Novel Detection Techniques for Ion Beams - Publications
In peer-reviewed journals
- R. Kirchgässner, M. Martišíková, P. Schlegel, P. Ochoa-Parra, S. Harrabi, O. Jäkel, J. Debus, L. Kelleter. Out-of-beam artifact suppression in charged nuclear fragment based carbon-ion radiotherapy monitoring. Medical Physics 53:e70351 (2026). https://doi.org/10.1002/mp.70351
- Y. Hamad, S. Barna, G. Magrin, H. Palmans, F. K. Sari, T. Gehrke and A. Mairani. Radiation quality assessment in a clinical helium-ion beam using a SOI microdosimeter and a Timepix3 detector. Frontiers in Physics 14:1698522 (2026). https://doi.org/10.3389/fphy.2026.1698522
- L. Kelleter, S. Harrabi, P. Ochoa-Parra, M. Winter, O. Jäkel, J. Debus, M. Martisikova. First In Vivo Monitoring of Helium-Ion Radiation Therapy With Secondary Ions. International Journal of Radiation Oncology*Biology*Physics (2026). https://doi.org/10.1016/j.ijrobp.2025.12.036
- M. Metzner, A. Schlechter, D. Zhevachevska, P. Schlegel, O. Jäkel, M. Martišíková and T. Gehrke. 2.5D imaging: obtaining depth information from 2D helium-beam radiographs. Physics in Medicine & Biology 70 205017 (2025). https://doi.org/10.1088/1361-6560/ae02de
- P. Schlegel, R. Kirchgaessner, P. Ochoa Parra, L. Kelleter, M. Gertz, R. Mikut, O. Jäkel, M. Martišíková. A data analysis framework for in vivo monitoring in carbon-ion radiotherapy (CIRT): towards 3D reconstruction of interfractional anatomical changes. Physics in Medicine & Biology 70 245009 (2025). https://iopscience.iop.org/article/10.1088/1361-6560/ae22bb/meta
- Y. Hamad, F. K. Sari, R. Félix-Bautista, M. Martišíková, A. Mairani, T. Gehrke. LET measurements in proton and helium-ion beams of therapeutic energies using a silicon pixel detector towards a tool for quality assurance. Medical Physics 52:e18085 (2025). https://doi.org/10.1002/mp.18085
- M. Metzner, F. K. Longarino, B. Ackermann, A. Schlechter, M. Saphörster, Y. Xu, J. Schlecker, P. Wohlfahrt, C. Richter, S. Brons, J. Debus, O. Jäkel, M. Martišíková, T. Gehrke. Accuracy of a helium-beam radiography system based on thin pixel detectors for an anthropomorphic head phantom. Medical Physics 52: 4757–4768 (2025). https://doi.org/10.1002/mp.17786
- L. Schweins, R. Kirchgässner, P. Ochoa-Parra, M. Winter, S. Harrabi, A. Mairani, O. Jäkel, J. Debus, M. Martišíková, L. Kelleter. Detection of an internal density change in an anthropomorphic head phantom via tracking of charged nuclear fragments in carbon-ion radiotherapy. Medical Physics 52: 2399–2411 (2025). https://doi.org/10.1002/mp.17590
- P. Ochoa-Parra, L. Schweins, N. Abbani, L. Ghesquière-Diérickx, T. Gehrke, J. Jakubek, L. Marek, C. Granja, F. Dinkel, G. Echner, M. Winter, A. Mairani, S. Harrabi, O. Jäkel, J. Debus, M. Martišíková, L. Kelleter. Experimental validation of a FLUKA Monte Carlo simulation for carbon-ion radiotherapy monitoring via secondary ion tracking. Medical Physics 51:9217–9229 (2024). https://doi.org/10.1002/mp.17408
- R. Félix-Bautista, L. Ghesquière-Diérickx, P. Ochoa-Parra, L. Kelleter, G. Echner, J. Debus, O. Jäkel, M. Martišíková and T. Gehrke. Inhomogeneity detection within a head-sized phantom using tracking of charged nuclear fragments in ion beam therapy. Physics in Medicine & Biology 69 225003 (2024). https://iopscience.iop.org/article/10.1088/1361-6560/ad8870
- J. B. Christensen, I. Domingo Muñoz, P. Bilski, V. Conte, P. Olko, L. Bossin, A. Vestergaard, S. Agosteo, A. Rosenfeld, L. Tran, Ž. Knežević, M. Majer, I. Ambrožová, A. Parisi, T. Gehrke, M. Martišíková, N. Bassler. Status of LET assessment with active and passive detectors in ion beams. Radiation Measurements 177, 107252 (2024). https://doi.org/10.1016/j.radmeas.2024.107252
