncoraglio G, Thijs V, Chen WM, Mitchell B, Rothwell P, Sharma P, Sudlow C, Vicente A, Markus H, Kourkoulis C, Pera J, Raffeld M, Silliman S, Boraska Perica V, Thornton LM, Huckins LM, William Rayner N, Lewis CM, Gratacos M, Rybakowski F, Keski-Rahkonen A, Raevuori A, Hudson JI, Reichborn-Kjennerud T, Monteleone P, Karwautz A, Mannik K, Baker JH, O'Toole JK, Trace SE, Davis OSP, Helder SG, Ehrlich S, Herpertz-Dahlmann B, Danner UN, van Elburg AA, Clementi M, Forzan M, Docampo E, Lissowska J, Hauser J, Tortorella A, Maj M, Gonidakis F, Tziouvas K, Papezova H, Yilmaz Z, Wagner G, Cohen-Woods S, Herms S, Julia A, Rabionet R, Dick DM, Ripatti S, Andreassen OA, Espeseth T, Lundervold AJ, Steen VM, Pinto D, Scherer SW, Aschauer H, Schosser A, Alfredsson L, Padyukov L, Halmi KA, Mitchell J, Strober M, Bergen AW, Kaye W, Szatkiewicz JP, Cormand B, Ramos-Quiroga JA, Sanchez-Mora C, Ribases M, Casas M, Hervas A, Arranz MJ, Haavik J, Zayats T, Johansson S, Williams N, Dempfle A, Rothenberger A, Kuntsi J, Oades RD, Banaschewski T, Franke B, Buitelaar JK, Arias Vasquez A, Doyle AE, Reif A, Lesch KP, Freitag C, Rivero O, Palmason H, Romanos M, Langley K, Rietschel M, Witt SH, Dalsgaard S, Borglum AD, Waldman I, Wilmot B, Molly N, Bau CHD, Crosbie J, Schachar R, Loo SK, McGough JJ, Grevet EH, Medland SE, Robinson E, Weiss LA, Bacchelli E, Bailey A, Bal V, Battaglia A, Betancur C, Bolton P, Cantor R, Celestino-Soper P, Dawson G, De Rubeis S, Duque F, Green A, Klauck SM, Leboyer M, Levitt P, Maestrini E, Mane S, De-Luca DM, Parr J, Regan R, Reichenberg A, Sandin S, Vorstman J, Wassink T, Wijsman E, Cook E, Santangelo S, Delorme R, Roge B, Magalhaes T, Arking D, Schulze TG, Thompson RC, Strohmaier J, Matthews K, Melle I, Morris D, Blackwood D, McIntosh A, Bergen SE, Schalling M, Jamain S, Maaser A, Fischer SB, Reinbold CS, Fullerton JM, Guzman-Parra J, Mayoral F, Schofield PR, Cichon S, Muhleisen TW, Degenhardt F, Schumacher J, Bauer M, Mitchell PB, Gershon ES, Rice J, Potash JB, Zandi PP, Craddock N, Ferrier IN, Alda M, Rouleau GA, Turecki G, Ophoff R, Pato C, Anjorin A, Stahl E, Leber M, Czerski PM, Cruceanu C, Jones IR, Posthuma D, Andlauer TFM, Forstner AJ, Streit F, Baune BT, Air T, Sinnamon G, Wray NR, MacIntyre DJ, Porteous D, Homuth G, Rivera M, Grove J, Middeldorp CM, Hickie I, Pergadia M, Mehta D, Smit JH, Jansen R, de Geus E, Dunn E, Li QS, Nauck M, Schoevers RA, Beekman AT, Knowles JA, Viktorin A, Arnold P, Barr CL, Bedoya-Berrio G, Bienvenu OJ, Brentani H, Burton C, Camarena B, Cappi C, Cath D, Cavallini M, Cusi D, Darrow S, Denys D, Derks EM, Dietrich A, Fernandez T, Figee M, Freimer N, Gerber G, Grados M, Greenberg E, Hanna GL, Hartmann A, Hirschtritt ME, Hoekstra PJ, Huang A, Huyser C, Illmann C, Jenike M, Kuperman S, Leventhal B, Lochner C, Lyon GJ, Macciardi F, Madruga-Garrido M, Malaty IA, Maras A, McGrath L, Miguel EC, Mir P, Nestadt G, Nicolini H, Okun MS, Pakstis A, Paschou P, Piacentini J, Pittenger C, Plessen K, Ramensky V, Ramos EM, Reus V, Richter MA, Riddle MA, Robertson MM, Roessner V, Rosario M, Samuels JF, Sandor P, Stein DJ, Tsetsos F, Van Nieuwerburgh F, Weatherall S, Wendland JR, Wolanczyk T, Worbe Y, Zai G, Goes FS, McLaughlin N, Nestadt PS, Grabe HJ, Depienne C, Konkashbaev A, Lanzagorta N, Valencia-Duarte A, Bramon E, Buccola N, Cahn W, Cairns M, Chong SA, Cohen D, Crespo-Facorro B, Crowley J, Davidson M, DeLisi L, Dinan T, Donohoe G, Drapeau E, Duan J, Haan L, Hougaard D, Karachanak-Yankova S, Khrunin A, Klovins J, Kucinskas V, Lee Chee Keong J, Limborska S, Loughland C, Lonnqvist J, Maher B, Mattheisen M, McDonald C, Murphy KC, Nenadic I, van Os J, Pantelis C, Pato M, Petryshen T, Quested D, Roussos P, Sanders AR, Schall U, Schwab SG, Sim K, So HC, Stogmann E, Subramaniam M, Toncheva D, Waddington J, Walters J, Weiser M, Cheng W, Cloninger R, Curtis D, Gejman PV, Henskens F, Mattingsdal M, Oh SY, Scott R, Webb B, Breen G, Churchhouse C, Bulik CM, Daly M, Dichgans M, Faraone SV, Guerreiro R, Holmans P, Kendler KS, Koeleman B, Mathews CA, Price A, Scharf J, Sklar P, Williams J, Wood NW, Cotsapas C, Palotie A, Smoller JW, Sullivan P, Rosand J, Corvin A, Neale BM, Schott JM, Anney R, Elia J, Grigoroiu-Serbanescu M, Edenberg HJ and Murray R: Analysis of shared heritability in common disorders of the brain. Science 2018, 360 (6395): Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/29930110

Blazquez R, Wlochowitz D, Wolff A, Seitz S, Wachter A, Perera-Bel J, Bleckmann A, Beissbarth T, Salinas G, Riemenschneider MJ, Proescholdt M, Evert M, Utpatel K, Siam L, Schatlo B, Balkenhol M, Stadelmann C, Schildhaus HU, Korf U, Reinz E, Wiemann S, Vollmer E, Schulz M, Ritter U, Hanisch UK and Pukrop T: PI3K: A master regulator of brain metastasis-promoting macrophages/microglia. Glia 2018, 66 (11):2438-55. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/30357946

Breunig C, Erdem N, Bott A, Greiwe JF, Reinz E, Bernhardt S, Giacomelli C, Wachter A, Kanthelhardt EJ, Beissbarth T, Vetter M and Wiemann S: TGFbeta1 regulates HGF-induced cell migration and hepatocyte growth factor receptor MET expression via C-ets-1 and miR-128-3p in basal-like breast cancer. Mol Oncol 2018, Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/30004628

Bure I, Geer S, Knopf J, Roas M, Henze S, Strobel P, Agaimy A, Wiemann S, Hoheisel JD, Hartmann A, Haller F, Moskalev EA: Long noncoding RNA HOTAIR is upregulated in an aggressive subgroup of gastrointestinal stromal tumors (GIST) and mediates the establishment of gene-specific DNA methylation patterns. Genes Chromosomes Cancer 2018, 57(11):584-597. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/30248209

Chiocchetti AG, Yousaf A, Bour HS, Haslinger D, Waltes R, Duketis E, Jarczok T, Sachse M, Biscaldi M, Degenhardt F, Herms S, Cichon S, Ackermann J, Koch I, Klauck SM and Freitag CM: Common functional variants of the glutamatergic system in Autism spectrum disorder with high and low intellectual abilities. J Neural Transm (Vienna) 2018, 125 (2):259-71. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/29147782

Dimitrov B, Himmelreich N, Hipgrave Ederveen AL, Luchtenborg C, Okun JG, Breuer M, Hutter AM, Carl M, Guglielmi L, Hellwig A, Thiemann KC, Jost M, Peters V, Staufner C, Hoffmann GF, Hackenberg A, Paramasivam N, Wiemann S, Eils R, Schlesner M, Strahl S, Brugger B, Wuhrer M, Christoph Korenke G and Thiel C: Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolomics as additional symptoms in a new patient with ATP6AP1-CDG. Mol Genet Metab 2018, 123 (3):364-74. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/29396028

Giotti B, Chen SH, Barnett MW, Regan T, Ly T, Wiemann S, Hume DA, Freeman TC: Assembly of a Parts List of the Human Mitotic Cell Cycle Machinery. J Mol Cell Biol 2018. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/30452682

Mishra RR, Belder N, Ansari SA, Kayhan M, Bal H, Raza U, Ersan PG, Tokat UM, Eyupoglu E, Saatci O, Jandaghi P, Wiemann S, Uner A, Cekic C, Riazalhosseini Y and Sahin O: Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer. Clin Cancer Res 2018, 24 (8):1987-2001. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/29386221

Paramasivam N, Granzow M, Evers C, Hinderhofer K, Wiemann S, Bartram C, Eils R and Schlesner M: Identification and Prioritization of Causal Variants of Human Genetic Disorders from Exome or Whole Genome Sequencing Data. OBM Genetics 2018, 2 (2):1 DOI: http://dx.doi.org/10.21926/obm.genet.1802017

Quandt J, Schlude C, Bartoschek M, Will R, Cid-Arregui A, Scholch S, Reissfelder C, Weitz J, Schneider M, Wiemann S, Momburg F, Beckhove P: Long-peptide vaccination with driver gene mutations in p53 and Kras induces cancer mutation-specific effector as well as regulatory T cell responses. Oncoimmunology 2018, 7(12):e1500671. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/30524892

Saatci O, Borgoni S, Akbulut O, Durmus S, Raza U, Eyupoglu E, Alkan C, Akyol A, Kutuk O, Wiemann S and Sahin O: Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer. Oncogene 2018, 37 (17):2251-69. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/29391599

Simm F, Griesbeck A, Choukair D, Weiss B, Paramasivam N, Klammt J, Schlesner M, Wiemann S, Martinez C, Hoffmann GF, Pfaffle RW, Bettendorf M and Rappold GA: Identification of SLC20A1 and SLC15A4 among other genes as potential risk factors for combined pituitary hormone deficiency. Genet Med 2018, 20 (7):728-36. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/29261175

Vega-Rubin-de-Celis S, Zou Z, Fernandez AF, Ci B, Kim M, Xiao G, Xie Y and Levine B: Increased autophagy blocks HER2-mediated breast tumorigenesis. Proc Natl Acad Sci U S A 2018, 115 (16):4176-81. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/29610308

2017

Agaimy A, Bieg M, Michal M, Geddert H, Markl B, Seitz J, Moskalev EA, Schlesner M, Metzler M, Hartmann A, Wiemann S, Michal M, Mentzel T and Haller F: Recurrent Somatic PDGFRB Mutations in Sporadic Infantile/Solitary Adult Myofibromas But Not in Angioleiomyomas and Myopericytomas. Am J Surg Pathol 2017, 41 (2):195-203. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/27776010

Bernhardt S, Bayerlova M, Vetter M, Wachter A, Mitra D, Hanf V, Lantzsch T, Uleer C, Peschel S, John J, Buchmann J, Weigert E, Burrig KF, Thomssen C, Korf U, Beissbarth T, Wiemann S and Kantelhardt EJ: Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors. Breast Cancer Res 2017, 19 (1):112. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/29020998

Bikker FJ, End C, Ligtenberg AJM, Blaich S, Lyer S, Renner M, Wittig R, Nazmi K, van Nieuw Amerongen A, Poustka A, Veerman ECI and Mollenhauer J: The scavenging capacity of DMBT1 is impaired by germline deletions. Immunogenetics 2017, 69 (6):401-7. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/28364129

Bott A, Erdem N, Lerrer S, Hotz-Wagenblatt A, Breunig C, Abnaof K, Worner A, Wilhelm H, Munstermann E, Ben-Baruch A and Wiemann S: miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A. Oncotarget 2017, 8(27):43897-43914. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/28159925

Breunig C, Pahl J, Kublbeck M, Miller M, Antonelli D, Erdem N, Wirth C, Will R, Bott A, Cerwenka A and Wiemann S: MicroRNA-519a-3p mediates apoptosis resistance in breast cancer cells and their escape from recognition by natural killer cells. Cell Death Dis 2017, 8 (8):e2973. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/28771222

Bure I, Braun A, Kayser C, Geddert H, Schaefer IM, Cameron S, Ghadimi MB, Strobel P, Werner M, Hartmann A, Wiemann S, Agaimy A, Haller F and Moskalev EA: The expression of hematopoietic progenitor cell antigen CD34 is regulated by DNA methylation in a site-dependent manner in gastrointestinal stromal tumours (GISTs). Int J Cancer 2017, 141(11): 2296-2304. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/28744850

Consortium ASDWGoTPG: Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. Mol Autism 2017, 8 21. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/28540026

Enuka Y, Feldman ME, Chowdhury A, Srivastava S, Lindzen M, Sas-Chen A, Massart R, Cheishvili D, Suderman MJ, Zaltsman Y, Mazza CA, Shukla K, Korner C, Furth N, Lauriola M, Oren M, Wiemann S, Szyf M and Yarden Y: Epigenetic mechanisms underlie the crosstalk between growth factors and a steroid hormone. Nucleic Acids Res 2017, 45(22):12681-12699. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/29036586

Evers C, Staufner C, Granzow M, Paramasivam N, Hinderhofer K, Kaufmann L, Fischer C, Thiel C, Opladen T, Kotzaeridou U, Wiemann S, Schlesner M, Eils R, Kolker S, Bartram CR, Hoffmann GF and Moog U: Impact of clinical exomes in neurodevelopmental and neurometabolic disorders. Mol Genet Metab 2017, 121 (4):297-307. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/28688840

Evrony GD, Cordero DR, Shen J, Partlow JN, Yu TW, Rodin RE, Hill RS, Coulter ME, Lam AN, Jayaraman D, Gerrelli D, Diaz DG, Santos C, Morrison V, Galli A, Tschulena U, Wiemann S, Martel MJ, Spooner B, Ryu SC, Elhosary PC, Richardson JM, Tierney D, Robinson CA, Chibbar R, Diudea D, Folkerth R, Wiebe S, Barkovich AJ, Mochida GH, Irvine J, Lemire EG, Blakley P and Walsh CA: Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factor DONSON as the cause of microcephaly-micromelia syndrome. Genome Res 2017, 27 (8):1323-35. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/28688840

Golan-Lavi R, Giacomelli C, Fuks G, Zeisel A, Sonntag J, Sinha S, Köstler W, Wiemann S, Korf U, Yarden Y and Domany E: Coordinated Pulses of mRNA and of Protein Translation or Degradation Produce EGF-Induced Protein Bursts. Cell Reports 2017, 18 (13):3129-42. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/28355565

Lerrer S, Liubomirski Y, Bott A, Abnaof K, Oren N, Yousaf A, Korner C, Meshel T, Wiemann S and Ben-Baruch A: Co-Inflammatory Roles of TGFbeta1 in the Presence of TNFalpha Drive a Pro-inflammatory Fate in Mesenchymal Stem Cells. Front Immunol 2017, 8(479):479. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/28553282

Peckys DB, Korf U, Wiemann S and de Jonge N: Liquid-phase electron microscopy of molecular drug response in breast cancer cells reveals irresponsive cell subpopulations related to lack of HER2 homodimers. Mol Biol Cell 2017, epub. Pubmed: www.ncbi.nlm.nih.gov/pubmed/28794264

Rafiullah R, Long AB, Ivanova AA, Ali H, Berkel S, Mustafa G, Paramasivam N, Schlesner M, Wiemann S, Wade RC, Bolthauser E, Blum M, Kahn RA, Caspary T, Rappold GA: A novel homozygous ARL13B variant in patients with Joubert syndrome impairs its guanine nucleotide-exchange factor activity. Eur J Hum Genet 2017, 25(12):1324-1334. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/29255182

Vega-Rubin-de-Celis S, Pena-Llopis S, Konda M and Brugarolas J: Multistep regulation of TFEB by MTORC1. Autophagy 2017, 13 (3):464-72. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/28055300

Weiner DJ, Wigdor EM, Ripke S, Walters RK, Kosmicki JA, Grove J, Samocha KE, Goldstein JI, Okbay A, Bybjerg-Grauholm J, Werge T, Hougaard DM, Taylor J, Skuse D, Devlin B, Anney R, Sanders SJ, Bishop S, Mortensen PB, Borglum AD, Smith GD, Daly MJ and Robinson EB: Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders. Nat Genet 2017, 49 (7):978-85. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/28504703

Wittig-Blaich S, Wittig R, Schmidt S, Lyer S, Bewerunge-Hudler M, Gronert-Sum S, Strobel-Freidekind O, Muller C, List M, Jaskot A, Christiansen H, Hafner M, Schadendorf D, Block I and Mollenhauer J: Systematic screening of isogenic cancer cells identifies DUSP6 as context-specific synthetic lethal target in melanoma. Oncotarget 2017, 8 (14):23760-74. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/28423600

2016

Bauer T, Trump S, Ishaque N, Thurmann L, Gu L, Bauer M, Bieg M, Gu Z, Weichenhan D, Mallm JP, Roder S, Herberth G, Takada E, Mucke O, Winter M, Junge KM, Grutzmann K, Rolle-Kampczyk U, Wang Q, Lawerenz C, Borte M, Polte T, Schlesner M, Schanne M, Wiemann S, Georg C, Stunnenberg HG, Plass C, Rippe K, Mizuguchi J, Herrmann C, Eils R and Lehmann I: Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children. Mol Syst Biol 2016, 12 (3):861 Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/27013061

Haller F, Knopf J, Ackermann A, Bieg M, Kleinheinz K, Schlesner M, Moskalev EA, Will R, Satir AA, Abdelmagid IE, Giedl J, Carbon R, Rompel O, Hartmann A, Wiemann S, Metzler M and Agaimy A: Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: a subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern. J Pathol 2016, 238 (5):700-10. Pubmed: www.ncbi.nlm.nih.gov/pubmed/26863915

Leszczynska KB, Göttgens EL, Biasoli D, Olcina MM, Ient J, Anbalagan S, Bernhardt S, Giaccia AJ, Hammond EM. Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1. Sci Rep. 2016 Feb 15;6:21698. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/26875667

Marzi MJ, Ghini F, Cerruti B, de Pretis S, Bonetti P, Giacomelli C, Gorski MM, Kress T, Pelizzola M, Muller H, Amati B and Nicassio F: Degradation dynamics of microRNAs revealed by a novel pulse-chase approach. Genome Res 2016, 26 (4):554-65. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/26821571

Prins BP, Abbasi A, Wong A, Vaez A, Nolte I, Franceschini N, Stuart PE, Guterriez Achury J, Mistry V, Bradfield JP, Valdes AM, Bras J, Shatunov A, Consortium P, International Stroke Genetics C, Systemic Sclerosis c, Treat OAc, Consortium D, Consortium CAD, consortium ALS, International Parkinson's Disease Genomics C, Autism Spectrum Disorder Working Group of the Psychiatric Genomics C, consortium CK, Consortium G, International Consortium for Blood P, Schizophrenia Working Group of the Psychiatric Genomics C, Inflammation Working Group of the CC, Lu C, Han B, Raychaudhuri S, Bevan S, Mayes MD, Tsoi LC, Evangelou E, Nair RP, Grant SF, Polychronakos C, Radstake TR, van Heel DA, Dunstan ML, Wood NW, Al-Chalabi A, Dehghan A, Hakonarson H, Markus HS, Elder JT, Knight J, Arking DE, Spector TD, Koeleman BP, van Duijn CM, Martin J, Morris AP, Weersma RK, Wijmenga C, Munroe PB, Perry JR, Pouget JG, Jamshidi Y, Snieder H and Alizadeh BZ: Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. PLoS Med 2016, 13 (6):e1001976. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/27327646

Rafiullah R, Aslamkhan M, Paramasivam N, Thiel C, Mustafa G, Wiemann S, Schlesner M, Wade RC, Rappold GA and Berkel S: Homozygous missense mutation in the LMAN2L gene segregates with intellectual disability in a large consanguineous Pakistani family. J Med Genet 2016, 53 (2):138-44. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/26566883

Salem O, Erdem N, Jung J, Munstermann E, Worner A, Wilhelm H, Wiemann S and Korner C: The highly expressed 5'isomiR of hsa-miR-140-3p contributes to the tumor-suppressive effects of miR-140 by reducing breast cancer proliferation and migration. BMC Genomics 2016, 17 566. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/27502506

Sas-Chen A, Aure MR, Leibovich L, Carvalho S, Enuka Y, Korner C, Polycarpou-Schwarz M, Lavi S, Nevo N, Kuznetsov Y, Yuan J, Azuaje F, Oslo Breast Cancer Research Consortium SauerTorillGeislerJurgenHofvindSolveigBathenTone FAMGCKK, Ulitsky I, Diederichs S, Wiemann S, Yakhini Z, Kristensen VN, Borresen-Dale AL and Yarden Y: LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer. EMBO Mol Med 2016, 8 (9):1052-64. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/27485121

