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Arunraj Dhamodaran

Position:

Postdoctoral Researcher

Scientific CV

Since April 2024
Postdoctoral Researcher, Microbiome and Cancer, DKFZ, Heidelberg Germany

2019-2023
T-knife Therapeutics, Berlin Germany & San Francisco USA
Founding Scientist (2019-2020), Team Lead & Sr. Manager (2020-2023)

2013-2019
PhD Fellow, Max Delbrück Center for Molecular Medicine, Berlin Germany

2010-2012
M.Sc.: Cancer Biology, International Program by DKFZ & Uni-Heidelberg Germany

2006-2010
Bachelor of Tech.: Biotechnology, VIT University - Vellore Campus, India

Publications

Dhamodaran, A., Chen, X., Fellmer, N., Agrawal, D., Danner, E., Kühn, R., Blankenstein, T. Mice with a diverse human T cell receptor repertoire selected on a complete HLA class I haplotype. In preparation.

Welters, C., Welters, M-L., Stadler, S., Bullinger, L., Strobel, J., Hackstein, H., Dhamodaran, A., Blankenstein, T., Hansmann, L. HLA-C*04:09N is expressed at the cell surface and triggers peptide-specific T-cell activation. Haematologica 10.3324, 283812 (2023).

Blanc, E., Holtgrewe, M., Dhamodaran, A. et al. Identification and ranking of recurrent neo-epitopes in cancer. BMC Med Genomics 12, 171 (2019).

Leliavski, A., Knackstedt, L., Oduro, J., Selck, C., Dhamodaran, A. et al. Generating optimal-affinity T cell receptors targeting the shared neoantigen KRAS G12V using the humanized TCR transgenic mouse platform HuTCR. Cancer Res 82, 5507 (2022).

T. Kalaivani, M. Sasirekha, Dhamodaran, Arunraj, et al. In Vitro evaluation of antibacterial activity of phytochemical extracts from aerial parts of Bacopa monnieri (L.) (Scorphulariaceae). Journal of Pharmacy Research 5(3),1636-1639 (2012).

IP/Patents

Patents on fully humanized HLA/TCR mouse model for TCR discovery.
A non-human mammal comprising in its genome at least two human leukocyte antigen (HLA) class I alleles, methods of making such mammal and uses thereof. Main inventor. MDC-Berlin & T-knife/2023-08-03. EPO Nr. EP4215042A1. PCT Nr. WO2023144087A1.
Patent on TCRs against KRAS neoantigen.
Antigen recognizing construct that binds specific peptide with determinable affinity and T cell receptor having antigenic specificity for KRAS as well as corresponding nucleic acid sequence, vector, host cell, pharmaceutical composition and kit. Co-inventor. T-knife/2023-07-27. PCT Nr. WO2023139257A1.

Connect with me - LinkedIn:
https://www.linkedin.com/in/arunraj-dhamodaran/