Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .

Essential

These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.
Statistics

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external video platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name Youtube
Purpose External media

European million grants for three DKFZ researchers

No. 20a | 07/04/2017 | by Sel

Three scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have each been awarded one of the prestigious European Research Council (ERC) Advanced Grants comprising €2 million. One of the grants goes to Hans-Reimer Rodewald, who has developed a barcode system that makes it possible to track the path of immune system cells in the living organism. Tobias Dick is studying how reactive oxygen compounds in altered metabolism influence an organism's resistance. Bernd Bukau, who also pursues research at the University of Heidelberg, wants to find out how proteins are given their final outfit.

From left to right: Bernd Bukau, Hans-Reimer Rodewald, Tobias Dick
© Roman Jowanowitsch/DKFZ

Established in 2007, the European Research Council (ERC) supports fundamental research with the goal of promoting visionary projects and opening up new interdisciplinary fields of research. For excellent established researchers, the ERC has annual calls for proposals for its Advanced Grants, which are awarded in a highly competitive scheme. "It is a tremendous success for the DKFZ that three of our scientists at once have been selected in this year's round of calls," said Michael Baumann, Chairman of the Management Board of the DKFZ.

Hans-Reimer Rodewald leads the Division of Cellular Immunology at the DKFZ. He is interested in the "family relationships" of cells in the immune system. In order to find out which processes underlie the formation and maintenance of immune system tissues, Rodewald and his co-workers developed a "barcode system". To this end, the scientists constructed a "genetic chance generator". As a result, cells that have been labeled in this way exhibit in their genome an artificial, neutral code that they pass on to their offspring. This facilitates conclusions about how tissues or cell lines are generated. "In this way, we found out that some blood stem cells in the bone marrow produce many different cell types while others generate only a few," said Rodewald. With his team, he now plans to use and enhance the barcode system with the goal of uncovering the secrets of the composition of various tissues in the body. The principle of this experiment may also help elucidate the family relationships of cells in other organs such as the brain or the liver, or to differentiate between a primary tumor and metastases in experimental models.

Tobias Dick leads the Division of Redox Regulation at the DKFZ. He investigates how hydrogen peroxide and other oxidants in the cells act as chemical messengers. "These molecules facilitate, for example, rapid responses to stress conditions," the biochemist explained. With his team, he has already been able to prove that oxidants in stress situations do not move freely in the cell; instead, they are caught by special proteins that transmit the signal via a cascade of other proteins to a specific target. "The ERC Grant will now enable us to study and comprehend the whole complexity of these so-called redox signaling pathways," said Dick, who is very pleased about the grant comprising €2 million. "Ultimately, it may become possible to specifically attack disrupted signaling pathways such as in a cancer cell."

Bernd Bukau leads the joint research department "Chaperones and Proteases" of the Center for Molecular Biology in Heidelberg (ZMBH) and the DKFZ. Bukau, a molecular biologist, is also the director of the DKFZ-ZMBH Alliance, which over the past ten years has closely linked molecular cell research activities of both institutes. Bukau is studying how the cell produces proteins. He sketched out the main goal of his group's research program: "Ribosomes use individual amino acids to synthesize polypeptide chains. We want to find out how they are subsequently given their three-dimensional structure and how several proteins are assembled into the active protein complexes." Talking about the EU funding, he added: "With the ERC Grant, we plan to uncover the molecular mechanisms of this process in the yeast model system and in human cells. We are very happy that the ERC grant will now enable us to provide answers to these pivotal research questions."

An image of the three grant recipients is available for download at:
www.dkfz.de/de/presse/pressemitteilungen/2017/bilder/erc-grants.jpg

Caption: From left to right: Bernd Bukau, Hans-Reimer Rodewald, Tobias Dick

Note on use of images related to press releases
Use is free of charge. The German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) permits one-time use in the context of reporting about the topic covered in the press release. Images have to be cited as follows: "Source: Jowanowitsch/DKFZ".
Distribution of images to third parties is not permitted unless prior consent has been obtained from DKFZ's Press Office (phone: ++49-(0)6221 42 2854, E-mail: presse@dkfz.de). Any commercial use is prohibited.

The German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) with its more than 3,000 employees is the largest biomedical research institution in Germany. More than 1,300 scientists at the DKFZ investigate how cancer develops, identify cancer risk factors and search for new strategies to prevent people from developing cancer. They are developing new methods to diagnose tumors more precisely and treat cancer patients more successfully. The DKFZ's Cancer Information Service (KID) provides patients, interested citizens and experts with individual answers to all questions on cancer.

Jointly with partners from the university hospitals, the DKFZ operates the National Center for Tumor Diseases (NCT) in Heidelberg and Dresden, and the Hopp Children's Tumour Center KiTZ in Heidelberg. In the German Consortium for Translational Cancer Research (DKTK), one of the six German Centers for Health Research, the DKFZ maintains translational centers at seven university partner locations. NCT and DKTK sites combine excellent university medicine with the high-profile research of the DKFZ. They contribute to the endeavor of transferring promising approaches from cancer research to the clinic and thus improving the chances of cancer patients.

The DKFZ is 90 percent financed by the Federal Ministry of Education and Research and 10 percent by the state of Baden-Württemberg. The DKFZ is a member of the Helmholtz Association of German Research Centers.

RSS-Feed

Subscribe to our RSS-Feed.

to top
powered by webEdition CMS