Computational Genomics and Systems Genetics

  • Functional and Structural Genomics
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Prof. Dr. Oliver Stegle

Division Head

Our research group develops and applies computational approaches to study molecular variations and their phenotypic consequences.

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Our Research

How does our genetic background shape phenotypic traits or cause cancer? How are genetic and environmental factors integrated at different molecular layers, and how variable are molecular states between individual cells?

We use statistical inference and machine learning as our main tools to address these scientific questions. Growing sample sizes and technological advances demand novel analytical strategies and tools that scale to datasets with millions of observations and account for spatial and temporal dependencies. We develop foundational methods in statistics and machine learning, including efficient parameter inference in models to probe genetic associations and methods for dimensionality reduction.

Find out more about our lab at https://steglelab.org/

Research Themes

The diagram consists of two main sections (a and b). Section (a) outlines a model involving gene impairment and phenotype prediction through various modules. Section (b) illustrates the processing of annotated variants, showing how they relate to gene embedding and scoring for gene impairment.

We develop statistical methods to dissect often overlooked dimensions of the genotype-phenotype relationship, including genetic effects of rare variants and indirect genetic effects.

Team

We are an interdisciplinary and international team jointly hosted at the German Cancer Research Center (DKFZ) and the European Molecular Biology Laboratory (EMBL) in Heidelberg. In our team we promote openness and collaboration, and value kindness in everything we do. We take pride in every single member and their achievements and are eager to foster their scientific development.

  • Bild Oliver Stegle

    Prof. Dr. Oliver Stegle

    Division Head

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    Rama Abdulhamid

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    Alexander Aivazidis

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    Thibault Bechtler

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    Eva Sabine Blum

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    Dr. Brian Clarke

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    Daniel Dimitrov

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    Kevin Domanegg

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    Jan Gunnar Gleixner

    Doktorand

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    Fritz Donald Hansen

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    John Andrew Hawkins

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    Elyas Heidari

    PhD Student

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    Dr. Florian Heyl

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    Dr. Ilia Kats

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    Sameesh Kher

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    Jessica Koski

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    Jonathan Kunz

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    Paul Kägy

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    Dr. Santiago Lago

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    Dr. Jusung Lee

    PostDoc

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    Jiawei Luo

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    Stefanie Mantz

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    Luca Marconato

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    Katharina Mikulik

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    Abdul Moeed

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    Marcel Mück

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    Mani Smaran Nair

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    Alexandra Reith

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    Manu Saraswat

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    Felix Schneider

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    Stefan Schrod

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    Ezgi Sen

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    Danai Vagiaki

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    Florin Walter

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    Dr. Hakime Öztürk

Entire Team

Open Positions

We are always looking for new talent to strengthen our team!

To apply for a postdoctoral position or PhD position in our group, please refer to the DKFZ Postdoctoral Fellowship and the DKFZ International PhD Programme
If you do not apply through one of the specific openings mentioned above, feel free to send your CV, a letter of motivation and ideally 2 references in a single pdf directly to Oliver Stegle

We are also pleased to offer opportunities for your BSc or MSc thesis or an internship in our lab. If you are interested, please contact us with a CV and a motivation letter tailored to our lab interests.

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Selected Publications

2024 - Nature Genetics
2024 - Nature Methods
2022 - Nature Biotechnology
2022 - Nature Methods
2021 - Nature Genetics
2021 - Nature Genetics

Get in touch with us

Bild Oliver Stegle

Prof. Dr. Oliver Stegle

Division Head
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Eva Sabine Blum

Administrative Assistant
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Kevin Domanegg

Scientific Manager
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