- L. Kelleter, L. Marek, G. Echner, P. Ochoa-Parra, M. Winter, S. Harrabi, J. Jakubek, O. Jäkel, J. Debus, M. Martisikova. An in-vivo treatment monitoring system for ion-beam radiotherapy based on 28 Timepix3 detectors. Scientific Reports 14, 15452 (2024). https://doi.org/10.1038/s41598-024-66266-9
- R. Félix-Bautista, Y. Hamad, T. Yáñez-González, P. Ochoa-Parra, C. Granja, M. Martišíková, A. Mairani and T. Gehrke. Towards precise LET measurements based on energy deposition of therapeutic ions in Timepix3 detectors. Physics in Medicine and Biology 69 (2024) 12503
- L. Kelleter, S. Schmidt, M. Subramanian, L. Marek, C. Granja, J. Jakubek, O. Jäkel, J. Debus and M. Martišíková. Characterisation of a customised 4-chip Timepix3 module for charged-particle tracking. Radiation Measurements 173 (2024) 107086
- M. Metzner, D. Zhevachevska, A. Schlechter, F. Kehrein, J. Schlecker, C. Murillo, S. Brons, O. Jäkel, M. Martišíková and T. Gehrke. Energy painting: helium-beam radiography with thin detectors and multiple beam energies. Physics in Medicine & Biology 69 (2024) 055002
- I. D. Muñoz, L. N. Burigo, T. Gehrke, S. Brons, S. Greilich, O. Jäkel. Sensitivity correction of fluorescent nuclear track detectors using alpha particles: Determining LET spectra of light ions with enhanced accuracy. Medical Physics 50: 2385–2401 (2023) https://doi.org/10.1002/mp.16083
- C. Knobloch, M. Metzner, F. Kehrein, C. Schömers, S. Scheloske, S. Brons, R. Hermann, A. Peters, O. Jäkel, M. Martišíková and T. Gehrke. Experimental helium-beam radiography with a high-energy beam: Water-equivalent thickness calibration and first image-quality results. Medical Physics 49 (2022) 5347-5362 Editor's Choice
- L. Ghesquière-Diérickx, R. Félix-Bautista, A. Schlechter, L. Kelleter, M. Reimold, G. Echner, P. Soukup, O. Jäkel, T. Gehrke and M. Martišíková. Detecting perturbations of a radiation field inside a head-sized phantom exposed to therapeutic carbon-ion beams through charged-fragment tracking. Medical Physics 29 (2022) 1776-1792 Editor's Choice
- L. Ghesquière-Diérickx, A. Schlechter, R. Félix-Bautista, T. Gehrke, G. Echner, L. Kelleter and M. Martišíková. Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking. Frontiers in Oncology 11 (2021) 780221
- R. Félix‐Bautista, L. Ghesquière‐Diérickx, L. Marek, C. Granja, P. Soukup, D. Turecek, L. Kelleter, S. Brons, M. Ellerbrock, O. Jäkel, T. Gehrke and M. Martišíková. Quality assurance method for monitoring of lateral pencil beam positions in scanned carbon‐ion radiotherapy using tracking of secondary ions. Medical Physics 8 (2021) 4411-4424
- C. Amato, M. Martišíková, and T. Gehrke: A technique for spatial resolution improvement in helium‐beam radiography. Medical Physics 5 (2020) 2212-2221
- A. Rosenfeld, S. Alnaghy, M. Petasecca, D. Cutajar, M. Lerch, S. Pospisil, V. Giacometti, R. Schulte, V. Rosso, M. Würl, C. Granja, M. Martišíková and K. Parodi. Medipix detectors in radiation therapy for advanced quality-assurance. Radiation Measurements 130 (2020) 106211
- R. Félix-Bautista, T. Gehrke, L. Ghesquière-Diérickx, M. Reimold, C. Amato, D. Turecek, J. Jakubek, M. Ellerbrock and M. Martišíková: Experimental l verification of a non-invasive method to monitor the lateral pencil beam position in an anthropomorphic phantom for carbon-ion radiotherapy. Physics in Medicine and Biology 64 (2019) 175019
- G. Arico, T. Gehrke, R. Gallas, A. Mairani, O. Jäkel and M. Martisikova: Investigation of single carbon ion fragmentation in water and PMMA for hadron therapy. Physics in Medicine and Biology 64 (2019) 055018