Surges R, Kretschmann A, Abnaof K, van Rikxoort M, Ridder K, Frohlich H, Danis B, Kaminski RM, Foerch P, Elger CE, Weinsberg F and Pfeifer A: Changes in serum miRNAs following generalized convulsive seizures in human mesial temporal lobe epilepsy. Biochem Biophys Res Commun 2016, 481 (1-2):13-8. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/27833019

von der Heyde S, Sonntag J, Kramer F, Bender C, Korf U and Beissbarth T: Reconstruction of Protein Networks Using Reverse-Phase Protein Array Data. Methods Mol Biol 2016, 1362 227-46. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/26519181

Weitzenfeld P, Kossover O, Korner C, Meshel T, Wiemann S, Seliktar D, Legler DF and Ben-Baruch A: Chemokine axes in breast cancer: factors of the tumor microenvironment reshape the CCR7-driven metastatic spread of luminal-A breast tumors. J Leukoc Biol 2016, 99 (6):1009-25. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/26936935

Wiemann S PC, Hu Y, Hunter P, Harbers M, Amiet A, Bethel G, Busse M, Carninci P, Dunham I, Hao T, Harper JW, Hayashizaki Y, Heil O, Hennig S, Hotz-Wagenblatt A, Jang W, Jöcker A, Kawai J, Koenig C, Korn B, Lambert C, LeBeau A, Lu S, Maurer J, Moore T, Ohara O, Park J, Rolfs A, Salehi-Ashtiani K, Seiler C, Simmons B, van Brabant Smith A, Steel J, Wagner L, Weaver T, Wellenreuther R, Yang S, Vidal M, Gerhard DS, LaBaer J, Temple G, Hill DE: The ORFeome Collaboration: a genome-scale human ORF-clone resource. Nat Methods 2016, 13 (3):191-2. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/26914201

Winkler EC and Wiemann S: Findings made in gene panel to whole genome sequencing: data, knowledge, ethics - and consequences? Expert Rev Mol Diagn 2016, 16 (12):1259-70. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/27409399

2015

Barrangou R, Birmingham A, Wiemann S, Beijersbergen RL, Hornung V, Smith A: Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference. Nucleic Acids Res 2015, 43(7):3407-3419. PMID: 25800748 Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25800748

Ben-Chetrit N, Chetrit D, Russell R, Korner C, Mancini M, Abdul-Hai A, Itkin T, Carvalho S, Cohen-Dvashi H, Koestler WJ, Shukla K, Lindzen M, Kedmi M, Lauriola M, Shulman Z, Barr H, Seger D, Ferraro DA, Pareja F, Gil-Henn H, Lapidot T, Alon R, Milanezi F, Symons M, Ben-Hamo R, Efroni S, Schmitt F, Wiemann S, Caldas C, Ehrlich M and Yarden Y: Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer. Sci Signal 2015, 8 (360):ra7. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25605973

Ceroni F, Simpson NH, Francks C, Baird G, Conti-Ramsden G, Clark A, Bolton PF, Hennessy ER, Donnelly P, Bentley DR, Martin H, Imgsac, Consortium SLI, Consortium WGS, Parr J, Pagnamenta AT, Maestrini E, Bacchelli E, Fisher SE and Newbury DF: Reply to Pembrey et al: 'ZNF277 microdeletions, specific language impairment and the meiotic mismatch methylation (3M) hypothesis'. Eur J Hum Genet 2015, 23 (9):1113-5. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25537359

Chiocchetti AG, Kopp M, Waltes R, Haslinger D, Duketis E, Jarczok TA, Poustka F, Voran A, Graab U, Meyer J, Klauck SM, Fulda S and Freitag CM: Variants of the CNTNAP2 5' promoter as risk factors for autism spectrum disorders: a genetic and functional approach. Mol Psychiatry 2015, 20 (7):839-49. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25224256

Cohen-Dvashi H, Ben-Chetrit N, Russell R, Carvalho S, Lauriola M, Nisani S, Mancini M, Nataraj N, Kedmi M, Roth L, Kostler W, Zeisel A, Yitzhaky A, Zylberg J, Tarcic G, Eilam R, Wigelman Y, Will R, Lavi S, Porat Z, Wiemann S, Ricardo S, Schmitt F, Caldas C and Yarden Y: Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression. EMBO Mol Med 2015, 7 (3):299-314. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25678558

Frohlich H, Bahamondez G, Gotschel F and Korf U: Dynamic Bayesian Network Modeling of the Interplay between EGFR and Hedgehog Signaling. PLoS One 2015, 10 (11):e0142646. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/26571415

Haller F, Bieg M, Moskalev EA, Barthelmess S, Geddert H, Boltze C, Diessl N, Braumandl K, Brors B, Iro H, Hartmann A, Wiemann S and Agaimy A: Recurrent mutations within the amino-terminal region of beta-catenin are probable key molecular driver events in sinonasal hemangiopericytoma. Am J Pathol 2015, 185 (2):563-71. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25482924

Haller F, Zhang JD, Moskalev EA, Braun A, Otto C, Geddert H, Riazalhosseini Y, Ward A, Balwierz A, Schaefer IM, Cameron S, Ghadimi BM, Agaimy A, Fletcher JA, Hoheisel J, Hartmann A, Werner M, Wiemann S and Sahin O: Combined DNA methylation and gene expression profiling in gastrointestinal stromal tumors reveals hypomethylation of SPP1 as an independent prognostic factor. Int J Cancer 2015, 136 (5):1013-23. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25046773

Kedmi M, Ben-Chetrit N, Korner C, Mancini M, Ben-Moshe NB, Lauriola M, Lavi S, Biagioni F, Carvalho S, Cohen-Dvashi H, Schmitt F, Wiemann S, Blandino G and Yarden Y: EGF induces microRNAs that target suppressors of cell migration: miR-15b targets MTSS1 in breast cancer. Sci Signal 2015, 8 (368):ra29. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25783158

Keklikoglou I, Hosaka K, Bender C, Bott A, Koerner C, Mitra D, Will R, Woerner A, Muenstermann E, Wilhelm H, Cao Y and Wiemann S: MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and KRAS genes. Oncogene 2015, Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25500542

Maier R, Moser G, Chen GB, Ripke S, Cross-Disorder Working Group of the Psychiatric Genomics C, Coryell W, Potash JB, Scheftner WA, Shi J, Weissman MM, Hultman CM, Landen M, Levinson DF, Kendler KS, Smoller JW, Wray NR and Lee SH: Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. Am J Hum Genet 2015, 96 (2):283-94. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25640677

Network and Pathway Analysis Subgroup of Psychiatric Genomics C: Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nat Neurosci 2015, 18 (2):199-209. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25599223

Peckys DB, Korf U and de Jonge N: Local variations of HER2 dimerization in breast cancer cells discovered by correlative fluorescence and liquid electron microscopy. Science Advances 2015, 1 (6): Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/26601217

Schuol S, Schickhardt C, Wiemann S, Bartram CR, Tanner K, Eils R, Meder B, Richter D, Glimm H, von Kalle C and Winkler EC: So rare we need to hunt for them: reframing the ethical debate on incidental findings. Genome Med 2015, 7 (1):83. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/26229554

Shukla K, Sharma AK, Ward A, Will R, Hielscher T, Balwierz A, Breunig C, Munstermann E, Konig R, Keklikoglou I and Wiemann S: MicroRNA-30c-2-3p negatively regulates NF-kappaB signaling and cell cycle progression through downregulation of TRADD and CCNE1 in breast cancer. Mol Oncol 2015, 9 (6):1106-19. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25732226

von der Heyde S, Wagner S, Czerny A, Nietert M, Ludewig F, Salinas-Riester G, Arlt D and Beissbarth T: mRNA profiling reveals determinants of trastuzumab efficiency in HER2-positive breast cancer. PLoS One 2015, 10 (2):e0117818. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25710561

Wachter A, Bernhardt S, Beissbarth T and Korf U: Analysis of Reverse Phase Protein Array Data: From Experimental Design towards Targeted Biomarker Discovery. Microarrays 2015, 4 (4):520. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/27600238

Wruck W, Kashofer K, Rehman S, Daskalaki A, Berg D, Gralka E, Jozefczuk J, Drews K, Pandey V, Regenbrecht C, Wierling C, Turano P, Korf U, Zatloukal K, Lehrach H, Westerhoff HV and Adjaye J: Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes. Sci Data 2015, 2 150068. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/26646939

Zanni G, Kalscheuer VM, Friedrich A, Barresi S, Alfieri P, Di Capua M, Haas SA, Piccini G, Karl T, Klauck SM, Bellacchio E, Emma F, Cappa M, Bertini E and Breitenbach-Koller L: A Novel Mutation in RPL10 (Ribosomal Protein L10) Causes X-Linked Intellectual Disability, Cerebellar Hypoplasia, and Spondylo-Epiphyseal Dysplasia. Hum Mutat 2015, 36 (12):1155-8. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/26290468

2014

Agaimy A, Barthelmess S, Geddert H, Boltze C, Moskalev E, Koch M, Wiemann S, Hartmann A and Haller F: Phenotypic And Molecular Distinctness of Sinonasal Hemangiopericytoma compared to Solitary Fibrous Tumor of the Sinonasal Tract. Histopathology 2014. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24807787

Akbani R, Becker KF, Carragher N, Goldstein T, de Koning L, Korf U, Liotta L, Mills GB, Nishizuka SS, Pawlak M, Petricoin EF, 3rd, Pollard HB, Serrels B and Zhu J: Realizing the Promise of Reverse Phase Protein Arrays for Clinical, Translational, and Basic Research: A Workshop Report: The RPPA (Reverse Phase Protein Array) Society. Mol Cell Proteomics 2014, 13(7):1625-43. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24777629

Barthelmess S, Geddert H, Boltze C, Moskalev EA, Bieg M, Sirbu H, Brors B, Wiemann S, Hartmann A, Agaimy A and Haller F: Solitary fibrous tumors/hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and distinct clinicopathological features. Am J Pathol 2014, 184(4):1209-18. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24513261

Breunig C, Mueller BJ, Umansky L, Wahl K, Hoffmann K, Lehner F, Manns MP, Bantel H and Falk CS: BRaf and MEK inhibitors differentially regulate cell fate and microenvironment in human hepatocellular carcinoma. Clin Cancer Res 2014, 20(9):2410-23. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24573550

Buxbaum JD, Bolshakova N, Brownfeld JM, Anney RJ, Bender P, Bernier R, Cook EH, Coon H, Cuccaro M, Freitag CM, Hallmayer J, Geschwind D, Klauck SM, Nurnberger JI, Oliveira G, Pinto D, Poustka F, Scherer SW, Shih A, Sutcliffe JS, Szatmari P, Vicente AM, Vieland V, Gallagher L: The Autism Simplex Collection: an international, expertly phenotyped autism sample for genetic and phenotypic analyses. Molecular autism 2014, 5:34. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25392729

Chiocchetti AG, Haslinger D, Boesch M, Karl T, Wiemann S, Freitag CM, Poustka F, Scheibe B, Bauer JW, Hintner H, Breitenbach M, Kellermann J, Lottspeich F, Klauck SM and Breitenbach-Koller L: Protein signatures of oxidative stress response in a patient specific cell line model for autism. Mol Autism 2014, 5(1):10. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24512814

De Rubeis S, He X, Goldberg AP, Poultney CS, Samocha K, Ercument Cicek A, Kou Y, Liu L, Fromer M, Walker S, Singh T, Klei L, Kosmicki J, Fu SC, Aleksic B, Biscaldi M, Bolton PF, Brownfeld JM, Cai J, Campbell NG, Carracedo A, Chahrour MH, Chiocchetti AG, Coon H, Crawford EL, Crooks L, Curran SR, Dawson G, Duketis E, Fernandez BA, Gallagher L, Geller E, Guter SJ, Sean Hill R, Ionita-Laza I, Jimenez Gonzalez P, Kilpinen H, Klauck SM, Kolevzon A, Lee I, Lei J, Lehtimaki T, Lin CF, Ma'ayan A, Marshall CR, McInnes AL, Neale B, Owen MJ, Ozaki N, Parellada M, Parr JR, Purcell S, Puura K, Rajagopalan D, Rehnstrom K, Reichenberg A, Sabo A, Sachse M, Sanders SJ, Schafer C, Schulte-Ruther M, Skuse D, Stevens C, Szatmari P, Tammimies K, Valladares O, Voran A, Wang LS, Weiss LA, Jeremy Willsey A, Yu TW, Yuen RK, Study DDD, Homozygosity Mapping Collaborative for A, Consortium UK, Autism Sequencing C, Cook EH, Freitag CM, Gill M, Hultman CM, Lehner T, Palotie A, Schellenberg GD, Sklar P, State MW, Sutcliffe JS, Walsh CA, Scherer SW, Zwick ME, Barrett JC, Cutler DJ, Roeder K, Devlin B, Daly MJ, Buxbaum JD: Synaptic, transcriptional and chromatin genes disrupted in autism. Nature 2014, 515(7526):209-215. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25363760

Doberstein K, Bretz NP, Schirmer U, Fiegl H, Blaheta R, Breunig C, Muller-Holzner E, Reimer D, Zeimet AG, Altevogt P: miR-21-3p is a positive regulator of L1CAM in several human carcinomas. Cancer Lett 2014. Aug 19. pii: S0304-3835(14)00450-9. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25149066

Haller F, Moskalev EA, Faucz FR, Barthelmess S, Wiemann S, Bieg M, Assie G, Bertherat J, Schaefer IM, Otto C, Rattenberry E, Maher ER, Strobel P, Werner M, Carney JA, Hartmann A, Stratakis CA and Agaimy A: Aberrant DNA hypermethylation of SDHC: a novel mechanism of tumor development in Carney triad. Endocr Relat Cancer 2014, 21(4):567-77. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24859990

Hulsmann HJ, Rolff J, Bender C, Jarahian M, Korf U, Herwig R, Frohlich H, Thomas M, Merk J, Fichtner I, Sultmann H, Kuner R: Activation of AMP-activated protein kinase sensitizes lung cancer cells and H1299 xenografts to erlotinib. Lung cancer (Amsterdam, Netherlands) 2014. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25240516

Lauriola M, Enuka Y, Zeisel A, D'Uva G, Roth L, Sharon-Sevilla M, Lindzen M, Sharma K, Nevo N, Feldman M, Carvalho S, Cohen-Dvashi H, Kedmi M, Ben-Chetrit N, Chen A, Solmi R, Wiemann S, Schmitt F, Domany E and Yarden Y: Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment. Nat Commun 2014, 5 5073. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25278152

Mleczko-Sanecka K, Roche F, da Silva AR, Call D, D'Alessio F, Ragab A, Lapinski PE, Ummanni R, Korf U, Oakes C, Damm G, D'Alessandro LA, Klingmuller U, King PD, Boutros M, Hentze MW and Muckenthaler MU: Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Blood 2014, 123(10):1574-85. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24385536

Nass N, Bromme HJ, Hartig R, Korkmaz S, Sel S, Hirche F, Ward A, Simm A, Wiemann S, Lykkesfeldt AE, Roessner A and Kalinski T: Differential Response to alpha-Axoaldehydes in Tamoxifen Resistant MCF-7 Breast Cancer Cells. PLoS One 2014, 9(7):e101473. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24983248

Negm OH, Mannsperger HA, McDermott EM, Drewe E, Powell RJ, Todd I, Fairclough LC and Tighe PJ: A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS). Eur J Immunol 2014, 44(7):2096-110. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24668260

Northcott PA, Lee C, Zichner T, Stutz AM, Erkek S, Kawauchi D, Shih DJ, Hovestadt V, Zapatka M, Sturm D, Jones DT, Kool M, Remke M, Cavalli FM, Zuyderduyn S, Bader GD, VandenBerg S, Esparza LA, Ryzhova M, Wang W, Wittmann A, Stark S, Sieber L, Seker-Cin H, Linke L, Kratochwil F, Jager N, Buchhalter I, Imbusch CD, Zipprich G, Raeder B, Schmidt S, Diessl N, Wolf S, Wiemann S, Brors B, Lawerenz C, Eils J, Warnatz HJ, Risch T, Yaspo ML, Weber UD, Bartholomae CC, von Kalle C, Turanyi E, Hauser P, Sanden E, Darabi A, Siesjo P, Sterba J, Zitterbart K, Sumerauer D, van Sluis P, Versteeg R, Volckmann R, Koster J, Schuhmann MU, Ebinger M, Grimes HL, Robinson GW, Gajjar A, Mynarek M, von Hoff K, Rutkowski S, Pietsch T, Scheurlen W, Felsberg J, Reifenberger G, Kulozik AE, von Deimling A, Witt O, Eils R, Gilbertson RJ, Korshunov A, Taylor MD, Lichter P, Korbel JO, Wechsler-Reya RJ and Pfister SM: Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. Nature 2014, 511(7510):428-34. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25043047

Pinto D, Delaby E, Merico D, Barbosa M, Merikangas A, Klei L, Thiruvahindrapuram B, Xu X, Ziman R, Wang Z, Vorstman JA, Thompson A, Regan R, Pilorge M, Pellecchia G, Pagnamenta AT, Oliveira B, Marshall CR, Magalhaes TR, Lowe JK, Howe JL, Griswold AJ, Gilbert J, Duketis E, Dombroski BA, De Jonge MV, Cuccaro M, Crawford EL, Correia CT, Conroy J, Conceicao IC, Chiocchetti AG, Casey JP, Cai G, Cabrol C, Bolshakova N, Bacchelli E, Anney R, Gallinger S, Cotterchio M, Casey G, Zwaigenbaum L, Wittemeyer K, Wing K, Wallace S, van Engeland H, Tryfon A, Thomson S, Soorya L, Roge B, Roberts W, Poustka F, Mouga S, Minshew N, McInnes LA, McGrew SG, Lord C, Leboyer M, Le Couteur AS, Kolevzon A, Jimenez Gonzalez P, Jacob S, Holt R, Guter S, Green J, Green A, Gillberg C, Fernandez BA, Duque F, Delorme R, Dawson G, Chaste P, Cafe C, Brennan S, Bourgeron T, Bolton PF, Bolte S, Bernier R, Baird G, Bailey AJ, Anagnostou E, Almeida J, Wijsman EM, Vieland VJ, Vicente AM, Schellenberg GD, Pericak-Vance M, Paterson AD, Parr JR, Oliveira G, Nurnberger JI, Monaco AP, Maestrini E, Klauck SM, Hakonarson H, Haines JL, Geschwind DH, Freitag CM, Folstein SE, Ennis S, Coon H, Battaglia A, Szatmari P, Sutcliffe JS, Hallmayer J, Gill M, Cook EH, Buxbaum JD, Devlin B, Gallagher L, Betancur C and Scherer SW: Convergence of genes and cellular pathways dysregulated in autism spectrum disorders. Am J Hum Genet 2014, 94(5):677-94. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24768552

Schirmer U, Doberstein K, Rupp AK, Bretz NP, Wuttig D, Kiefel H, Breunig C, Fiegl H, Muller-Holzner E, Zeillinger R, Schuster E, Zeimet AG, Sultmann H and Altevogt P: Role of miR-34a as a suppressor of L1CAM in endometrial carcinoma. Oncotarget 2014, 5(2):462-72. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24497324

Sonntag J, Bender C, Soons Z, der Heyde Sv, König R, Wiemann S, Sinn H-P, Schneeweiss A, Beißbarth T and Korf U: Reverse phase protein array based tumor profiling identifies a biomarker signature for risk classification of hormone receptor-positive breast cancer. Translational Proteomics 2014, 2(0):52-9. URL: http://www.sciencedirect.com/science/article/pii/S2212963414000023

Sonntag J, Schluter K, Bernhardt S, Korf U: Subtyping of breast cancer using reverse phase protein arrays. Expert Rev Proteomics 2014, 11(6):757-770. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25400094

Srivastava S, Sharma K, Kumar N and Roy P: Bradykinin regulates osteoblast differentiation by Akt/ERK/NFkappaB signalling axis. J Cell Physiol 2014, epub. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24825463

Ummanni R, Mannsperger HA, Sonntag J, Oswald M, Sharma AK, Konig R and Korf U: Evaluation of reverse phase protein array (RPPA)-based pathway-activation profiling in 84 non-small cell lung cancer (NSCLC) cell lines as platform for cancer proteomics and biomarker discovery. Biochim Biophys Acta 2014, 1844(5):950-9. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24361481

von der Heyde S, Bender C, Henjes F, Sonntag J, Korf U and Beissbarth T: Boolean ErbB network reconstructions and perturbation simulations reveal individual drug response in different breast cancer cell lines. BMC Syst Biol 2014, 8(75). Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24970389

von der Heyde S, Sonntag J, Kaschek D, Bender C, Bues J, Wachter A, Timmer J, Korf U, Beissbarth T: RPPanalyzer toolbox: an improved R package for analysis of reverse phase protein array data. Biotechniques 2014, 57(3):125-135. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/2520904

Waltes R, Duketis E, Knapp M, Anney RJ, Huguet G, Schlitt S, Jarczok TA, Sachse M, Kampfer LM, Kleinbock T, Poustka F, Bolte S, Schmotzer G, Voran A, Huy E, Meyer J, Bourgeron T, Klauck SM, Freitag CM and Chiocchetti AG: Common variants in genes of the postsynaptic FMRP signalling pathway are risk factors for autism spectrum disorders. Hum Genet 2014, 133(6):781-92. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24442360

