Phase IX 01.01.2007 - 31.12.2009

Ca.-No 121

Hypomethylation-induced genetic instability as a factor in tumor formation

Israeli Partner: A. Eden, Hebrew Univ.
German Partner: F. Lyko, DKFZ

Ca.-No 122

Epigenetic mechanisms regulating transcriptions and genome stability in cancer cells

Israeli Partner: M. Kupiec, Tel Aviv Univ.
German Partner: I. Grummt, DKFZ

Publications

2010 - PLoS Genet, 6 (5): p. e1000971
Gronniger, E.; Weber, B.; Heil, O.; Peters, N.; Stab, F.; Wenck, H.; Korn, B.; Winnefeld, M.; Lyko, F.
2010 - Oncogene, 29 (43): p. 5775-84
Weber, B.; Kimhi, S.; Howard, G.; Eden, A.; Lyko, F.
2010 - Stem Cells, 28 (8): p. 1349-54
Ron-Bigger, S.; Bar-Nur, O.; Isaac, S.; Bocker, M.; Lyko, F.; Eden, A.

Ca.-No 123

Contribution of endoplasmic reticulum (ER) stress and mitochondrial perturbation in the death of breast and colon cancer cells induced by plant cytotoxic agents

Israeli Partner: E. Flescher, Tel Aviv. Univ.
German Partner: M. Berger, DKFZ

Publications

2007 - PLoS Comput Biol, 3 (12): p. e248
Tuller, T.; Kupiec, M.; Ruppin, E.
2008 - Proc Natl Acad Sci U S A, 105 (38): p. 14482-7
Borenstein, E.; Kupiec, M.; Feldman, M. W.; Ruppin, E.
2008 - Genome Biol, 9 (9): p. R142
Tuller, T.; Kupiec, M.; Ruppin, E.
2007 - Nat Genet, 39 (3): p. 303-9
Steinfeld, I.; Shamir, R.; Kupiec, M.
2008 - Mol Syst Biol, 4: p. 209
Ulitsky, I.; Shlomi, T.; Kupiec, M.; Shamir, R.
2009 - BMC Genomics, 10: p. 391
Tuller, T.; Ruppin, E.; Kupiec, M.

Ca.-No 124

The role of DNA damage-mediated BID phosphorylation for TRAIL-induced apoptosis

Israeli Partner: A. Gross, Weizmann Institute of Science
German Partner: H. Walczak, DKFZ

Publications

2011 - Br J Pharmacol, 164 (5): p. 1433-44
Raviv, Z.; Zilberberg, A.; Cohen, S.; Reischer-Pelech, D.; Horrix, C.; Berger, M. R.; Rosin-Arbesfeld, R.; Flescher, E.
2011 - Cell Mol Life Sci, 68 (7): p. 1269-81
Horrix, C.; Raviv, Z.; Flescher, E.; Voss, C.; Berger, M. R.

Ca.-No 125

Identification and characterization of cytokinetic targets in cancer therapy

Israeli Partner: S. Lev, Weizmann Institute of Science
German Partner: I. Hoffmann, DKFZ

Publications

2012 - Nat Cell Biol, 14 (5): p. 535-41
Maryanovich, M.; Oberkovitz, G.; Niv, H.; Vorobiyov, L.; Zaltsman, Y.; Brenner, O.; Lapidot, T.; Jung, S.; Gross, A.

Ca.-No 126

High resolution assessment of antiogenesis and normalization of tumor vessel phenotype under therapy using implanted MR-coils and functional and molecular MR-imaging methods

Israeli Partner: M. Neeman, Weizmann Institute of Science
German Partner: F. Kiessling (div. of W. Semmler), DKFZ

Publications

2009 - Embo j, 28 (14): p. 2006-17
Laufman, O.; Kedan, A.; Hong, W.; Lev, S.
2013 - J Cell Biol, 200 (6): p. 773-87
Zhu, M.; Settele, F.; Kotak, S.; Sanchez-Pulido, L.; Ehret, L.; Ponting, C. P.; Gonczy, P.; Hoffmann, I.

Ca.-No 127

Human heparanase - a promising target for the development of therapeutic strategies in cancer

Israeli Partner: I. Vlodavsky, Cancer and Vascular Biology Res. Center
German Partner: P. Beckhove (div. of V. Schirrmacher), DKFZ

Publications

2009 - Radiology, 253 (2): p. 462-9
Kiessling, F.; Huppert, J.; Zhang, C.; Jayapaul, J.; Zwick, S.; Woenne, E. C.; Mueller, M. M.; Zentgraf, H.; Eisenhut, M.; Addadi, Y.; Neeman, M.; Semmler, W.

