Publications

(This is not a complete list of publications, but only a selection of the major ones.)

Trauth, BC, Klas, C, Peters, AMJ, Matzku, S, Möller, P, Falk, W, Debatin, KM, Krammer, PH, 1989. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245, 301-305.

Debatin, KM, Goldmann, CK, Bamford, R, Waldmann, TA, Krammer, PH (1990) Monoclonal antibody-mediated apoptosis in adult T cell leukemia. Lancet 335, 497-500.

Dhein, J, Walczak, H, Bäumler, C, Debatin, KM, Krammer, PH, 1995. Autocrine T-cell suicide mediated by APO-1/Fas (CD95). Nature 373, 438-441.

Rieux-Laucat, F, Le Deist, F, Hivroz, C, Roberts, IAG, Debatin, KM, Fischer, A, De Villartay, JP, 1995. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science 268, 1347-1349.

Friesen, C, Herr, I, Krammer, PH, Debatin, KM, 1996. Involvement of the CD95 (APO-1/Fas) receptor/ ligand system in drug induced apoptosis in leukemia cell. Nat. Med. 2, 574-577.

Fulda, S, Wick, W, Weller, M, Debatin, KM, 2002. Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nat. Med. 8(8), 808-815.

Meyer, LH, Karawajew, L, Schrappe, E, Ludwig, WD, Stahnke, K, Debatin, KM, 2006. Cytochrome c related caspase activation determines treatment response and relapse in childhood B-precursor ALL. Blood 107(11), 4524-3.

Opel, D, Poremba, C, Simon, T, Debatin, KM, Fulda, S, 2007. Activation of Akt predicts poor outcome in neuroblastoma. Cancer Research 67(2), 735-745.

Meyer, LH, Queudeville, M, Eckhoff, SM, Creutzig, U, Reinhardt, D, Karawajew, L, Ludwig, WD, Stahnke, K, Debatin, KM, 2008. Intact apoptosis signaling in myeloid leukaemia cells determines treatment outcome in childhood AML. Blood 111(5), 2899-2903.

Vogler, M, Walczak, H, Stadel, D, Genze, F, Haas, T, Jovanovic, M, Gschwend, J, Simmet, T, Debatin, KM, Fulda, S, 2008. Targeting XIAP bypasses Bcl-2-mediated resistance to TRAIL and cooperates with TRAIL to suppress pancreatic cancer growth in vitro and in vivo. Cancer Research 68(19), 7956-7965.

Fakler, M, Loeder, S, Vogler, M, Schneider, K, Jeremias, I, Debatin, KM, Fulda, S, 2009. Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance. Blood 113(8), 1710-1722.

Strauss, G, Lindquist, JA, Arhel, N, Felder, E, Karl, S, Haas, T, Fulda, S, Walczak, H, Kirchhoff, F, Debatin, KM, 2009. CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling. Journal of Experimental Medicine 206, 1379-93.

Meyer, LH, Eckhoff, SM, Queudeville, M, Kraus, JM, Giordan, M, Stursberg, J, Zangrando, A, Vendramini, E, Möricke, A, Zimmermann, M, Schrauder, A, Lahr, G, Holzmann, K, Schrappe, M, Basso, G, Stahnke, K, Kestler, HA, te Kronnie, G, Debatin, KM, 2011. Early relapse in pediatric ALL is identified by Time To Leukemia (TTL) in NOD/SCID mice and is characterized by a gene signature involving survival pathways. Cancer Cell 19(2), 206-17.

Queudeville, M, Seyfried, F, Eckhoff, SM, Trentin, L, Ulrich, S, Schirmer, M, Debatin, KM, Meyer, LH, 2012. Rapid engraftment of human ALL in NOD/SCID mice involves deficient apoptosis signaling. Cell Death Dis 3, e364.

Hartmann, N, Messmann, JJ, Leithäuser, F, Weiswange, M, Kluge, M, Fricke, H, Debatin, KM, Strauss, G, 2013. Recombinant CD95-Fc (APG101) prevents graft-versus-host disease in mice without disabling antitumor cytotoxicity and T-cell functions. Blood 121(3):556-65.

Wabitsch, M, Funcke, JB, Lennerz, B, Kuhnle-Krahl, U, Lahr, G, Debatin, KM, Vatter, P, Gierschik, P, Moepps, B, Fischer-Posovszky, P, 2015. Biologically inactive leptin and early-onset extreme obesity. N Engl J Med 372 (1), 48-54.

Münch, V, Trentin, L, Herzig, J, Demir, S, Seyfried, F, Kraus, JM, Kestler, HA, Köhler, R, Barth, TFE, Te Kronnie, G, Debatin, KM, Meyer, LH, 2017. Central nervous system involvement in acute lymphoblastic 2

leukemia is mediated by vascular endothelial growth factor. Blood 130 (5), 643-654.

Trentin, L, Queudeville, M, Eckhoff, SM, Hasan, MN, Münch, V, Boldrin, E, Seyfried, F, Enzenmüller, S, Debatin, KM*, Meyer, LH*, 2018. Leukemia reconstitution in vivo is driven by cells in early cell cycle and low metabolic state. Haematologica 103(6):1008-1017

Dorneburg, C, Fischer, M, Barth, TFE, Mueller-Klieser, W, Hero, B, Gecht, J, Carter, DR, De Preter, K, Mayer, B, Christner, L, Speleman, F, Marshall, GM, Debatin, KM, Beltinger, C, 2018. LDHA in neuroblastoma is associated with poor outcome and its depletion decreases neuroblastoma growth independent of aerobic glycolysis. Clin Cancer Res 24 (22), 5772-5783.

Demir, S, Boldrin, E, Sun, Q, Hampp, S, Tausch, E, Eckert, C, Ebinger, M, Handgretinger, R, Te Kronnie, G, Wiesmüller, L, Stilgenbauer, S, Selivanova, G, Debatin, KM, Meyer, LH, 2019. Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia. Haematologica [ePub ahead of print].