This research area focuses on the identification of normal and malignant lung epithelial stem cells and the delineation of regulatory pathways within these cell types in vivo. We developed genetically engineered mouse models that enable us to study the detailed composition of the lung epithelial stem and progenitor cell compartment after cell type-restricted damage using single-cell RNA sequencing. In addition, we are analyzing cancer stem cell function in mutant KRAS-induced lung tumors in mice. This project is part of the Collaborative Research Center SFB873.