Original- und Übersichtsarbeiten im Jahr 2021 und im Druck

Brenner H.
Vitamin D supplementation to prevent COVID-19 infections and deaths – accumulating evidence from epidemiological and intervention studies calls for immediate action.
Nutrients 2021; 13:411.

Schöttker B, Kuznia S, Brenner H.
Efficacy of vitamin D3 supplementation on cancer mortality in the general population and the prognosis of patients with cancer: protocol of a systemtic review and individual patient data meta-analysis of randomised controlled trials.
BMJ Open 2021; 11:e041607.

Bhardwaj M, Terzer T, Schrotz-King P, Brenner H.
Comparison of proteomic technologies for blood-based detection of colorectal cancer.
International Journal of Molecular Sciences 2021; 22:1189.

Jansen L, Kanbach J, Finke I, Arndt V, Emrich K, Holleczek B, Kajüter H, Kieschke J, Maier W, Pritzkuleit R, Sirri E, Schwettmann L, Erb C, Brenner H.
Estimation of the potentially avoidable premature excess deaths associated with socioeconomic inequalities in cancer survival in Germany.
Cancers 2021; 13:357.

Brenner H.
Focusing COVID-19 vaccinations on the elderly.
The Lancet Regional Health – Europe 2021; 100044.

Heisser T, Hoffmeister M, Brenner H.
Effects of screening for colorectal cancer: development, documentation and validation of a multistate Markov model.
International Journal of Cancer 2021; 148:1973-1981.

Johnson N, Maguire S, Morra A, Kapoor PM, Tomczyk K,..., Arndt V,..., Brenner H,..., Chang-Claude J, Schmidt MK, Orr N, Fletcher O.
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers.
British Journal of Cancer 2021; 124:842-854.

Gies A, Niedermaier T, Gruner LF, Heißer T, Schrotz-King P, Brenner H.
Fecal immunochmical tests detect screening participants with multiple advanced adenomas better than T1 colorectal cancers.
Cancers 2021; 13:644.

Rehm M, Büchele G, Brenner RE, Günther KP, Brenner H, König W, Rothenbacher D.
Repeated measurements of cardiac troponin T and N-terminal pro-B-type natriuretic peptide to assess long-term mortality risk in subjects with osteoarthritis.
Biomolecules 2021; 11:230.

Lin HY, Wang X, Tseng TS, Kao YH, Fang Z, Molina P, Cheng CH, Berglund A, Eeles R, Muir K, Pashayan N, Haiman C, Brenner H, the PRACTICAL consortium, Park J.
Alcohol intake and alcohol-SNP interactions associated with prostate cancer aggressiveness.
Journal of Clinical Medicine 2021; 10:553.

Huang L, Jansen L, Balavarca Y, van der Geest L, Lemmens V, Groot Koerkamp B, van Santvoort HC, Grützmann R, Besselink MG, Schrotz-King P, Brenner H.
Significance of exmined lymp node number in accurate staging and long-term survival in resected stage I-II pancreatic cancer-more is better? A large international population-based cohort study.
Annals of Surgery (im Druck).

Laetsch DC, Hoppe LK, Saum KU, Haefeli WE, Brenner H, Schöttker B.
Investigation of a possible association of potentially inappropriate medication for older adults and frailty in a prospective cohort study from Germany.
Age and Ageing (im Druck).

Niedermaier T, Tikk K, Gies A, Bieck S, Brenner H.
Sensitivity of fecal immunochemical test for colorectal cancer detection differs strongly according to stage and location.
Clinical Gastroenterology and Hepatology (im Druck).

Campbell PT, Lin Y, Bien SA, Figueiredo JC, Harrison TA, Guinter MJ, Berndt SI, Brenner H, Chan AT, Chang-Claude J, Gallinger SJ, Gapstur SM, Giles GG, Giovannucci E, Gruber SB, Gunter M, Hoffmeister M, Jacobs EJ, Jenkins MA, Le Marchand L, Li L, McLaughlin JR, Murphy N, Milne RL, Newcomb PA, Newton C, Ogino S, Potter JD, Rennert G, Rennert HS, Robinson J, Sakoda LC, Slattery ML, Song Y, White E, Woods MO, Casey G, Hsu L, Peters U.
Association of body mass index with colorectal cancer risk according to genome-wide variants.
Journal of the National Cancer Institute (im Druck).