Ward A, Shukla K, Balwierz A, Soons Z, Konig R, Sahin O and Wiemann S: MicroRNA-519a is a novel oncomir conferring tamoxifen resistance by targeting a network of tumour-suppressor genes in ER+ breast cancer. J Pathol 2014, 233(4):368-79. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24752803

2013

Cross-Disorder Group of the Psychiatric Genomics C, Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH, Backlund L, Badner JA, Bailey AJ, Banaschewski T, Barchas JD, Barnes MR, Barrett TB, Bass N, Battaglia A, Bauer M, Bayes M, Bellivier F, Bergen SE, Berrettini W, Betancur C, Bettecken T, Biederman J, Binder EB, Black DW, Blackwood DH, Bloss CS, Boehnke M, Boomsma DI, Breen G, Breuer R, Bruggeman R, Cormican P, Buccola NG, Buitelaar JK, Bunney WE, Buxbaum JD, Byerley WF, Byrne EM, Caesar S, Cahn W, Cantor RM, Casas M, Chakravarti A, Chambert K, Choudhury K, Cichon S, Cloninger CR, Collier DA, Cook EH, Coon H, Cormand B, Corvin A, Coryell WH, Craig DW, Craig IW, Crosbie J, Cuccaro ML, Curtis D, Czamara D, Datta S, Dawson G, Day R, De Geus EJ, Degenhardt F, Djurovic S, Donohoe GJ, Doyle AE, Duan J, Dudbridge F, Duketis E, Ebstein RP, Edenberg HJ, Elia J, Ennis S, Etain B, Fanous A, Farmer AE, Ferrier IN, Flickinger M, Fombonne E, Foroud T, Frank J, Franke B, Fraser C, Freedman R, Freimer NB, Freitag CM, Friedl M, Frisen L, Gallagher L, Gejman PV, Georgieva L, Gershon ES, Geschwind DH, Giegling I, Gill M, Gordon SD, Gordon-Smith K, Green EK, Greenwood TA, Grice DE, Gross M, Grozeva D, Guan W, Gurling H, De Haan L, Haines JL, Hakonarson H, Hallmayer J, Hamilton SP, Hamshere ML, Hansen TF, Hartmann AM, Hautzinger M, Heath AC, Henders AK, Herms S, Hickie IB, Hipolito M, Hoefels S, Holmans PA, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hultman CM, Hus V, Ingason A, Ising M, Jamain S, Jones EG, Jones I, Jones L, Tzeng JY, Kahler AK, Kahn RS, Kandaswamy R, Keller MC, Kennedy JL, Kenny E, Kent L, Kim Y, Kirov GK, Klauck SM, Klei L, Knowles JA, Kohli MA, Koller DL, Konte B, Korszun A, Krabbendam L, Krasucki R, Kuntsi J, Kwan P, Landen M, Langstrom N, Lathrop M, Lawrence J, Lawson WB, Leboyer M, Ledbetter DH, Lee PH, Lencz T, Lesch KP, Levinson DF, Lewis CM, Li J, Lichtenstein P, Lieberman JA, Lin DY, Linszen DH, Liu C, Lohoff FW, Loo SK, Lord C, Lowe JK, Lucae S, MacIntyre DJ, Madden PA, Maestrini E, Magnusson PK, Mahon PB, Maier W, Malhotra AK, Mane SM, Martin CL, Martin NG, Mattheisen M, Matthews K, Mattingsdal M, McCarroll SA, McGhee KA, McGough JJ, McGrath PJ, McGuffin P, McInnis MG, McIntosh A, McKinney R, McLean AW, McMahon FJ, McMahon WM, McQuillin A, Medeiros H, Medland SE, Meier S, Melle I, Meng F, Meyer J, Middeldorp CM, Middleton L, Milanova V, Miranda A, Monaco AP, Montgomery GW, Moran JL, Moreno-De-Luca D, Morken G, Morris DW, Morrow EM, Moskvina V, Muglia P, Muhleisen TW, Muir WJ, Muller-Myhsok B, Murtha M, Myers RM, Myin-Germeys I, Neale MC, Nelson SF, Nievergelt CM, Nikolov I, Nimgaonkar V, Nolen WA, Nothen MM, Nurnberger JI, Nwulia EA, Nyholt DR, O'Dushlaine C, Oades RD, Olincy A, Oliveira G, Olsen L, Ophoff RA, Osby U, Owen MJ, Palotie A, Parr JR, Paterson AD, Pato CN, Pato MT, Penninx BW, Pergadia ML, Pericak-Vance MA, Pickard BS, Pimm J, Piven J, Posthuma D, Potash JB, Poustka F, Propping P, Puri V, Quested DJ, Quinn EM, Ramos-Quiroga JA, Rasmussen HB, Raychaudhuri S, Rehnstrom K, Reif A, Ribases M, Rice JP, Rietschel M, Roeder K, Roeyers H, Rossin L, Rothenberger A, Rouleau G, Ruderfer D, Rujescu D, Sanders AR, Sanders SJ, Santangelo SL, Sergeant JA, Schachar R, Schalling M, Schatzberg AF, Scheftner WA, Schellenberg GD, Scherer SW, Schork NJ, Schulze TG, Schumacher J, Schwarz M, Scolnick E, Scott LJ, Shi J, Shilling PD, Shyn SI, Silverman JM, Slager SL, Smalley SL, Smit JH, Smith EN, Sonuga-Barke EJ, St Clair D, State M, Steffens M, Steinhausen HC, Strauss JS, Strohmaier J, Stroup TS, Sutcliffe JS, Szatmari P, Szelinger S, Thirumalai S, Thompson RC, Todorov AA, Tozzi F, Treutlein J, Uhr M, van den Oord EJ, Van Grootheest G, Van Os J, Vicente AM, Vieland VJ, Vincent JB, Visscher PM, Walsh CA, Wassink TH, Watson SJ, Weissman MM, Werge T, Wienker TF, Wijsman EM, Willemsen G, Williams N, Willsey AJ, Witt SH, Xu W, Young AH, Yu TW, Zammit S, Zandi PP, Zhang P, Zitman FG, Zollner S, International Inflammatory Bowel Disease Genetics C, Devlin B, Kelsoe JR, Sklar P, Daly MJ, O'Donovan MC, Craddock N, Sullivan PF, Smoller JW, Kendler KS and Wray NR: Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 2013, 45 (9):984-94. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23933821

Garding A, Bhattacharya N, Claus R, Ruppel M, Tschuch C, Filarsky K, Idler I, Zucknick M, Caudron-Herger M, Oakes C, Fleig V, Keklikoglou I, Allegra D, Serra L, Thakurela S, Tiwari V, Weichenhan D, Benner A, Radlwimmer B, Zentgraf H, Wiemann S, Rippe K, Plass C, Dohner H, Lichter P, Stilgenbauer S and Mertens D: Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB. PLoS Genet 2013, 9 (4):e1003373. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23593011

Gotschel F, Berg D, Gruber W, Bender C, Eberl M, Friedel M, Sonntag J, Rungeler E, Hache H, Wierling C, Nietfeld W, Lehrach H, Frischauf A, Schwartz-Albiez R, Aberger F and Korf U: Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1. PLoS One 2013, 8 (6):e65403. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23762360

Horvat EA, Zhang JD, Uhlmann S, Sahin O and Zweig KA: A network-based method to assess the statistical significance of mild co-regulation effects. PLoS One 2013, 8 (9):e73413. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24039936

Issa A, Gill JW, Heideman MR, Sahin O, Wiemann S, Dey JH and Hynes NE: Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models. Breast Cancer Res 2013, 15 (1):R8. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23343422

Korner C, Keklikoglou I, Bender C, Worner A, Munstermann E and Wiemann S: MicroRNA-31 sensitizes human breast cells to apoptosis by direct targeting of protein kinase C epsilon (PKCepsilon). J Biol Chem 2013, 288 (12):8750-61. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23364795

Kostler WJ, Zeisel A, Korner C, Tsai JM, Jacob-Hirsch J, Ben-Chetrit N, Sharma K, Cohen-Dvashi H, Yitzhaky A, Lader E, Tschulena U, Rechavi G, Domany E, Wiemann S and Yarden Y: Epidermal growth-factor-induced transcript isoform variation drives mammary cell migration. PLoS One 2013, 8 (12):e80566. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24324612

Shahmoradgoli M, Riazalhosseini Y, Haag D, Becker N, Hovestadt V, Heck S, Sinn HP, Schneeweiss A, Mannherz O, Sahin O and Lichter P: Protein phosphatase 1, regulatory subunit 15B is a survival factor for ERalpha-positive breast cancer. Int J Cancer 2013, 132 (11):2714-9. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23169272

Vorstman JA, Anney RJ, Derks EM, Gallagher L, Gill M, de Jonge MV, van Engeland H, Kahn RS, Ophoff RA and Autism Genome Project tISC: No evidence that common genetic risk variation is shared between schizophrenia and autism. Am J Med Genet B Neuropsychiatr Genet 2013, 162B (1):55-60. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23193033

Ward A, Balwierz A, Zhang JD, Kublbeck M, Pawitan Y, Hielscher T, Wiemann S and Sahin O: Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer. Oncogene 2013, 32 (9):1173-82. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22508479

Zeisel A, Yitzhaky A, Koerner C, Lauriola M, Cohen-Dvashi H, Kostler WJ, Yarden Y, Wiemann S and Domany E: qCMA: a desktop application for quantitative collective cell migration analysis. J Biomol Screen 2013, 18 (3):356-60. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23042078

2012

Anney R, Klei L, Pinto D, Almeida J, Bacchelli E, Baird G, Bolshakova N, Bolte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Casey J, Conroy J, Correia C, Corsello C, Crawford EL, de Jonge M, Delorme R, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Fombonne E, Gilbert J, Gillberg C, Glessner JT, Green A, Green J, Guter SJ, Heron EA, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Jacob S, Kenny GP, Kim C, Kolevzon A, Kustanovich V, Lajonchere CM, Lamb JA, Law-Smith M, Leboyer M, Le Couteur A, Leventhal BL, Liu XQ, Lombard F, Lord C, Lotspeich L, Lund SC, Magalhaes TR, Mantoulan C, McDougle CJ, Melhem NM, Merikangas A, Minshew NJ, Mirza GK, Munson J, Noakes C, Nygren G, Papanikolaou K, Pagnamenta AT, Parrini B, Paton T, Pickles A, Posey DJ, Poustka F, Ragoussis J, Regan R, Roberts W, Roeder K, Roge B, Rutter ML, Schlitt S, Shah N, Sheffield VC, Soorya L, Sousa I, Stoppioni V, Sykes N, Tancredi R, Thompson AP, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Vorstman JA, Wallace S, Wing K, Wittemeyer K, Wood S, Zurawiecki D, Zwaigenbaum L, Bailey AJ, Battaglia A, Cantor RM, Coon H, Cuccaro ML, Dawson G, Ennis S, Freitag CM, Geschwind DH, Haines JL, Klauck SM, McMahon WM, Maestrini E, Miller J, Monaco AP, Nelson SF, Nurnberger JI Jr, Oliveira G, Parr JR, Pericak-Vance MA, Piven J, Schellenberg GD, Scherer SW, Vicente AM, Wassink TH, Wijsman EM, Betancur C, Buxbaum JD, Cook EH, Gallagher L, Gill M, Hallmayer J, Paterson AD, Sutcliffe JS, Szatmari P, Vieland VJ, Hakonarson H, Devlin B (2012) Individual common variants exert weak effects on the risk for autism spectrum disorderspi. Human Molecular Genetics 21(21):4781-92. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22843504

Botla SK, Gholami AM, Malekpour M, Moskalev EA, Fallah M, Jandaghi P, Aghajani A, Bondar IS, Omranipour R, Malekpour F, Mohajeri A, Babadi AJ, Sahin O, Bubnov VV, Najmabadi H, Hoheisel JD, Riazalhosseini Y (2012) Diagnostic values of GHSR DNA methylation pattern in breast cancer. Breast Cancer Research and Treatment 135(3):705-13. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22899222

Casey JP, Magalhaes T, Conroy JM, Regan R, Shah N, Anney R, Shields DC, Abrahams BS, Almeida J, Bacchelli E, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bolton PF, Bourgeron T, Brennan S, Cali P, Correia C, Corsello C, Coutanche M, Dawson G, de Jonge M, Delorme R, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Foley S, Fombonne E, Freitag CM, Gilbert J, Gillberg C, Glessner JT, Green J, Guter SJ, Hakonarson H, Holt R, Hughes G, Hus V, Igliozzi R, Kim C, Klauck SM, Kolevzon A, Lamb JA, Leboyer M, Le Couteur A, Leventhal BL, Lord C, Lund SC, Maestrini E, Mantoulan C, Marshall CR, McConachie H, McDougle CJ, McGrath J, McMahon WM, Merikangas A, Miller J, Minopoli F, Mirza GK, Munson J, Nelson SF, Nygren G, Oliveira G, Pagnamenta AT, Papanikolaou K, Parr JR, Parrini B, Pickles A, Pinto D, Piven J, Posey DJ, Poustka A, Poustka F, Ragoussis J, Roge B, Rutter ML, Sequeira AF, Soorya L, Sousa I, Sykes N, Stoppioni V, Tancredi R, Tauber M, Thompson AP, Thomson S, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Vorstman JA, Wallace S, Wang K, Wassink TH, White K, Wing K, Wittemeyer K, Yaspan BL, Zwaigenbaum L, Betancur C, Buxbaum JD, Cantor RM, Cook EH, Coon H, Cuccaro ML, Geschwind DH, Haines JL, Hallmayer J, Monaco AP, Nurnberger JI, Jr., Pericak-Vance MA, Schellenberg GD, Scherer SW, Sutcliffe JS, Szatmari P, Vieland VJ, Wijsman EM, Green A, Gill M, Gallagher L, Vicente A, Ennis S (2012) A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Hum Genet 131: 565-579. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21996756

Florkowska M, Tymoszuk P, Balwierz A, Skucha A, Kochan J, Wawro M, Stalinska K, Kasza A (2012) EGF activates TTP expression by activation of ELK-1 and EGR-1 transcription factors. BMC Molecular Biology 13:8. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22433566

Gottschling S, Jauch A, Kuner R, Herpel E, Mueller-Decker K, Schnabel PA, Xu EC, Muley T, Sueltmann H, Bender C, Granzow M, Efferth T, Hoffmann H, Dienemann H, Herth FJ, Meister M (2012) Establishment and comparative characterization of novel squamous cell non-small cell lung cancer cell lines and their corresponding tumor tissue. Lung Cancer 75(1):45-57. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21684623

Henjes F, Bender C, von der Heyde S, Braun L, Mannsperger H, Schmidt C, Wiemann S, Hasmann M, Aulmann S, Beissbarth T, Korf U (2012) Strong EGFR signaling in cell line models of ERBB2-amplified breast cancer attenuates response towards ERBB2-targeting drugs. Oncogenesis 1: e16. Pubmed: http://www.nature.com/oncsis/journal/v1/n7/full/oncsis201216a.html

Jones DT, Jager N, Kool M, Zichner T, Hutter B, Sultan M, Cho YJ, Pugh TJ, Hovestadt V, Stutz AM, Rausch T, Warnatz HJ, Ryzhova M, Bender S, Sturm D, Pleier S, Cin H, Pfaff E, Sieber L, Wittmann A, Remke M, Witt H, Hutter S, Tzaridis T, Weischenfeldt J, Raeder B, Avci M, Amstislavskiy V, Zapatka M, Weber UD, Wang Q, Lasitschka B, Bartholomae CC, Schmidt M, von Kalle C, Ast V, Lawerenz C, Eils J, Kabbe R, Benes V, van Sluis P, Koster J, Volckmann R, Shih D, Betts MJ, Russell RB, Coco S, Tonini GP, Schuller U, Hans V, Graf N, Kim YJ, Monoranu C, Roggendorf W, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, von Deimling A, Witt O, Maass E, Rossler J, Ebinger M, Schuhmann MU, Fruhwald MC, Hasselblatt M, Jabado N, Rutkowski S, von Bueren AO, Williamson D, Clifford SC, McCabe MG, Collins VP, Wolf S, Wiemann S, Lehrach H, Brors B, Scheurlen W, Felsberg J, Reifenberger G, Northcott PA, Taylor MD, Meyerson M, Pomeroy SL, Yaspo ML, Korbel JO, Korshunov A, Eils R, Pfister SM, Lichter P (2012) Dissecting the genomic complexity underlying medulloblastoma. Nature 488(7409):100-105. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22832583

Jozefczuk J, Kashofer K, Ummanni R, Henjes F, Rehman S, Geenen S, Wruck W, Regenbrecht C, Daskalaki A, Wierling C, Turano P, Bertini I, Korf U, Zatloukal K, Westerhoff HV, Lehrach H, Adjaye J (2012) A Systems Biology Approach to Deciphering the Etiology of Steatosis Employing Patient-Derived Dermal Fibroblasts and iPS Cells. Frontiers in Physiology 3:339. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22969728

Jurmeister S, Baumann M, Balwierz A, Keklikoglou I, Ward A, Uhlmann S, Zhang JD, Wiemann S, Sahin O (2012) MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F. Mol Cell Biol 32: 633-651. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22144583

Jurmeister S, Uhlmann S, Sahin Ö. MIR200C (microRNA 200c). Atlas Genet Cytogent Oncol Haematol.16 (2) 92-99. URL : http://AtlasGeneticsOncology.org/Genes/MIR200CID51054ch12p13.html

Kahn N, Meister M, Eberhardt R, Muley T, Schnabel P-A, Bender C, Johannes M, Keitel D, Sueltmann H, Herth FJF, Kuner R (2012) Early Detection of Lung Cancer by Molecular Markers in Endobronchial Epithelial-Lining Fluid. Journal of Thoracic Oncology 7(6):1001-8. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22588153

Keklikoglou I, Koerner C, Schmidt C, Zhang JD, Heckmann D, Shavinskaya A, Allgayer H, Guckel B, Fehm T, Schneeweiss A, Sahin O, Wiemann S, Tschulena U (2012) MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-kappaB and TGF-beta signaling pathways. Oncogene 31(37):4150-63. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22158050

Leblond CS, Heinrich J, Delorme R, Proepper C, Betancur C, Huguet G, Konyukh M, Chaste P, Ey E, Rastam M, Anckarsater H, Nygren G, Gillberg IC, Melke J, Toro R, Regnault B, Fauchereau F, Mercati O, Lemiere N, Skuse D, Poot M, Holt R, Monaco AP, Jarvela I, Kantojarvi K, Vanhala R, Curran S, Collier DA, Bolton P, Chiocchetti A, Klauck SM, Poustka F, Freitag CM, Waltes R, Kopp M, Duketis E, Bacchelli E, Minopoli F, Ruta L, Battaglia A, Mazzone L, Maestrini E, Sequeira AF, Oliveira B, Vicente A, Oliveira G, Pinto D, Scherer SW, Zelenika D, Delepine M, Lathrop M, Bonneau D, Guinchat V, Devillard F, Assouline B, Mouren MC, Leboyer M, Gillberg C, Boeckers TM, Bourgeron T (2012) Genetic and functional analyses of SHANK2 mutations suggest a multiple hit model of autism spectrum disorders. PLoS Genet 8: e1002521. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22346768

Lisauskas T, Matula P, Claas C, Reusing S, Wiemann S, Erfle H, Lehmann L, Fischer P, Eils R, Rohr K, Storrie B, Starkuviene V (2012) Live-cell assays to identify regulators of ER-to-Golgi trafficking. Traffic 13: 416-432. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22132776

Malinowsky K, Wolff C, Berg D, Schuster T, Walch A, Bronger H, Mannsperger H, Schmidt C, Korf U, Hofler H, Becker KF (2012) uPA and PAI-1-Related Signaling Pathways Differ between Primary Breast Cancers and Lymph Node Metastases. Transl Oncol 5: 98-104. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22496926

Nelson LD, Bender C, Mannsperger H, Buergy D, Kambakamba P, Mudduluru G, Korf U, Hughes D, Van Dyke MW, Allgayer H (2012) Triplex DNA-binding proteins are associated with clinical outcomes revealed by proteomic measurements in patients with colorectal cancer. Mol Cancer 11: 38. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22682314

Schlecker E, Stojanovic A, Eisen C, Quack C, Falk CS, Umansky V, Cerwenka A (2012) Tumor-Infiltrating Monocytic Myeloid-Derived Suppressor Cells Mediate CCR5-Dependent Recruitment of Regulatory T Cells Favoring Tumor Growth. Journal of Immunology 189(12):5602-11. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23152559

Shahmoradgoli, M.*, Riazalhosseini, Y.*, Haag, D., Becker, N., Hovestadt, V., Heck, S., Sinn, H.P., Schneeweiss, A., Mannherz, O., Sahin, Ö., Lichter, P. (*= equal contribution): Protein phosphatase 1, regulatory subunit 15B is a survival factor for ER alpha-positive breast cancer. International Journal of Cancer 2012. http://http://www.ncbi.nlm.nih.gov/pubmed/23169272

Shamu CE, Wiemann S, Boutros M (2012) On target: a public repository for large-scale RNAi experiments. Nat Cell Biol 14: 115. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22298037

