Clinical Epidemiology and Aging Research

PD Dr. Michael Hoffmeister

PD Dr. Michael Hoffmeister

PD Dr. Michael Hoffmeister


Deputy division head, group leader


+49 (0)6221 42-1303


+49 (0)6221 42-1302


Im Neuenheimer Feld 581


S 1.200

Deputy division head
Group head "Molecular pathological epidemiology"

Research focuses

Colorectal cancer prevention
Risk and prognostic factors
Molecular pathological epidemiology


Current research projects, studies, activities

DACHS study, principal investigator (since 2011)
IMPACT Consortium, network coordinator (since 2009), co-principal investigator
KolosSal study, co-principal investigator (since 2009)
SAMS study, co-principal investigator (since 2012)
GECCO Consortium (Seattle, USA), co-investigator (since 2009)
RAPS study, co-investigator (since 2014)
DARIO study, co-investigator (since 2015)

Elected member of the Scientific Council of DKFZ (since 2015)


Current group members MPE

Elizabeth Alwers, MD
Efrat Amitay, PhD
Prudence Carr, PhD
Margherita D'Errico, MSc

Former group members MPE

Stefanie Bienert, MSc
Min Jia, PhD



Articles in PubMed 


Selected publications


Hoffmeister M, Holleczek B, Stock C, Zwink N, Stolz T, Stegmaier C, Brenner H. Utilization and determinants of follow-up colonoscopies within 6 years after screening colonoscopy: prospective cohort study. Int J Cancer 2019;144(2):402-10

Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K; International Agency for Research on Cancer Handbook Working Group. The IARC Perspective on Colorectal Cancer Screening. N Engl J Med 2018;378(18):1734-40

Hoffmeister M, Holleczek B, Zwink N, Stock C, Stegmaier C, Brenner H. Screening for Bowel Cancer: Increasing Participation via Personal Invitation. Dtsch Arztebl Int 2017;114(6):87-93

Brenner H, Stock C, Hoffmeister M. Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies. BMJ 2014;348:g2467

Brenner H, Chang-Claude J, Jansen L, Knebel P, Stock C, Hoffmeister M. Reduced risk of colorectal cancer up to 10 y after screening, surveillance, or diagnostic colonoscopy. Gastroenterology 2014;146(3);709-17

Risk and prognostic factors
Carr PR, Weigl K, Jansen L, Walter V, Erben V, Chang-Claude J, Brenner H, Hoffmeister M. Healthy Lifestyle Factors Associated With Lower Risk of Colorectal Cancer Irrespective of Genetic Risk. Gastroenterology 2018;155(6):1805-15

Carr PR, Banbury B, Berndt SI, Campbell PT, Chang-Claude J, Hayes RB, Howard BV, Jansen L, Jacobs E, Lane DS, Nishihara R, Ogino S, Phipps AI, Slattery ML, Stefanick ML, Wallace R, Walter V, White E, Wu K, Peters U, Chan AT, Newcomb PA, Brenner H, Hoffmeister M. Association Between Intake of Red and Processed Meat and Survival in Patients With Colorectal Cancer in a Pooled Analysis. Clin Gastroenterol Hepatol 2018, doi: 10.1016/j.cgh.2018.11.036. [Epub ahead of print]

Hoffmeister M, Jansen L, Rudolph A, Toth C, Kloor M, Roth W, Bläker H, Chang-Claude J, Brenner H. Statin use and survival after colorectal cancer: the importance of comprehensive confounder adjustment. J Natl Cancer Inst 2015;107(6):djv045

Carr PR, Walter V, Brenner H, Hoffmeister M. Meat subtypes and their association with colorectal cancer: systematic review and meta-analysis. Int J Cancer 2015;138(2):293-302

Molecular pathological epidemiology
Jia M, Zhang Y, Jansen L, Walter V, Edelmann D, Gündert M, Tagscherer KE, Roth W, Bewerunge-Hudler M, Herpel E, Kloor M, Ulrich A, Burwinkel B, Bläker H, Chang-Claude J, Brenner H, Hoffmeister M. A prognostic CpG score derived from epigenome-wide profiling of tumor tissue was independently associated with colorectal cancer survival. Clin Epigenetics 2019;11(1):109.

Kather JN, Pearson AT, Halama N, Jäger D, Krause J, Loosen SH, Marx A, Boor P, Tacke F, Neumann UP, Grabsch HI, Yoshikawa T, Brenner H, Chang-Claude J, Hoffmeister M, Trautwein C, Luedde T. Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer. Nat Med 2019;25(7):1054-56

Amitay EL, Carr PR, Jansen L, Walter V, Roth W, Herpel E, Kloor M, Bläker H, Chang-Claude J, Brenner H, Hoffmeister M. Association of Aspirin and Nonsteroidal Anti-Inflammatory Drugs With Colorectal Cancer Risk by Molecular Subtypes. J Natl Cancer Inst 2019;111(5):475-83

Alwers E, Jia M, Kloor M, Bläker H, Brenner H, Hoffmeister M. Associations Between Molecular Classifications of Colorectal Cancer and Patient Survival: A Systematic Review. Clin Gastroenterol Hepatol 2019;17(3):402-10

Bläker H*, Alwers E*, Arnold A, Herpel E, Tagscherer KE, Roth W, Jansen L, Walter V, Kloor M, Chang-Claude J, Brenner H, Hoffmeister M. The Association Between Mutations in BRAF and Colorectal Cancer-Specific Survival Depends on Microsatellite Status and Tumor Stage. Clin Gastroenterol Hepatol 2019;17(3):455-62 (*equal contribution)

Carr PR*, Alwers E*, Bienert S, Weberpals J, Kloor M, Brenner H, Hoffmeister M. Lifestyle factors and risk of sporadic colorectal cancer by microsatellite instability status: a systematic review and meta-analyses. Ann Oncol 2018;29(4):825-34 (*equal contribution)

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