Bianca Kraft, Ph.D.

My research focuses on an Achilles’ heel of cancer cells: the centrosomal clustering. This mechanism is a cancer-specific survival strategy to limit chromosomal instability by preventing multipolar mitosis which normally leads to cell death. By uncovering the pathways responsible for centrosomal clustering, I aspire to identify novel targets for clustering inhibitors. My team develops an integrated target validation approach combining whole exome sequencing data of inhibitor-resistant cell lines with findings generated by new proteomic-based methods and functional cell-based assays including CRISPR/Cas. In close collaboration with Mads H. Clausen from the Chemical Biology of DTU Chemistry (Denmark), I aim to design and introduce novel clustering inhibitors as potential cancer therapeutic agents.

Research Experience

Education