Publications

• Gogolin S, Ehemann V, Becker G, Brueckner LM, Dreidax D, Bannert S, Nolte I, Savelyeva L, Bell E, Westermann F., CDK4 inhibition restores G₁-S arrest in MYCN-amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage.
• Gogolin S, Batra R, Harder N, Ehemann V, Paffhausen T, Diessl N, Sagulenko V, Benner A, Gade S, Nolte I, Rohr K, König R, Westermann F., MYCN-mediated overexpression of mitotic spindle regulatory genes and loss of p53-p21 function jointly support the survival of tetraploid neuroblastoma cells.
• Dreidax D, Gogolin S, Schroeder C, Muth D, Brueckner LM, Hess EM, Zapatka M, Theißen J, Fischer M, Ehemann V, Schwab M, Savelyeva L, Westermann F., Low p14ARF expression in neuroblastoma cells is associated with repressed histone mark status, and enforced expression induces growth arrest and apoptosis.
• Lodrini M, Oehme I, Schroeder C, Milde T, Schier MC, Kopp-Schneider A, Schulte JH, Fischer M, De Preter K, Pattyn F, Castoldi M, Muckenthaler MU, Kulozik AE, Westermann F, Witt O, Deubzer HE., MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma

• Henrich KO, Schwab M, Westermann F., 1p36 tumor suppression--a matter of dosage?
• Brueckner LM, Sagulenko E, Hess EM, Zheglo D, Blumrich A, Schwab M, Savelyeva L., Genomic rearrangements at the FRA2H common fragile site frequently involve non-homologous recombination events across LTR and L1(LINE) repeats.

• Afanasyeva EA, Mestdagh P, Kumps C, Vandesompele J, Ehemann V, Theissen J, Fischer M, Zapatka M, Brors B, Savelyeva L, Sagulenko V, Speleman F, Schwab M, Westermann F., MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival.
• Henrich KO, Bauer T, Schulte JH, Ehemann V, Deubzer H, Gogolin S, Muth D, Fischer M, Benner A, Konig R, Schwab M, Westermann F. CAMTA1, a 1p36 tumor suppressor candidate, inhibits growth and activates differentiation programs in neuroblastoma cells. Cancer Res 2011, in press.
• Blumrich A, Zapatka M, Brueckner LM, Zheglo D, Schwab M, Savelyeva L. The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different cancers. Hum Mol Genetics

• Muth D, Ghazaryan S, Eckerle I, Beckett B, Pöhler C, Batzler J, Beisel C, Gogolin S, Fischer M, Henrich KO, Ehemann V, Gillespie P, Schwab M, Westermann F. Transcriptional Repression of SKP2 is Impaired in MYCN-Amplified Neuroblastoma
• Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D, Teruya-Feldstein J, Reinhardt F, Onder TT, Valastyan S, Westermann F, Speleman F, Vandesompele J, Weinberg RA. miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis, Nat Cell Biology
• Henrich, Kai-Oliver (Author-in-Chief, 2010). CAMTA1. Henrich, Kai-Oliver, Westermann, Frank (originators), Springer Reference Live: Cancer.
• Henrich, Kai-Oliver. CAMTA1. Atlas Genet Cytogenet Oncol Haematol. 2010.
• MAQC-II consortium, The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol,
• Schramm, G., S. Wiesberg, N. Diessl, A.L. Kranz, V. Sagulenko, M. Oswald, G. Reinelt, F. Westermann, R. Eils, and R. Konig, PathWave: discovering patterns of differentially regulated enzymes in metabolic pathways. Bioinformatics
• Oberthuer, A., D. Juraeva, L. Li, Y. Kahlert, F. Westermann, R. Eils, F. Berthold, L. Shi, R.D. Wolfinger, M. Fischer, and B. Brors, Comparison of performance of one-color and two-color gene-expression analyses in predicting clinical endpoints of neuroblastoma patients. Pharmacogenomics J
• Oberthuer, A., B. Hero, F. Berthold, D. Juraeva, A. Faldum, Y. Kahlert, S. Asgharzadeh, R. Seeger, P. Scaruffi, G.P. Tonini, I. Janoueix-Lerosey, O. Delattre, G. Schleiermacher, J. Vandesompele, J. Vermeulen, F. Speleman, R. Noguera, M. Piqueras, J. Benard, A. Valent, S. Avigad, I. Yaniv, A. Weber, H. Christiansen, R.G. Grundy, K. Schardt, M. Schwab, R. Eils, P. Warnat, L. Kaderali, T. Simon, B. Decarolis, J. Theissen, F. Westermann*, B. Brors*, and M. Fischer*, Prognostic impact of gene expression-based classification for neuroblastoma. J Clin Oncol
• Mestdagh, P., E. Fredlund, F. Pattyn, J.H. Schulte, D. Muth, J. Vermeulen, C. Kumps, S. Schlierf, K. De Preter, N. Van Roy, R. Noguera, G. Laureys, A. Schramm, A. Eggert, F. Westermann, F. Speleman, and J. Vandesompele, MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumors. Oncogene
• Gogolin, S., D. Dreidax, G. Becker, V. Ehemann, M. Schwab, and F. Westermann, MYCN/MYC-mediated drug resistance mechanisms in neuroblastoma. Int J Clin Pharmacol Ther
• Fischer, M., T. Bauer, A. Oberthur, B. Hero, J. Theissen, M. Ehrich, R. Spitz, R. Eils, F. Westermann, B. Brors, R. Konig, and F. Berthold, Integrated genomic profiling identifies two distinct molecular subtypes with divergent outcome in neuroblastoma with loss of chromosome 11q. Oncogene
• De Preter, K., J. Vermeulen, B. Brors, O. Delattre, A. Eggert, M. Fischer, I. Janoueix-Lerosey, C. Lavarino, J.M. Maris, J. Mora, A. Nakagawara, A. Oberthuer, M. Ohira, G. Schleiermacher, A. Schramm, J.H. Schulte, Q. Wang, F. Westermann, F. Speleman, and J. Vandesompele, Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signature. Clin Cancer Res