Simpson JC, Joggerst B, Laketa V, Verissimo F, Cetin C, Erfle H, Bexiga MG, Singan VR, Heriche JK, Neumann B, Mateos A, Blake J, Bechtel S, Benes V, Wiemann S, Ellenberg J, Pepperkok R (2012) Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway. Nat Cell Biol 14: 764-774. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22660414

Spaich S, Will RD, Just S, Kuhn C, Frank D, Berger I, Wiemann S, Korn B, Koegl M, Backs J, Katus HA, Rottbauer W, Frey N (2012) Fbxl22, a cardiac-enriched F-box protein, regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo. Circulation Research Epub Sep 12. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22972877

Uhlmann S, Mannsperger H, Zhang JD, Horvat EA, Schmidt C, Kublbeck M, Henjes F, Ward A, Tschulena U, Zweig K, Korf U, Wiemann S, Sahin O (2012) Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer. Mol Syst Biol 8: 570. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22333974

Ummanni R, Barreto F, Venz S, Scharf C, Barett C, Mannsperger HA, Brase JC, Kuner R, Schlomm T, Sauter G, Sultmann H, Korf U, Bokemeyer C, Walther R, Brummendorf TH, Balabanov S (2012) Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro. J Proteome Res 11: 2452-2466. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22424448

Walde S, Thakar K, Hutten S, Spillner C, Nath A, Rothbauer U, Wiemann S, Kehlenbach RH (2012) The nucleoporin Nup358/RanBP2 promotes nuclear import in a cargo- and transport receptor-specific manner. Traffic 13: 218-233. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21995724

2011

Anney RJ, Kenny EM, O'Dushlaine C, Yaspan BL, Parkhomenka E, Buxbaum JD, Sutcliffe J, Gill M, Gallagher L, Bailey AJ, Fernandez BA, Szatmari P, Scherer SW, Patterson A, Marshall CR, Pinto D, Vincent JB, Fombonne E, Betancur C, Delorme R, Leboyer M, Bourgeron T, Mantoulan C, Roge B, Tauber M, Freitag CM, Poustka F, Duketis E, Klauck SM, Poustka A, Papanikolaou K, Tsiantis J, Anney R, Bolshakova N, Brennan S, Hughes G, McGrath J, Merikangas A, Ennis S, Green A, Casey JP, Conroy JM, Regan R, Shah N, Maestrini E, Bacchelli E, Minopoli F, Stoppioni V, Battaglia A, Igliozzi R, Parrini B, Tancredi R, Oliveira G, Almeida J, Duque F, Vicente A, Correia C, Magalhaes TR, Gillberg C, Nygren G, Jonge MD, Van Engeland H, Vorstman JA, Wittemeyer K, Baird G, Bolton PF, Rutter ML, Green J, Lamb JA, Pickles A, Parr JR, Couteur AL, Berney T, McConachie H, Wallace S, Coutanche M, Foley S, White K, Monaco AP, Holt R, Farrar P, Pagnamenta AT, Mirza GK, Ragoussis J, Sousa I, Sykes N, Wing K, Hallmayer J, Cantor RM, Nelson SF, Geschwind DH, Abrahams BS, Volkmar F, Pericak-Vance MA, Cuccaro ML, Gilbert J, Cook EH, Guter SJ, Jacob S, Nurnberger Jr JI, McDougle CJ, Posey DJ, Lord C, Corsello C, Hus V, Kolevzon A, Soorya L, Parkhomenko E, Leventhal BL, Dawson G, Vieland VJ, Hakonarson H, Glessner JT, Kim C, Wang K, Schellenberg GD, Devlin B, Klei L, Minshew N, Sutcliffe JS, Haines JL, Lund SC, Thomson S, Coon H, Miller J, McMahon WM, Munson J, Estes A, Wijsman EM (2011) Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders. Eur J Hum Genet. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21522181

Bai SW, Herrera-Abreu MT, Rohn JL, Racine V, Tajadura V, Suryavanshi N, Bechtel S, Wiemann S, Baum B, Ridley AJ (2011) Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. BMC Biol 9: 54. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21834987

Bender C, Heyde S, Henjes F, Wiemann S, Korf U, Beissbarth T (2011) Inferring signalling networks from longitudinal data using sampling based approaches in the R-package 'ddepn'. BMC Bioinformatics 12: 291. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21771315

Brase JC, Johannes M, Mannsperger H, Falth M, Metzger J, Kacprzyk LA, Andrasiuk T, Gade S, Meister M, Sirma H, Sauter G, Simon R, Schlomm T, Beissbarth T, Korf U, Kuner R, Sultmann H (2011a) TMPRSS2-ERG -specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-beta signaling. BMC Cancer 11: 507. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22142399

Brase JC, Johannes M, Schlomm T, Falth M, Haese A, Steuber T, Beissbarth T, Kuner R, Sultmann H (2011b) Circulating miRNAs are correlated with tumor progression in prostate cancer. Int J Cancer 128: 608-616. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20473869

Brase JC, Mannsperger H, Sultmann H, Korf U (2011c) Antibody-mediated signal amplification for reverse phase protein array-based protein quantification. Methods Mol Biol 785: 55-64. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21901593

Bu H, Bormann S, Schafer G, Horninger W, Massoner P, Neeb A, Lakshmanan VK, Maddalo D, Nestl A, Sultmann H, Cato AC, Klocker H (2011) The anterior gradient 2 (AGR2) gene is overexpressed in prostate cancer and may be useful as a urine sediment marker for prostate cancer detection. Prostate 71: 575-587. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20945500

Chiocchetti A, Klauck SM (2011) [Genetic analyses for identifying molecular mechanisms in autism spectrum disorders]. Z Kinder Jugendpsychiatr Psychother 39: 101-111. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21442598

Chiocchetti A, Pakalapati G, Duketis E, Wiemann S, Poustka A, Poustka F, Klauck SM (2011) Mutation and expression analyses of the ribosomal protein gene RPL10 in an extended German sample of patients with autism spectrum disorder. Am J Med Genet A 155A: 1472-1475. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21567917

Curran S, Bolton P, Rozsnyai K, Chiocchetti A, Klauck SM, Duketis E, Poustka F, Schlitt S, Freitag CM, Lee I, Muglia P, Poot M, Staal W, de Jonge MV, Ophoff RA, Lewis C, Skuse D, Mandy W, Vassos E, Fossdal R, Magnusson P, Hreidarsson S, Saemundsen E, Stefansson H, Stefansson K, Collier D (2011) No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 Gene and Autism Spectrum Disorder. Am J Med Genet B Neuropsychiatr Genet. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21656903

El Debs BW, Tschulena U, Griffiths AD, Merten CA (2011) A competitive co-cultivation assay for cancer drug specificity evaluation. J Biomol Screen 16: 818-824. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21788393

Fussbroich B, Wagener N, Macher-Goeppinger S, Benner A, Falth M, Sultmann H, Holzer A, Hoppe-Seyler K, Hoppe-Seyler F (2011) EZH2 depletion blocks the proliferation of colon cancer cells. PLoS One 6: e21651. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21765901

Gade S, Porzelius C, Faelth M, Brase JC, Wuttig D, Kuner R, Binder H, Sueltmann H, Beissbarth T (2011) Graph based fusion of miRNA and mRNA expression data improves clinical outcome prediction in prostate cancer. BMC Bioinformatics 12: 488. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22188670

Hellwinkel OJ, Asong LE, Rogmann JP, Sultmann H, Wagner C, Schlomm T, Eichelberg C (2011) Transcription alterations of members of the ubiquitin-proteasome network in prostate carcinoma. Prostate Cancer Prostatic Dis 14: 38-45. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21102547

Henjes F, Gotschel F, Jocker A, Korf U (2011) Quantitative analysis of phosphoproteins using microspot immunoassays. Methods Mol Biol 785: 191-201. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21901601

Johannes M, Frohlich H, Sultmann H, Beissbarth T (2011) pathClass: an R-package for integration of pathway knowledge into support vector machines for biomarker discovery. Bioinformatics 27: 1442-1443. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21450711

Kerick M, Isau M, Timmermann B, Sultmann H, Herwig R, Krobitsch S, Schaefer G, Verdorfer I, Bartsch G, Klocker H, Lehrach H, Schweiger MR (2011) Targeted high throughput sequencing in clinical cancer settings: formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity. BMC Med Genomics 4: 68. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21958464

Klauck SM, Poustka L, Chiocchetti A (2011) [Genetics and animal modeling of autism spectrum disorders. New developments]. Nervenarzt 82: 553-562. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21472451

Luckert K, Gotschel F, Sorger PK, Hecht A, Joos TO, Potz O (2011) Snapshots of protein dynamics and post-translational modifications in one experiment--beta-catenin and its functions. Mol Cell Proteomics 10: M110 007377. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21378377

Mannsperger H, Uhlmann S, Korf U, Sahin O (2011) Utilization of RNAi to validate antibodies for reverse phase protein arrays. Methods Mol Biol 785: 45-54. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21901592

Minner S, Enodien M, Sirma H, Luebke AM, Krohn A, Mayer PS, Simon R, Tennstedt P, Muller J, Scholz L, Brase JC, Liu AY, Schluter H, Pantel K, Schumacher U, Bokemeyer C, Steuber T, Graefen M, Sauter G, Schlomm T (2011) ERG status is unrelated to PSA recurrence in radically operated prostate cancer in the absence of antihormonal therapy. Clin Cancer Res 17: 5878-5888. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21791629

Rupp AK, Rupp C, Keller S, Brase JC, Ehehalt R, Fogel M, Moldenhauer G, Marme F, Sultmann H, Altevogt P (2011) Loss of EpCAM expression in breast cancer derived serum exosomes: role of proteolytic cleavage. Gynecol Oncol 122: 437-446. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21601258

Schetelig MF, Gotschel F, Viktorinova I, Handler AM, Wimmer EA (2011) Recombination technologies for enhanced transgene stability in bioengineered insects. Genetica 139: 71-78. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20844938

Sonntag J, Mannsperger H, Jocker A, Korf U (2011) Microspot immunoassay-based analysis of plasma protein profiles for biomarker discovery strategies. Methods Mol Biol 785: 237-245. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21901604

Tschulena U, Sanzenbacher R, Muhlebach MD, Berger A, Munch J, Schindler M, Kirchhoff F, Plesker R, Coulibaly C, Panitz S, Prufer S, Muckenfuss H, Hamdorf M, Schweizer M, Cichutek K, Flory E (2011) Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease. Retrovirology 8: 14. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21366921

Ummanni R, Jost E, Braig M, Lohmann F, Mundt F, Barett C, Schlomm T, Sauter G, Senff T, Bokemeyer C, Sultmann H, Meyer-Schwesinger C, Brummendorf TH, Balabanov S (2011a) Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation. Mol Cancer 10: 129. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21999842

Ummanni R, Mundt F, Pospisil H, Venz S, Scharf C, Barett C, Falth M, Kollermann J, Walther R, Schlomm T, Sauter G, Bokemeyer C, Sultmann H, Schuppert A, Brummendorf TH, Balabanov S (2011b) Identification of clinically relevant protein targets in prostate cancer with 2D-DIGE coupled mass spectrometry and systems biology network platform. PLoS One 6: e16833. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21347291

Warth A, Muley T, Meister M, Herpel E, Pathil A, Hoffmann H, Schnabel PA, Bender C, Buness A, Schirmacher P, Kuner R (2011) Loss of aquaporin-4 expression and putative function in non-small cell lung cancer. BMC Cancer 11: 161. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21548930

Wittig-Blaich SM, Kacprzyk LA, Eismann T, Bewerunge-Hudler M, Kruse P, Winkler E, Strauss WS, Hibst R, Steiner R, Schrader M, Mertens D, Sultmann H, Wittig R (2011) Matrix-dependent regulation of AKT in Hepsin-overexpressing PC3 prostate cancer cells. Neoplasia 13: 579-589. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21750652

Zhang JD, Koerner C, Bechtel S, Bender C, Keklikoglou I, Schmidt C, Irsigler A, Ernst U, Sahin O, Wiemann S, Tschulena U (2011) Time-resolved human kinome RNAi screen identifies a network regulating mitotic-events as early regulators of cell proliferation. PLoS One 6: e22176. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21765947

2010

Anney R, Klei L, Pinto D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Sykes N, Pagnamenta AT, Almeida J, Bacchelli E, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bolte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Carson AR, Casallo G, Casey J, Chu SH, Cochrane L, Corsello C, Crawford EL, Crossett A, Dawson G, de Jonge M, Delorme R, Drmic I, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Fombonne E, Freitag CM, Gilbert J, Gillberg C, Glessner JT, Goldberg J, Green J, Guter SJ, Hakonarson H, Heron EA, Hill M, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Kim C, Klauck SM, Kolevzon A, Korvatska O, Kustanovich V, Lajonchere CM, Lamb JA, Laskawiec M, Leboyer M, Le Couteur A, Leventhal BL, Lionel AC, Liu XQ, Lord C, Lotspeich L, Lund SC, Maestrini E, Mahoney W, Mantoulan C, Marshall CR, McConachie H, McDougle CJ, McGrath J, McMahon WM, Melhem NM, Merikangas A, Migita O, Minshew NJ, Mirza GK, Munson J, Nelson SF, Noakes C, Noor A, Nygren G, Oliveira G, Papanikolaou K, Parr JR, Parrini B, Paton T, Pickles A, Piven J, Posey DJ, Poustka A, Poustka F, Prasad A, Ragoussis J, Renshaw K, Rickaby J, Roberts W, Roeder K, Roge B, Rutter ML, Bierut LJ, Rice JP, Salt J, Sansom K, Sato D, Segurado R, Senman L, Shah N, Sheffield VC, Soorya L, Sousa I, Stoppioni V, Strawbridge C, Tancredi R, Tansey K, Thiruvahindrapduram B, Thompson AP, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Wallace S, Wang K, Wang Z, Wassink TH, Wing K, Wittemeyer K, Wood S, Yaspan BL, Zurawiecki D, Zwaigenbaum L, Betancur C, Buxbaum JD, Cantor RM, Cook EH, Coon H, Cuccaro ML, Gallagher L, Geschwind DH, Gill M, Haines JL, Miller J, Monaco AP, Nurnberger JI, Jr., Paterson AD, Pericak-Vance MA, Schellenberg GD, Scherer SW, Sutcliffe JS, Szatmari P, Vicente AM, Vieland VJ, Wijsman EM, Devlin B, Ennis S, Hallmayer J (2010) A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet 19: 4072-4082. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20663923

Bender C, Henjes F, Frohlich H, Wiemann S, Korf U, Beissbarth T (2010) Dynamic deterministic effects propagation networks: learning signalling pathways from longitudinal protein array data. Bioinformatics 26: i596-602. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20823327

Brase JC, Mannsperger H, Frohlich H, Gade S, Schmidt C, Wiemann S, Beissbarth T, Schlomm T, Sultmann H, Korf U (2010a) Increasing the sensitivity of reverse phase protein arrays by antibody-mediated signal amplification. Proteome Sci 8: 36. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20569466

Brase JC, Schmidt M, Fischbach T, Sultmann H, Bojar H, Koelbl H, Hellwig B, Rahnenfuhrer J, Hengstler JG, Gehrmann MC (2010b) ERBB2 and TOP2A in breast cancer: a comprehensive analysis of gene amplification, RNA levels, and protein expression and their influence on prognosis and prediction. Clin Cancer Res 16: 2391-2401. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20371687

Brase JC, Wuttig D, Kuner R, Sultmann H (2010c) Serum microRNAs as non-invasive biomarkers for cancer. Mol Cancer 9: 306. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21110877

de Souza Rocha Simonini P, Breiling A, Gupta N, Malekpour M, Youns M, Omranipour R, Malekpour F, Volinia S, Croce CM, Najmabadi H, Diederichs S, Sahin O, Mayer D, Lyko F, Hoheisel JD, Riazalhosseini Y (2010) Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells. Cancer Res 70: 9175-9184. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20978187

Freitag CM, Staal W, Klauck SM, Duketis E, Waltes R (2010) Genetics of autistic disorders: review and clinical implications. Eur Child Adolesc Psychiatry 19: 169-178. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19941018

Haller F, von Heydebreck A, Zhang JD, Gunawan B, Langer C, Ramadori G, Wiemann S, Sahin O (2010a) Localization- and mutation-dependent microRNA (miRNA) expression signatures in gastrointestinal stromal tumours (GISTs), with a cluster of co-expressed miRNAs located at 14q32.31. J Pathol 220: 71-86. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19768731

Haller F, Zhang DJ, Lobke C, von Heydebreck A, Korf U, Fuzesi L, Sahin O (2010b) [Multilayer analysis of signal transduction and cell cycle control in GIST. Identifying new interaction partners with differential regulation]. Pathologe 31 Suppl 2: 134-137. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20714898

Holt R, Barnby G, Maestrini E, Bacchelli E, Brocklebank D, Sousa I, Mulder EJ, Kantojarvi K, Jarvela I, Klauck SM, Poustka F, Bailey AJ, Monaco AP (2010) Linkage and candidate gene studies of autism spectrum disorders in European populations. Eur J Hum Genet 18: 1013-1019. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20442744

Jocker A, Sonntag J, Henjes F, Gotschel F, Tresch A, Beissbarth T, Wiemann S, Korf U (2010) QuantProReloaded: quantitative analysis of microspot immunoassays. Bioinformatics 26: 2480-2481. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20709689

Johannes M, Brase JC, Frohlich H, Gade S, Gehrmann M, Falth M, Sultmann H, Beissbarth T (2010) Integration of pathway knowledge into a reweighted recursive feature elimination approach for risk stratification of cancer patients. Bioinformatics 26: 2136-2144. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20591905

Maestrini E, Pagnamenta AT, Lamb JA, Bacchelli E, Sykes NH, Sousa I, Toma C, Barnby G, Butler H, Winchester L, Scerri TS, Minopoli F, Reichert J, Cai G, Buxbaum JD, Korvatska O, Schellenberg GD, Dawson G, de Bildt A, Minderaa RB, Mulder EJ, Morris AP, Bailey AJ, Monaco AP (2010) High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. Mol Psychiatry 15: 954-968. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19401682

Mannsperger HA, Gade S, Henjes F, Beissbarth T, Korf U (2010a) RPPanalyzer: Analysis of reverse-phase protein array data. Bioinformatics 26: 2202-2203. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20634205

Mannsperger HA, Uhlmann S, Schmidt C, Wiemann S, Sahin O, Korf U (2010b) RNAi-based validation of antibodies for reverse phase protein arrays. Proteome Sci 8: 69. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21182776

Noor A, Whibley A, Marshall CR, Gianakopoulos PJ, Piton A, Carson AR, Orlic-Milacic M, Lionel AC, Sato D, Pinto D, Drmic I, Noakes C, Senman L, Zhang X, Mo R, Gauthier J, Crosbie J, Pagnamenta AT, Munson J, Estes AM, Fiebig A, Franke A, Schreiber S, Stewart AF, Roberts R, McPherson R, Guter SJ, Cook EH, Jr., Dawson G, Schellenberg GD, Battaglia A, Maestrini E, Autism Genome Project Consortium, Jeng L, Hutchison T, Rajcan-Separovic E, Chudley AE, Lewis SM, Liu X, Holden JJ, Fernandez B, Zwaigenbaum L, Bryson SE, Roberts W, Szatmari P, Gallagher L, Stratton MR, Gecz J, Brady AF, Schwartz CE, Schachar RJ, Monaco AP, Rouleau GA, Hui CC, Lucy Raymond F, Scherer SW, Vincent JB (2010) Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability. Sci Transl Med 2: 49ra68. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20844286

Pagnamenta AT, Bacchelli E, de Jonge MV, Mirza G, Scerri TS, Minopoli F, Chiocchetti A, Ludwig KU, Hoffmann P, Paracchini S, Lowy E, Harold DH, Chapman JA, Klauck SM, Poustka F, Houben RH, Staal WG, Ophoff RA, O'Donovan MC, Williams J, Nothen MM, Schulte-Korne G, Deloukas P, Ragoussis J, Bailey AJ, Maestrini E, Monaco AP (2010) Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia. Biol Psychiatry 68: 320-328. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20346443