Stocker H, Perna L, Weigl K, Möllers T, Schöttker B, Thomsen H, Holleczek B, Rujescu D, Brenner H. Prediction of clinical diagnosis of Alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic riskscore and APOE status in a community-based prospectively followed over 17 years. Molecular Psychiatry (im Druck).

Kather JN, Heij LR, Grabsch HI, Loeffler C, Echle A, Muti HS, Krause J, Niehues JM, Sommer KAJ, Bankhead P, Kooreman LFS, Schulte JJ, Cipriani NA, Buelow RD, Boor P, Ortiz-Brüchle N, Hanby AM, Speirs V, Kochanny S, Patnaik A, Srisuwananukorn A, Brenner H, Hoffmeister M, van den Brandt PA, Jäger D, Trautwein C, Pearson AT, Luedde T.
Pan-cancer image-based detection of clinically actionable genetic alterations.
Nature Cancer (im Druck).

Kapoor PM, Mavaddat N, Choudhury PP, Wilcox AN, Lindström S,..., Arndt V,..., Brenner H,..., Holleczek B,..., Schöttker B,..., Easton DF, Milne RL, Garcia-Closas M, Chang-Claude J.
Combined associations of a polygenic risk score and classical risk factors with breast cancer risk.
Journal of the National Cancer Institute (im Druck).

Chen LJ, Trares K, Laetsch DC, Nguyen Thi Ngoc M, Brenner H, Schöttker B.
Systematic review and meta-analysis on the associations of polypharmacy and potentially inappropriate medication with adverse outcomes in older cancer patients.
Journal of Gerontology: Medical Sciences (im Druck).

Bravi F, Lee YCA, Hashibe M, Boffetta P, Conway DI, Ferraroni M, La Vecchia C, Edefonti V, on behalf of the INHANCE Consortium investigators.*
Lessons learned from the INHANCE consortium: an overview of recent results on head and neck cancer. Oral Diseases (im Druck).
*Collaborators from DKFZ: Brenner H

Karunamuni R, Huynh-Le MP, Fan C, Eeles R, Easton D,..., Brenner H, Schöttker B, Holleczek B,..., Andreassen O, Dale AM, Seibert T, and the Practical Consortium.
The effect of sample size on polygenic hazard models for prostate cancer.
Nature (im Druck).

Hoffmeister M, Bläker H, Jansen L, Alwers E, Amitay EL, Carr PR, Kloor M, Herpel E, Roth W, Chang-Claude J, Brenner H.
Colonoscopy and reduction of colorectal cancer risk by molecular tumor subtypes: a population-based case-control study.
American Journal of Gastroenterology (im Druck).

Xu X, Kharazmi E, Tian Y, Sundquist K, Sundquist J, Brenner H, Fallah M.
Risk of invasive prostate cancer and prostate cancer death in relatives of patients with prostatic borderline or in situ neoplasia: A nationwide cohort study.
Cancer (im Druck). 

Nguyen TNM, Laetsch DC, Chen LJ, Haefeli WE, Meid AD, Brenner H, Schöttker B.
Pain severity and analgesics use in the community-dwelling older population. A drug utilization study from Germany.
European Journal of Clinical Pharmacology (im Druck).

Ahadova A, Seppälä T, Engel C, Gallon R, Burn J, Holinski-Feder E, Steinke-Lange V, Möslein G, Nielsen M, ten Broeke S, Laghi L, Dominguez-Valentin M, Capella G, Macrae F, Hüneburg R, Nattermann J, Hoffmeister M, Brenner H, Bläker H, von Knebel Doeberitz M, Sampson JR, Vasen H, Mecklin JP, Moller P, Kloor M.
The "unnatural" history of colorectal cancer in Lynch syndrome: lessons from colonoscopy surveillance. International Journal of Cancer (im Druck).

Jarvik GP, Wang X, Fontanillas P, Kim E, Chanprasert S,..., Brenner H,..., Hoffmeister M,..., Jenkins MA, Mountain J, Peters U, Crosslin DR.
Hemochromatosis risk genotype is not associated with colorectal cancer or age at its diagnosis.
Human Genetics and Genomics Advances (im Druck).