• Mestdagh P, Van Vlierberghe P, De Weer A, Muth D, Westermann F, Speleman F, Vandesompele J. A novel and universal method for microRNA RT-qPCR data normalization. Genome Biol.
• Oberthuer A, Theissen J, Westermann F, Hero B, Fischer M. Molecular characterization and classification of neuroblastoma. Future Oncol.
• Eckerle I, Muth D, Batzler J, Henrich KO, Lutz W, Fischer M, Witt O, Schwab M, Westermann F. Regulation of BIRC5 and its isoform BIRC5-2B in neuroblastoma. Cancer Lett.
• Theissen J, Boensch M, Spitz R, Betts D, Stegmaier S, Christiansen H, Niggli F, Schilling F, Schwab M, Simon T, Westermann F, Berthold F, Hero B. Heterogeneity of the MYCN oncogene in neuroblastoma. Clin Cancer Res.
• Oehme I, Deubzer HE, Wegener D, Pickert D, Linke JP, Hero B, Kopp-Schneider A, Westermann F, Ulrich SM, von Deimling A, Fischer M, Witt O. Histone deacetylase 8 in neuroblastoma tumorigenesis. Clin Cancer Res.

• Oberthuer A, Kaderali L, Kahlert Y, Hero B, Westermann F, Berthold F, Brors B, Eils R, Fischer M. Subclassification and individual survival time prediction from gene expression data of neuroblastoma patients by using CASPAR. Clin Cancer Res.
• Westermann F, Muth D, Benner A, Bauer T, Henrich KO, Oberthuer A, Brors B, Beissbarth T, Vandesompele J, Pattyn F, Hero B, König R, Fischer M, Schwab M. Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas. Genome Biol.
• Praml C, Schulz W, Claas A, Mollenhauer J, Poustka A, Ackermann R, Schwab M, Henrich KO. Genetic Variation of Aflatoxin B1 Aldehyde Reductase genes (AFAR) in human tumour cells. Cancer Lett.
• Henrich KO, Westermann F. CAMTA1. In: Encyclopedia of Cancer, Second Edition. Springer-Verlag; Berlin, New York, Heidelberg.
• Sagulenko V, Muth D, Sagulenko E, Paffhausen T, Schwab M, Westermann F. Cathepsin D Protects Human Neuroblastoma Cells from Doxorubicin-Induced Cell Death. Carcinogenesis.
• Fischer M, Spitz R, Oberthür A, Westermann F, Berthold F. Risk estimation of neuroblastoma patients using molecular markers. Klin Padiatr.
• Deubzer HE, Ehemann V, Kulozik AE, Westermann F, Savelyeva L, Kopp-Schneider A, Riester D, Schwab M, Witt O. Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro. Cancer Lett.
• Deubzer HE, Ehemann V, Westermann F, Heinrich R, Mechtersheimer G, Kulozik AE, Schwab M, Witt O. Histone deacetylase inhibitor Helminthosporium carbonum (HC)-toxin suppresses the malignant phenotype of neuroblastoma cells. Int J Cancer.
• Afanasyeva EA, Hotz-Wagenblatt A, Glatting KH, Westermann F. New miRNAs cloned from neuroblastoma. BMC Genomics.
• Nowacki S, Skowron M, Oberthuer A, Fagin A, Voth H, Brors B, Westermann F, Eggert A, Hero B, Berthold F, Fischer M. Expression of the tumour suppressor gene CADM1 is associated with favourable outcome and inhibits cell survival in neuroblastoma. Oncogene.

