Alumni

Publications

(This is not a complete list of publications, but only a selection of the major ones.)

 

KEPPLER, D., LESCH, R., REUTTER, W., and DECKER, K., Experimental Hepatitis Induced by D-Galactosamine. Exptl. Mol. Pathol. 9: 279-290 (1968).

 

KEPPLER, D., PAUSCH, J., and DECKER, K., Selective Uridine Triphosphate Deficiency Induced by D-Galactosamine in Liver and Reversed by Pyrimidine Nucleotide Precursors: Effect on Ribonucleic Acid Synthesis. J. Biol. Chem. 249: 211-216 (1974).

 

DECKER, K. and KEPPLER, D., Galactosamine Hepatitis: Key Role of the Nucleotide Deficiency Period in the Pathogenesis of Cell Injury and Cell Death. Rev. Physiol. Biochem. Pharmacol. 71: 77-106 (1974).

 

Ishikawa, T., Müller, M., Klünemann, C., Schaub, T., and Keppler, D., ATP-Dependent Primary Active Transport of Cysteinyl Leukotrienes Across Liver Canalicular Membrane. Role of the ATP-Dependent Transport System for Glutathione S-Conjugates. J. Biol. Chem. 265: 19279-19286 (1990).

 

KEPPLER, D., Leukotrienes: Biosynthesis, Transport, Inactivation, and Analysis. Rev. Physiol. Biochem. Pharmacol. 121: 1-30 (1992).

 

JEDLITSCHKY, G., LEIER, I., BUCHHOLZ, U., CENTER, M., and KEPPLER, D., ATP-Dependent Transport of Glutathione S-Conjugates by the Multidrug Resistance-Associated Protein. Cancer Res. 54: 4833-4836 (1994).

 

LEIER, I., JEDLITSCHKY, G., BUCHHOLZ, U., COLE, S. P. C., DEELEY, R. G., and KEPPLER, D., The MRP Gene Encodes an ATP-Dependent Export Pump for Leukotriene C4 and Structurally Related Conjugates. J. Biol. Chem.269: 27807-27810 (1994).

 

GUHLMANN, A., KRAUSS, K., OBERDORFER, F., SIEGEL, T., SCHEUBER, P. H., MÜLLER, J., CSUK-GLÄNZER, B., ZIEGLER, S., OSTERTAG, H., and KEPPLER, D., Noninvasive Assessment of Hepatobiliary and Renal Elimination of Cysteinyl Leukotrienes by Positron Emission Tomography. Hepatology 21: 1568-1575 (1995).

 

KARTENBECK, J., LEUSCHNER, U., MAYER, R., and KEPPLER, D., Absence of the Canalicular Isoform of the MRP  Gene-encoded Conjugate Export Pump from the Hepatocytes in Dubin-Johnson Syndrome. Hepatology 23: 1061-1066 (1996).

 

BÜCHLER, M., KÖNIG, J., BROM, M., KARTENBECK, J., SPRING, H., HORIE, T., and KEPPLER, D., cDNA Cloning of the Hepatocyte Canalicular Isoform of the Multidrug Resistance Protein, cMrp, Reveals a Novel Conjugate Export Pump Deficient in Hyperbilirubinemic Mutant Rats. J. Biol. Chem. 271: 15091-15098 (1996).

 

KEPPLER, D., JEDLITSCHKY, G., and LEIER, I., Transport Function and Substrate Specificity of Multidrug Resistance Protein. Methods Enzymol. 292: 607-616 (1998).

 

KÖNIG, J., ROST, D., CUI, Y., and KEPPLER, D., Characterization of the Human Multidrug Resistance Protein Isoform MRP3 Localized to the Basolateral Hepatocyte Membrane. Hepatology 29: 1156-1163 (1999).

 

CUI, Y., KÖNIG, J., BUCHHOLZ, U., SPRING, H., LEIER, I., and KEPPLER, D., Drug Resistance and ATP-dependent Conjugate Transport Mediated by the Apical Multidrug Resistance Protein, MRP2, Permanently Expressed in Human and Canine Cells. Mol. Pharmacol. 55: 929-937 (1999).

 

KÖNIG, J., CUI, Y., NIES, A. T., and KEPPLER, D., A Novel Human Organic Anion Transporting Polypeptide Localized to the Basolateral Hepatocyte Membrane. Am. J. Physiol. Gastrointest. Liver Physiol. 278: G156-G164 (2000).

 

KÖNIG, J., CUI, Y., NIES, A. T., and KEPPLER, D., Localization and Genomic Organization of a New Hepatocellular Organic Anion Transporting Polypeptide. J. Biol. Chem. 275: 23161-23168 (2000).

 

CUI, Y., KÖNIG, J., LEIER, I., BUCHHOLZ, U., and KEPPLER, D., Hepatic Uptake of Bilirubin and its Conjugates by the Human Organic Anion Transporter SLC21A6. J. Biol. Chem. 276: 9626-9630 (2001).

 

CUI, Y., KÖNIG, J., and KEPPLER, D., Vectorial Transport by Double-transfected Cells Expressing the Human Uptake Transporter SLC21A8 and the Apical Export Pump ABCC2. Mol. Pharmacol. 60: 934-943 (2001).

 

RIUS, M., NIES, A. T., HUMMEL-EISENBEISS, J., JEDLITSCHKY, G., and KEPPLER, D., Cotransport of Reduced Glutathione with Bile Salts by MRP4 (ABCC4) Localized to the Basolateral Hepatocyte Membrane. Hepatology 38: 374-384 (2003).

 

Giacomini, K. M., Huang, S. M., Tweedie, D. J., Benet, L. Z., Brouwer, K. L., Chu, X., Dahlin, A., Evers, R., Fischer, V., Hillgren, K. M., Hoffmaster, K. A., Ishikawa, T., Keppler, D., Kim, R. B., Lee, C. A., Niemi, M., Polli, J. W., Sugiyama, Y., Swaan, P. W., Ware, J. A., Wright, S. H., Yee, S. W., Zamek-Gliszczynski, M. J., and Zhang, L. Membrane Transporters in Drug Development. Nature Rev. Drug Discov. 9: 215-236 (2010).   

 

KEPPLER, D., Progress in the Molecular Characterization of Hepatobiliary Transporters. Digestive Diseases 35: 197-203 (2017).

 

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