- C. Granja, J. Jakubek, M. Martisikova, S. Kodaira, S. Polansky, P. Krist, V. Zach and T. Matlocha: Dynamic range and resolving power of the Timepix detector to heavy charged particles. Journal of Instrumentation 13 (2018) C11003
- C. Granja, ..., M. Martišíková: Resolving power of pixel detector Timepix for wide-range electron, proton and ion detection, Nucl. Instrum. Meth A 908 (2018) 60-71
- M. Martišíková, T. Gehrke, S. Berke, G.Aricò and O. Jäkel: Helium ion beam imaging for image guided ion radiotherapy, Radiation Oncology 13(1) (2018) 109
- T. Gehrke, C. Amato and M. Martišíková: Theoretical and experimental comparison of proton and helium-beam radiography using silicon pixel detectors, Physics in Medicine and Biology 63 (2018) 035037 Medical Physics Web: http://medicalphysicsweb.org/cws/article/research/71208
- T. Gehrke, R. Gallas, O. Jäkel and M. Martišíková: Proof of principle of helium-beam radiography using silicon pixel detectors for energy deposition measurement, identification, and tracking of single ions, Medical Physics 45(2) (2018) 817-829
- G. Aricò, T. Gehrke, J. Jakubek, R. Gallas, S. Berke, O. Jäkel, A. Mairani, A. Ferrari and M. Martišíková: Investigation of mixed ion fields in the forward direction for 220.5 MeV/u helium ion beams: comparison between water and PMMA targets, Phys. Med. Biol. 62 (20) (2017) 8003–8
- R. Gallas, G. Arico, L.N. Burigo, T. Gehrke , J.Jakubek, C. Granja, D. Turecek and M. Martišíková: A Novel Method for Assessment of Fragmentation and Beam-Material Interactions in Helium Ion Radiotherapy with a Miniaturized Setup, Physica Medica, 42C (2017) 116-126
- T. Gehrke, L. Burigo, G. Arico, S. Berke, J. Jakubek, D. Turecek, T. Tessonnier, A. Mairani and M. Martišíková: Energy deposition measurements of single 1H, 4He and 12C ions of therapeutic energies in a silicon pixel detector, Journal of Instrumentation 12 (2017) P04025 Citations: https://www.webofscience.com/wos/woscc/summary/8d23c425-650b-4509-8cb3-a0e0457738d5-5ad3bc4b/date-descending/1
- R. Castriconi, M. Ciocca, A. Mirandola, C. Sini, S. Broggi, M. Schwarz, F. Fracchiolla, M. Martisikova, G. Arico, G. Mettivier and P. Russo: Dose-response of EBT3 radiochromic films to proton and carbon ion clinical beams, Phys. Med. Biol. 62(2) (2017) 377-39
- A.M. Reinhart, C.K. Spindeldreier, J. Jakubek and M. Martišíková: Three dimensional reconstruction of carbon ion beams in phantoms using single secondary ion tracks, Phys. Med. Biol. 62 (12) (2017) 4884-4896
- T. Gaa, A.M. Reinhart, B. Hartmann, J. Jakubek, P. Soukup, O. Jäkel and M. Martišíková: Visualization of air and metal inhomogeneities in phantoms irradiated by carbon ion beams using prompt secondary ions, Physica Medica 38 (2017) 140-147
- B. Hartmann, K. Gwosch, J. Jakubek, C. Granja, O. Jäkel and M. Martišíková: A Novel Method for Fragmentation Studies in Particle Therapy Using a Small Set-Up: Basic Principles, International Journal of Particle Therapy, Vol.3, No.4, (2017) p. 439
- B. Hartmann, P. Soukup, C. Granja, J. Jakubek, S. Pospisil, O. Jäkel and M. Martišíková: Distortion of the Per-Pixel Signal in the Timepix detector observed in high energy carbon ion beams, Journal of Instrumentation 9 P09006 (2014)
- J. Telsemeyer, B. Ackermann, S. Ecker, O. Jäkel and M. Martišíková: Experimental verification of ion range calculation in a treatment planning system using a flat-panel detector, Phys. Med. Biol. 59 (2014) p. 3737
- K. Gwosch, B. Hartmann, J. Jakubek, C. Granja, P. Soukup, O Jäkel and M. Martišíková: Noninvasive monitoring of therapeutic carbon ion beams in a homogeneous phantom by tracking of secondary ions, Phys. Med. Biol. 58 (2013) 3755-3773 Medical Physics Web: http://medicalphysicsweb.org/cws/article/research/53601
