Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .

Essential

These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.
Statistics

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name YouTube
Purpose Show YouTube content
Name Twitter
Purpose activate Twitter Feeds
data privacy protection Impressum
Home
Research
Research Topics
Functional and Structural Genomics
Molecular Genetics

Research

Cytogenetic and immunohistochemical characterization of squamous cell carcinoma of the head and neck by means of tissue microarrays and matrix-CGH.

senior researcher: PD Dr. Stefan Joos in colaboration with: Dr. med. dent. Christof Hofele, Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie der Universität Heidelberg.

Fig.1: Detection of gene copy number gains by FISH in squamous cell head and neck carcinomas.
© dkfz.de

Squamous cell carcinoma of the head and neck represents the six most frequent tumor in the western world with more than 750,000 new diseases every year. Despite of advantages in diagnostics and therapy the prognosis of patients is still very bad. In order to improve the sub-typing of these tumors our aim is to determine chromosomal aberrations or aberration patterns which correlate with different clinical stages (Fig. 1). By generating CGH and Matrix-CGH profiles numerical aberrations are identified and correlated with clinical and histopathological parameters (staging, grading etc.) as well as the clinical course. Candidate genes are further tested in high-throughput analyses using tissue microarrays containing hundreds of different squamous cell carcinoma of the head and neck.



Funding


This project is funded by the 'Deutsche Krebshilfe e.V.'(Project 10-1745-HO1). (click icon to view www.krebshilfe.de)





to top
powered by webEdition CMS