Sagulenko E, Savelyeva L, Ehemann V, Sagulenko V, Hofmann W, Arnold K, Claas A, Scherneck S, Schwab M. Suppression of polyploidy by the BRCA2 protein. Cancer Lett. PMID: 17686574

Sawińska M, Schmitt JG, Sagulenko E, Westermann F, Schwab M, Savelyeva L. Novel Aphidicolin-Inducible Common Fragile Site FRA9G Maps to 9p22.2, Within the C9orf39 Gene. Genes Chromosome Canc. PMID: 17668870

Westermann, F, Henrich KO, Wei JS, Lutz W, Fischer M, König R, Wiedemeyer R, Ehemann V, Brors B, Ernestus K, Leuschner I, Benner A, Khan J, Schwab M, High Skp2 expression characterizes high-risk neuroblastomas independent of MYCN status. Clin Cancer Res. PMID: 17652624

Warnat P, Oberthuer A, Fischer M, Westermann F, Eils R, Brors B. Cross-study analysis of gene expression data for intermediate neuroblastoma identifies two biological subtypes. BMC Cancer. PMID: 17531100

Oberthuer A, Warnat P, Kahlert Y, Westermann F, Spitz R, Brors B, Hero B, Eils R, Schwab M, Berthold F, Fischer M. Classification of neuroblastoma patients by published gene-expression markers reveals a low sensitivity for unfavorable courses of MYCN non-amplified disease. Cancer Lett. PMID: 17126996

Fechter A, Buettel I, Kuehnel E, Schwab M, Savelyeva L. Cloning of genetically tagged chromosome break sequences reveals new fragile sites at 6p21 and 13q22. Int J Cancer. PMID: 17290399

Paffhausen T, Schwab M, Westermann F. Targeted MYCN Expression Affects Cytotoxic Potential of Chemotherapeutic Drugs in Neuroblastoma Cells. Cancer Lett. PMID: 17141950

Suspitsin EN, Sokolenko AP, Togo AV, Lazareva YR, Turkevich EA, Matsko DE, Henrich KO, Borresen-Dale AL, Schwab M, Cornelisse CJ, Imyanitov EN. Nonrandom distribution of oncogene amplifications in bilateral breast carcinomas: Possible role of host factors and survival bias. Int J Cancer. PMID: 17066426

Henrich KO, Claas A, Praml C, Benner A, Mollenhauer J, Poustka A, Schwab M, Westermann F. Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma. Eur J Cancer. PMID: 17222547

Fechter A, Buettel I, Kuehnel E, Savelyeva L, Schwab M. Common fragile site FRA11G and rare fragile site FRA11B at 11q23.3 encompass distinct genomic regions. Genes Chromosomes Cancer. 46(1):98-106. PMID: 17063465

Oberthuer A, Berthold F, Warnat P, Hero B, Kahlert Y, Spitz R, Ernestus K, Konig R, Haas S, Eils R, Schwab M, Brors B, Westermann F, Fischer M. Customized oligonucleotide microarray gene expression-based classification of neuroblastoma patients outperforms current clinical risk stratification. J Clin Oncol. 24(31):5070-8. PMID: 17075126