Jansen L, Boakye D, Alwers E, Carr PR, Reissfelder C, Schneider M, Martens UM, Chang-Claude J, Hoffmeister M, Brenner H.
Uptake rates of novel therapies and survival among privately compared to publicly insured colorectal cancer patients in Germany.
Journal of the National Comprehensive Cancer Network (im Druck).

Bläker H, Haupt S, Morak M, Holinski-Feder E, Arnold A,..., Alwers E,..., Brenner H,..., von Knebel Doeberitz M, Ahadova A, Hoffmeister M, Kloor M.
Age-dependent performance of BRAF mutations testing in Lynch syndrome diagnostics.
International Journal of Cancer (im Druck).

Barahona Ponce C, Scherer D, Brinster R, Boekstegers F, Marcelain K,..., Brenner H,..., Gallo C, Ruiz Linares A, Rothhammer F, Lorenzo Bermejo J.
Gallstones, body mass index, C-reactive protein and gallbladder cancer – Mendelian randomization analysis of Chilean and European genotype data.
Hepatology (im Druck).

Heisser T, Guo F, Niedermaier T, Holleczek B, Hoffmeister M, Brenner H.
Low risk of advanced neoplasms for up to 20 years after negative colonoscopy: potential for personalized follow-up screening intervals.
Gastroenterology (im Druck).

Perna L, Zhang Y, Wild B, Kliegel M, Ihle A, Schöttker B, Mons U, Brenner H.
Childhood exposure to hunger: Associations with health outcomes in later life and epigenetic markers. Epigenomics (im Druck).

Matsushita K, Jassal SK, Sang Y, Ballew SH Grams ME,..., Brenner H,..., Yatsuya H, Zhang L, Schaeffner E, Coresh J.
Incorporating kidney disease measures into cardiovascular risk prediction: development and validation in 9 million adults from 72 datasets.
EClinicalMedicine (im Druck).

Doege D, Thong M, Koch-Gallenkamp L, Jansen L, Bertram H, Eberle A, Holleczek B, Pritzkuleit R, Waldmann A, Zeissig S, Brenner H, Arndt V.
Age-specific prevalence and determinants of depression in long-term breast cancer survivors compared to female population controls.
Cancer Medicine (im Druck).

Mukama T, Fallah M, Brenner H, Xu X, Sundquist K, Sundquist J, Kharazmi E.
Risk of invasive breast cancer in relatives of patients with breast carcinoma in situ: a prospective cohort study.
BMC Medicine (im Druck).

Siziba LP, Lorenz L, Brenner H, Carr P, Stahl B, Mank M, Marosvölgyi T, Decsi T, Rothenbacher D, Genuneit J.
Changes in human milk fatty acid composition and maternal lifestyle-related factors over a decade: a comparison between the two Ulm Birth Cohort studies.
British Journal of Nutrition (im Druck).

Gorski M, Jung B, Li Y, Matias-Garcia P, Böger C,..., Brenner H,..., Schöttker B,..., Köttgen A, Kronenberg F, Pattaro C, Heid I.
Genome-wide significant variants for rapid kidney function decline from a meta-analysis of up to 35,000 cases and >100,000 controls.
Kidney International (im Druck).

Huang L, Jansen L, Balavarca Y, Verhoeven RHA, Ruurda JP, van Eycken L, de Schutter H, Johansson J, Lindblad M, Johannesen TB, Zadnik V, Zagar T, Mägi M, Bastiaannet E, Lagarde SM, van de Velde CJH, Schrotz-King P, Brenner H.
Decreasing resection rates for non-metastatic gastric cancer in Europe and the US.
Clinical and Translation Medicine (im Druck). 

Ali Khan U, Fallah M, Sundquist K, Sundquist J, Brenner H, Kharazmi E.
Risk of colorectal cancer in patients with diabetes mellitus: A Swedish nationwide cohort study.
PLOS Medicine (im Druck).

Möllers T, Schwab M, Gildein L, Hoffmeister M, Albert J, Brenner H, Jäger S.
The second generation of colon capsule endoscopy in the detection of colorectal polyps: A systematic review and meta-analysis of clinical trials.
Endoscopy International Open (im Druck).

