(This is not a complete list of publications, but only a selection of the major ones.)


M. Hassel, E. Frei, A. J. Streeter, M. Wiessler, Pharmacokinetics of N-nitrodimethylamine and N-nitromethylamine in the rat. Carcinogenesis, 11, 357-360, 1990.


M. Weigand, E. Frei, M. Wiessler, Mechanisms of resistance to methotrexate in childhood leukemia. J. Cancer Res. Clin. Oncol., 121, 55, 1995.


E. Frei, F. Gilberg, M. Schröder, A. Breuer, L. Edler, M. Wiessler, Analysis of the inhibition of N-nitroso-dimethylamine activation in the liver by N-nitro-dimethylamine using a new non-linear statistical method. Carcinogenesis, 20, 459-464, 1999.


M. Stiborová, E. Frei, H.H. Schmeiser, Aristolochic acids and renal disease – Chinese herbs nephropathy. Chem. Listy 94, 186-189, 2000.


E. Frei, F. Kuchenmeister, R. Gliniorz, A. Breuer, P. Schmezer, N-nitrosodimethylamine is activated in microsomes from hepatocytes to reactive metabolites which damage DNA of non-parenchymal cells in rat liver. Toxicology Letters 123, 227-234, 2001.


M. Stiborová, E. Frei, B. Sopko, M. Wiessler, H.H. Schmeiser, Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy. Carcinogenesis 23, 617-625, 2002.


M. Weigand, G. Hartung, J. Roboz, S. Sieger, M. Wolf, H. Sinn, H-H. Schrenk, M. Wiessler, E. Frei, Mode of action of methotrexate-albumin in a human T-cell leukemia line and its activity against an MTX-resistant clone. Anti-Cancer Drug Design 16, 227-237, 2001.


M. Stiborová, V. Martínek, H. Rýdlová, P. Hodek, E. Frei, Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver micrososmes. Cancer Research 62, 5678-5684, 2002.


E. Frei. Albumin conjugated anticancer drugs-a novel concept in tumour therapy. Science and Culture (India) 70, 127-130, 2004.


Kim E. Y-L., Gronewold C., Chatterjee A., von der Lieth C-W., Kliem C., Schmauser B., Wiessler M., Frei E. Oligosaccharide mimics containing galactose and fucose specifically label tumour cell surfaces and inhibit cell adhesion to fibronectin. ChemBioChem 6, 422-431, 2005.


Wolff,D., Frei, E., Hofmeister, N., Steiner, B., Kleine H-D., Junghans,C., Sievert, K., Terpe, H., Schrenk, H-H., Freund, M., Hartung, G. Methotrexate-albumin and aminopterin-albumin effectively prevent experimental acute graft-versus-host disease. Transplantation 82 (4) 527-533, 2006.


Funk D, Schrenk H-H, Frei E. Serum albumin leads to false-positive results in the XTT and the MTT assay. BioTechniques 43, 178-182, 2007.


Stiborová M, Dračínská H., Mizerovská J., Frei E., Schmeiser HH., Hudeček J., Hodek P., Phillips DH. Arlt VM. The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity. Toxicology 247, 11-22, 2008.


Kremer P., Fardanesh M., Ding R., Pritsch M., Zoubaa S., Frei E. Intra-operative fluorescence staining of malignant brain tumors using 5-aminofluorescein-labeled albumin. Neurosurgery, 64/ Operative Neurosurgery 1, 53-61, 2009.


Martínek V., Sklenář J., Dračínský M., Šulc M., Hofbauerová K., Bezouška K., Frei E., Stiborová M. Glycosylation protects proteins against free radicals generated from toxic xenobiotics. Toxicological Sciences 117, 359-374, 2010.


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