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Clinical Epidemiology and Aging Research

Prof. Dr. Michael Hoffmeister

Prof. Dr. Michael Hoffmeister

Prof. Dr. Michael Hoffmeister


Deputy Division Head, Group Leader


+49 (0)6221 42-1303


+49 (0)6221 42-1302


Im Neuenheimer Feld 581


S 1.200

Deputy Division Head
Group Leader "Molecular Pathological Epidemiology"

Research focuses

Colorectal cancer prevention
Risk and prognostic factors
Molecular pathological epidemiology

Current research projects, studies, activities

PEARL Study, PEARL Consortium, DACHS Study, BLITZ Study,
Smartphone-based stool test, IMPACT Consortium, KolosSal Study,
GECCO Consortium, DARIO Study, GEKKO Study, LEO Study, UK Biobank

Promotion committee (PhD), Medical Faculty, University of Heidelberg a European initiative to better understand cancer
ECICC: European Commission Initiative on Colorectal Cancer
BBMRI: Biobanking and Biomolecular Resources Research Infrastructure

Current group members MPE

Tanwei Yuan, MSc
Jie Ding, MSc
Durgesh Wankhede, MS

Former group members MPE

Elizabeth Alwers, PhD
Efrat Amitay, PhD
Prudence Carr, PhD
Marie Wosny, MSc
Margherita D'Errico, MSc
Stefanie Bienert, MSc
Min Jia, PhD


Articles in PubMed 


Selected publications

Hoffmeister M, Cardoso R, Brenner H. Colonoscopy Screening and Colorectal Cancer Incidence and Mortality. N Engl J Med 2023;388(4):377-378.

Hoffmeister M. Interim evaluation of the colorectal cancer screening programme in the Netherlands. Lancet Gastroenterol Hepatol 2022;7(1):8-9.

Hoffmeister M, Brenner H, Amitay EL. Smoking Is Consistently Associated With Major Molecular Subtypes of Colorectal Cancer. Am J Gastroenterol 2021;116(5):1092-1093.

Hoffmeister M, Bläker H, Jansen L, Alwers E, Amitay EL, Carr PR, Kloor M, Herpel E, Roth W, Chang-Claude J, Brenner H. Colonoscopy and Reduction of Colorectal Cancer Risk by Molecular Tumor Subtypes: A Population-Based Case-Control Study. Am J Gastroenterol 2020;115(12):2007-2016.

Kather JN, Pearson AT, Halama N, Jäger D, Krause J, Loosen SH, Marx A, Boor P, Tacke F, Neumann UP, Grabsch HI, Yoshikawa T, Brenner H, Chang-Claude J, Hoffmeister M, Trautwein C, Luedde T. Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer. Nat Med 2019;25(7):1054-56.

Amitay EL, Carr PR, Jansen L, Walter V, Roth W, Herpel E, Kloor M, Bläker H, Chang-Claude J, Brenner H, Hoffmeister M. Association of Aspirin and Nonsteroidal Anti-Inflammatory Drugs With Colorectal Cancer Risk by Molecular Subtypes. J Natl Cancer Inst 2019;111(5):475-83.

Alwers E, Jia M, Kloor M, Bläker H, Brenner H, Hoffmeister M. Associations Between Molecular Classifications of Colorectal Cancer and Patient Survival: A Systematic Review. Clin Gastroenterol Hepatol 2019;17(3):402-10.

Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K; International Agency for Research on Cancer Handbook Working Group. The IARC Perspective on Colorectal Cancer Screening. N Engl J Med 2018;378(18):1734-40.

Carr PR, Weigl K, Jansen L, Walter V, Erben V, Chang-Claude J, Brenner H, Hoffmeister M. Healthy Lifestyle Factors Associated With Lower Risk of Colorectal Cancer Irrespective of Genetic Risk. Gastroenterology 2018;155(6):1805-15.

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