Dr. Jens Puschhof

Scientific CV

Until 12/2021
Postdoc, Cancer-Microbiome interactions
Clevers group, Hubrecht Institute, Utrecht, The Netherlands

Until 03/2021
PhD, Cancer, Stem Cells and Developmental Biology
Universiteit Utrecht, The Netherlands

Until 11/2016
MSc, Oncology
University of Oxford, United Kingdom

Until 10/2014
BSc, Molecular Biotechnology
Ruprecht-Karls-Universität Heidelberg, Germany

Awards

1. International Society on Toxinology award for best academic talk (IST 2019, Buenos Aires)
2. International Society for Stem Cell Research awards for scientific excellence: Abstract Merit Award (ISSCR 2019, Los Angeles)
3. International Society for Stem Cell Research awards for scientific excellence: Travel Award (ISSCR 2019, Los Angeles)

Selected peer-reviewed publications (*: co-first; #: co-corresponding)

(1) Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. Pleguezuelos-Manzano C*, Puschhof J*, Rosendahl Huber A*, van Hoeck A, Wood HM, Nomburg J, Gurjao C, Manders F, Dalmasso G, Stege PB, Paganelli FL, Geurts MH, Beumer J, Mizutani T, Miao Y, van der Linden R, van der Elst S; Genomics England Research Consortium, Garcia KC, Top J, Willems RJL, Giannakis M, Bonnet R, Quirke P, Meyerson M, Cuppen E, van Boxtel R#, Clevers H#. Nature. 2020 Apr;580(7802):269-273. doi: 10.1038/s41586-020-2080-8.
(2) Intestinal organoid co-cultures with microbes. Puschhof J*, Pleguezuelos-Manzano C*, Martinez-Silgado A, Akkerman N, Saftien A, Boot C, de Waal A, Beumer J, Dutta D, Heo I, Clevers H. Nature Protocols. 2021 Aug 11. doi: 10.1038/s41596-021-00589-z.
(3) High Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells. Beumer J*, Puschhof J*, Bauzá-Martinez J*, Martínez-Silgado A, Elmentaite R, James KR, Ross A, Hendriks D, Artegiani B, Busslinger G, Ponsioen B, Andersson-Rolf A, Saftien A, Boot C, Kretzschmar K, Geurts MH, Bar-Ephraim YE, Pleguezuelos-Manzano C, Post Y, Begthel H, van der Linden F, Lopez-Iglesias C, van de Wetering WJ, van der Linden R, Peters PJ, Heck AJR, Goedhart J, Snippert H, Zilbauer M, Teichmann SA, Wu W#, Clevers H#.
Cell. 2020 Jun 11;181:1-16 doi: 10.1016/j.cell.2020.04.036
(4) Snake Venom Gland Organoids. Post Y*, Puschhof J*, Beumer J*, Kerkkamp HM, de Bakker MAG, Slagboom J, de Barbanson B, Wevers NR, Spijkers XM, Olivier T, Kazandjian TD, Ainsworth S, Iglesias CL, van de Wetering WJ, Heinz MC, van Ineveld RL, van Kleef RGDM, Begthel H, Korving J, Bar-Ephraim YE, Getreuer W, Rios AC, Westerink RHS, Snippert HJG, van Oudenaarden A, Peters PJ, Vonk FJ, Kool J, Richardson MK, Casewell NR, Clevers H.
Cell. 2020 Jan 23;180(2):233-247.e21. doi: 10.1016/j.cell.2019.11.038.
(5) Snake venom gland organoids to understand venom production in vitro.
Puschhof J*, Post Y*, Beumer J*, Kerkkamp HM, Vonk FJ, Casewell NR, Richardson MK, Clevers H. Nature Protocols. 2021 Mar;16(3):1494-1510. doi: 10.1038/s41596-020-00463-4.
(6) SARS-CoV-2 productively infects human gut enterocytes. Lamers MM*, Beumer J*, van der Vaart J*, Knoops K, Puschhof J, Breugem TI, Ravelli RBG, Paul van Schayck J, Mykytyn AZ, Duimel HQ, van Donselaar E, Riesebosch S, Kuijpers HJH, Schippers D, van de Wetering WJ, de Graaf M, Koopmans M, Cuppen E, Peters PJ, Haagmans BL, Clevers H.
Science. 2020 May 1. pii: eabc1669. doi: 10.1126/science.abc1669.
(7) A bacterial mutational footprint in colorectal cancer genomes. Rosendahl Huber A #*, Pleguezuelos-Manzano C #*, Puschhof J#*. British Journal of Cancer. Br J Cancer. 2021 May;124(11):1751-1753. doi: 10.1038/s41416-021-01273-5.
(8) Organoids and organs-on-chip: insights into human gut-microbe interactions. Puschhof J*, Pleguezuelos-Manzano C*, Clevers H. Cell Host & Microbe. 2021 Jun 9;29(6):867-878. doi: 10.1016/j.chom.2021.04.002.

More information

https://scholar.google.com/citations?user=Jp9acu8AAAAJ&hl=en
https://pubmed.ncbi.nlm.nih.gov/?term=puschhof
https://twitter.com/JensPuschhof
https://www.linkedin.com/in/jens-puschhof-483998b5/