Molecular Oncology of Gastrointestinal Tumors

Michael Volkmar

Michael Volkmar

Michael Volkmar


Scientist Immunology Biomarkers


Ext. 3141





Evaluation of biomarkers related to tumor-immune interaction and immune intervention against cancer  

The main focus of our research is to identify biomarkers of pancreatic cancer that will aid the development of immunotherapeutic strategies but also allow earlier diagnosis and/or predict response to current state-of-the-art anti-cancer therapies. Drawing extensively on biopsies and patient data, available through the European Pancreas Center, we will use genetic, epigenetic/gene expression as well as immunological techniques in order to identify and validate biomarkers.

Scientific Background

  • Study of Biochemistry, Martin Luther University Halle-Wittenberg, Halle, Germany ·  
  • PhD student, Institute of Genetics, Section Developmental Genetics (Dr. Rainer Dorn), Martin Luther University Halle-Wittenberg, Halle, Germany ·  
  • Postdoc Research Fellow, Lab of Cancer Epigenetics (Maître de Recherche du FNRS Dr. François Fuks), Free University of Brussels (U.L.B.), Brussels, Belgium    


  • Volkmar, M., S. Dedeurwaerder, D.A. Cunha, M.N. Ndlovu, M. Defrance, R. Deplus, E. Calonne, U. Volkmar, M. Igoillo-Esteve, N. Naamane et al. 2012. DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J 31: 1405-1426.
  • Dedeurwaerder, S., C. Desmedt, E. Calonne, S.K. Singhal, B. Haibe-Kains, M. Defrance, S. Michiels, M. Volkmar, R. Deplus, J. Luciani et al. 2011a. DNA methylation profiling reveals a predominant immune component in breast cancers. EMBO Mol Med 3: 726-741.
  • Gabler, M., M. Volkmar, S. Weinlich, A. Herbst, P. Dobberthien, S. Sklarss, L. Fanti, S. Pimpinelli, H. Kress, G. Reuter et al. 2005. Trans-splicing of the mod(mdg4) complex locus is conserved between the distantly related species Drosophila melanogaster and D. virilis. Genetics 169: 723-736.
  • Soling, A., M. Sackewitz, M. Volkmar, D. Schaarschmidt, R. Jacob, H.J. Holzhausen, and N.G. Rainov 2005. Minichromosome maintenance protein 3 elicits a cancer-restricted immune response in patients with brain malignancies and is a strong independent predictor of survival in patients with anaplastic astrocytoma. Clin Cancer Res 11: 249-258.  

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