Human heparanase – a promising target for the development of therapeutic strategies in cancer

Number of publications: 16
Israeli Partner: I. Vlodavsky, Cancer and Vascular Biology Res. Center
German Partner: P. Beckhove (div. of V. Schirrmacher), DKFZ


Abboud-Jarrous, G., Atzmon, R., Peretz, T., Palermo, C., Gadea, B. B., Joyce, J. A., Vlodavsky, I.

Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment 283 (26), J Biol Chem, 18167-76, 2008

Barash, U., Cohen-Kaplan, V., Arvatz, G., Gingis-Velitski, S., Levy-Adam, F., Nativ, O., Shemesh, R., Ayalon-Sofer, M., Ilan, N., Vlodavsky, I.

A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics 24 (4), Faseb j, 1239-48, 2010

Ben-Zaken, O., Shafat, I., Gingis-Velitski, S., Bangio, H., Kelson, I. K., Alergand, T., Amor, Y., Maya, R. B., Vlodavsky, I., Ilan, N.

Low and high affinity receptors mediate cellular uptake of heparanase 40 (3), Int J Biochem Cell Biol, 530-42, 2008

Bonertz, A., Weitz, J., Pietsch, D. H., Rahbari, N. N., Schlude, C., Ge, Y., Juenger, S., Vlodavsky, I., Khazaie, K., Jaeger, D., Reissfelder, C., Antolovic, D., Aigner, M., Koch, M., Beckhove, P.

Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma 119 (11), J Clin Invest, 3311-21, 2009

Casu, B., Vlodavsky, I., Sanderson, R. D.

Non-anticoagulant heparins and inhibition of cancer 36 (3), Pathophysiol Haemost Thromb, 195-203, 2008

Cohen, E., Doweck, I., Naroditsky, I., Ben-Izhak, O., Kremer, R., Best, L. A., Vlodavsky, I., Ilan, N.

Heparanase is overexpressed in lung cancer and correlates inversely with patient survival 113 (5), Cancer, 1004-11, 2008

Cohen-Kaplan, V., Doweck, I., Naroditsky, I., Vlodavsky, I., Ilan, N.

Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression 68 (24), Cancer Res, 10077-85, 2008

Cohen-Kaplan, V., Naroditsky, I., Zetser, A., Ilan, N., Vlodavsky, I., Doweck, I.

Heparanase induces VEGF C and facilitates tumor lymphangiogenesis 123 (11), Int J Cancer, 2566-73, 2008

Domschke, C., Schuetz, F., Ge, Y., Seibel, T., Falk, C., Brors, B., Vlodavsky, I., Sommerfeldt, N., Sinn, H. P., Kuhnle, M. C., Schneeweiss, A., Scharf, A., Sohn, C., Schirrmacher, V., Moldenhauer, G., Momburg, F., Beckhove, P.

Intratumoral cytokines and tumor cell biology determine spontaneous breast cancer-specific immune responses and their correlation to prognosis 69 (21), Cancer Res, 8420-8, 2009

Fux, L., Feibish, N., Cohen-Kaplan, V., Gingis-Velitski, S., Feld, S., Geffen, C., Vlodavsky, I., Ilan, N.

Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling 69 (5), Cancer Res, 1758-67, 2009

Lerner, I., Baraz, L., Pikarsky, E., Meirovitz, A., Edovitsky, E., Peretz, T., Vlodavsky, I., Elkin, M.

Function of heparanase in prostate tumorigenesis: potential for therapy 14 (3), Clin Cancer Res, 668-76, 2008

Pusterla, T., Nemeth, J., Stein, I., Wiechert, L., Knigin, D., Marhenke, S., Longerich, T., Kumar, V., Arnold, B., Vogel, A., Bierhaus, A., Pikarsky, E., Hess, J., Angel, P.

Receptor for advanced glycation endproducts (RAGE) is a key regulator of oval cell activation and inflammation-associated liver carcinogenesis in mice 58 (1), Hepatology, 363-73, 2013

Schuetz, F., Ehlert, K., Ge, Y., Schneeweiss, A., Rom, J., Inzkirweli, N., Sohn, C., Schirrmacher, V., Beckhove, P.

Treatment of advanced metastasized breast cancer with bone marrow-derived tumour-reactive memory T cells: a pilot clinical study 58 (6), Cancer Immunol Immunother, 887-900, 2009

Shafat, I., Barak, A. B., Postovsky, S., Elhasid, R., Ilan, N., Vlodavsky, I., Arush, M. W.

Heparanase levels are elevated in the plasma of pediatric cancer patients and correlate with response to anticancer treatment 9 (11), Neoplasia, 909-16, 2007

Shafat, I., Pode, D., Peretz, T., Ilan, N., Vlodavsky, I., Nisman, B.

Clinical significance of urine heparanase in bladder cancer progression 10 (2), Neoplasia, 125-30, 2008

Zcharia, E., Jia, J., Zhang, X., Baraz, L., Lindahl, U., Peretz, T., Vlodavsky, I., Li, J. P.

Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases 4 (4), PLoS One, e5181, 2009

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