Chen QR, Bilke S, Wei JS, Greer BT, Steinberg SM, Westermann F, Schwab M, Khan J. Increased WSB1 copy number correlates with its over-expression which associates with increased survival in neuroblastoma. Genes Chromosomes Cancer. 45(9):856-62. PMID: 16804916

Henrich KO, Fischer M, Mertens D, Benner A, Wiedemeyer R, Brors B, Oberthuer A, Berthold F, Wei JS, Khan J, Schwab M, Westermann F. Reduced expression of CAMTA1 correlates with adverse outcome in neuroblastoma patients. Clin Cancer Res. 12(1):131-8. PMID: 16397034

Hormozian F, Schmitt JG, Sagulenko E, Schwab M, Savelyeva L. FRA1E common fragile site breaks map within a 370kilobase pair region and disrupt the dihydropyrimidine dehydrogenase gene (DPYD). Cancer Lett. PMID: 16556484

Sugihara E, Kanai M, Saito S, Nitta T, Toyoshima H, Nakayama K, Nakayama KI, Fukasawa K, Schwab M, Saya H, Miwa M. Suppression of centrosome amplification after DNA damage depends on p27 accumulation. Cancer Res. 66(8):4020-9. PMID: 16618721

Askoxylakis V, Mier W, Zitzmann S, Ehemann V, Zhang J, Kramer S, Beck C, Schwab M, Eisenhut M, Haberkorn U. Characterization and Development of a Peptide (p160) with Affinity for Neuroblastoma Cells. J Nucl Med. 47(6):981-988. PMID: 16741308

Abe M, Westermann F, Nakagawara A, Takato T, Schwab M, Ushijima T Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas. Cancer Lett. PMID: 16759796

Arnold K, Kim MK, Frerk K, Edler L, Savelyeva L, Schmezer P, Wiedemeyer R. Lower level of BRCA2 protein in heterozygous mutation carriers is correlated with an increase in DNA double strand breaks and an impaired DSB repair. Cancer Lett. 243(1):90-100. PMID: 16448746

Bilke S., Chen Q.R., Westerman F., Schwab M., Catchpoole D., Khan J. Inferring a tumor progression model for neuroblastoma from genomic data . J. Clin. Oncol. 23, 7322-31 PMID: 16145061

Askoxylakis V., Zitzmann S., Mier W., Graham K., von Wegner F., Fink R.H., Schwab M., Eisenhut M., Haberkorn U. Preclinical evaluation of the breast cancer cell-binding peptide, p160. Clin. Cancer Res. 11, 6705-12 PMID: 16166451

Oberthuer A, Skowron M, Spitz R, Kahlert Y, Westermann F, Mehler K, Berthold F, Fischer M. Characterization of a complex genomic alteration on chromosome 2p that leads to four alternatively spliced fusion transcripts in the neuroblastoma cell lines IMR-5, IMR-5/75 and IMR-32. Gene. 19;363:41-50. PMID: 16216448

Krasnoselsky AL, Whiteford CC, Wei JS, Bilke S, Westermann F, Chen QR, Khan J. Altered expression of cell cycle genes distinguishes aggressive neuroblastoma. Oncogene. 24;24(9):1533-41. PMID: 15592497

Schwab M. Fragilome: Determining the role of fragile sites in human disease. Cancer Lett. PMID: 16239063

Savelyeva L., Sagulenko E., Schmitt J.G., Schwab M. The neurobeachin gene spans the common fragile site FRA13A. Hum. Genet. PMID: 16244873

Savelyeva L., Sagulenko E., Schmitt J.G., Schwab M. Low-frequency common fragile sites: Link to neuropsychiatric disorders? Cancer Lett.. PMID: 16298041

Schwab, M.,MYCN in neuronal tumours, Cancer Letters 204, 179-187 PMID: 15013217

Sugihara, E., Kanai, M., Matsui, A., Onodera, M., Schwab, M., Miwa, M. Enhanced expression of MYCN leads to centrosome hyperamplification after DNA damage in neuroblastoma cells, Oncogene 23, 1005-1009 PMID: 14647433

Kim, M.-K., Zitzmann, S., Westerman, F., Arnold, K., Brouwers, S., Schwab. M. Savelyeva, L., Increased rates of spontaneous sister chromatid exchange in lymphocytes of BRCA2 +/- carriers of familial breast cancer clusters, Cancer Letters 210, 85-94 PMID: 15172125

