Our lab is dedicated to uncovering the key extrinsic and intrinsic signals that drive immune hijacking in cancer.
To do this, we bring a dynamic perspective to single-cell analysis, constructing immunodynamic maps that integrate the temporal dimension. By arranging cell states in chronological order, we can trace the evolution of immune hijacking, identifying the molecular signals that orchestrate this process—and predicting the ones that matter most. Our approach combines cutting-edge techniques like Zman-seq with the development of novel genomic technologies, pushing the boundaries of what’s possible in cancer immunology.
D. Kirschenbaum, K. Xie, F. Ingelfinger, Y. Katzenelenbogen, K. Abadie, T. Look, F. Sheban, T. S. Phan, B. Li, P. Zwicky, I. Yofe, E. David, K. Mazuz, J. Hou, Y. Chen, H. Shaim, M. Shanley, S. Becker, J. Qian, M. Colonna, F. Ginhoux, K. Rezvani, F. J. Theis, N. Yosef, T. Weiss, A. Weiner, I. Amit
Time-resolved single-cell RNA-seq using metabolic RNA labelling.
F. Erhard, A.-E. Saliba, A. Lusser, C. Toussaint, T. Hennig, B. K. Prusty, D. Kirschenbaum, K. Abadie, E. A. Miska, C. C. Friedel, I. Amit, R. Micura, L. Dölken
D. Kirschenbaum, E. Dadgar-Kiani, F. Catto, F. F. Voigt, C. Trevisan, O. Bichsel, H. Shirani, K. P. R. Nilsson, K. J. Frontzek, P. Paganetti, F. Helmchen, J. H. Lee, A. Aguzzi
D. Kirschenbaum, L. L. Imbach, S. Ulrich, E. J. Rushing, E. Keller, R. R. Reimann, K. B. M. Frauenknecht, M. Lichtblau, M. Witt, T. Hummel, P. Steiger, A. Aguzzi, K. Frontzek
F. F. Voigt, D. Kirschenbaum, E. Platonova, S. Pages, R. A. A. Campbell, R. Kastli, M. Schaettin, L. Egolf, A. van der Bourg, P. Bethge, K. Haenraets, N. Frezel, T. Topilko, P. Perin, D. Hillier, S. Hildebrand, A. Schueth, A. Roebroeck, B. Roska, E. T. Stoeckli, R. Pizzala, N. Renier, H. U. Zeilhofer, T. Karayannis, U. Ziegler, L. Batti, A. Holtmaat, C. Luscher, A. Aguzzi, F. Helmchen