Amitay EL, Carr PR, Gies A, Laetsch DC, Brenner H.
Pro-/symbiotic treatment and postoperative complications in colorectal cancer patients: systematic review and meta-analysis of randomized controlled trials.
Clinical and Translation Gastroenterology (im Druck).

Bull CJ, Bell JA, Murphy N, Sanderson E, Smith GD,..., Brenner H,..., Hoffmeister M,..., Zheng W, Peters U, Vincent EE, Gunter MJ.
Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study.
BMC Medicine (im Druck).

Rehm M, Büchele G, Peter RS, Brenner RE, Günther KP, Brenner H, König W, Rothenbacher D. Relationship between cardiac biomarker concentration and long-term mortality in subjects with osteoarthritis.
PLOS One (im Druck).

Gredner T, Niedermaier T, Brenner H, Mons U.
Impact of reducing alcohol consumption through price-based policies on cancer incidence in Germany 2020 to 2050 – a simulation study.
Addiction (im Druck).

Conti DV, Darst BF, Moss L, Saunders EJ, Sheng X,..., Brenner H, Cuk K, Holleczek B, Saum KU,..., Witte JS, Eeles RA, Kote-Jarai Z, Haiman CA.
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
Nature Genetics (im Druck).

Karunamuni RA, Huynh-Le MP, Fan CC, Thompson W, Eeles RA,..., Brenner H,..., Andreassen OA, Dale AM, Seibert TM, The PRACTICAL Consortium.
Additional SNPs improve risk stratification of a polgenic hazard score for prostate cancer.
Prostate Cancer and Prostatic Dieseases (im Druck).

Coignard J, Lush M, Beesley J, O'Mara T,..., Arndt V,..., Brenner H,..., Chenevix-Trench G, Easton D, Andrieu N, Antoniou A.
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers. Nature Communications (im Druck).

Schündeln MM, Lange T, Knoll M, Spix C, Brenner H, Bozorgmehr K, Stock C.
Statistical methods for spatial cluster detection in childhood cancer incidence: a simulation study.
Cancer Epidemiology (im Druck).

Gao X, Zhang Y, Boakye D, Li X, Chang-Claude J, Hoffmeister M, Brenner H.
Whole blood DNA methylation aging markers predict colorectal cancer survival: prospective cohort study. Clinical Epigenetics (im Druck).

Boakye D, Jansen L, Schöttker B, Jansen EHJM, Halama N, Maalmi H, Gao X, Chang-Claude J, Hoffmeister M, Brenner H.
The association of vitamin D with survival in coloretal cancer patients depends on antioxidant capacity.
The American Journal of Clinical Nutrition (im Druck).

Schöttker B, Kuznia S, Brenner H.
Efficacy of Vitamin D3 supplementation on cancer mortality in the general population and the prognosis of cancer patients: Protocol of a systematic review and individual patient data meta-analysis of randomized controlled trials.
BMJ Open (im Druck).

Guo F, Chen X, Chang-Claude J, Hoffmeister M, Brenner H.
Colorectal cancer risk by genetic variants in populations with and without colonoscopy history.
JNCI Cancer Spectrum (im Druck).

Tian Y, Kharazmi E, Brenner H, Xu X, Sundquist K, Sundquist J, Fallah M.
Family history of colorectal carcinoma in situ as important as family history of invasive colorectal cancer: a nationwide cohort study.
Journal of the National Comprehensive Cancer Network (im Druck).

Tsilidis KK, Papadimitriou N, Dimou N, Gill D, Lewis SJ,..., Arndt V,..., Brenner H,..., Hoffmeister M,..., Banbury BL, Gruber SB, Peters U, Gunter MJ, on behalf of GECCO, CORECT and CCFR.
Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study.
The American Journal of Clinical Nutrition (im Druck).

Vishram-Nielsen JKK, Dyrvig Kristensen AM, Pareek M, Laurent S, Nilsson PM,..., Brenner H, Grimsgaard S, Savallampi M, Olsen MH.
Predictive importance of blood pressure characteristics with increasing age in healthy men and women: The MORGAM Project.
Hypertension (im Druck).