Pinto D, Pagnamenta AT, Klei L, Anney R, Merico D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Almeida J, Bacchelli E, Bader GD, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bolte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Bryson SE, Carson AR, Casallo G, Casey J, Chung BH, Cochrane L, Corsello C, Crawford EL, Crossett A, Cytrynbaum C, Dawson G, de Jonge M, Delorme R, Drmic I, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Fombonne E, Freitag CM, Gilbert J, Gillberg C, Glessner JT, Goldberg J, Green A, Green J, Guter SJ, Hakonarson H, Heron EA, Hill M, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Kim C, Klauck SM, Kolevzon A, Korvatska O, Kustanovich V, Lajonchere CM, Lamb JA, Laskawiec M, Leboyer M, Le Couteur A, Leventhal BL, Lionel AC, Liu XQ, Lord C, Lotspeich L, Lund SC, Maestrini E, Mahoney W, Mantoulan C, Marshall CR, McConachie H, McDougle CJ, McGrath J, McMahon WM, Merikangas A, Migita O, Minshew NJ, Mirza GK, Munson J, Nelson SF, Noakes C, Noor A, Nygren G, Oliveira G, Papanikolaou K, Parr JR, Parrini B, Paton T, Pickles A, Pilorge M, Piven J, Ponting CP, Posey DJ, Poustka A, Poustka F, Prasad A, Ragoussis J, Renshaw K, Rickaby J, Roberts W, Roeder K, Roge B, Rutter ML, Bierut LJ, Rice JP, Salt J, Sansom K, Sato D, Segurado R, Sequeira AF, Senman L, Shah N, Sheffield VC, Soorya L, Sousa I, Stein O, Sykes N, Stoppioni V, Strawbridge C, Tancredi R, Tansey K, Thiruvahindrapduram B, Thompson AP, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Wallace S, Wang K, Wang Z, Wassink TH, Webber C, Weksberg R, Wing K, Wittemeyer K, Wood S, Wu J, Yaspan BL, Zurawiecki D, Zwaigenbaum L, Buxbaum JD, Cantor RM, Cook EH, Coon H, Cuccaro ML, Devlin B, Ennis S, Gallagher L, Geschwind DH, Gill M, Haines JL, Hallmayer J, Miller J, Monaco AP, Nurnberger JI, Jr., Paterson AD, Pericak-Vance MA, Schellenberg GD, Szatmari P, Vicente AM, Vieland VJ, Wijsman EM, Scherer SW, Sutcliffe JS, Betancur C (2010) Functional impact of global rare copy number variation in autism spectrum disorders. Nature 466: 368-372. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20531469

Rostamiani K, Klauck SM, Heiss N, Poustka A, Khaleghi M, Rosales R, Metzenberg AB (2010) Novel mutations of the DKC1 gene in individuals affected with dyskeratosis congenita. Blood Cells Mol Dis 44: 88. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19879169

Sousa I, Clark TG, Holt R, Pagnamenta AT, Mulder EJ, Minderaa RB, Bailey AJ, Battaglia A, Klauck SM, Poustka F, Monaco AP (2010) Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry. Mol Autism 1: 7. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20678249

Uhlmann S, Zhang JD, Schwager A, Mannsperger H, Riazalhosseini Y, Burmester S, Ward A, Korf U, Wiemann S, Sahin O (2010) miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer. Oncogene 29: 4297-4306. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20514023

Wilber A, Tschulena U, Hargrove PW, Kim YS, Persons DA, Barbas CF, 3rd, Nienhuis AW (2010) A zinc-finger transcriptional activator designed to interact with the gamma-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts. Blood 115: 3033-3041. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20190190

Will RD, Eden M, Just S, Hansen A, Eder A, Frank D, Kuhn C, Seeger TS, Oehl U, Wiemann S, Korn B, Koegl M, Rottbauer W, Eschenhagen T, Katus HA, Frey N (2010) Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing. Circ Res 107: 1253-1264. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20847312

Youns M, Fu YJ, Zu YG, Kramer A, Konkimalla VB, Radlwimmer B, Sultmann H, Efferth T (2010) Sensitivity and resistance towards isoliquiritigenin, doxorubicin and methotrexate in T cell acute lymphoblastic leukaemia cell lines by pharmacogenomics. Naunyn Schmiedebergs Arch Pharmacol 382: 221-234. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20668838

2009

Calabro A, Beissbarth T, Kuner R, Stojanov M, Benner A, Asslaber M, Ploner F, Zatloukal K, Samonigg H, Poustka A, Sultmann H (2009) Effects of infiltrating lymphocytes and estrogen receptor on gene expression and prognosis in breast cancer. Breast Cancer Res Treat 116: 69-77. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18592372

End C, Bikker F, Renner M, Bergmann G, Lyer S, Blaich S, Hudler M, Helmke B, Gassler N, Autschbach F, Ligtenberg AJ, Benner A, Holmskov U, Schirmacher P, Nieuw Amerongen AV, Rosenstiel P, Sina C, Franke A, Hafner M, Kioschis P, Schreiber S, Poustka A, Mollenhauer J (2009) DMBT1 functions as pattern-recognition molecule for poly-sulfated and poly-phosphorylated ligands. Eur J Immunol 39: 833-842. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19189310

Felder B, Radlwimmer B, Benner A, Mincheva A, Todt G, Beyer KS, Schuster C, Bolte S, Schmotzer G, Klauck SM, Poustka F, Lichter P, Poustka A (2009) FARP2, HDLBP and PASK are downregulated in a patient with autism and 2q37.3 deletion syndrome. Am J Med Genet A 149A: 952-959. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19365831

Hagist S, Sultmann H, Millonig G, Hebling U, Kieslich D, Kuner R, Balaguer S, Seitz HK, Poustka A, Mueller S (2009) In vitro-targeted gene identification in patients with hepatitis C using a genome-wide microarray technology. Hepatology 49: 378-386. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19177570

Helmke BM, Renner M, Poustka A, Schirmacher P, Mollenhauer J, Kern MA (2009) DMBT1 expression distinguishes anorectal from cutaneous melanoma. Histopathology 54: 233-240. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19207948

Kahn N, Kuner R, Eberhardt R, Meister M, Muley T, Winteroll S, Schnabel PA, Ishizaka A, Herth FJ, Poustka A, Sultmann H, Hoffmann H (2009) Gene expression analysis of endobronchial epithelial lining fluid in the evaluation of indeterminate pulmonary nodules. J Thorac Cardiovasc Surg 138: 474-479. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19619798

Korf U, Lobke C, Sahin O, Haller F, Sultmann H, Arlt D, Poustka A (2009) Reverse-phase protein arrays for application-orientated cancer research. Proteomics Clin Appl 3: 1140-1150. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21136941

Kuner R, Hoffmann H, Sultmann H (2009a) [Gene expression profiling in lung cancer. Experimental research and clinical application]. Dtsch Med Wochenschr 134: 519-521. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19259908

Kuner R, Muley T, Meister M, Ruschhaupt M, Buness A, Xu EC, Schnabel P, Warth A, Poustka A, Sultmann H, Hoffmann H (2009b) Global gene expression analysis reveals specific patterns of cell junctions in non-small cell lung cancer subtypes. Lung Cancer 63: 32-38. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18486272

Pagnamenta AT, Wing K, Sadighi Akha E, Knight SJ, Bolte S, Schmotzer G, Duketis E, Poustka F, Klauck SM, Poustka A, Ragoussis J, Bailey AJ, Monaco AP (2009) A 15q13.3 microdeletion segregating with autism. Eur J Hum Genet 17: 687-692. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19050728

Poustka F, Freitag C, Klauck S, Hebebrand J (2009) [Autism]. Z Kinder Jugendpsychiatr Psychother 37: 269-275. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20306783

Pressinotti NC, Klocker H, Schafer G, Luu VD, Ruschhaupt M, Kuner R, Steiner E, Poustka A, Bartsch G, Sultmann H (2009) Differential expression of apoptotic genes PDIA3 and MAP3K5 distinguishes between low- and high-risk prostate cancer. Mol Cancer 8: 130. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20035634

Sahin O, Frohlich H, Lobke C, Korf U, Burmester S, Majety M, Mattern J, Schupp I, Chaouiya C, Thieffry D, Poustka A, Wiemann S, Beissbarth T, Arlt D (2009) Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance. BMC Syst Biol 3: 1. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19118495

Sahin O, Wiemann S (2009) Functional genomics and proteomics approaches to study the ERBB network in cancer. FEBS Lett 583: 1766-1771. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19303877

Schlomm T, Hellwinkel OJ, Buness A, Ruschhaupt M, Lubke AM, Chun FK, Simon R, Budaus L, Erbersdobler A, Graefen M, Huland H, Poustka A, Sultmann H (2009a) Molecular cancer phenotype in normal prostate tissue. Eur Urol 55: 885-890. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18501497

Schlomm T, Sultmann H, Kollermann J (2009b) [Identification and validation of clinically relevant molecular alterations in prostate cancer]. Pathologe 30: 111-116. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19139898

Sers C, Kuner R, Falk CS, Lund P, Sueltmann H, Braun M, Buness A, Ruschhaupt M, Conrad J, Mang-Fatehi S, Stelniec I, Krapfenbauer U, Poustka A, Schafer R (2009) Down-regulation of HLA Class I and NKG2D ligands through a concerted action of MAPK and DNA methyltransferases in colorectal cancer cells. Int J Cancer 125: 1626-1639. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19569244

Temple G, Gerhard DS, Rasooly R, Feingold EA, Good PJ, Robinson C, Mandich A, Derge JG, Lewis J, Shoaf D, Collins FS, Jang W, Wagner L, Shenmen CM, Misquitta L, Schaefer CF, Buetow KH, Bonner TI, Yankie L, Ward M, Phan L, Astashyn A, Brown G, Farrell C, Hart J, Landrum M, Maidak BL, Murphy M, Murphy T, Rajput B, Riddick L, Webb D, Weber J, Wu W, Pruitt KD, Maglott D, Siepel A, Brejova B, Diekhans M, Harte R, Baertsch R, Kent J, Haussler D, Brent M, Langton L, Comstock CL, Stevens M, Wei C, van Baren MJ, Salehi-Ashtiani K, Murray RR, Ghamsari L, Mello E, Lin C, Pennacchio C, Schreiber K, Shapiro N, Marsh A, Pardes E, Moore T, Lebeau A, Muratet M, Simmons B, Kloske D, Sieja S, Hudson J, Sethupathy P, Brownstein M, Bhat N, Lazar J, Jacob H, Gruber CE, Smith MR, McPherson J, Garcia AM, Gunaratne PH, Wu J, Muzny D, Gibbs RA, Young AC, Bouffard GG, Blakesley RW, Mullikin J, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Hirst M, Zeng T, Tse K, Moksa M, Deng M, Ma K, Mah D, Pang J, Taylor G, Chuah E, Deng A, Fichter K, Go A, Lee S, Wang J, Griffith M, Morin R, Moore RA, Mayo M, Munro S, Wagner S, Jones SJ, Holt RA, Marra MA, Lu S, Yang S, Hartigan J, Graf M, Wagner R, Letovksy S, Pulido JC, Robison K, Esposito D, Hartley J, Wall VE, Hopkins RF, Ohara O, Wiemann S (2009) The completion of the Mammalian Gene Collection (MGC). Genome Res 19: 2324-2333. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19767417

Tschulena U, Peterson KR, Gonzalez B, Fedosyuk H, Barbas CF, 3rd (2009) Positive selection of DNA-protein interactions in mammalian cells through phenotypic coupling with retrovirus production. Nat Struct Mol Biol 16: 1195-1199. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19838191

Zhang JD, Wiemann S (2009) KEGGgraph: a graph approach to KEGG PATHWAY in R and bioconductor. Bioinformatics 25: 1470-1471. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19307239

2008

Boeuf S, Steck E, Pelttari K, Hennig T, Buness A, Benz K, Witte D, Sultmann H, Poustka A, Richter W (2008) Subtractive gene expression profiling of articular cartilage and mesenchymal stem cells: serpins as cartilage-relevant differentiation markers. Osteoarthritis Cartilage 16: 48-60. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17604188

Cheung W, Darfler MM, Alvarez H, Hood BL, Conrads TP, Habbe N, Krizman DB, Mollenhauer J, Feldmann G, Maitra A (2008) Application of a global proteomic approach to archival precursor lesions: deleted in malignant brain tumors 1 and tissue transglutaminase 2 are upregulated in pancreatic cancer precursors. Pancreatology 8: 608-616. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18849643

Eisenberger S, Ackermann K, Voggenreiter G, Sultmann H, Kasperk C, Pyerin W (2008) Metastases and multiple myeloma generate distinct transcriptional footprints in osteocytes in vivo. J Pathol 214: 617-626. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18266311

Frohlich H, Beissbarth T, Tresch A, Kostka D, Jacob J, Spang R, Markowetz F (2008a) Analyzing gene perturbation screens with nested effects models in R and bioconductor. Bioinformatics 24: 2549-2550. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18718939

Frohlich H, Fellmann M, Sultmann H, Poustka A, Beissbarth T (2008b) Estimating Large Scale Signaling Networks through Nested Effect Models with Intervention Effects from Microarray Data. Bioinformatics. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18227117

Frohlich H, Fellmann M, Sultmann H, Poustka A, Beissbarth T (2008c) Predicting pathway membership via domain signatures. Bioinformatics 24: 2137-2142. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18676972

Genome Information Integration P, Invitational H, Yamasaki C, Murakami K, Fujii Y, Sato Y, Harada E, Takeda J, Taniya T, Sakate R, Kikugawa S, Shimada M, Tanino M, Koyanagi KO, Barrero RA, Gough C, Chun HW, Habara T, Hanaoka H, Hayakawa Y, Hilton PB, Kaneko Y, Kanno M, Kawahara Y, Kawamura T, Matsuya A, Nagata N, Nishikata K, Noda AO, Nurimoto S, Saichi N, Sakai H, Sanbonmatsu R, Shiba R, Suzuki M, Takabayashi K, Takahashi A, Tamura T, Tanaka M, Tanaka S, Todokoro F, Yamaguchi K, Yamamoto N, Okido T, Mashima J, Hashizume A, Jin L, Lee KB, Lin YC, Nozaki A, Sakai K, Tada M, Miyazaki S, Makino T, Ohyanagi H, Osato N, Tanaka N, Suzuki Y, Ikeo K, Saitou N, Sugawara H, O'Donovan C, Kulikova T, Whitfield E, Halligan B, Shimoyama M, Twigger S, Yura K, Kimura K, Yasuda T, Nishikawa T, Akiyama Y, Motono C, Mukai Y, Nagasaki H, Suwa M, Horton P, Kikuno R, Ohara O, Lancet D, Eveno E, Graudens E, Imbeaud S, Debily MA, Hayashizaki Y, Amid C, Han M, Osanger A, Endo T, Thomas MA, Hirakawa M, Makalowski W, Nakao M, Kim NS, Yoo HS, De Souza SJ, Bonaldo Mde F, Niimura Y, Kuryshev V, Schupp I, Wiemann S, Bellgard M, Shionyu M, Jia L, Thierry-Mieg D, Thierry-Mieg J, Wagner L, Zhang Q, Go M, Minoshima S, Ohtsubo M, Hanada K, Tonellato P, Isogai T, Zhang J, Lenhard B, Kim S, Chen Z, Hinz U, Estreicher A, Nakai K, Makalowska I, Hide W, Tiffin N, Wilming L, Chakraborty R, Soares MB, Chiusano ML, Suzuki Y, Auffray C, Yamaguchi-Kabata Y, Itoh T, Hishiki T, Fukuchi S, Nishikawa K, Sugano S, Nomura N, Tateno Y, Imanishi T, Gojobori T (2008) The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts. Nucleic Acids Res 36: D793-799. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18089548

Hahne F, Mehrle A, Arlt D, Poustka A, Wiemann S, Beissbarth T (2008) Extending pathways based on gene lists using InterPro domain signatures. BMC Bioinformatics 9: 3. Pubmed: www.ncbi.nlm.nih.gov/pubmed/18177498

Haller F, Lobke C, Ruschhaupt M, Cameron S, Schulten HJ, Schwager S, von Heydebreck A, Gunawan B, Langer C, Ramadori G, Sultmann H, Poustka A, Korf U, Fuzesi L (2008a) Loss of 9p leads to p16INK4A down-regulation and enables RB/E2F1-dependent cell cycle promotion in gastrointestinal stromal tumours (GISTs). J Pathol 215: 253-262. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18438954

Haller F, Lobke C, Ruschhaupt M, Schulten HJ, Schwager S, Gunawan B, Armbrust T, Langer C, Ramadori G, Sultmann H, Poustka A, Korf U, Fuzesi L (2008b) Increased KIT signalling with up-regulation of cyclin D correlates to accelerated proliferation and shorter disease-free survival in gastrointestinal stromal tumours (GISTs) with KIT exon 11 deletions. J Pathol 216: 225-235. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18729075

Kissling C, Retz W, Wiemann S, Coogan AN, Clement RM, Hunnerkopf R, Conner AC, Freitag CM, Rosler M, Thome J (2008) A polymorphism at the 3'-untranslated region of the CLOCK gene is associated with adult attention-deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 147: 333-338. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17948273

Kleber S, Sancho-Martinez I, Wiestler B, Beisel A, Gieffers C, Hill O, Thiemann M, Mueller W, Sykora J, Kuhn A, Schreglmann N, Letellier E, Zuliani C, Klussmann S, Teodorczyk M, Grone HJ, Ganten TM, Sultmann H, Tuttenberg J, von Deimling A, Regnier-Vigouroux A, Herold-Mende C, Martin-Villalba A (2008) Yes and PI3K bind CD95 to signal invasion of glioblastoma. Cancer Cell 13: 235-248. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18328427

Kohl T, Schmidt C, Wiemann S, Poustka A, Korf U (2008) Automated production of recombinant human proteins as resource for proteome research. Proteome Sci 6: 4. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18226205

Korf U, Derdak S, Tresch A, Henjes F, Schumacher S, Schmidt C, Hahn B, Lehmann WD, Poustka A, Beissbarth T, Klingmuller U (2008a) Quantitative protein microarrays for time-resolved measurements of protein phosphorylation. Proteomics 8: 4603-4612. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18972530

Korf U, Henjes F, Schmidt C, Tresch A, Mannsperger H, Lobke C, Beissbarth T, Poustka A (2008b) Antibody microarrays as an experimental platform for the analysis of signal transduction networks. Adv Biochem Eng Biotechnol 110: 153-175. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18528667

Kuner R, Barth AS, Ruschhaupt M, Buness A, Zwermann L, Kreuzer E, Steinbeck G, Poustka A, Sultmann H, Nabauer M (2008) Genomic analysis reveals poor separation of human cardiomyopathies of ischemic and nonischemic etiologies. Physiol Genomics 34: 88-94. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18430805

Lobke C, Laible M, Rappl C, Ruschhaupt M, Sahin O, Arlt D, Wiemann S, Poustka A, Sultmann H, Korf U (2008) Contact spotting of protein microarrays coupled with spike-in of normalizer protein permits time-resolved analysis of ERBB receptor signaling. Proteomics 8: 1586-1594. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18351692

Mathivanan S, Ahmed M, Ahn NG, Alexandre H, Amanchy R, Andrews PC, Bader JS, Balgley BM, Bantscheff M, Bennett KL, Bjorling E, Blagoev B, Bose R, Brahmachari SK, Burlingame AS, Bustelo XR, Cagney G, Cantin GT, Cardasis HL, Celis JE, Chaerkady R, Chu F, Cole PA, Costello CE, Cotter RJ, Crockett D, DeLany JP, De Marzo AM, DeSouza LV, Deutsch EW, Dransfield E, Drewes G, Droit A, Dunn MJ, Elenitoba-Johnson K, Ewing RM, Van Eyk J, Faca V, Falkner J, Fang X, Fenselau C, Figeys D, Gagne P, Gelfi C, Gevaert K, Gimble JM, Gnad F, Goel R, Gromov P, Hanash SM, Hancock WS, Harsha HC, Hart G, Hays F, He F, Hebbar P, Helsens K, Hermeking H, Hide W, Hjerno K, Hochstrasser DF, Hofmann O, Horn DM, Hruban RH, Ibarrola N, James P, Jensen ON, Jensen PH, Jung P, Kandasamy K, Kheterpal I, Kikuno RF, Korf U, Korner R, Kuster B, Kwon MS, Lee HJ, Lee YJ, Lefevre M, Lehvaslaiho M, Lescuyer P, Levander F, Lim MS, Lobke C, Loo JA, Mann M, Martens L, Martinez-Heredia J, McComb M, McRedmond J, Mehrle A, Menon R, Miller CA, Mischak H, Mohan SS, Mohmood R, Molina H, Moran MF, Morgan JD, Moritz R, Morzel M, Muddiman DC, Nalli A, Navarro JD, Neubert TA, Ohara O, Oliva R, Omenn GS, Oyama M, Paik YK, Pennington K, Pepperkok R, Periaswamy B, Petricoin EF, Poirier GG, Prasad TS, Purvine SO, Rahiman BA, Ramachandran P, Ramachandra YL, Rice RH, Rick J, Ronnholm RH, Salonen J, Sanchez JC, Sayd T, Seshi B, Shankari K, Sheng SJ, Shetty V, Shivakumar K, Simpson RJ, Sirdeshmukh R, Siu KW, Smith JC, Smith RD, States DJ, Sugano S, Sullivan M, Superti-Furga G, Takatalo M, Thongboonkerd V, Trinidad JC, Uhlen M, Vandekerckhove J, Vasilescu J, Veenstra TD, Vidal-Taboada JM, Vihinen M, Wait R, Wang X, Wiemann S, Wu B, Xu T, Yates JR, Zhong J, Zhou M, Zhu Y, Zurbig P, Pandey A (2008) Human Proteinpedia enables sharing of human protein data. Nat Biotechnol 26: 164-167. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18259167

Michaud J, Simpson KM, Escher R, Buchet-Poyau K, Beissbarth T, Carmichael C, Ritchie ME, Schutz F, Cannon P, Liu M, Shen X, Ito Y, Raskind WH, Horwitz MS, Osato M, Turner DR, Speed TP, Kavallaris M, Smyth GK, Scott HS (2008) Integrative analysis of RUNX1 downstream pathways and target genes. BMC Genomics 9: 363. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18671852

Muller H, End C, Weiss C, Renner M, Bhandiwad A, Helmke BM, Gassler N, Hafner M, Poustka A, Mollenhauer J, Poeschl J (2008) Respiratory Deleted in Malignant Brain Tumours 1 (DMBT1) levels increase during lung maturation and infection. Clin Exp Immunol 151: 123-129. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17991292