Chen Q-R., Bilke S., Wei J.S., Whiteford C., Cenacchi N., Krasnoselsky A., Greer B., Son C-G., Westermann F., Berthold F., Schwab M., Catchpoole D., and Javed Khan cDNA array-CGH profiling identifies genomic alterations specific to stage and MYCN-amplification in neuroblastoma, BMC Genomics 5, 70 PMID: 15380028

Wei, J.S., Braden T.G., Westermann F., Steinberg S., Son C-G., Chen Q-R., Whiteford C., Bilke S., Krasnoselsky A., Cenacchi N., Catchpoole D., Berthold F., Schwab M and Khan J. Prediction of clinical outcome using gene expression profiling and artificial neural networks for patients with neuroblastoma, Cancer Research 64, 6883-6891 PMID: 15466177

Büttel, I., Fechter A., Schwab M. Common fragile sites and cancer: Targeted cloning by insertional mutagenesis. Ann. N.Y. Acad. Scie. 1028:14-27 PMID: 15650228

Schwab, M. Modifikationsgene bei Brustkrebs, Krebsforschung Heute

Matzner, I., Savelyeva, L., Schwab, M. Preferential integration of transfected marker gene into spontaneously expressed fragile sites of a breast cancer cell line, Cancer Letters 189, 207-219 (2003) PMID: 12490314

Wiedemeyer, R., Westermann, F., Wittke, I., Nowock, J., Schwab, M. Ataxin-2 promotes apoptosis of human neuroblastoma cells, Oncogene 22, 401-411 (2003) PMID: 12545161

Praml, C., Saveleva, L., Schwab, M., Aflatoxin B 1 Aldehyde Reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells, Oncogene 22, 4765-4773 (2003) PMID: 12879023

Schwab, M., Evans, A., Neuroblastoma – developmental and molecular biology meet therapy design, Cancer Letters 197, 1 (2003) PMID: 12880952

Schwab, M., Westermann, F., Hero, B., Berthold, F., Neuroblastoma: biology and molecular and chromosomal pathology, Lancet Oncology 4, 472-480 (2003) PMID: 12901961

Mädge, B., Geisen, C., Möröy, T., Schwab, M., Yaf2 inhibits Myc biological function. Cancer Letters 193, 171-176 (2003) PMID: 12706874

Wittke, I., Wiedemeyer, R., Pillmann, A., Savelyeva, L., Westermann, F., Schwab, M., Neuroblastoma-derived sulfhydryl oxidase, a new member of the sulhydryl oxidase/quiescin6 family, regulates sensitization to Interferon gamma-induced cell death in human neuroblastoma cell. Cancer Research 63, 7742-7752 (2003) PMID: 14633699

Schwab, M., Claas, A., Savelyeva, L., BRCA2: A genetic risk factor for breast cancer, Cancer Letters 175 1-8 (2002) PMID: 11734330

Godfried, M.B., Veenstra, M., v. Sluis, P., Bonn, K., v. Asperen, R., Hermus, M.C., v. Schaik, B.D.C., Voute, T.P.A., Schwab, M., Versteeg, R., Caron, H.N. The N-myc and c-myc downstream pathways include the cromosome 17q genes nm23-H1 and nm23-H2. Oncogene 21, 2097-2101 (2002) PMID: 11960382

Spitz, R., Hero, B., Westermann, F., Ernestus, K., Schwab, M., Berthold, F. Fluorescence in situ hybridization analyses of chromosome band Ip36 in neuroblastoma detect two classes of alterations. Genes, Chromosomes & Cancer 34:299-305 (2002) PMID: 12007190

Schwab, M.. Amplified MYCN in Human Neuroblastoma. Paradigm for the Translation of Molecular Genetics to Clinical Oncology, Ann. N.Y. Acad. Sci. 963, 63-73 (2002) PMID: 12095930

Westermann, F., Schwab, M. Genetic parameters of neuroblastomas. Cancer Letters 184, 127-147 (2002) PMID: 12127685

Zitzmann, S., Ehemann, V., Schwab, M. Arginine-Glycine-Aspartic Acid (RGD)-peptide binds to both tumor and tumor-endothelial cells in vivo. Cancer Research 62, 5139-5143 (2002) PMID: 12234975

