Research
- Research Topics
- Cell Biology and Tumor Biology
- Stem Cells and Cancer
- Experimental Hematology
- Molecular Embryology
- Signal Transduction and Growth Control
- Epigenetics
- Redox Regulation
- Vascular Oncology and Metastasis
- Clinical Neurobiology
- Molecular Neurogenetics
- Chaperones and Proteases
- Vascular Signaling and Cancer
- Molecular Neurobiology
- Molecular Biology of Centrosomes and Cilia
- Dermato-Oncology
- Molecular Hematology - Oncology
- Stress-induced Activation of Hematopoietic Stem Cells
- Metastatic Niches
- Molecular Leukemogenesis
- DNA Repair Mechanisms and Cancer
- Neuronal Signaling and Morphogenesis
- Cell Signaling and Metabolism
- Cell Fate Engineering and Disease Modeling
- Cancer Drug Development
- Metabolism and Stem Cell Plasticity
- Team
- Open positions
- Associated unit
- Cell Morphogenesis and Signal Transduction
- Helmholtz Professorship Cell Biology
- Functional and Structural Genomics
- Biophysics of Macromolecules
- Cancer Epigenomics
- Molecular Genome Analysis
- Applied Functional Genomics
- Molecular Genetics
- Pediatric Neurooncology
- Applied Bioinformatics
- Cancer Genome Research
- Chromatin Networks
- Functional Genome Analysis
- Theoretical Systems Biology
- Neuroblastoma Genomics
- Signaling and Functional Genomics
- Signal Transduction in Cancer and Metabolism
- Brain Cancer Metabolism
- Neurooncology
- Pediatric Oncology
- RNA Biology and Cancer
- Systems Biology of Signal Transduction
- Neuropathology
- Molecular thoracic Oncology
- Proteomics of Stem Cells and Cancer
- Computational Genomics and System Genetics
- Regulatory Genomics and Cancer Evolution
- Pediatric Glioma Research
- Somatic Evolution and Early Detection
- Bioinformatics and Omics Data Analytics
- Translational Control and Metabolism
- Mechanisms of Leukemogenesis
- Brain Tumor Translational Targets
- Molecular Genetics of Breast Cancer
- Functional Proteome Analysis
- Translational Functional Cancer Genomics
- Cancer Risk Factors and Prevention
- Tumor Immunology
- Imaging and Radiooncology
- Radiology
- Research
- Contrast Agents In Radiology Research Group
- Neuro-Oncologic Imaging Research Group
- Radiological Early Response Assessment Of Modern Cancer Therapies
- Imaging In Monoclonal Plasma Cell Disorders
- 7 Tesla MRI - Novel Imaging Biomarkers
- Functional Imaging
- Visualization And Forensic Imaging
- PET/MRI
- Dual- and Multienergy CT
- Radiomics Research Group
- Prostate Research Group
- Breast Imaging Research Group
- Bone marrow
- Musculoskeletal Imaging
- Staff
- Patients
- Research
- Medical Physics in Radiology
- X-Ray Imaging and Computed Tomography
- Medical Informatics for Translational Oncology
- Radiopharmaceutical Chemistry
- Medical Physics in Radiation Oncology
- Faculty & Staff
- DKFZ PhD Programm
- Research
- Computational Patient Models
- Applied Medical Radiation Physics
- Therapy Planning - Development
- Current Projects
- Former Projects
- Adaptive Radiotherapy
- Registration
- Functional Imaging
- Knowledge based radiotherapy planning (TAPIR)
- New technologies for transferring therapeutical knowledge (IRIS)
- Planning System for proton therapy of eye tumors (OCTOPUS)
- Image Processing and Represenation (VIS-A-VIS)
- Stereotactic laser neurosurgery (STELA)
- Contact
- Research Interest
- Radiotherapy Optimization
- Medical Engineering
- Novel Detection Techniques for Ion Beams
- Physical Quality Assurance in Radiation Therapy
- Ion Beam Therapy
- MR-guided RadioTherapy
- Clinical Research Group
- Publications
- Vacancies
- Awards
- Education and Training
- Events
- Biomedical Physics in Radiation Oncology
- Computer Assisted Medical Interventions
