Redox regulation is a process by which endogenous oxidants and reductants, derived from metabolism, dynamically modify proteins (including metabolic enzymes and transcription factors) to change their functional behavior in an adaptive manner. Research in recent years has started to reveal how tumor cells sense redox changes to trigger rapid adaptation and lasting cytoprotection.
Our group aims to understand the relevant sensing and signaling pathways, as well as the mechanisms of stress tolerance. Based on mechanistic insight, we develop tools enabling the visualization and manipulation of redox regulation inside living cells and model organisms. We employ these tools to better understand stress adaptation in both healthy and malignant situations. We are interested in intervention strategies that selectively disrupt cytoprotective mechanisms in malignant cells.