- L. Opalka, C. Granja, B. Hartmann, J. Jakubek, O. Jäkel, M. Martišíková, S. Pospisil and J. Solc: Linear energy transfer and track pattern recognition of secondary radiation generated in hadron therapy beam in a PMMA target, Journal of Instrumentation 8 (2013) C02047
- M. Martišíková, S. Brons, B.M. Hesse and O. Jäkel: High-resolution fluence verification for treatment plan specific QA in ion beam radiotherapy, Phys. Med. Biol. 58 (2013) 1725-1738
- J. Telsemeyer, O. Jäkel and M. Martišíková: Quantitative carbon ion beam radiography and tomography with a flat-panel detector, Phys. Med. Biol. 57 7957-7971 (2012) One of the 19 PMB highlights in 2012. Read more in: Medical Physics Web: http://medicalphysicsweb.org/cws/article/research/51844
- M. Martišíková, B. Hartmann, B.M. Hesse, S. Brons, B. Ackermann and O. Jäkel: Characterization of a flat-panel detector for ion beam spot measurements, Phys. Med. Biol. 57 485-497 (2012)
- B. Hartmann, J. Telsemeyer, L. Huber, B. Ackermann, O. Jäkel and M. Martišíková: Investigations of a flat-panel detector for quality assurance measurements in ion beam therapy, Phys. Med. Biol. 57 51-68 (2012)
- L.Opalka, C. Granja, B. Hartmann, J. Jakubek, O. Jäkel, M. Martišíková, S. Pospisil and J.Solc: 3D measurement of the radiation distribution in a water-phantom in a hadron therapy beam, Journal of Instrumentation 7 C01085 (2012)
- J. Jakubek, C. Granja, B. Hartmann, O. Jäkel, M. Martišíková, L. Opalka and S. Pospisil: Selective Detection of Secondary Particles and Neutrons Produced during Ion Beam Therapy with 3D Sensitive Voxel Detector, Journal of Instrumentation 6 C12010 (2011)
- L. Huber, J. Telsemeyer, M. Martišíková and O. Jäkel: Patient position verification in ion-beam therapy using ion-beam radiography and fiducial markers, Journal of Instrumentation 6 C11008 (2011)
- M. Martišíková, J. Jakubek, C. Granja, B. Hartmann, L. Opálka, S. Pospíšil and O. Jäkel: Measurement of secondary radiation during ion beam therapy with the pixel detector Timepix, Journal of Instrumentation 6 C11014 (2011)
- M. Martišíková and O. Jäkel: Dosimetric properties of Gafchromic EBT films in medical carbon ion beams, Phys. Med. Biol. 55 5557-67 (2010)
- M. Martišíková and O. Jäkel: Dosimetric properties of Gafchromic EBT films in monoenergetic medical ion beams, Phys. Med. Biol. 55 3741-51 (2010)
- M. Martišíková and O. Jäkel: Gafchromic EBT films for ion dosimetry, Radiation Measurements 45 1268-70 (2010)
- B. Hartmann, M. Martišíková and O. Jäkel: Homogeneity of Gafchromic EBT2 film, Technical note in Med. Phys. 37 1753-6 (2010)
- M. Martišíková and O. Jäkel: Study of Gafchromic EBT film response over a large dose range, Phys. Med. Biol. 55 N281-90 (2010)
- M. Martišíková, B. M. Hesse and O. Jäkel: Test of an amorphous silicon detector in medical proton beams, Nucl. Instrum. Meth A 633 Supplement 1 S259-61 (2010)
- M. Martišíková: Introduction to ion beam therapy, Proceedings of the 5th International Summer School on Nuclear Physics Methods and Accelerators in Biology and Medicine, American Institute of Physics Conf. Proc. 1204 103-10 (2009)
- M. Martišíková, B. Ackermann, S. Klemm and O. Jäkel: Use of Gafchromic films in heavy ion therapy, Nucl. Instrum. Meth. A 591 171-3 (2008)
- M. Martišíková, B. Ackermann and O. Jäkel: Analysis of uncertainties in Gafchromic EBT film dosimetry of photon beams, Phys. Med. Biol. 53 7013-27 (2008) Belonged to the 3% of the most downloaded papers among all IOP journals in the first half of 2009
For a full list of articles, theses etc. from the division, see here.