Nguyen TNM, Laetsch DC, Chen LJ, Holleczek B, Meid A, Brenner H, Schöttker B.
Comparison of five lists to identify potentially inappropriate use of non-steroidal anti-inflammatoriy drugs in older adults.
Pain Medicine (im Druck).

Cardoso R, Zhu A, Heisser T, Hoffmeister M, Brenner H.
Proximal and distal colorectal cancer incidence and mortality in Germany - trends in the era of screening colonoscopy.
Deutsches Ärzteblatt International (im Druck).

Koole JL, Bours MJL, Geijsen AJMR, Gigic B, Ulvik A,..., Brenner H, Hoffmeister M, Ueland PM, Ulrich CM, Kampman E, Weijenberg MP.
Circulating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal cancer: results from the FOCUS consortium.
The American Journal of Clinical Nutrition (im Druck).

Guo F, Chen C, Holleczek B, Schöttker B, Hoffmeister M, Brenner H.
Strong reduction of colorectal cancer incidence and mortality after screening colonoscopy: prospective cohort study from Germany.
American Journal of Gastroenterology (im Druck).

Möllers T, Stocker H, Perna L, Nabers A, Rujescu D, Hartmann AM, Holleczek B, Schöttker B, Gerwert K, Brenner H.
Aβ misfolding in blood plasma measured by immuno-infrared-sensor as an age-independent risk marker of Alzheimer's disease.
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring (im Druck).

Niedermaier T, Gredner T, Kuznia S, Schöttker B, Mons U, Brenner H.
Potential for cost-saving prevention of almost 30,000 cancer deaths per year by vitamin D supplementation of the older adult population in Germany.
Molecular Oncology (im Druck).

Karabegovic I, Portilla-Fernandez E, Li Y, Ma J, Maas SCE,..., Schöttker B,..., Brenner H,..., Fornage M, Levy D, Kayser M, Ghanbari M.
Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption.
Nature Communications (im Druck).

Finke I, Behrens G, Maier W, Schwettmann L, Pritzkuleit R, Holleczek B, Kajüter H, Gerken M, Mattutat J, Emrich K, Jansen L, Brenner H.
Small-area analysis on socioeconomic inequalities in cancer survival for 25 cancer sites in Germany.
International Journal of Cancer (im Druck).

Chen X, Jansen L, Guo F, Hoffmeister M, Chang-Claude J, Brenner H.
Smoking, genetic predisposition and colorectal cancer risk.
Clinical and Translational Gastroenterology (im Druck).

Brenner H, Cross AJ.
Merits, challenges and limitations of randomized trials on colorectal cancer screening effectiveness.
Gastroenterology (im Druck).

Brenner H.
Vitamin D supplementation to prevent COVID-19 infections and deaths – accumulating evidence from epidemiological and intervention studies calls for immediate action.
Nutrients (im Druck).

Schündeln M, Lange T, Knoll M, Spix C, Brenner H, Bozorgmehr K, Stock C.
Methods of spatial cluster detection in rare childhood cancers: Benchmarking data and results from a simulation study on nephroblastoma.
Data in Brief (im Druck).

Erben V, Carr PR, Guo F, Weigl K, Hoffmeister M, Brenner H.
Individual and joint associations of a polygenic risk score and the healthy lifestyle score with non-advanced and advanced neoplasms among participants of screening colonoscopy.
Cancer Prevention Research (im Druck).

Krilaviciute A, Brenner H.
Low positive predictive value of computed tomography screening for lung cancer irrespective of commonly employed definitions of target population.
International Journal of Cancer (im Druck).

Jansen L, Erb C, Nennecke A, Finke I, Pritzkuleit R, Holleczek B, Brenner H, for the German Cancer Survival Working Group.
Socioeconomic deprivation and cancer survival in a metropolitan area: an analysis of cancer registration data from Hamburg, Germany.
The Lancet Regional Health – Europe (im Druck).

Thong M, Boakye D, Jansen L, Martens U, Chang-Claude J, Hoffmeister M, Brenner H, Arndt V.
Comorbidities rather than older age are strongly associated with higher utilization of healthcare in colorectal cancer survivors.
Journal of the National Comprehensive Cancer Network (im Druck).

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