Publications

2010 - Faseb j, 24 (4): p. 1239-48
Barash, U.; Cohen-Kaplan, V.; Arvatz, G.; Gingis-Velitski, S.; Levy-Adam, F.; Nativ, O.; Shemesh, R.; Ayalon-Sofer, M.; Ilan, N.; Vlodavsky, I.
2008 - Pathophysiol Haemost Thromb, 36 (3): p. 195-203
Casu, B.; Vlodavsky, I.; Sanderson, R. D.
2008 - Cancer, 113 (5): p. 1004-11
Cohen, E.; Doweck, I.; Naroditsky, I.; Ben-Izhak, O.; Kremer, R.; Best, L. A.; Vlodavsky, I.; Ilan, N.
2009 - Cancer Immunol Immunother, 58 (6): p. 887-900
Schuetz, F.; Ehlert, K.; Ge, Y.; Schneeweiss, A.; Rom, J.; Inzkirweli, N.; Sohn, C.; Schirrmacher, V.; Beckhove, P.
2007 - Neoplasia, 9 (11): p. 909-16

Heparanase levels are elevated in the plasma of pediatric cancer patients and correlate with response to anticancer treatment

Shafat, I.; Barak, A. B.; Postovsky, S.; Elhasid, R.; Ilan, N.; Vlodavsky, I.; Arush, M. W.
2008 - Int J Cancer, 123 (11): p. 2566-73
Cohen-Kaplan, V.; Naroditsky, I.; Zetser, A.; Ilan, N.; Vlodavsky, I.; Doweck, I.
2009 - J Clin Invest, 119 (11): p. 3311-21
Bonertz, A.; Weitz, J.; Pietsch, D. H.; Rahbari, N. N.; Schlude, C.; Ge, Y.; Juenger, S.; Vlodavsky, I.; Khazaie, K.; Jaeger, D.; Reissfelder, C.; Antolovic, D.; Aigner, M.; Koch, M.; Beckhove, P.
2008 - J Biol Chem, 283 (26): p. 18167-76
Abboud-Jarrous, G.; Atzmon, R.; Peretz, T.; Palermo, C.; Gadea, B. B.; Joyce, J. A.; Vlodavsky, I.
2009 - PLoS One, 4 (4): p. e5181
Zcharia, E.; Jia, J.; Zhang, X.; Baraz, L.; Lindahl, U.; Peretz, T.; Vlodavsky, I.; Li, J. P.
2013 - Hepatology, 58 (1): p. 363-73
Pusterla, T.; Nemeth, J.; Stein, I.; Wiechert, L.; Knigin, D.; Marhenke, S.; Longerich, T.; Kumar, V.; Arnold, B.; Vogel, A.; Bierhaus, A.; Pikarsky, E.; Hess, J.; Angel, P.
2009 - Cancer Res, 69 (5): p. 1758-67
Fux, L.; Feibish, N.; Cohen-Kaplan, V.; Gingis-Velitski, S.; Feld, S.; Geffen, C.; Vlodavsky, I.; Ilan, N.
2008 - Int J Biochem Cell Biol, 40 (3): p. 530-42
Ben-Zaken, O.; Shafat, I.; Gingis-Velitski, S.; Bangio, H.; Kelson, I. K.; Alergand, T.; Amor, Y.; Maya, R. B.; Vlodavsky, I.; Ilan, N.
2008 - Clin Cancer Res, 14 (3): p. 668-76
Lerner, I.; Baraz, L.; Pikarsky, E.; Meirovitz, A.; Edovitsky, E.; Peretz, T.; Vlodavsky, I.; Elkin, M.
2009 - Cancer Res, 69 (21): p. 8420-8
Domschke, C.; Schuetz, F.; Ge, Y.; Seibel, T.; Falk, C.; Brors, B.; Vlodavsky, I.; Sommerfeldt, N.; Sinn, H. P.; Kuhnle, M. C.; Schneeweiss, A.; Scharf, A.; Sohn, C.; Schirrmacher, V.; Moldenhauer, G.; Momburg, F.; Beckhove, P.
2008 - Cancer Res, 68 (24): p. 10077-85
Cohen-Kaplan, V.; Doweck, I.; Naroditsky, I.; Vlodavsky, I.; Ilan, N.
2008 - Neoplasia, 10 (2): p. 125-30

Clinical significance of urine heparanase in bladder cancer progression

Shafat, I.; Pode, D.; Peretz, T.; Ilan, N.; Vlodavsky, I.; Nisman, B.
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