Pepperkok R, Wiemann S (2008) Integrating systems biology with clinical research. Genome Biol 9: 314. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18598389

Praml C, Schulz W, Claas A, Mollenhauer J, Poustka A, Ackermann R, Schwab M, Henrich KO (2008) Genetic variation of Aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells. Cancer Lett 272: 160-166. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18752886

Retz W, Rosler M, Kissling C, Wiemann S, Hunnerkopf R, Coogan A, Thome J, Freitag C (2008) Norepinephrine transporter and catecholamine-O-methyltransferase gene variants and attention-deficit/hyperactivity disorder symptoms in adults. J Neural Transm 115: 323-329. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17994190

Sansone SA, Rocca-Serra P, Brandizi M, Brazma A, Field D, Fostel J, Garrow AG, Gilbert J, Goodsaid F, Hardy N, Jones P, Lister A, Miller M, Morrison N, Rayner T, Sklyar N, Taylor C, Tong W, Warner G, Wiemann S (2008) The first RSBI (ISA-TAB) workshop: "can a simple format work for complex studies?". Omics 12: 143-149. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18447634

Sauermann M, Sahin O, Sultmann H, Hahne F, Blaszkiewicz S, Majety M, Zatloukal K, Fuzesi L, Poustka A, Wiemann S, Arlt D (2008) Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells. Oncogene 27: 1320-1326. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17724469

Schlomm T, Nakel E, Lubke A, Buness A, Chun FK, Steuber T, Graefen M, Simon R, Sauter G, Poustka A, Huland H, Erbersdobler A, Sultmann H, Hellwinkel OJ (2008a) Marked gene transcript level alterations occur early during radical prostatectomy. Eur Urol 53: 333-346. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17448597

Schlomm T, Sultmann H, Kollermann J (2008b) [Identification and validation of clinically relevant molecular alterations in prostate cancer]. Urologe A 47: 1193-1198. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18712514

Stadler V, Felgenhauer T, Beyer M, Fernandez S, Leibe K, Guttler S, Groning M, Konig K, Torralba G, Hausmann M, Lindenstruth V, Nesterov A, Block I, Pipkorn R, Poustka A, Bischoff FR, Breitling F (2008) Combinatorial synthesis of peptide arrays with a laser printer. Angew Chem Int Ed Engl 47: 7132-7135. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18671222

Taylor CF, Field D, Sansone SA, Aerts J, Apweiler R, Ashburner M, Ball CA, Binz PA, Bogue M, Booth T, Brazma A, Brinkman RR, Michael Clark A, Deutsch EW, Fiehn O, Fostel J, Ghazal P, Gibson F, Gray T, Grimes G, Hancock JM, Hardy NW, Hermjakob H, Julian RK, Jr., Kane M, Kettner C, Kinsinger C, Kolker E, Kuiper M, Le Novere N, Leebens-Mack J, Lewis SE, Lord P, Mallon AM, Marthandan N, Masuya H, McNally R, Mehrle A, Morrison N, Orchard S, Quackenbush J, Reecy JM, Robertson DG, Rocca-Serra P, Rodriguez H, Rosenfelder H, Santoyo-Lopez J, Scheuermann RH, Schober D, Smith B, Snape J, Stoeckert CJ, Jr., Tipton K, Sterk P, Untergasser A, Vandesompele J, Wiemann S (2008) Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project. Nat Biotechnol 26: 889-896. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18688244

Van Laere S, Beissbarth T, Van der Auwera I, Van den Eynden G, Trinh XB, Elst H, Van Hummelen P, van Dam P, Van Marck E, Vermeulen P, Dirix L (2008) Relapse-free survival in breast cancer patients is associated with a gene expression signature characteristic for inflammatory breast cancer. Clin Cancer Res 14: 7452-7460. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19010862

Westermann F, Muth D, Benner A, Bauer T, Henrich KO, Oberthuer A, Brors B, Beissbarth T, Vandesompele J, Pattyn F, Hero B, Konig R, Fischer M, Schwab M (2008) Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas. Genome Biol 9: R150. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18851746

Yamasaki C, Murakami K, Fujii Y, Sato Y, Harada E, Takeda J, Taniya T, Sakate R, Kikugawa S, Shimada M, Tanino M, Koyanagi KO, Barrero RA, Gough C, Chun HW, Habara T, Hanaoka H, Hayakawa Y, Hilton PB, Kaneko Y, Kanno M, Kawahara Y, Kawamura T, Matsuya A, Nagata N, Nishikata K, Noda AO, Nurimoto S, Saichi N, Sakai H, Sanbonmatsu R, Shiba R, Suzuki M, Takabayashi K, Takahashi A, Tamura T, Tanaka M, Tanaka S, Todokoro F, Yamaguchi K, Yamamoto N, Okido T, Mashima J, Hashizume A, Jin L, Lee KB, Lin YC, Nozaki A, Sakai K, Tada M, Miyazaki S, Makino T, Ohyanagi H, Osato N, Tanaka N, Suzuki Y, Ikeo K, Saitou N, Sugawara H, O'Donovan C, Kulikova T, Whitfield E, Halligan B, Shimoyama M, Twigger S, Yura K, Kimura K, Yasuda T, Nishikawa T, Akiyama Y, Motono C, Mukai Y, Nagasaki H, Suwa M, Horton P, Kikuno R, Ohara O, Lancet D, Eveno E, Graudens E, Imbeaud S, Debily MA, Hayashizaki Y, Amid C, Han M, Osanger A, Endo T, Thomas MA, Hirakawa M, Makalowski W, Nakao M, Kim NS, Yoo HS, De Souza SJ, Bonaldo Mde F, Niimura Y, Kuryshev V, Schupp I, Wiemann S, Bellgard M, Shionyu M, Jia L, Thierry-Mieg D, Thierry-Mieg J, Wagner L, Zhang Q, Go M, Minoshima S, Ohtsubo M, Hanada K, Tonellato P, Isogai T, Zhang J, Lenhard B, Kim S, Chen Z, Hinz U, Estreicher A, Nakai K, Makalowska I, Hide W, Tiffin N, Wilming L, Chakraborty R, Soares MB, Chiusano ML, Auffray C, Yamaguchi-Kabata Y, Itoh T, Hishiki T, Fukuchi S, Nishikawa K, Sugano S, Nomura N, Tateno Y, Imanishi T, Gojobori T (2008) The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts. Nucleic Acids Res 36: D793-799. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18089548

2007

Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I (2007) The full-ORF clone resource of the German cDNA Consortium. BMC Genomics 8: 399. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17974005

Blackburn AC, Hill LZ, Roberts AL, Wang J, Aud D, Jung J, Nikolcheva T, Allard J, Peltz G, Otis CN, Cao QJ, Ricketts RS, Naber SP, Mollenhauer J, Poustka A, Malamud D, Jerry DJ (2007) Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk. Am J Pathol 170: 2030-2041. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17525270

Brueckner B, Stresemann C, Kuner R, Mund C, Musch T, Meister M, Sultmann H, Lyko F (2007) The Human let-7a-3 Locus Contains an Epigenetically Regulated MicroRNA Gene with Oncogenic Function. Cancer Res 67: 1419-1423. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17308078

Buness A, Kuner R, Ruschhaupt M, Poustka A, Sultmann H, Tresch A (2007) Identification of aberrant chromosomal regions from gene expression microarray studies applied to human breast cancer. Bioinformatics 23: 2273-2280. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17599933

Conde AR, Martins AP, Brito M, Manuel A, Ramos S, Malta-Vacas J, Renner M, Poustka A, Mollenhauer J, Monteiro C (2007) DMBT1 is frequently downregulated in well-differentiated gastric carcinoma but more frequently upregulated across various gastric cancer types. Int J Oncol 30: 1441-1446. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17487364

Froehlich H, Fellmann M, Sueltmann H, Poustka A, Beissbarth T (2007) Large scale statistical inference of signaling pathways from RNAi and microarray data. BMC Bioinformatics 8: 386. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17937790

Frohlich H, Speer N, Poustka A, Beissbarth T (2007) GOSim--an R-package for computation of information theoretic GO similarities between terms and gene products. BMC Bioinformatics 8: 166. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17519018

Geldyyev A, Koleganova N, Piecha G, Sueltmann H, Finis K, Ruschaupt M, Poustka A, Gross ML, Berger I (2007) High expression level of bone degrading proteins as a possible inducer of osteolytic features in pigmented villonodular synovitis. Cancer Lett 255: 275-283. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17601661

Henrich KO, Claas A, Praml C, Benner A, Mollenhauer J, Poustka A, Schwab M, Westermann F (2007) Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma. Eur J Cancer 43: 607-616. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17222547

Kissling C, Retz W, Wiemann S, Coogan AN, Clement RM, Hunnerkopf R, Conner AC, Freitag CM, Rosler M, Thome J (2007) A polymorphism at the 3'-untranslated region of the CLOCK gene is associated with adult attention-deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17948273

Klauck SM, Poustka F, Poustka A (2007) Autismus mit einem Spektrum an Verhaltensstörungen. Ursachenforschung zwischen Phänotyp und Genotyp im internationalen Netzwerk. GenomXPress 3: 19-22. Pubmed:

Kuner R, Vogt M, Sultmann H, Buness A, Dymalla S, Bulkescher J, Fellmann M, Butz K, Poustka A, Hoppe-Seyler F (2007) Identification of cellular targets for the human papillomavirus E6 and E7 oncogenes by RNA interference and transcriptome analyses. J Mol Med. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17589817

Laketa V, Simpson JC, Bechtel S, Wiemann S, Pepperkok R (2007) High-content microscopy identifies new neurite outgrowth regulators. Mol Biol Cell 18: 242-252. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17093056

Ligtenberg AJ, Veerman EC, Nieuw Amerongen AV, Mollenhauer J (2007) Salivary agglutinin/glycoprotein-340/DMBT1: a single molecule with variable composition and with different functions in infection, inflammation and cancer. Biol Chem 388: 1275-1289. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18020944

Loebke C, Sueltmann H, Schmidt C, Henjes F, Wiemann S, Poustka A, Korf U (2007) Infrared-based protein detection arrays for quantitative proteomics. Proteomics 7: 558-564. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17309101

Muller H, End C, Renner M, Helmke BM, Gassler N, Weiss C, Hartl D, Griese M, Hafner M, Poustka A, Mollenhauer J, Poeschl J (2007) Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant. Respir Res 8: 69. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17908325

Renner M, Bergmann G, Krebs I, End C, Lyer S, Hilberg F, Helmke B, Gassler N, Autschbach F, Bikker F, Strobel-Freidekind O, Gronert-Sum S, Benner A, Blaich S, Wittig R, Hudler M, Ligtenberg AJ, Madsen J, Holmskov U, Annese V, Latiano A, Schirmacher P, Amerongen AV, D'Amato M, Kioschis P, Hafner M, Poustka A, Mollenhauer J (2007) DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease. Gastroenterology 133: 1499-1509. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17983803

Rosenstiel P, Sina C, End C, Renner M, Lyer S, Till A, Hellmig S, Nikolaus S, Folsch UR, Helmke B, Autschbach F, Schirmacher P, Kioschis P, Hafner M, Poustka A, Mollenhauer J, Schreiber S (2007) Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion. J Immunol 178: 8203-8211. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17548659

Sahin O, Lobke C, Korf U, Appelhans H, Sultmann H, Poustka A, Wiemann S, Arlt D (2007) Combinatorial RNAi for quantitative protein network analysis. Proc Natl Acad Sci U S A 104: 6579-6584. Pubmed: www.ncbi.nlm.nih.gov/pubmed/17420474

Sauermann M, Hahne F, Schmidt C, Majety M, Rosenfelder H, Bechtel S, Huber W, Poustka A, Arlt D, Wiemann S (2007) High-throughput flow cytometry-based assay to identify apoptosis-inducing proteins. J Biomol Screen 12: 510-520. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17478479

Schlomm T, Sultmann H, Poustka A, Sauter G, Hellwinkel OJ, Huland H (2007) Molekulare Hochdurchsatzforschung beim Prostatakarzinom. Urologe A 46: 1097-1100. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17628772

Szatmari P, Paterson AD, Zwaigenbaum L, Roberts W, Brian J, Liu XQ, Vincent JB, Skaug JL, Thompson AP, Senman L, Feuk L, Qian C, Bryson SE, Jones MB, Marshall CR, Scherer SW, Vieland VJ, Bartlett C, Mangin LV, Goedken R, Segre A, Pericak-Vance MA, Cuccaro ML, Gilbert JR, Wright HH, Abramson RK, Betancur C, Bourgeron T, Gillberg C, Leboyer M, Buxbaum JD, Davis KL, Hollander E, Silverman JM, Hallmayer J, Lotspeich L, Sutcliffe JS, Haines JL, Folstein SE, Piven J, Wassink TH, Sheffield V, Geschwind DH, Bucan M, Brown WT, Cantor RM, Constantino JN, Gilliam TC, Herbert M, Lajonchere C, Ledbetter DH, Lese-Martin C, Miller J, Nelson S, Samango-Sprouse CA, Spence S, State M, Tanzi RE, Coon H, Dawson G, Devlin B, Estes A, Flodman P, Klei L, McMahon WM, Minshew N, Munson J, Korvatska E, Rodier PM, Schellenberg GD, Smith M, Spence MA, Stodgell C, Tepper PG, Wijsman EM, Yu CE, Roge B, Mantoulan C, Wittemeyer K, Poustka A, Felder B, Klauck SM, Schuster C, Poustka F, Bolte S, Feineis-Matthews S, Herbrecht E, Schmotzer G, Tsiantis J, Papanikolaou K, Maestrini E, Bacchelli E, Blasi F, Carone S, Toma C, Van Engeland H, de Jonge M, Kemner C, Koop F, Langemeijer M, Hijmans C, Staal WG, Baird G, Bolton PF, Rutter ML, Weisblatt E, Green J, Aldred C, Wilkinson JA, Pickles A, Le Couteur A, Berney T, McConachie H, Bailey AJ, Francis K, Honeyman G, Hutchinson A, Parr JR, Wallace S, Monaco AP, Barnby G, Kobayashi K, Lamb JA, Sousa I, Sykes N, Cook EH, Guter SJ, Leventhal BL, Salt J, Lord C, Corsello C, Hus V, Weeks DE, Volkmar F, Tauber M, Fombonne E, Shih A, Meyer KJ (2007) Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet 39: 319-328. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17322880

Tresch A, Beissbarth T, Sultmann H, Kuner R, Poustka A, Buness A (2007) Discrimination of direct and indirect interactions in a network of regulatory effects. J Comput Biol 14: 1217-1228. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17990974

2006

Arlt D, Sahin O, Korf U, Loebke C, Beissbarth T, Hahne F, Wiemann S, Poustka A (2006) Modeling breast cell cycle regulation - overcoming drug resistance. Conf Proc IEEE Eng Med Biol Soc 1: 40-43. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17946776

Barth AS, Kuner R, Buness A, Ruschhaupt M, Merk S, Zwermann L, Kaab S, Kreuzer E, Steinbeck G, Mansmann U, Poustka A, Nabauer M, Sultmann H (2006) Identification of a common gene expression signature in dilated cardiomyopathy across independent microarray studies. J Am Coll Cardiol 48: 1610-1617. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17045896

Blasi F, Bacchelli E, Carone S, Toma C, Monaco AP, Bailey AJ, Maestrini E (2006a) SLC25A12 and CMYA3 gene variants are not associated with autism in the IMGSAC multiplex family sample. Eur J Hum Genet 14: 123-126. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16205742

Blasi F, Bacchelli E, Pesaresi G, Carone S, Bailey AJ, Maestrini E (2006b) Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection. Am J Med Genet B Neuropsychiatr Genet 141: 220-221. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16508939

del Val C, Kuryshev VY, Glatting KH, Ernst P, Hotz-Wagenblatt A, Poustka A, Suhai S, Wiemann S (2006) CAFTAN: a tool for fast mapping, and quality assessment of cDNAs. BMC Bioinformatics 7: 473. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17064411

Finis K, Sultmann H, Ruschhaupt M, Buness A, Helmchen B, Kuner R, Gross ML, Fink B, Schirmacher P, Poustka A, Berger I (2006) Analysis of pigmented villonodular synovitis with genome-wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches. Arthritis Rheum 54: 1009-1019. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16508983

Fleischer S, Wiemann S, Will H, Hofmann TG (2006) PML-associated repressor of transcription (PAROT), a novel KRAB-zinc finger repressor, is regulated through association with PML nuclear bodies. Exp Cell Res 312: 901-912. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16412420

Gassler N, Newrzella D, Bohm C, Lyer S, Li L, Sorgenfrei O, van Laer L, Sido B, Mollenhauer J, Poustka A, Schirmacher P, Gretz N (2006) Molecular characterisation of non-absorptive and absorptive enterocytes in human small intestine. Gut 55: 1084-1089. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16556670

Haase B, Humphray SJ, Lyer S, Renner M, Poustka A, Mollenhauer J, Leeb T (2006) Molecular characterization of the porcine deleted in malignant brain tumors 1 gene (DMBT1). Gene 376: 184-191. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16624504

Hahne F, Arlt D, Sauermann M, Majety M, Poustka A, Wiemann S, Huber W (2006) Statistical methods and software for the analysis of high throughput reverse genetic assays using flow cytometry readouts. Genome Biol 7: R77. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16916453

Klauck SM (2006) Genetics of autism spectrum disorder. Eur J Hum Genet 14: 714-720. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16721407

Klauck SM, Felder B, Kolb-Kokocinski A, Schuster C, Chiocchetti A, Schupp I, Wellenreuther R, Schmotzer G, Poustka F, Breitenbach-Koller L, Poustka A (2006) Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism. Mol Psychiatry 11: 1073-1084. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16940977

Kolb-Kokocinski A, Mehrle A, Bechtel S, Simpson A, Kioschis P, Wiemann S, Wellenreuther R, Poustka A (2006) The systematic functional characterisation of Xq28 genes prioritises candidate disease genes. BMC Genomics 7: 29. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16503986

Kuryshev VY, Vorobyov E, Zink D, Schmitz J, Rozhdestvensky TS, Munstermann E, Ernst U, Wellenreuther R, Moosmayer P, Bechtel S, Schupp I, Horst J, Korn B, Poustka A, Wiemann S (2006) An anthropoid-specific segmental duplication on human chromosome 1q22. Genomics 88: 143-151. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16545939

Mehrle A, Rosenfelder H, Schupp I, Del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006) The LIFEdb database in 2006. Nucleic Acids Res 34: D415-418. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16381901

Orchard S, Apweiler R, Barkovich R, Field D, Garavelli JS, Horn D, Jones A, Jones P, Julian R, McNally R, Nerothin J, Paton N, Pizarro A, Seymour S, Taylor C, Wiemann S, Hermjakob H (2006) Proteomics and Beyond: a report on the 3rd Annual Spring Workshop of the HUPO-PSI 21-23 April 2006, San Francisco, CA, USA. Proteomics 6: 4439-4443. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16897683

Schneider J, Ruschhaupt M, Buness A, Asslaber M, Regitnig P, Zatloukal K, Schippinger W, Ploner F, Poustka A, Sultmann H (2006) Identification and meta-analysis of a small gene expression signature for the diagnosis of estrogen receptor status in invasive ductal breast cancer. Int J Cancer 119: 2974-2979. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17019712

Seiler M, Mehrle A, Poustka A, Wiemann S (2006) The 3of5 web application for complex and comprehensive pattern matching in protein sequences. BMC Bioinformatics 7: 144. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16542452

Sultmann H, Poustka A (2006) [Microarrays for the identification of molecular markers in the diagnosis and therapy of renal cell carcinomas.]. Urologe A 45: 297-304. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16465525

Takeda J, Suzuki Y, Nakao M, Barrero RA, Koyanagi KO, Jin L, Motono C, Hata H, Isogai T, Nagai K, Otsuki T, Kuryshev V, Shionyu M, Yura K, Go M, Thierry-Mieg J, Thierry-Mieg D, Wiemann S, Nomura N, Sugano S, Gojobori T, Imanishi T (2006) Large-scale identification and characterization of alternative splicing variants of human gene transcripts using 56,419 completely sequenced and manually annotated full-length cDNAs. Nucleic Acids Res 34: 3917-3928. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16914452

Treutlein J, Kissling C, Frank J, Wiemann S, Dong L, Depner M, Saam C, Lascorz J, Soyka M, Preuss UW, Rujescu D, Skowronek MH, Rietschel M, Spanagel R, Heinz A, Laucht M, Mann K, Schumann G (2006) Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples. Mol Psychiatry 11: 594-602. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16550213

2005

Arlt D, Huber W, Liebel U, Schmidt C, Majety M, Sauermann M, Rosenfelder H, Bechtel S, Mehrle A, Bannasch D, Schupp I, Seiler M, Simpson JC, Hahne F, Moosmayer P, Ruschhaupt M, Guilleaume B, Wellenreuther R, Pepperkok R, Sultmann H, Poustka A, Wiemann S (2005) Functional Profiling: From Microarrays via Cell-Based Assays to Novel Tumor Relevant Modulators of the Cell Cycle. Cancer Res 65: 7733-7742. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16140941

