Breast cancer risk factors survey


MARIE is a large population-based case-control study, conducted between 2002 and 2005 with more than 10,000 participants to identify potential risk factors for the development of postmenopausal breast cancer. In addition, in 2009­ - 2010 a follow-up was conducted patients (MARIEplus). Study leaders are Prof. Dr. Jenny Chang-Claude (DKFZ Heidelberg) and Prof. Dr. Dieter Flesch-­Janys (University Hospital Hamburg-Eppendorf).

Our group under the direction of Prof. Karen Steindorf investigated in MARIE and MARIEplus the physical activity behavior before and after the cancer diagnosis and its effect on cancer risk, biological mechanism and the overall and diesease-free survival.
In MARIEplus we further examined cancer related fatigue and quality of life. The aim of our research is to gain a better understanding of the causes, factors and different manifestations of fatigue to enable a more effective treatment.


Jung A, Behrens S, Schmidt M, Thoene K, Obi N, Hüsing A, Benner A, Steindorf K, Chang-Claude J.
Pre- to postdiagnosis leisure-time physical activity and prognosis in postmenopausal breast cancer survivors. Breast Cancer Research (accepted Sep 2019).
Kühl T, Behrens S, Jung AY, Obi N, Thöne K, Schmidt ME, Becher H, Chang-Claude J.
Brain Behav Immun. 2018 Oct;73:252-260.
Schmidt, M. E., Chang-Claude, J., Seibold, P., Vrieling, A., Heinz, J., Flesch-Janys, D., and Steindorf, K.
Determinants of long-term fatigue in breast cancer survivors: results of a prospective patient cohort study. Psychooncology. 2014.
Nickels S, Truong S, Hein R, Stevens K, Buck K, Behrens S, Eilber U, Schmidt ME, et al. Evidence of Gene-Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors. Accepted by PLOS genetics, 2013
Schmidt, M. E., Chang-Claude, J., Vrieling, A., Seibold, P., Heinz, J., Obi, N., Flesch-Janys, D., and Steindorf, K.
Association of pre-diagnosis physical activity with recurrence and mortality among women with breast cancer. Int J Cancer 2013; 133:1431-1440.
Bock C, Schmidt ME, Vrieling A, Chang-Claude J, Steindorf K (2013) Walking, bicycling, and sports in postmenopausal breast cancer survivors-results from a German patient cohort study. Psychooncology, 22, 1291-8. doi: 10.1002/pon.3134. Epub 2012 Jul 16.
Schmidt, M. E., Chang-Claude, J., Vrieling, A., Heinz, J., Flesch-Janys, D., and Steindorf, K. Fatigue and quality of life in breast cancer survivors: temporal courses and long-term pattern. J Cancer Surviv. 2012; 6:11-19.
Huy C, Schmidt ME, Vrieling A, Chang-Claude J, Steindorf K (2012): Physical activity in a German breast cancer patient cohort: one-year trends and characteristics associated with change in activity level. European Journal of Cancer, 48(3):297-304. Epub 2011 Sep 14.
Barnes, B. B., Steindorf, K., Hein, R., Flesch-Janys, D., and Chang-Claude, J.
Population attributable risk of invasive postmenopausal breast cancer and breast cancer subtypes for modifiable and non-modifiable risk factors. Cancer Epidemiol 2011; 35:345-352.
Liedtke S, Schmidt M, Becker S, Kaaks R, Zaineddin KA, Buck K, Flesch-Janys D, Wahrendorf J, Chang-Claude J, Steindorf K (2011): Physical Activity and Endogenous Sex Hormones in Postmenopausal Women: To what extent are observed associations confounded or modified by BMI? Cancer Causes and Control, 22, 81-89.
Schmidt ME, Chang-Claude J, Slanger T, Obi N, Flesch-Janys D, Steindorf K.
Physical activity and postmenopausal breast cancer: effect modification by other breast cancer risk factors. Methods Inf Med. 2009;48(5):444-50.
Barnes BB, Chang-Claude J, Flesch-Janys D, Kinscherf R, Schmidt M, Slanger T, Bonaterra G, Steindorf K.
Cancer risk factors associated with insulin-like growth factor (IGF)-I and IGF-binding protein-3 levels in healthy women: effect modification by menopausal status. Cancer Causes Control. 2009 Jul 12.
Schmidt ME, Steindorf K, Mutschelknauss E, Slanger T, Kropp S, Obi N, Flesch-Janys D, Chang-Claude J.

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