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Bianca Kraft, Ph.D.

Bianca Kraft, Ph.D.

Bianca Kraft, Ph.D.




Molecular Hematology/Oncology


+49 6221 42 1442


+49 6221 42 1444


INF 581/TP 4



Project description

My research focuses on an Achilles’ heel of cancer cells: the centrosomal clustering. This mechanism is a cancer-specific survival strategy to limit chromosomal instability by preventing multipolar mitosis which normally leads to cell death. By uncovering the pathways responsible for centrosomal clustering, I aspire to identify novel targets for clustering inhibitors. My team develops an integrated target validation approach combining whole exome sequencing data of inhibitor-resistant cell lines with findings generated by new proteomic-based methods and functional cell-based assays including CRISPR/Cas. In close collaboration with Mads H. Clausen from the Chemical Biology of DTU Chemistry (Denmark), I aim to design and introduce novel clustering inhibitors as potential cancer therapeutic agents.



Research Experience

Since 2014

Postdoctoral research fellow at the German Cancer Research Center (DKFZ), Heidelberg

Clinical Cooperation Unit   Molecular Hematology/Oncology




Postdoctoral research fellow at the Karlsruhe Institute of  Technology (KIT), Karlsruhe


Department of Cell and   Developmental Biology





Doctoral thesis (PhD) at the   Karlsruhe Institute of Technology (KIT)


Diploma at the University of   Karlsruhe (TH)


Studies of Biology at the   University of Karlsruhe (TH)

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