Bonora E, Lamb JA, Barnby G, Sykes N, Moberly T, Beyer KS, Klauck SM, Poustka F, Bacchelli E, Blasi F, Maestrini E, Battaglia A, Haracopos D, Pedersen L, Isager T, Eriksen G, Viskum B, Sorensen EU, Brondum-Nielsen K, Cotterill R, Engeland H, Jonge M, Kemner C, Steggehuis K, Scherpenisse M, Rutter M, Bolton PF, Parr JR, Poustka A, Bailey AJ, Monaco AP (2005) Mutation screening and association analysis of six candidate genes for autism on chromosome 7q. Eur J Hum Genet 13: 198-207. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15523497

Buness A, Huber W, Steiner K, Sultmann H, Poustka A (2005) arrayMagic: two-colour cDNA microarray quality control and preprocessing. Bioinformatics 21: 554-556. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15454413

End C, Lyer S, Renner M, Stahl C, Ditzer J, Holloschi A, Kuhn HM, Flammann HT, Poustka A, Hafner M, Mollenhauer J, Kioschis P (2005) Generation of a vector system facilitating cloning of DMBT1 variants and recombinant expression of functional full-length DMBT1. Protein Expr Purif 41: 275-286. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15866713

Guilleaume B, Buness A, Schmidt C, Klimek F, Moldenhauer G, Huber W, Arlt D, Korf U, Wiemann S, Poustka A (2005) Systematic comparison of surface coatings for protein microarrays. Proteomics 5: 4705-4712. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16267812

Hawtin P, Hardern I, Wittig R, Mollenhauer J, Poustka A, Salowsky R, Wulff T, Rizzo C, Wilson B (2005) Utility of lab-on-a-chip technology for high-throughput nucleic acid and protein analysis. Electrophoresis 26: 3674-3681. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16136523

Karenko L, Hahtola S, Paivinen S, Karhu R, Syrja S, Kahkonen M, Nedoszytko B, Kytola S, Zhou Y, Blazevic V, Pesonen M, Nevala H, Nupponen N, Sihto H, Krebs I, Poustka A, Roszkiewicz J, Saksela K, Peterson P, Visakorpi T, Ranki A (2005) Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue. Cancer Res 65: 8101-8110. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16166283

Korf U, Kohl T, van der Zandt H, Zahn R, Schleeger S, Ueberle B, Wandschneider S, Bechtel S, Schnolzer M, Ottleben H, Wiemann S, Poustka A (2005) Large-scale protein expression for proteome research. Proteomics. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16127724

Korf U, Wiemann S (2005) Protein microarrays as a discovery tool for studying protein-protein interactions. Expert Rev Proteomics 2: 13-26. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15966849

Michaelovsky E, Frisch A, Leor S, Stein D, Danziger Y, Carel C, Fennig S, Mimouni M, Klauck SM, Benner A, Poustka A, Apter A, Weizman A (2005) Haplotype analysis of the COMT-ARVCF gene region in Israeli anorexia nervosa family trios. Am J Med Genet B Neuropsychiatr Genet. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16118784

Neubrand VE, Will RD, Mobius W, Poustka A, Wiemann S, Schu P, Dotti CG, Pepperkok R, Simpson AJ (2005) gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking. EMBO Journal 24: 1122-1133. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15775984

Ross MT, Grafham DV, Coffey AJ, Scherer S, McLay K, Muzny D, Platzer M, Howell GR, Burrows C, Bird CP, Frankish A, Lovell FL, Howe KL, Ashurst JL, Fulton RS, Sudbrak R, Wen G, Jones MC, Hurles ME, Andrews TD, Scott CE, Searle S, Ramser J, Whittaker A, Deadman R, Carter NP, Hunt SE, Chen R, Cree A, Gunaratne P, Havlak P, Hodgson A, Metzker ML, Richards S, Scott G, Steffen D, Sodergren E, Wheeler DA, Worley KC, Ainscough R, Ambrose KD, Ansari-Lari MA, Aradhya S, Ashwell RI, Babbage AK, Bagguley CL, Ballabio A, Banerjee R, Barker GE, Barlow KF, Barrett IP, Bates KN, Beare DM, Beasley H, Beasley O, Beck A, Bethel G, Blechschmidt K, Brady N, Bray-Allen S, Bridgeman AM, Brown AJ, Brown MJ, Bonnin D, Bruford EA, Buhay C, Burch P, Burford D, Burgess J, Burrill W, Burton J, Bye JM, Carder C, Carrel L, Chako J, Chapman JC, Chavez D, Chen E, Chen G, Chen Y, Chen Z, Chinault C, Ciccodicola A, Clark SY, Clarke G, Clee CM, Clegg S, Clerc-Blankenburg K, Clifford K, Cobley V, Cole CG, Conquer JS, Corby N, Connor RE, David R, Davies J, Davis C, Davis J, Delgado O, Deshazo D, Dhami P, Ding Y, Dinh H, Dodsworth S, Draper H, Dugan-Rocha S, Dunham A, Dunn M, Durbin KJ, Dutta I, Eades T, Ellwood M, Emery-Cohen A, Errington H, Evans KL, Faulkner L, Francis F, Frankland J, Fraser AE, Galgoczy P, Gilbert J, Gill R, Glockner G, Gregory SG, Gribble S, Griffiths C, Grocock R, Gu Y, Gwilliam R, Hamilton C, Hart EA, Hawes A, Heath PD, Heitmann K, Hennig S, Hernandez J, Hinzmann B, Ho S, Hoffs M, Howden PJ, Huckle EJ, Hume J, Hunt PJ, Hunt AR, Isherwood J, Jacob L, Johnson D, Jones S, de Jong PJ, Joseph SS, Keenan S, Kelly S, Kershaw JK, Khan Z, Kioschis P, Klages S, Knights AJ, Kosiura A, Kovar-Smith C, Laird GK, Langford C, Lawlor S, Leversha M, Lewis L, Liu W, Lloyd C, Lloyd DM, Loulseged H, Loveland JE, Lovell JD, Lozado R, Lu J, Lyne R, Ma J, Maheshwari M, Matthews LH, McDowall J, McLaren S, McMurray A, Meidl P, Meitinger T, Milne S, Miner G, Mistry SL, Morgan M, Morris S, Muller I, Mullikin JC, Nguyen N, Nordsiek G, Nyakatura G, O'Dell C N, Okwuonu G, Palmer S, Pandian R, Parker D, Parrish J, Pasternak S, Patel D, Pearce AV, Pearson DM, Pelan SE, Perez L, Porter KM, Ramsey Y, Reichwald K, Rhodes S, Ridler KA, Schlessinger D, Schueler MG, Sehra HK, Shaw-Smith C, Shen H, Sheridan EM, Shownkeen R, Skuce CD, Smith ML, Sotheran EC, Steingruber HE, Steward CA, Storey R, Swann RM, Swarbreck D, Tabor PE, Taudien S, Taylor T, Teague B, Thomas K, Thorpe A, Timms K, Tracey A, Trevanion S, Tromans AC, d'Urso M, Verduzco D, Villasana D, Waldron L, Wall M, Wang Q, Warren J, Warry GL, Wei X, West A, Whitehead SL, Whiteley MN, Wilkinson JE, Willey DL, Williams G, Williams L, Williamson A, Williamson H, Wilming L, Woodmansey RL, Wray PW, Yen J, Zhang J, Zhou J, Zoghbi H, Zorilla S, Buck D, Reinhardt R, Poustka A, Rosenthal A, Lehrach H, Meindl A, Minx PJ, Hillier LW, Willard HF, Wilson RK, Waterston RH, Rice CM, Vaudin M, Coulson A, Nelson DL, Weinstock G, Sulston JE, Durbin R, Hubbard T, Gibbs RA, Beck S, Rogers J, Bentley DR (2005) The DNA sequence of the human X chromosome. Nature 434: 325-337. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15772651

Schlomm T, Luebke AM, Sultmann H, Hellwinkel OJ, Sauer U, Poustka A, David KA, Chun FK, Haese A, Graefen M, Erbersdobler A, Huland H (2005) Extraction and processing of high quality RNA from impalpable and macroscopically invisible prostate cancer for microarray gene expression analysis. Int J Oncol 27: 713-720. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16077921

Sultmann H, von Heydebreck A, Huber W, Kuner R, Buness A, Vogt M, Gunawan B, Vingron M, Fuzesi L, Poustka A (2005) Gene expression in kidney cancer is associated with cytogenetic abnormalities, metastasis formation, and patient survival. Clin Cancer Res 11: 646-655. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15701852

Wiemann S, Kolb-Kokocinski A, Poustka A (2005) Alternative pre-mRNA processing regulates cell-type specific expression of the IL4l1 and NUP62 genes. BMC Biol 3: 16. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16029492

Wittig R, Salowsky R, Blaich S, Lyer S, Maa JS, Muller O, Mollenhauer J, Poustka A (2005) Multiplex reverse transcription-polymerase chain reaction combined with on-chip electrophoresis as a rapid screening tool for candidate gene sets. Electrophoresis 26: 1687-1691. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15812845

2004

Bannasch D, Mehrle A, Glatting KH, Pepperkok R, Poustka A, Wiemann S (2004) LIFEdb: a database for functional genomics experiments integrating information from external sources, and serving as a sample tracking system. Nucleic Acids Res 32 Database issue: D505-508. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/14681468

Bikker FJ, Ligtenberg AJ, End C, Renner M, Blaich S, Lyer S, Wittig R, Van 't Hof W, Veerman EC, Nazmi K, De Blieck-Hogervorst JM, Kioschis P, Nieuw Amerongen AV, Poustka A, Mollenhauer J (2004a) Bacteria binding by DMBT1/SAG/gp-340 is confined to the VEVLXXXXW motif in its scavenger receptor cysteine-rich domains. J Biol Chem. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15355985

Bikker FJ, Van Der Wal JE, Ligtenberg AJ, Mollenhauer J, De Blieck-Hogervorst JM, Van Der Waal I, Poustka A, Nieuw Amerongen AV (2004b) Salivary Agglutinin/DMBT1(SAG) Expression is Up-regulated in the Presence of Salivary Gland Tumors. J Dent Res 83: 567-571. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15218048

Braidotti P, Nuciforo PG, Mollenhauer J, Poustka A, Pellegrini C, Moro A, Bulfamante G, Coggi G, Bosari S, Pietra GG (2004) DMBT1 expression is down-regulated in breast cancer. BMC Cancer 4: 46. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15301691

D'Adamo P, Bacchelli E, Blasi F, Lipp HP, Toniolo D, Maestrini E, (IMGSAC) atMGSoAC (2004) DNA variants in the human RAB3A gene are not associated with autism. Genes Brain Behav 3: 123-124. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15005721

del Val C, Mehrle A, Falkenhahn M, Seiler M, Glatting KH, Poustka A, Suhai S, Wiemann S (2004) High-throughput protein analysis integrating bioinformatics and experimental assays. Nucleic Acids Res 32: 742-748. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/14762202

Gassler N, Kopitz J, Tehrani A, Ottenwalder B, Schnolzer M, Kartenbeck J, Lyer S, Autschbach F, Poustka A, Otto HF, Mollenhauer J (2004) Expression of acyl-CoA synthetase 5 reflects the state of villus architecture in human small intestine. J Pathol 202: 188-196. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/14743501

Haller F, Kulle B, Schwager S, Gunawan B, von Heydebreck A, Sultmann H, Fuzesi L (2004) Equivalence test in quantitative reverse transcription polymerase chain reaction: confirmation of reference genes suitable for normalization. Anal Biochem 335: 1-9. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15519565

Helmke BM, Mollenhauer J, Herold-Mende C, Benner A, Thome M, Gassler N, Wahl W, Lyer S, Poustka A, Otto HF, Deichmann M (2004) BRAF mutations distinguish anorectal from cutaneous melanoma at the molecular level. Gastroenterology 127: 1815-1820. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15578519

Huber W, Gentleman R (2004) matchprobes: a Bioconductor package for the sequence-matching of microarray probe elements. Bioinformatics 20: 1651-1652. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/14988118

Imanishi T, Itoh T, Suzuki Y, O'Donovan C, Fukuchi S, Koyanagi KO, Barrero RA, Tamura T, Yamaguchi-Kabata Y, Tanino M, Yura K, Miyazaki S, Ikeo K, Homma K, Kasprzyk A, Nishikawa T, Hirakawa M, Thierry-Mieg J, Thierry-Mieg D, Ashurst J, Jia L, Nakao M, Thomas MA, Mulder N, Karavidopoulou Y, Jin L, Kim S, Yasuda T, Lenhard B, Eveno E, Yamasaki C, Takeda J, Gough C, Hilton P, Fujii Y, Sakai H, Tanaka S, Amid C, Bellgard M, Bonaldo Md Mde F, Bono H, Bromberg SK, Brookes AJ, Bruford E, Carninci P, Chelala C, Couillault C, Souza SJ, Debily MA, Devignes MD, Dubchak I, Endo T, Estreicher A, Eyras E, Fukami-Kobayashi K, G RG, Graudens E, Hahn Y, Han M, Han ZG, Hanada K, Hanaoka H, Harada E, Hashimoto K, Hinz U, Hirai M, Hishiki T, Hopkinson I, Imbeaud S, Inoko H, Kanapin A, Kaneko Y, Kasukawa T, Kelso J, Kersey P, Kikuno R, Kimura K, Korn B, Kuryshev V, Makalowska I, Makino T, Mano S, Mariage-Samson R, Mashima J, Matsuda H, Mewes HW, Minoshima S, Nagai K, Nagasaki H, Nagata N, Nigam R, Ogasawara O, Ohara O, Ohtsubo M, Okada N, Okido T, Oota S, Ota M, Ota T, Otsuki T, Piatier-Tonneau D, Poustka A, Ren SX, Saitou N, Sakai K, Sakamoto S, Sakate R, Schupp I, Servant F, Sherry S, Shiba R, Shimizu N, Shimoyama M, Simpson AJ, Soares B, Steward C, Suwa M, Suzuki M, Takahashi A, Tamiya G, Tanaka H, Taylor T, Terwilliger JD, Unneberg P, Veeramachaneni V, Watanabe S, Wilming L, Yasuda N, Yoo HS, Stodolsky M, Makalowski W, Go M, Nakai K, Takagi T, Kanehisa M, Sakaki Y, Quackenbush J, Okazaki Y, Hayashizaki Y, Hide W, Chakraborty R, Nishikawa K, Sugawara H, Tateno Y, Chen Z, Oishi M, Tonellato P, Apweiler R, Okubo K, Wagner L, Wiemann S, Strausberg RL, Isogai T, Auffray C, Nomura N, Gojobori T, Sugano S (2004) Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol 2: 856-875. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15103394

Kontou M, Will RD, Adelfalk C, Wittig R, Poustka A, Hirsch-Kauffmann M, Schweiger M (2004) Thioredoxin, a regulator of gene expression. Oncogene 23: 2146-2152. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/14730345

Mollenhauer J, Helmke B, Medina D, Bergmann G, Gassler N, Muller H, Lyer S, Diedrichs L, Renner M, Wittig R, Blaich S, Hamann U, Madsen J, Holmskov U, Bikker F, Ligtenberg A, Carlen A, Olsson J, Otto HF, O'Malley B, Poustka A (2004) Carcinogen inducibility in vivo and down-regulation of DMBT1 during breast carcinogenesis. Genes Chromosomes Cancer 39: 185-194. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/14732920

Poustka AJ, Kuhn A, Radosavljevic V, Wellenreuther R, Lehrach H, Panopoulou G (2004) On the origin of the chordate central nervous system: expression of onecut in the sea urchin embryo. Evol Dev 6: 227-236. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15230963

Ruschhaupt M, Huber W, Poustka A, Mansmann U (2004) A Compendium to Ensure Computational Reproducibility in High-Dimensional Classification Tasks. Statistical Applications in Genetics and Molecular Biology 3: Article 37. Pubmed: http://www.bepress.com/sagmb/vol3/iss1/art37

Sasaki M, Tsuneyama K, Saito T, Kataoka H, Mollenhauer J, Poustka A, Nakanuma Y (2004) Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor-1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology. Liver Int 24: 29-37. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15101998

Schneider J, Buness A, Huber W, Volz J, Kioschis P, Hafner M, Poustka A, Sultmann H (2004) Systematic analysis of T7 RNA polymerase based in vitro linear RNA amplification for use in microarray experiments. BMC Genomics 5: 29. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15119961

Starkuviene V, Liebel U, Simpson JC, Erfle H, Poustka A, Wiemann S, Pepperkok R (2004) High-content screening microscopy identifies novel proteins with a putative role in secretory membrane traffic. Genome Res 14: 1948-1956. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15466293

Sultmann H, Poustka A (2004) Recent advances in transcription profiling of human cancer. Curr Opin Mol Ther 6: 593-599. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15663323

Wellenreuther R, Schupp I, Consortium TGc, Poustka A, Wiemann S (2004) SMART amplification combined with cDNA size fractionation in order to obtain large full-length clones. BMC Genomics 5: 36. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15198809

Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sultmann H, Poustka A (2004) From ORFeome to Biology: A Functional Genomics Pipeline. Genome Res 14: 2136-2144. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15489336

2003

Apic G, Huber W, Teichmann SA (2003) Multi-domain protein families and domain pairs: comparison with known structures and a random model of domain recombination. J Struct Funct Genom 4: 67-78. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/14649290

Bacchelli E, Blasi F, Biondolillo M, Lamb JA, Bonora E, Barnby G, Parr J, Beyer KS, Klauck SM, Poustka A, Bailey A, Monaco AP, Maestrini E, IMGSAC (2003) Screening of nine candidate genes for autism on chromosome 2q reveals rare non-sysnonymous variants in the cAMP-GEFII gene. Mol Psychiatry 8: 916 -924. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/14593429

Bonora E, Beyer KS, Lamb JA, Parr JR, Klauck SM, Benner A, Paolucci M, Abbot A, Ragoussis I, Poustka A, Bailey A, Monaco AP, IMGSAC (2003) Analysis of reelin as a candidate gene for autism. Mol Psychiatry 8: 885-892. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/14515139

Broders O, Breitling F, Dubel S (2003) Hyperphage. Improving antibody presentation in phage display. Methods Mol Biol 205: 295-302. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12491895

Gunawan B, von Heydebreck A, Huber W, Vingron M, Füzesi L (2003) Cytogenetic and Morphologic Typing of 58 Papillary Renal Cell Carcinomas: Evidence for a Cytogeneitc Evolution of Type 2 from Type 1 Tumors. Cancer Res 63: 6200-6205. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/14559804

Heiss NS, Poustka A (2003) Dyskeratosis Congenita. In: Chromosomal instability and aging: basic science and clinical implication. Pubmed:

Langer C, Gunawan B, Schuler P, Huber W, Füzesi L, Becker H (2003) Prognostic factors influencing surgical management and outcome of gastrointestinal stromal tumors. Br J Surg 90: 332-339. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12594669

Liebel U, Starkuviene V, Erfle H, Simpson JC, Poustka A, Wiemann S, Pepperkok R (2003) A microscope-based screening platform for large-scale functional protein analysis in intact cells. FEBS Lett 554: 394-398. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/14623100

Madsen J, Tornoe I, Nielsen O, Lausen M, Krebs I, Mollenhauer J, Kollender G, Poustka A, Skjodt K, Holmskov U (2003) CRP-ductin, the mouse homologue of gp-340/deleted in malignant brain tumors 1 (DMBT1), binds gram-positive and gram-negative bacteria and interacts with lung surfactant protein D. Eur J Immunol 33: 2327-2336. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12884308

Mollenhauer J, Deichmann M, Helmke B, Muller H, Kollender G, Holmskov U, Ligtenberg T, Krebs I, Wiemann S, Bantel-Schaal U, Madsen J, Bikker F, Klauck SM, Otto HF, Moldenhauer G, Poustka A (2003) Frequent downregulation of DMBT1 and galectin-3 in epithelial skin cancer. Int J Cancer 105: 149-157. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12673672

Sasaki M, Huang SF, Chen MF, Jan YY, Yeh TS, Ishikawa A, Mollenhauer J, Poustka A, Tsuneyama K, Nimura Y, Oda K, Nakanuma Y (2003a) Decrease of deleted in malignant brain tumour-1 (DMBT-1) expression is a crucial late event in intrahepatic cholangiocarcinoma. Histopathology 43: 340-346. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/14511252

Sasaki M, Huang SF, Chen MF, Jan YY, Yeh TS, Ishikawa A, Mollenhauer J, Poustka A, Tsuneyama K, Nimura Y, Oda K, Nakanuma Y (2003b) Expression of deleted in malignant brain tumor-1 (DMBT1) molecule in biliary epithelium is augmented in hepatolithiasis: possible participation in lithogenesis. Dig Dis Sci 48: 1234-1240. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12870778

Schumann G, Rujescu D, Kissling C, Soyka M, Dahmen N, Preuss UW, Wiemann S, Müller A, Wellek S, Lascorz J, Bondy B, Giegling I, Anghelescu I, Cowen MS, Poustka A, Spanagel R, Mann K, Henn FA, Szegedi A (2003a) Analysis of genetic variations of Protein Tyrosine Kinase fyn and their as-sociation with alcohol dependence in two independent cohorts. Biol Psychiatry 54: 1422-1426. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/14675807

