mRNA Cancer Immunotherapies

  • HI-TRON Mainz
  • Immunology, Infection and Cancer
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Prof. Dr. Ugur Sahin

Head of Division

Immunotherapy revolutionized cancer treatment, but remains limited in solid tumors such as pancreatic and MSS colorectal cancer. The mRNA-LNP technology opens new avenues by leveraging the versatility and adjuvant properties of mRNA to fine-tune immunomodulation and enhance immunostimulatory effects in the tumor microenvironment.

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Our Research

The image shows a laboratory setting featuring a sunscreen manufacturing machine labeled "sunscreen" from Lichained Labs. The device includes several connected components and tubes for processing. In the background, there's a computer monitor and glass containers, indicating a scientific workspace.
Lipid nanoparticle formulation device

Our lab conducts research on "mRNA cancer immunotherapies", including antigen-specific immunotherapies using both antibody- and T-cell-based approaches. In addition to classical laboratory techniques, the focus is on sequencing techniques and bioinformatics methods. The aim is - in line with the philosophy of HI-TRON Mainz - to promote the rapid transfer of laboratory research into the clinic.

Team

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    Prof. Dr. Ugur Sahin

    Head of Division

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    Dr. Alexandra Alves Duarte

    Deputy Head, Senior Scientist

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    Dr. Jannis Wißfeld

    Postdoctoral Researcher

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    Dr. Akhil Velluva

    Postdoctoral Researcher, Bioinformatician

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    Dr. Thomas Kerzel-Gnaneswaran

    Postdoctoral Researcher

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    Nele Sophie Kuhr

    PhD Student

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    Kevin De Azevedo

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    Florian Heeg

    Technical Assistant

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    Jule Dettweiler

    Student Assistant

Selected Publications

2024 - Cancer Cell

Beck JD, Diken M, Suchan M, Streuber M, Diken E, Kolb L, Vascotto F, Peters D, Beißert T, Türeci Ö, Kreiter S, Vormehr M, Sahin U.

2022 - Nature Biotechnology

Weber D, Ibn-Salem J, Sorn P, Suchan M, Holtsträter C, Lahrmann U, Vogler I, Schmoldt K, Lang F, Schrörs B, Löwer M, Sahin U.

2020 - Nature

Sahin U, Oehm P, Derhovanessian E, Jabulowsky RA, Vormehr M, Gold M, Maurus D, Schwarck-Kokarakis D, Kuhn AN, Omokoko T, Kranz LM, Diken M, Kreiter S, Haas H, Attig S, Rae R, Cuk K, Kemmer-Brück A, Breitkreuz A, Tolliver C, Caspar J, Quinkhardt J, Hebich L, Stein M, Hohberger A, Vogler I, Liebig I, Renken S, Sikorski J, Leierer M, Müller V, Mitzel-Rink H, Miederer M, Huber C, Grabbe S, Utikal J, Pinter A, Kaufmann R, Hassel JC, Loquai C, Türeci Ö.

Get in touch with us

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Dr. Alexandra Alves Duarte

Deputy Head, Senior Scientist
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