Research
- Research Topics
- Cell Biology and Tumor Biology
- Stem Cells and Cancer
- Inflammatory Stress in Stem Cells
- Experimental Hematology
- Molecular Embryology
- Signal Transduction and Growth Control
- Epigenetics
- Redox Regulation
- Vascular Oncology and Metastasis
- Clinical Neurobiology
- Molecular Neurogenetics
- Molecular Neurobiology
- Mechanisms Regulating Gene Expression
- Molecular Biology of Centrosomes and Cilia
- Dermato-Oncology
- Pediatric Leukemia
- Tumour Metabolism and Microenvironment
- Personalized Medical Oncology
- Molecular Hematology - Oncology
- Cancer Progression and Metastasis
- Translational Surgical Oncology
- Neuronal Signaling and Morphogenesis
- Cell Signaling and Metabolism
- Cell Fate Engineering and Disease Modeling
- Cancer Drug Development
- Cell Morphogenesis and Signal Transduction
- Functional and Structural Genomics
- Molecular Genome Analysis
- Molecular Genetics
- Pediatric Neurooncology
- Cancer Genome Research
- Chromatin Networks
- Functional Genome Analysis
- Theoretical Systems Biology
- Neuroblastoma Genomics
- Signaling and Functional Genomics
- Signal Transduction in Cancer and Metabolism
- RNA-Protein Complexes and Cell Proliferation
- Systems Biology of Signal Transduction
- Areas of Interest
- Advancement of clinical proteomics for systems medicine
- Bridging from the single cell to the cell population – Epo-induced cellular responses and erythroleukemia
- Deciphering tumor microenvironment interactions determining lung cancer development
- Mechanisms controlling the compensation of liver injury and towards model-based biomarkers for early detection of liver cancer
- Application of dynamic pathway modelling for personalized medicine
- Group Members
- Publications
- Open Positions
- Funding
- Teaching
- Areas of Interest
- Molecular thoracic Oncology
- Proteomics of Stem Cells and Cancer
- Computational Genomics and System Genetics
- Applied Functional Genomics
- Applied Bioinformatics
- Translational Medical Oncology
- Metabolic crosstalk in cancer
- Pediatric Glioma Research
- Cancer Epigenomics
- Translational Pediatric Sarcoma Research
- Artificial Intelligence in Oncology
- Mechanisms of Genomic Variation and Data Science
- Neuropathology
- Pediatric Oncology
- Neurooncology
- Somatic Evolution and Early Detection
- Translational Control and Metabolism
- Soft-Tissue Sarcoma
- Precision Sarcoma Research
- Brain Mosaicism and Tumorigenesis
- Mechanisms of Genome Control
- Translational Gastrointestinal Oncology and Preclinical Models
- Translational Lymphoma Research
- Mechanisms of Leukemogenesis
- Genome Instability in Tumors
- Developmental Origins of Pediatric Cancer
- Brain Tumor Translational Targets
- Translational Functional Cancer Genomics
- Regulatory Genomics and Cancer Evolution
- SPRINT
- Cancer Risk Factors and Prevention
- Cancer Epidemiology
- Biostatistics
- Clinical Epidemiology and Aging Research
- Health Economics
- Physical Activity, Prevention and Cancer
- Primary Cancer Prevention
- Personalized Early Detection of Prostate Cancer
- Digital prevention, diagnostics and therapy guidance
- Policy and Implementation Research for Cancer Prevention
- Tumorigenesis and molecular cancer prevention
- Genomic Epidemiology
- Cancer Survivorship
- Immunology, Infection and Cancer
- Structural Biology of Infection and Immunity
- Cellular Immunology
- B Cell Immunology
- Immune Diversity
- Immunoproteomics
- Personalized Immunotherapy
- mRNA Cancer Immunotherapies
- Tumor Immunology and Tumor Immunotherapy
- Infections and Cancer Epidemiology
- Pathogenesis of Virus-Associated Tumors
- Immunotherapy and Immunoprevention
- Virus-associated Carcinogenesis
- Chronic Inflammation and Cancer
- Microbiome and Cancer
- Molecular Oncology of Gastrointestinal Tumors
- Applied Tumor Immunity
- Neuroimmunology and Brain Tumor Immunology
- Applied Tumor Biology
- Virotherapy
- Adaptive Immunity and Lymphoma
- Dermal Oncoimmunology
- Immune Regulation in Cancer