Schumann G, Rujescu D, Szegedi A, Singer P, Wiemann S, Wellek S, Giegling I, Klawe C, Anghelescu I, Heinz A, Spanagel R, Mann K, Henn FA, Dahmen N (2003b) No association of alcohol dependence with a NMDA-receptor 2B gene variant. Mol Psychiatry 8: 11-12. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12556902

Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, Spring H, Hatzfeld M, Franke WW (2003) A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells. J Cell Sci 116: 4985-4995. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/14625392

Wellenreuther R, Bechtel S (2003) Identifying transcribed sequences and beyond. Genome Biol 4: 306. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12620115

Wiemann S, Bechtel S, Bannasch D, Pepperkok R, Poustka A, Network TGc (2003a) The German cDNA Network: cDNAs, functional genomics and proteomics. J Struct Funct Genom 4: 87-96. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/14649292

Wiemann S, Mehrle A, Bechtel S, Wellenreuther R, Pepperkok R, Poustka A, Consortium TGc (2003b) cDNAs in functional genomics and proteomics: The German cDNA Consortium. CRBiologies 326: 1003-1009. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/14744107

2002

Aradhya S, Woffendin H, Bonnen P, Heiss NS, Yamagata T, Esposito T, Bardaro T, Poustka A, D'Urso M, Kenwrick S, Nelson DL (2002) Physical and genetic characterization reveals a pseudogene, an evolutionary junction, and unstable loci in distal Xq28. Genomics 79: 31-40. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11827455

Beyer KS, Blasi F, Bacchelli E, Klauck SM, Maestrini E, Poustka A (2002a) Mutation analysis of the coding sequence of the MECP2 gene in infantile autism. Hum Genet 111: 305-309. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12384770

Beyer KS, Klauck SM, Benner A, Poustka F, Poustka A (2002b) Association studies of the HOPA dodecamer duplication variant in different subtypes of autism. Am J Med Genet 114: 110-115. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11840515

Bikker FJ, Ligtenberg AJ, Nazmi K, Veerman EC, van't Hof W, Bolscher JG, Poustka A, Nieuw Amerongen AV, Mollenhauer J (2002) Identification of the bacteria-binding peptide domain on salivary agglutinin (gp-340/DMBT1), a member of the scavenger receptor cysteine-rich superfamily. J Biol Chem 277: 32109-32115. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12050164

Bonora E, Bacchelli E, Levy RE, Blasi F, Marlow A, Monaco AP, Maestrini E, IMGSAC (2002) Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region. Mol Psychiatry 7: 289-301. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11920156

Copley LM, Zhao WD, Kopacz K, Herman GE, Kioschis P, Poustka A, Taudien S, Platzer M (2002) Exclusion of mutations in the MTMR1 gene as a frequent cause of X-linked myotubular myopathy. Am J Med Genet 107: 256-258. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11807911

Coy JF, Wiemann S, Bechmann I, Bachner D, Nitsch R, Kretz O, Christiansen H, Poustka A (2002) Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms. Gene 290: 73-94. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12062803

Deichmann M, Mollenhauer J, Helmke B, Thome M, Hartschuh W, Poustka A, Naher H (2002) Analysis of losses of heterozygosity of the candidate tumour suppressor gene DMBT1 in melanoma resection specimens. Oncology 63: 166-172. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12239452

Heiss NS, Poustka A, Gene) DD (2002) DKC1 Gene. In: Creighton T, Ed, editor. In: Encyclopedia of Molecular Medicine. Publisher: John Wiley & Sons Inc. New York. pp. 1121 - 1126.

Huber W, Boer JM, von Heydebreck A, Gunawan B, Vingron M, Fuzesi L, Poustka A, Sultmann H (2002a) Transcription profiling of renal cell carcinoma. Verh Dtsch Ges Pathol 86: 153-164. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12647365

Huber W, Von Heydebreck A, Sultmann H, Poustka A, Vingron M (2002b) Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Bioinformatics 18 Suppl 1: S96-S104. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12169536

Klauck SM, Lindsay S, Beyer KS, Splitt M, Burn J, Poustka A (2002) A mutation hot spot for nonspecific X-linked mental retardation in the MECP2 gene causes the PPM-X syndrome. Am J Hum Genet 70: 1034-1037. Pubmed: www.ncbi.nlm.nih.gov/entrez/query.fcgi

Mollenhauer J, Helmke B, Muller H, Kollender G, Krebs I, Wiemann S, Holmskov U, Madsen J, Otto HF, Poustka A (2002a) An integrative model on the role of DMBT1 in epithelial cancer. Cancer Detect Prev 26: 266-274. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12430631

Mollenhauer J, Helmke B, Muller H, Kollender G, Lyer S, Diedrichs L, Holmskov U, Ligtenberg T, Herbertz S, Krebs I, Wiemann S, Madsen J, Bikker F, Schmitt L, Otto HF, Poustka A (2002b) Sequential changes of the DMBT1 expression and location in normal lung tissue and lung carcinomas. Genes Chromosomes Cancer 35: 164-169. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12203780

Mollenhauer J, Muller H, Kollender G, Lyer S, Diedrichs L, Helmke B, Holmskov U, Ligtenberg T, Herbertz S, Krebs I, Madsen J, Bikker F, Schmitt L, Wiemann S, Scheurlen W, Otto HF, von Deimling A, Poustka A (2002c) The SRCR/SID region of DMBT1 defines a complex multi-allele system representing the major basis for its variability in cancer. Genes Chromosomes Cancer 35: 242-255. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12353266

Mueller W, Mollenhauer J, Stockhammer F, Poustka A, von Deimling A (2002) Rare mutations of the DMBT1 gene in human astrocytic gliomas. Oncogene 21: 5956-5959. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12185598

Newbury DF, Bonora E, Lamb JA, Fisher SE, Lai C, Baird G, Jannoun L, Solonims V, Stott CM, Merricks J, Bolton P F, A.J. B, Monaco AP, IMGSAC (2002) FOXP2 is not a major susceptibility gene for autism or specific language impairment. Am J Hum Genet 70: 1318-1327. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11894222

Poland J, Sinha P, Siegert A, Schnolzer M, Korf U, Hauptmann S (2002) Comparison of protein expression profiles between monolayer and spheroid cell culture of HT-29 cells revealed fragmentation of CK18 in three-dimensional cell culture. Electrophoresis 23: 1174-1184. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11981867

Salowsky R, Heiss NS, Benner A, Wittig R, Poustka A (2002) Basal transcription activity of the dyskeratosis congenita gene is mediated by Sp1 and Sp3 and a patient mutation in a Sp1 binding site is associated with decreased promoter activity. Gene 293: 9-19. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12137939

Schumann G, D. R, Szegedi A, Singer P, Wiemann S, Welek S, Giegling I, C. K, I. A, Heinz A, Spanagel R, Mann K, Henn FA, Dahmen N (2002) Alcohol dependence is associated with NMDN receptor 2B gene variant. Eur Psychiatry 17: 212. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12556902

von Heydebreck A, Huber W, Poustka A, Vingron M (2002) Variance stabilization and robust normalization for microarray gene expression data. Proceeding in Computational Statistics: 623-628. Pubmed: https://link.springer.com/chapter/10.1007/978-3-642-57489-4_97

Wittig R, Nessling M, Will RD, Mollenhauer J, Salowsky R, Munstermann E, Schick M, Helmbach H, Gschwendt B, Korn B, Kioschis P, Lichter P, Schadendorf D, Poustka A (2002) Candidate genes for cross-resistance against DNA-damaging drugs. Cancer Res 62: 6698-6705. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12438269

2001

(IMGSAC) IMGSoAC, Palfermann S, Matthews N, Turner M, Moore J, Haervas A, Aubin A, Wallace S, Michelotti J, Wainhouse D, Paul A, Thompson E, Murin M, Gupta R, Garner C, Pickles A, Rutter M, Bailey A, Lamb JA, Marlow A, Scudder P, Barnby G, Monaco AP, Baird G, Cox A, Docherty Z, Warburton P, Green ED, Abbs SJ, Le Couteur A, McConachie HR, Klauck SM, Beyer KS, Epp S, Poustka A, Brenner A, al. e (2001) Further characterization of the autism susceptibility locus AUTS 1 on chromosome 7q. Hum Mol Genet 10: 973-982. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11392322

Beyer KS, Klauck SM, Wiemann S, Poustka A (2001) Construction of a physical map of an autism susceptibility region in 7q32.3-q33. Gene 272: 85-91. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11470513

Boer JM, Huber WK, Sultmann H, Wilmer F, von Heydebreck A, Haas S, Korn B, Gunawan B, Vente A, Fuzesi L, Vingron M, Poustka A (2001) Identification and classification of differentially expressed genes in renal cell carcinoma by expression profiling on a global human 31,500-element cDNA array. Genome Res 11: 1861-1870. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11691851

Gotte K, Riedel F, Neubuer J, Schafer C, Coy J, Hormann K (2001) The relationship between allelic imbalance on 17p, p53 overexpression in head and neck cancer. Int J Oncology 19: 331-336. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11445847

Gunawan B, Huber W, Holtrup M, von Heydebreck A, Efferth T, Poustka A, Ringert RH, Jakse G, Fuzesi L (2001) Prognostic impacts of cytogenetic findings in clear cell renal cell carcinoma: gain of 5q31-qter predicts a distinct clinical phenotype with favorable prognosis. Cancer Res 61: 7731-7738. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11691785

Heiss NS, Megarbane A, Klauck SM, Kreuz FR, Makhoul E, Majewski F, Poustka A (2001) One novel and two recurrent missense DKC1 mutations in patients with dyskeratosis congenita (DKC). Genet Couns 12: 129-136. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11491307

Hoff C, Mollenhauer J, Waldau B, Hamann U, Poustka A (2001) Allelic imbalance and fine mapping of the 17p13.3 subregion in sporadic breast carcinomas. Cancer Genet Cytogenet 129: 145-149. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11566345

Huber W, von Heydebreck A, Sültmann H, Poustka A, Vingron M (2001) Data preprocessing and quality control for DNA array expression profiling experiments. In: Mabrouk NE, Lengauer T, Sankoff D, Eds, editors. In: Currents in Computational Molecular Biology. Publisher: Les Publications CRM Montreal. pp. 181-182.

International Molecular Genetic Study of Autism Consortium (IMGSAC), Palfermann S, Matthews N, Turner M, J. M, Hervas A, Aubin A, S. W, Michelotti J, Wainhouse D, Paul A, Thompson E, Gupta R, Garner C, Murin M, Freitag C, Ryder N, Cottington E, Parr J, Pickles A, Rutter M, Bailey A, Barnby G, Lamb JA, Marlow A, Scudder P, Monaco AP, Baird G, Cox A, Docherty Z, Warburton P, S.M. K, Beyer KS, Epp S, Poustka A, Brenner A, al. e (2001) A genome wide screen for autism: Strong evidence for linkage to chromosomes 2q, 7q and 16p. Am J Hum Genet 69: 570-581. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11481586

McPherson JD, Marra M, Hillier L, Waterston RH, Chinwalla A, Wallis J, Sekhon M, Wylie K, Mardis ER, Wilson RK, Fulton R, Kucaba TA, Wagner-McPherson C, Barbazuk WB, Gregory SG, Humphray SJ, French L, Evans RS, Bethel G, Whittaker A, Holden JL, McCann OT, Dunham A, Soderlund C, Scott CE, Bentley DR, Schuler G, Chen HC, Jang W, Green ED, Idol JR, Maduro VV, Montgomery KT, Lee E, Miller A, Emerling S, Kucherlapati, Gibbs R, Scherer S, Gorrell JH, Sodergren E, Clerc-Blankenburg K, Tabor P, Naylor S, Garcia D, de Jong PJ, Catanese JJ, Nowak N, Osoegawa K, Qin S, Rowen L, Madan A, Dors M, Hood L, Trask B, Friedman C, Massa H, Cheung VG, Kirsch IR, Reid T, Yonescu R, Weissenbach J, Bruls T, Heilig R, Branscomb E, Olsen A, Doggett N, Cheng JF, Hawkins T, Myers RM, Shang J, Ramirez L, Schmutz J, Velasquez O, Dixon K, Stone NE, Cox DR, Haussler D, Kent WJ, Furey T, Rogic S, Kennedy S, Jones S, Rosenthal A, Wen G, Schilhabel M, Gloeckner G, Nyakatura G, Siebert R, Schlegelberger B, Korenberg J, Chen XN, Fujiyama A, Hattori M, Toyoda A, Yada T, Park HS, Sakaki Y, Shimizu N, Asakawa S, Kawasaki K, Sasaki T, Shintani A, Shimizu A, Shibuya K, Kudoh J, Minoshima S, Ramser J, Seranski P, Hoff C, Poustka A, Reinhardt R, Lehrach H (2001) A physical map of the human genome. Nature 409: 934-941. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11237014

Mollenhauer J, Herbertz S, Helmke B, Kollender G, Krebs I, Madsen J, Holmskov U, Sorger K, Schmitt L, Wiemann S, Otto HF, Grone HJ, Poustka A (2001) Deleted in Malignant Brain Tumors 1 is a versatile mucin-like molecule likely to play a differential role in digestive tract cancer. Cancer Res 61: 8880-8886. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11751412

Nadeau JH, Balling R, Barsh G, Beier D, Brown SD, Bucan M, Camper S, Carlson G, Copeland N, Eppig J, Fletcher C, Frankel WN, Ganten D, Goldowitz D, Goodnow C, Guenet JL, Hicks G, de Angelis MH, Jackson I, Jacob HJ, Jenkins N, Johnson D, Justice M, Kay S, Kingsley D, Lehrach H, Magnuson T, Meisler M, Poustka A, Rinchik EM, Rossant J, Russell LB, Schimenti J, Shiroishi T, Skarnes WC, Soriano P, Stanford W, Takahashi JS, Wurst W, Zimmer A (2001) Sequence interpretation. Functional annotation of mouse genome sequences. Science 291: 1251-1255. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11233449

Pepperkok R, Simpson JC, Wiemann S (2001) Being in the right location at the right time. Genome Biol 2: REVIEWS1024. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11574061

Rondot S, Koch J, Breitling F, Dubel S (2001) A helper phage to improve single-chain antibody presentation in phage display. Nat Biotechnol 19: 75-78. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11135557

Seranski P, Hoff C, Radelof U, Hennig S, Reinhardt R, Schwartz CE, Heiss NS, Poustka A (2001) RAI1 is a novel polyglutamine encoding gene that is deleted in Smith-Magenis syndrome patients. Gene 270: 69-76. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11404004

Simpson JC, Neubrand VE, Wiemann S, Pepperkok R (2001) Illuminating the human genome. Histochem Cell Biol 115: 23-29. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11219604

von Heydebreck A, Huber W, Poustka A, Vingron M (2001) Identifying splits with clear separation: a new class discovery method for gene expression data. Bioinformatics 17 Suppl 1: S107-114. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11472999

Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001) Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Res 11: 422-435. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11230166

Wirth J, Back E, Hüttenhofer A, Nothwang HG, Lich C, Groß S, Menzel CS, A., Kioschis P, Tommerup N, Ropers HH, Horsthemke B, Buiting K (2001) A transcriptional breakpoint cluster disrupts the newly defined 3' end of the SNURF-SNRPN transcription unit on chromosome 15. Hum Mol Genet 10: 201-210. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11159938

2000

Aradhya S, Ahobila P, Lewis RA, Nelson DL, Esposito T, Ciccodicola A, Bardaro T, D'Urso M, Woffendin H, Kenwrick S, Smahi A, Heuertz S, Munnich A, Heiss NS, Poustka A, Chishti AH (2000a) Filamin (FLN1), plexin (SEX), major palmitoylated protein p55 (MPP1), and von-Hippel Lindau binding protein (VBP1) are not involved in incontinentia pigmenti type 2. Am J Med Genet 94: 79-84. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10982489

Aradhya S, Nelson DL, Heiss NS, Poustka A, Woffendin H, Kenwrick S, Esposito T, Ciccodicola A, Bardaro T, D'Urso M, Smahi A, Munnich A, Herman GE, Lewis RA (2000b) Human homologue of the murine bare patches/striated gene is not mutated in incontinentia pigmenti type 2. Am J Med Genet 91: 241-244. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10756353

Beissbarth T, Fellenberg K, Brors B, Arribas-Prat R, Boer J, Hauser NC, Scheideler M, Hoheisel JD, Schutz G, Poustka A, Vingron M (2000) Processing and quality control of DNA array hybridization data. Bioinformatics 16: 1014-1022. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11159313

Breitling F, Schmiedl A, Winter CH, Queitsch I, Dübel S (2000) Effect of engineered cysteines on yield, solubility and activity in various recombinant antibody formats expressed in E. coli. Protein Eng 13: 725-734. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11112512

Briault S, Villard L, Rogner U, Coy J, Odent S, Lucas J, Passage E, Zhu D, Shrimpton A, Pembrey M, Till M, Guichet A, Dessay S, Fontes M, Poustka A, Moraine C (2000) Mapping of X chromosome inversion breakpoints [inv(X)(q11q28)] associated with FG syndrome: a second FG locus [FGS2]? Am J Med Genet 95: 178-181. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11078572

Finzer P, Soto U, Delius H, Patzelt A, Coy JF, Poustka A, zur Hausen H, Rosl F (2000) Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition. Oncogene 19: 3235-3244. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10918580

Heiss NS, Bachner D, Salowsky R, Kolb A, Kioschis P, Poustka A (2000) Gene structure and expression of the mouse dyskeratosis congenita gene, dkc1. Genomics 67: 153-163. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10903840

Hoff C, Seranski P, Mollenhauer J, Korn B, Detzel T, Reinhardt R, Ramser J, Poustka A (2000) Physical and transcriptional mapping of the 17p13.3 region that is frequently deleted in human cancer. Genomics 70: 26-33. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11087658

Koch J, Breitling F, Dubel S (2000) Rapid titration of multiple samples of filamentous bacteriophage (M13) on nitrocellulose filters. Biotechniques 29: 1196-1198, 2002. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11126120

Los M, Neubuser D, Coy JF, Mozoluk M, Poustka A, Schulze-Osthoff K (2000) Functional characterization of DNase X, a novel endonuclease expressed in muscle cells. Biochemistry 39: 7365-7373. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10858283

Mallon AM, Platzer M, Bate R, Gloeckner G, Botcherby MR, Nordsiek G, Strivens MA, Kioschis P, Dangel A, Cunningham D, Straw RN, Weston P, Gilbert M, Fernando S, Goodall K, Hunter G, Greystrong JS, Clarke D, Kimberley C, Goerdes M, Blechschmidt K, Rump A, Hinzmann B, Mundy CR, Miller W, Poustka A, Herman GE, Rhodes M, Denny P, Rosenthal A, Brown SD (2000) Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. Genome Res 10: 758-775. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10854409

Mollenhauer J, Herbertz S, Holmskov U, Tolnay M, Krebs I, Merlo A, Schroder HD, Maier D, Breitling F, Wiemann S, Grone HJ, Poustka A (2000) DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer. Cancer Res 60: 1704-1710. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10749143

Reichwald K, Thiesen J, Wiehe T, Weitzel J, Poustka A, Rosenthal A, Platzer M, Stratling WH, Kioschis P (2000) Comparative sequence analysis of the MECP2ßlocus in man and mouse reveals novel transcribed regions. Mamm Genome 11: 182-190. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10723722

Schmiedl A, Breitling F, Dubel S (2000a) Expression of a bispecific dsFv-dsFv' antibody fragment in Escherichia coli. Protein Eng 13: 725-734. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11112512

Schmiedl A, Breitling F, Winter CH, Queitsch I, Dubel S (2000b) Effects of unpaired cysteines on yield, solubility and activity of different recombinant antibody constructs expressed in E. coli. J Immunol Methods 242: 101-114. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10986393

Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2000) Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. EMBO Rep 1: 287-292. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11256614

Smahi A, Courtois G, Vabres P, Yamaoka S, Heuertz S, Munnich A, Israel A, Heiss NS, Klauck SM, Kioschis P, Wiemann S, Poustka A, Esposito T, Bardaro T, Gianfrancesco F, Ciccodicola A, D'Urso M, Woffendin H, Jakins T, Donnai D, Stewart H, Kenwrick SJ, Aradhya S, Yamagata T, Levy M, Lewis RA, Nelson DL (2000) Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium. Nature 405: 466-472. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10839543

Thullner S, Gesellchen F, Wiemann S, Pyerin W, Kinzel V, Bossemeyer D (2000) The protein kinase A catalytic subunit Cbeta2: molecular characterization and distribution of the splice variant. Biochem J 351: 123-132. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10998354

von Deimling A, Fimmers R, Schmidt MC, Bender B, Fassbender F, Nagel J, Jahnke R, Kaskel P, Duerr EM, Koopmann J, Maintz D, Steinbeck S, Wick W, Platten M, Muller DJ, Przkora R, Waha A, Blumcke B, Wellenreuther R, Meyer-Puttlitz B, Schmidt O, Mollenhauer J, Poustka A, Stangl AP, Lenartz D, von Ammon K (2000) Comprehensive allelotype and genetic anaysis of 466 human nervous system tumors. J Neuropathol Exp Neurol 59: 544-558. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10850867

Yaghmai R, Kimyai-Asadi A, Rostamiani K, Heiss NS, Poustka A, Eyaid W, Bodurtha J, Nousari HC, Hamosh A, Metzenberg A (2000) Overlap of dyskeratosis congenita with the Hoyeraal-Hreidarsson syndrome. J Pediatr 136: 390-393. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10700698