Berwanger, B., Hartmann, O., Bergmann, E., Bernard, S., Nielsen, D., Krause, M., Kartal, A., Flynn, D., Wiedemeyer, R., Schwab, M., Schäfer, H., Christiansen, H., Eilers, M., Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma, Cancer Cell 2, 1-10 (2002) PMID: 12450793

Zitzmann, S. Askoxylakis, V., Mier, W. Phagen-Display Bibliotheken: mit Viren auf der Suche nach neuen Targets, BIOforum 25 (2002) 490-491

Reviews:
Schwab, M., Wittke, I., Wiedemeyer, R., Sagulenko, V., Henrich, K., Westermann, F., Molecular signaling pathways as clinical markers in progression and spontaneous regression of neuroblastomas, In: Progress Report 1999-2002, Published by: German Human Genomr Project, 2002, pp. 114-115

Savelyeva, L., Schwab, M. Genetic risk of breast cancer - What is the role of modifier genes and genetic instabilities? In: Current Cancer Research 2002 (ed. Deutsches Krebsforschungszentrum). Steinkopff, Springer: Darmstadt, New York, 188-193

O’Neill, S., Ekstrom, L., Lastowska, M., Roberts, P., Brodeur, G.M., Kees, U.R., Schwab, M., Bown, N. MYCN Amplification and 17q in Neuroblastoma: Evidence for Structural Association. Genes, Chromosomes & Cancer 90, 30:87 (2001) PMID: 11107180

Wittke, I., Mädge, B., Wiedemeyer, R., Kimchi, A., Schwab, M. DAP-5 is involved in MycN/IFNgamma-induced apoptosis in human neuroblastoma cells. Cancer Letters 162, 237:243 (2001) PMID: 11146231

Rössler, J., Schwab, M., Havers, W., Schweigerer, L. Hypoxia promotes apoptosis of human neuroblastoma cell lines with enhanced N-myc expression. Biochemical and Biophysical Research Communication 281, 272-276 (2001) PMID: 11181040

Boon, K., Caron, H.N., van Asperen, R., Velantijn, L., Hermus, M.-C., van Sluis, P., Roobeek, I., Weis, I., Voute, P.A., Schwab, M., Versteeg, R. N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis. EMBO Journal 20, 1-11 (2001) PMID: 11250904

Würfel, J., Seiter, S., Stassar, M., Claas, A., Kläs, R., Rösel, M., Marhaba, R., Savelyeva, L., Schwab, M., Matzku, S., Zöller, M., Cloning of the human homologue of the metastasis-associated rat C4.4A. Gene 262, 35-41 (2001) PMID: 11179665

Schilling, T., Bürck, J., Sinn, H.-P., Clemens, A., Otto, H. F., Höppner, W., Herfahrth, C., Ziegler, R., Schwab, M., Raue, F., Prognostic value of codon 918 (ATG-ACG) RET proto-oncogene mutations in sporadic medullary thyroid carcinoma. Int. J. Cancer (Pred. Oncol.) 95, 62-66 (2001) PMID: 11241313

Savelyeva, L., Schwab, M, Amplification of oncogenes revisited: From expression profiling to clinical application, Cancer Letters 167, 115-123 (2001) PMID: 11369131

Khan, J., Wei, J.S., Ringnér, M., Saal, L.H., Ladanyi, M., Westermann, F., Berthold, F., Schwab, M., Antonescu, C.R., Peterson, C., Meltzer, P.S. Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks. Nature Medicine 7, 673-679 (2001) PMID: 11385503

Bauer, A., Savelyeva, L., Claas, A., Praml, C., Berthold, F., Schwab, M. Smallest region of overlapping deletion in 1p36 in human neuroblastoma: A 1-Mbp cosmid and PAC contig. Genes, Chromosomes & Cancer 31, 228-239 (2001) PMID: 11391793

Savelyeva, L., Claas, A., Matzner, I., Schlag, P., Hofmann, W, Scherneck, S., Weber, B., Schwab, M. Constitutional genomic instability with inversions, duplications and amplification in 9p23-24 in BRCA2 mutation carrires. Cancer Research 61, 5179-5185 (2001) PMID: 11431357