- Systems Immunology and Single Cell Biology
- Pediatric Immuno-Oncology
- Epithelium Microbiome lnteractions
- Experimental Hepatology, Inflammation and Cancer
- GMP & T Cell Therapy
- Tumorvirus-specific Vaccination Strategies
- Mammalian Cell Cycle Control Mechanisms
- Molecular Therapy of Virus-Associated Cancers
- DNA Vectors
- Episomal-Persistent DNA in Cancer- and Chronic Diseases
- Immune Monitoring
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- Imaging and Radiooncology
- Radiology
- Research
- Computational Radiology Research Group
- Contrast Agents In Radiology Research Group
- Neuro-Oncologic Imaging Research Group
- Radiological Early Response Assessment Of Modern Cancer Therapies
- Imaging In Monoclonal Plasma Cell Disorders
- 7 Tesla MRI - Novel Imaging Biomarkers
- Functional Imaging
- Visualization And Forensic Imaging
- PET/MRI
- Dual- and Multienergy CT
- Radiomics Research Group
- Prostate Research Group
- Bone marrow
- Musculoskeletal Imaging
- Microstructural Imaging Research Group
- Staff
- Patients
- Research
- Medical Physics in Radiology
- X-Ray Imaging and Computed Tomography
- Federated Information Systems
- Translational Molecular Imaging
- Medical Physics in Radiation Oncology
- Biomedical Physics in Radiation Oncology
- Intelligent Medical Systems
- Medical Image Computing
- Radiooncology - Radiobiology
- Smart Technologies for Tumor Therapy
- Team
- Research
- Microrobots and Miniaturize Devices for Minimally-invasive Surgery
- Magnetic localization and sensing for biomedical devices
- Nanorobots for Targeted Delivery in Deep Biological Tissues
- 3D Additive Manufacturing of Soft Materials as In Vitro Tumor Models
- Surgical Simulation on Cyber-physical Organ Models
- News
- Vacancies
- Radiation Oncology
- Molecular Radiooncology
- Nuclear Medicine
- Translational Radiation Oncology
- Translational Radiotheranostics
- Interactive Machine Learning
- Intelligent Systems and Robotics in Urology
- Multiparametric methods for early detection of prostate cancer
- Translational Molecular Imaging in Oncologic Therapy Monitoring
- Radiology
- Cell Biology and Tumor Biology
- Research Groups A-Z
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- Antibodies
- Cellular Tools
- Center for Preclinical Research
- Central Library
- Chemical Biology
- Dieter Morszeck Biorepository
- Electron Microscopy
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- Information Technology ITCF
- Light Microscopy
- Metabolomics
- Microarray
- Microbiological Diagnostics
- Next Generation Sequencing
- Omics IT and Data Management
- Proteomics
- Radiopharmaceuticals and Preclinical Trials
- Single-cell Open Lab
- Small Animal Imaging
- Transgenic Service
- Tumor Models
- OMERO@DKFZ
- List of Technologies
- DKFZ Core Facilities Publication Policy
- Enabling Technology
- Data Science @ DKFZ
- INFORM
- Baden-Württemberg Cancer Registry
- Cooperations & Networks
- National Cooperations
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- Cooperational Research Program with Israel: DKFZ - MOST in Cancer Research
- Program
- Members of the Program Committee
- Call
- Publication Database
- German-Israeli Cancer Research Schools
- Archive
- Heidelberg - Israel, Science and Culture
- Symposium 40 Years of German-Israeli Cooperation
- 35th Anniversary Symposium
- 34th Meeting of the DKFZ-MOST Program
- 40th Anniversary Publication
- 30th Anniversary Publication
- 20th Anniversary Publication
- Flyer - The Cancer Cooperation Program
- List Publications 1976-2004
- Highlight-Projects
- Cooperational Research Program with Israel: DKFZ - MOST in Cancer Research
- Cooperations with industrial companies
- DKFZ PostDoc Network
- Cross Program Topic RNA@DKFZ
- Cross Program Topic Epigenetics@dkfz
- Cross Program Topic Single Cell Sequencing
- WHO Collaborating Centers
- DKFZ Site Dresden
- Health + Life Science Alliance Heidelberg Mannheim
Publications in 2019
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Helm, M. ; Lyko, F. ; Motorin, Y.
