Bianca Kraft, Ph.D.

Bianca Kraft, Ph.D.

Bianca Kraft, Ph.D.

Position:

Postdoc

Affiliation:

Molecular Hematology/Oncology

Phone:

+49 6221 42 1442

Fax:

+49 6221 42 1444

Building:

INF 581/TP 4

Room:

S4.124

Project description

My research focuses on an Achilles’ heel of cancer cells: the centrosomal clustering. This mechanism is a cancer-specific survival strategy to limit chromosomal instability by preventing multipolar mitosis which normally leads to cell death. By uncovering the pathways responsible for centrosomal clustering, I aspire to identify novel targets for clustering inhibitors. My team develops an integrated target validation approach combining whole exome sequencing data of inhibitor-resistant cell lines with findings generated by new proteomic-based methods and functional cell-based assays including CRISPR/Cas. In close collaboration with Mads H. Clausen from the Chemical Biology of DTU Chemistry (Denmark), I aim to design and introduce novel clustering inhibitors as potential cancer therapeutic agents.

 

 

Research Experience

Since 2014

Postdoctoral research fellow at the German Cancer Research Center (DKFZ), Heidelberg

Clinical Cooperation Unit   Molecular Hematology/Oncology

 

2011-2012

 

Postdoctoral research fellow at the Karlsruhe Institute of  Technology (KIT), Karlsruhe

 

Department of Cell and   Developmental Biology

 

 

Education

2010

Doctoral thesis (PhD) at the   Karlsruhe Institute of Technology (KIT)

2007

Diploma at the University of   Karlsruhe (TH)

2000-2007

Studies of Biology at the   University of Karlsruhe (TH)

to top