Heparanase: a promising target and tumor antigen for therapeutic strategies in cancer

Number of publications: 9
Israeli Partner: I. Vlodavsky, Technion
German Partner: P. Beckhove, DKFZ


Arvatz, G., Shafat, I., Levy-Adam, F., Ilan, N., Vlodavsky, I.

The heparanase system and tumor metastasis: is heparanase the seed and soil? 30 (2), Cancer Metastasis Rev, 253-68, 2011

Blich, M., Golan, A., Arvatz, G., Sebbag, A., Shafat, I., Sabo, E., Cohen-Kaplan, V., Petcherski, S., Avniel-Polak, S., Eitan, A., Hammerman, H., Aronson, D., Axelman, E., Ilan, N., Nussbaum, G., Vlodavsky, I.

Macrophage activation by heparanase is mediated by TLR-2 and TLR-4 and associates with plaque progression 33 (2), Arterioscler Thromb Vasc Biol, e56-65, 2013

Borsig, L., Vlodavsky, I., Ishai-Michaeli, R., Torri, G., Vismara, E.

Sulfated hexasaccharides attenuate metastasis by inhibition of P-selectin and heparanase 13 (5), Neoplasia, 445-52, 2011

Horn, T., Grab, J., Schusdziarra, J., Schmid, S., Maurer, T., Nawroth, R., Wolf, P., Pritsch, M., Gschwend, J. E., Kubler, H. R., Beckhove, P.

Antitumor T cell responses in bladder cancer are directed against a limited set of antigens and are modulated by regulatory T cells and routine treatment approaches 133 (9), Int J Cancer, 2145-56, 2013

Lerner, I., Hermano, E., Zcharia, E., Rodkin, D., Bulvik, R., Doviner, V., Rubinstein, A. M., Ishai-Michaeli, R., Atzmon, R., Sherman, Y., Meirovitz, A., Peretz, T., Vlodavsky, I., Elkin, M.

Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice 121 (5), J Clin Invest, 1709-21, 2011

Mogler, C., Herold-Mende, C., Dyckhoff, G., Jenetzky, E., Beckhove, P., Helmke, B. M.

Heparanase expression in head and neck squamous cell carcinomas is associated with reduced proliferation and improved survival 58 (6), Histopathology, 944-52, 2011

Shafat, I., Ben-Arush, M. W., Issakov, J., Meller, I., Naroditsky, I., Tortoreto, M., Cassinelli, G., Lanzi, C., Pisano, C., Ilan, N., Vlodavsky, I., Zunino, F.

Pre-clinical and clinical significance of heparanase in Ewing's sarcoma 15 (9), J Cell Mol Med, 1857-64, 2011

Vlodavsky, I., Beckhove, P., Lerner, I., Pisano, C., Meirovitz, A., Ilan, N., Elkin, M.

Significance of heparanase in cancer and inflammation 5 (2), Cancer Microenviron, 115-32, 2012

Vlodavsky, I., Blich, M., Li, J. P., Sanderson, R. D., Ilan, N.

Involvement of heparanase in atherosclerosis and other vessel wall pathologies 32 (5), Matrix Biol, 241-51, 2013

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