Limited antibody specificity compromises epitranscriptomic analyses.
Nature Communications 10(1), 5669 (2019) [10.1038/s41467-019-13684-3]2019
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Müller, M. ; Legrand, C. ; Tuorto, F. ; Kelly, V. P. ; Atlasi, Y. ; Lyko, F. ; Ehrenhofer-Murray, A. E.
Queuine links translational control in eukaryotes to a micronutrient from bacteria.
Nucleic acids research 47(7), 3711 - 3727 (2019) [10.1093/nar/gkz063]2019
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Rodríguez-Paredes, M. (First author) ; Lyko, F. (Last author)
The importance of non-histone protein methylation in cancer therapy.
Nature reviews / Molecular cell biology Molecular cell biology 20(10), 569-570 (2019) [10.1038/s41580-019-0147-x]2019
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Zhang, Y. ; Shi, J. ; Rassoulzadegan, M. ; Tuorto, F. ; Chen, Q.
Sperm RNA code programmes the metabolic health of offspring.
Nature reviews / Endocrinology Endocrinology [...] 15(8), 489-498 (2019) [10.1038/s41574-019-0226-2]2019
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Wiehle, L. (First author) ; Thorn, G. J. ; Raddatz, G. ; Clarkson, C. T. ; Rippe, K. ; Lyko, F. ; Breiling, A. ; Teif, V. B.
DNA (de)methylation in embryonic stem cells controls CTCF-dependent chromatin boundaries.
Genome research 29(5), 750 - 761 (2019) [10.1101/gr.239707.118]2019
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Delacher, M. (First author) ; Schmidl, C. ; Herzig, Y. ; Breloer, M. ; Hartmann, W. ; Brunk, F. ; Kägebein, D. ; Träger, U. ; Hofer, A.-C. ; Bittner, S. ; Weichenhan, D. ; Imbusch, C. D. ; Hotz-Wagenblatt, A. ; Hielscher, T. ; Breiling, A. ; Federico, G. ; Gröne, H.-J. ; Schmid, R. M. ; Rehli, M. ; Abramson, J. ; Feuerer, M. (Last author)
Rbpj expression in regulatory T cells is critical for restraining TH2 responses.
Nature Communications 10(1), 1621 (2019) [10.1038/s41467-019-09276-w]2019
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Bormann, F. (First author) ; Tuorto, F. ; Cirzi, C. ; Lyko, F. ; Legrand, C. (Last author)
BisAMP: A web-based pipeline for targeted RNA cytosine-5 methylation analysis.
Methods 156, 121 - 127 (2019) [10.1016/j.ymeth.2018.10.013]2019
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Tuorto, F. (First author) ; Parlato, R.
rRNA and tRNA Bridges to Neuronal Homeostasis in Health and Disease.
Journal of molecular biology 431(9), 1763-1779 (2019) [10.1016/j.jmb.2019.03.004]2019
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Müller, M. ; Samel-Pommerencke, A. ; Legrand, C. ; Tuorto, F. ; Lyko, F. ; Ehrenhofer-Murray, A. E.
Division of labour: tRNA methylation by the NSun2 tRNA methyltransferases Trm4a and Trm4b in fission yeast.
RNA biology 16(3), 249 - 256 (2019) [10.1080/15476286.2019.1568819]2019
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Andriantsoa, R. (First author) ; Tönges, S. ; Panteleit, J. ; Theissinger, K. ; Carneiro, V. C. ; Rasamy, J. ; Lyko, F. (Last author)
Ecological plasticity and commercial impact of invasive marbled crayfish populations in Madagascar.
BMC ecology 19(1), 8 (2019) [10.1186/s12898-019-0224-1]2019
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Gatzmann, F. (First author) ; Lyko, F. (Last author)
Whole-Genome Bisulfite Sequencing for the Methylation Analysis of Insect Genomes.
Methods in molecular biology 1858, 141-156 (2019) [10.1007/978-1-4939-8775-7_11]2019
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