Functional profiling discovers new cancer-relevant genes and proteins


Christian Breunig, Cindy Körner, Kirti Sharma, Chiara Giacomelli, Alexander Bott, Devina Mitra, Heike Wilhelm, Moritz Küblbeck, Ewald Münstermann, Angelika Wörner

Former members

Ioanna Keklikoglou, Daniela Antonelli, Uli Tschulena, Dorit Arlt, Özgür Sahin, Ruth Wellenreuther, Mamatha Sauermann, Meher Majety, Florian Hahne, Andreja Vasiljev, Alexander Mehrle, Detlev Bannasch, Petra Moosmayer, Regina Albert, Markus Seiler, Rainer Will, Esther Backes, Cornelia Wirth, Stephanie Bechtel, Ute Ernst, Nina Claudino, Anja Irsigler, Angelika Duda, Christian Schmidt

Current projects

The function of many human genes/proteins and their possible relationship to disease is unknown. To obtain a insights into protein function(s), we have established RNAi and ORFeome Tools and Resources for gene loss- and gain-of-function phenotypic anlyses. Process Automation has been key to foster reproducibility and consistency of results from large-scale experiments. Proteins encoded by FL-cDNAs have been systematically analyzed for their sub-cellular Protein Localization and we have established high-throughput (and lower throughput) cell-based assays to carry out cancer-relevant screens.


We have established a number of cellular assays to investigate cancer-relevant cellular processes.

A. Ben-Baruch, Tel-Aviv University, Israel
A. Schneeweiss, University Clinics and National Center for Tumor Diseases (NCT) Heidelberg, Germany
R. König, University Jena, Germany
F. Haller, A. Hartmann, University Erlangen, Germany
M. Hasmann, Roche Diagnostics, Penzberg, Germany
Y. Yarden & Eytan Domany, Weizmann Institute of Science, Rehovot, Israel
R. Pepperkok, EMBL Heidelberg, Germany
J. Simpson, University Dublin, Ireland
M. Vidal & D. Hill, Dana Farber Cancer Institute, Boston, USA
D. Gerhard, NIH/NCI, Washinton DC, USA
M. Harbers, DNAform, Yokohama, Japan
Y. Hu, Harvard Medical School, Boston, USA
J. LaBaer, ASU, Austin Texas, USA
O. Ohara, Kazusa DNA Research Institute, Japan
N. Hynes, Friedrich-Miescher Institute, Basel, Switzerland
A. Ridley, University College London, UK
T. Fehm & B. Gueckel, University Clinics Tuebingen, Germany
T. Beissbarth, University Goettingen, Germany


e:Bio - SysMetBc
e:Med - HER2low
German National Genome Research Network (NGFN).
Medical Systems Biology (MedSys) - BreastSys

Deutsche Forschungsgemeinschaft (DFG)
Deutsch-Israelisches Projekt - DIP

DKFZ-Weizmann joint PhD-program
DKFZ Helmholtz International Graduate School
Helmholtz-Israel Personalized Medicine Program

Landesstiftung Baden-Württemberg

HBIGS - Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology
Sander Stiftung

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