Claas, A., Savelyeva, L., Pillmann, A., Schwab, M. Chromosomal mapping of human genes by radioactive hybridization of cDNAs to CEPH-YAC high density gridded filter sets. Cancer Letters 162, 125-131 (2001) PMID: 11121870

Zhang, J., Spring, H., Schwab, M. Neuroblastoma tumor cell-binding peptides identified through random peptide phage display, Cancer Letters 171, 153-164 PMID: 11520599

Bannasch, D., Mädge, B., Schwab, M. Functional interaction of Yaf2 with the central region of MycN. Oncogene 20, 5913-5919 PMID: 11593398


II. Book articles, reviews

1. Schwab, M. Krebs und Gene. BioSpektrum 3.01, 7. Jahrgang, 211-212 (2001)

2. Schwab, M., Amplified MYCN in human neuroblastoma: A paradigm for the translation of molecular genetics to clinical oncology, Ann. N.Y. Acad. Sci. (in press)

3. Schwab M, Claas A, Savelyeva L., BRCA2: a genetic risk factor for breast cancer. Cancer Lett. 10;175(1):1-8. Review. PMID: 11734330


III. Herausgeberbände:

1. Schwab, M.
Cancer Research
An Encyclopedic Reference
Springer-Verlag, 2001

Amler, L.C., Bauer, A., Corvi, R., Dihlmann, S., Praml, C., Cavenee, W.K., Schwab, M., Hampton, G.M. Identification and caracterization of novel genes locate at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP. Genomics 64, 195-202 (2000) PMID: 10729226

Claas, A., Savelyeva, L., Pillmann, A., Schwab, M. Chromosomal mapping of human genes by radioactive hybridization of cDNAs to Centre d'Etude du Polymorphisme Humain high density gridded filter sets. Cancer Letters 156, 19-25 (2000) PMID: 10840155

Müller, S., van den Boom, D., Zirkel, D., Köser, H., Berthold, F., Schwab, M., Westphal, M., Zumkeller, W. Retention of impriting of the human apoptosis-related gene TSSC3 in human brain tumors. Human Mol. Genet. 9, 757-763 (2000) PMID: 10749982

Solovei, I., Kienle, D., Littlel, G., Eilsl, R., Savelyeva, L., Schwab, M., Jäger, W., Cremer, Cremer, T. Topology of double minutes (dmins) and homogeneously staining regions (HSRs) in nuclei of human neuroblastoma cell lines. Genes, Chromosomes & Cancer, 29, 297-308 (2000). PMID: 11066073

Fulda, S., Lutz, W., Schwab, M., Debatin, K.-M. MycN sensitizes neuroblastoma cells for drug-triggered apoptosis. Medical and Pediatric Oncology 35, 582-884 (2000) PMID: 11107122

Savelyeva, L., Claas, A., An, Hanxiang, Weber, R.G., Lichter, P. Schwab, M. Retention of Polysomy at 9p23-24 during karyotypic evolution in human breast cancer cell line COLO-824. Genes, Chromosomes & Cancer 24, 87-93 (1999) PMID:9892114

Fotsis, T., Breit, S., Lutz,W., Rössler, J.,Hatzi, E., Schwab, M., Schweigerer, L. Down-regulation of endothelial cell growth inhibitors by enhanced MYCN oncogene expression in human neuroblastoma cells. Eur J Biochem 263, 757-764 (1999) PMID:10469139

Fulda, S., Lutz, W., Schwab, M. and Debatin, K.-M. MYCN sensitizes neuroblastoma cells for drug induced apoptosis. Oncogene 18, 1479-1486 (1999) PMID:10050884

Schwab, M. Oncogene amplification in solid tumors. Seminars in Cancer Biology 9, 319-325 (1999) PMID: 10448118

Schwab, M. Human neuroblastoma: From basic science to clinical debut of cellular oncogenes. Naturwissenschaften 86, 71-78 (1999) PMID: 10084150

Bannasch, D., Schwab, M. A versatile bait vector for rapid Gal4 dependent two-hybrid screens. Plasmid 42, 139-143 (1999) PMID: 10489331

Perri, P., Praml, C., Savelyeva, L., Pillmann, A., Schwab, M. Fine-mapping of distal 1p loci reveals p73 at D1S468. Cytogenet Cell Genet 84, 111-114 (1999) PMID:10343122