- Medical Image Computing
- Optical Nanoscopy
- Radiooncology - Radiobiology
- Radiation Oncology
- Molecular Radiooncology
- Nuclear Medicine
- Translational Radiation Oncology
- Molecular Mechanisms of Head and Neck Tumors
- Radiology
- Infection, Inflammation and Cancer
- Tumor Virology
- Viral Transformation Mechanisms
- Pathogenesis of Virus-Associated Tumors
- Applied Tumor Biology
- Virus-associated Carcinogenesis
- Chronic Inflammation and Cancer
- Episomal-Persistent DNA in Cancer- and Chronic Diseases
- Immunotherapy and Immunoprevention
- Cell Plasticity and Epigenetic Remodeling
- Cellular Polarity and Viral Infection
- Noroviruses
- Laboratory of Oncolytic Virus Immuno-Therapeutics
- Infections and Cancer Epidemiology
- Tumorvirus-specific Vaccination Strategies
- Mammalian Cell Cycle Control Mechanisms
- Molecular Therapy of Virus-Associated Cancers
- DNA Vectors
- Translational Cancer Research
- Cell Biology and Tumor Biology
- Research Groups A-Z
- Junior Research Groups
- Core Facilities
- Center for Preclinical Research
- Chemical Biology Core Facility
- Genomics and Proteomics
- Imaging and Cytometry
- Information Technology
- Library
- Kataloge - Catalogues
- Zeitschriften - Journals
- E-Books - Ebooks
- Datenbanken - Databases
- Dokument-Lieferung - Document Delivery
- Publikationsdatenbank - Publication database
- DKFZ Archiv - DKFZ Archive
- Open Access
- Science 2.0
- Ansprechpartner - Contact
- More Information - Service
- Anschrift - Address
- Antiquariat - Second Hand
- Aufstellungssystematik - Shelf Classification
- Ausleihe - Circulation
- Benutzerhinweise - Library Use
- Beschaffungsvorschläge - Desiderata
- Fakten und Zahlen - Facts and Numbers
- Kooperationen, Konsortien - Cooperations, Consortia
- Kopieren, Scannen - Copying, Scans
- Kurse, Führungen - Courses, Introductions
- Öffnungszeiten - Opening Hours
- Neue Medien - New Media
- DEAL-Info
- DKFZ-Intern - internal only
- Omics IT and Data Management Core Facility
- WHO Collaborating Centers
- Cooperations & Networks
- National Cooperations
- International Cooperations
- Cooperational Research Program with Israel: DKFZ - MOST in Cancer Research
- Program
- Members of the Program Committee
- Call 2018
- Publication Database
- German-Israeli Cancer Research Schools
- Archive
- Heidelberg - Israel, Science and Culture
- Symposium 40 Years of German-Israeli Cooperation
- 35th Anniversary Symposium
- 34th Meeting of the DKFZ-MOST Program
- 40th Anniversary Publication
- 30th Anniversary Publication
- 20th Anniversary Publication
- Flyer - The Cancer Cooperation Program
- List Publications 1976-2004
- Highlight-Projects
- Cooperational Research Program with Israel: DKFZ - MOST in Cancer Research
- Cooperations with industrial companies
- Helmholtz Alliances
- DKFZ PostDoc Network
- Cross Program Topic RNA@DKFZ
- Cross Program Topic Cancer Inflammation
- Cross Program Topic Epigenetics@dkfz
- Cross Program Topic Single Cell Sequencing
- iMed
- INFORM
- Baden-Württemberg Cancer Registry
Studying lung stem cells in tissue maintenance, repair, and cancer
This research area focuses on the identification of normal and malignant lung epithelial stem cells and the delineation of regulatory pathways within these cell types in vivo. We developed genetically engineered mouse models that enable us to study the detailed composition of the lung epithelial stem and progenitor cell compartment after cell type-restricted damage using single-cell RNA sequencing. In addition, we are analyzing cancer stem cell function in mutant KRAS-induced lung tumors in mice. This project is part of the Collaborative Research Center SFB873.