Vulnerabilities in acute myeloid leukemia

© C. Scholl

In close collaboration with the laboratory of Stefan Fröhling (NCT Heidelberg, Heidelberg University Hospital), we aim to identify and characterize context-dependent functional vulnerabilities in acute myeloid leukemia. For example, we identified a novel, non-canonical anti-differentiation function of CDK6 in leukemias driven by MLL rearrangements (Placke et al. Blood 2014), and are now working to understand the mechanistic link between CDK6 inhibition and differentiation induction. Furthermore, we used large-scale RNA interference screening to identify an unexpected dependence of various acute myeloid leukemia subtypes on the RET receptor tyrosine kinase (Rudat et al. Leukemia 2018).

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