An, HX., Claas, A., Savelyeva, L., Seitz, S., Schlag, P., Scherneck, S., Schwab, M. Two regions of deletion in 9p23-24 in sporadic breast cancer. Cancer Research 59, 3941-3943 (1999) PMID:10463588

Schwab, M. From fish to FISH: the comperative pathology of neuroblastomas in humans, mice and fish. Cancer Res. Clin. Oncol. 125, 141-149 (1999) PMID: 10235467

Zumkeller, W., Schwab, M. Insulin-like growth factor system in neuroblastoma tumorigenesis and apoptosis: potential diagnostic and therapeutic perspectives. Horm. Metab. Res. 31, 138-141 (1999) PMID: 10226794

Bannasch, D., Weis, I., Schwab, M. Nmi protein interacts with region that differ between MycN and Myc is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN. Oncogene 18, 6810-6817 (1999) PMID: 10597290

Savelyeva, L., Claas, A., Finke, L., Kaisers, H., Schlag, P., Mangion, J., Stratton, M.R., Schwab, M. An interstitial tandem duplication of 9p23-24 coexists with a mutation in the BRCA2 gene in the germ line of three brothers with breast cancer. Cancer Res. 58, 863-866 (1998) PMID:9500439

Schwab, M. Amplification of oncogenes in cancer cells. BioEssays20 (6), 473-479 (1998) PMID:9699459

Neuhausen, S., Godwin, A.K., Schubert, E., Stoppa-Lyonnet, D., Csokay, B., Lalloo, F., Stratton, M., Boyd, J., Scott, R.J., Teugels, E., Bishop, T., King, M.-C., Weber, B., Borg, A., Goldgar, D., Gershoni-Baruch, R., Garber, J., Olah, E., Serova, O., Osorio, A., Offit, K., Caligo, M.A., Schofield, A., Schwab, M., Benitez, J., Ponder, B.A.J., Devilee, P., Narod, S.A. and Easton, D. Haplotype and phenotype analysis on nine recurrent BRCA2 mutations in 111 families: Results of an international study. Am. J. Hum. Genet. 62, 1381-1388 (1998) PMID:9585613

Lutz, W., Fulda, S., Jeremias, I., Debatin, K.-M., Schwab, M. MycN and IFNg cooperate in apoptosis of of human neuroblastoma cells. Oncogene 17, 339-346 (1998) PMID:9690515

Kordes, E., Savelyeva, L., Schwab, M., Rommelaere, J., Jauniaux, J.-C. and Cziepluch, C. Isolation and characterization of human SGT and identification of homologoues in S. cerevisiae and C. elegans. Genomics 52, 90-94 (1998) PMID:9740675

Claas, C., Seiter, S., Claas, A., Savelyeva, L., Schwab, M., Zöller, M. Association between the rat homologue of CO-029, a metastasis-associated tetraspanin molecule and consumption coagulopathy. Journal of Cell Biology141, 267-280 (1998) PMID:9531564

Schilling, T. and Schwab, M. Molekulare Screening. Was bringt die genetische Diagnostik in der klinischen Anwendung? Der Kassenarzt 38, 34-37 (1998)
Praml, C., Amler, L.C., Dihlmann, S., Finke, L.H., Schlag, P., Schwab, M. Secretory type II phospholipase A2 (PLA2G2A) expression status in colorectal carcinoma derived cell lines and in normal colonic mucosa. Oncogene17, 2009-2012 (1998) PMID:9788445

Praml, C., Savelyeva, L., Perri, P., Schwab, M. Cloning of the human Afltoxin By-Aldehyde Reductase gene at 1p35-1p36.1 in a region frequently altered in human tumor cells. Cancer Res. 58, 5014-5018 (1998) PMID:9823300

Schwab, M. Where pathology meets molecular biology: MYCN amplification in human neuroblastoma as a paradigm for the clinical use on an oncogene alteration. Periodicum Biologorum 100, 281-287 (1998)

Schwab, M. Genetic elements of childhood cancer. In: Vo?te, Barrett & Kalifa (eds.) Cancer in Children. Oxford University Press, pp. 21-30 (1998)

Schwab, M., Rabes, H., Munk, K., Hofschneider, P. Genes and Environment in Cancer Recent Results in Cancer Research Springer-Verlag, 1998