Original- und Übersichtsarbeiten im Jahr 2018 und im Druck

Jansen H, Jänsch A, Breitling LP, Hoppe L, Dallmeier D, Schmucker R, Brenner H, König W, Rothenbacher D.
Hs-cTroponins for the prediction of recurrent cardiovascular events in patients with established CHD – A comparative analysis from the KAROLA study.
International Journal of Cardiology 2018; 250:247-252.

Jansen L, Buttmann-Schweiger N, Listl S, Ressing M, Holleczek B, Katalinic A, Luttmann S, Kraywinkel K, Brenner H, for the GEKID Cancer Survival Working Group.
Differences in incidence and survival of oral cavity and pharyngeal cancers between Germany and the United States depend on the HPV-association of the cancer site.
Oral Oncology 2018; 76:8-15.

Campa D, Pastore M, Capurso G, Hackert T, Di Leo M,…, Brenner H,…, Oliverius M, Pezzilli R, Landi S, Canzian F.
Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation.
International Journal of Cancer 2018; 142:290-296.

Chen C, Stock C, Hoffmeister M, Brenner H.
Public health impact of colonoscopy use on colorectal cancer mortality in Germany and the United States.
Gastrointestinal Endoscopy 2018; 87:213-221.

Seibert TM, Fan CC, Wang Y, Zuber V, Karunamuni R,…, Brenner H,…, Andreassen OA, Dale AM, The PRACTICAL Consortium.
Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large-scale cohorts.
BMJ 2018; 360:j5757.

Gigic B, Boeing H, Toth R, Böhm J, Habermann N, Scherer D, Schrotz-King P, Abbenhardt-Martin C, Skender S, Brenner H, Chang-Claude J, Hoffmeister M, Syrjala K, Jacobsen PB, Schneider M, Ulrich A, Ulrich CM.
Associations between dietary patterns and longitudinal quality of life changes in colorectal cancer patients: the ColoCare study.
Nutrition and Cancer 2018; 70:51-60.

Gies A, Cuk K, Schrotz-King P, Brenner H.
Direct comparison of diagnostic performance of 9 quantitative fecal immunochemical tests for colorectal cancer screening.
Gastroenterology 2018; 154:93-104.

Weigl K, Chang-Claude J, Knebel P, Hsu L, Hoffmeister M, Brenner H.
Strongly enhanced colorectal cancer risk stratification by combining family history and genetic risk score.
Clinical Epidemiology 2018; 10:143-152.

Klein AP, Wolpin BM, Risch HA, Stolzenberg-Solomon RZ, Mocci E,…, Brenner H,…, Chanock S, Obazee O, Petersen GM, Amundadottir TL.
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
Nature Communications 2018; 9:556.

Babaei M, Balavarca Y, Jansen L, Lemmens V, van Erning FN, van Eycken L, Vaes E, Sjövall A, Glimelius B, Ulrich CM, Schrotz-King P, Brenner H.
Administration of adjuvant chemotherapy for stage II-III colon cancer patients: an European population-based study.
International Journal of Cancer 2018; 142:1480-1489.

Boakye D, Rillmann B, Walter V, Jansen L, Hoffmeister M, Brenner H.
Impact of comorbidity and frailty on prognosis in colorectal cancer patients: a systematic review and meta-analysis.
Cancer Treatment Reviews 2018; 64:30-39.

Ordóñez-Mena JM, Walter V, Schöttker B, Jenab M, O’Doherty MG, Kee F, Bueno-de-Mesquita B, Peeters PHM, Stricker BH, Ruiter R, Hofman A, Söderberg S, Jousilahti P, Kuulasmaa K, Freedman ND, Wilsgaard T, Wolk A, Nilsson LM, Tjonneland A, Quirós JR, van Duijnhoven FJB, Siersema PD, Boffetta P, Trichopoulou A, Brenner H, on behalf of the Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES).
Impact of prediagnostic smoking and smoking cessation on colorectal cancer prognosis: a meta-analysis of individual patient data from cohorts within the CHANCES consortium.
Annals of Oncology 2018; 29:472-483.

Babaei M, Balavarca Y, Jansen L, Sjövall A, Bos A, Van de Velde T, Moreau M, Gabriel L, Goncalves AF, Bento MJ, Ulrich CM, Schrotz-King P, Lemmens V, Glimelius B, Brenner H.
Neoadjuvant therapy in rectal cancer patients with clinical stage II-III across European countries: variations and outcomes.
Clinical Colorectal Cancer 2018; 17; e129-e142.

Hajek A, Bock JO, Saum KU, Matschinger H, Brenner H, Holleczek B, Haefeli WE, Heider D, König HH.
Frailty and health care costs – longitudinal results of a prospective cohort study.
Age and Ageing 2018; 47:233-241.

Niedermaier T, Weigl K, Hoffmeister M, Brenner H.
Fecal immunochemical tests in combination with blood tests for colorectal cancer and advanced ademona detection - systematic review.
United European Gastroenterology Journal 2018; 6:13-21.

Erben V, Carr PR, Holleczek B, Stegmaier C, Hoffmeister M, Brenner H.
Dietary patterns and risk of advanced colorectal neoplasms: a large population based screening study in Germany.
Preventive Medicine 2018; 111:101-109.

Büchele G, Günther KP, Brenner H, Puhl W, Stürmer T, Rothenbacher D, Brenner RE.
Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality: 20 years follow-up in patients after hip or knee replacement.
Scientific Reports 2018; 8:5253.

Minicozzi P, Walsh PM, Sánchez MJ, Trama A, Innos K, Marcos-Gragera R, Dimitrova N, Botta L, Johannesen TB, Rossi S, Sant M, EUROCARE-5 Working Group*.
Is low survival for cancer in Eastern Europe due principally to late stage at diagnosis?
European Journal of Cancer 2018; 93:127-137.
*Collaborators from DKFZ: Brenner H

Brenner H, Qian J, Werner S.
Variation of diagnostic performance of fecal immunochemical testing for hemoglobin by sex and age: results from a large screening cohort.
Clinical Epidemiology 2018; 10:381-389.

Wood AM, Kaptoge S, Butterworth AS, Willeit P, Warnakula S,…, Arndt V,…, Brenner H,…, Jackson R, Banks E, Di Angelantonio E, Danesh J, for the Emerging Risk Factors Collaboration/EPIC-CVD/UK Biobank Alcohol Study Group.
Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599912 current drinkers in 83 prospective studies.
Lancet 2018; 391:1513-1523.

Vijayakrishnan J, Studd J, Broderick P, Kinnersley B, Holroyd A, Law PJ, Kumar R, Allan JM, Harrison CJ, Moorman AV, Vora A, Roman E, Rachakonda S, Kinsey SE, Sheridan E, Thompson PD, Irving JA, Koehler R, Hoffmann P, Nöthen MM, Heilmann-Heimbach S, Jöckel KH, Easton DF, Pharaoh PDP, Dunning AM, Peto J, Canzian F, Swerdlow A, Eeles RA, Kote-Jarai Z, Muir K, Pashayan N, The PRACTICAL consortium*, Greaves M, Zimmerman M, Bartram CR, Schrappe M, Stanulla M, Hemminki K, Houlston RS.
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
Nature Communications 2018; 9:1340.
*Collaborator from DKFZ: Brenner H

Zhang Y, Saum KU, Schöttker B, Holleczek B, Brenner H.
Methylomic survival predictors, frailty, and mortality.
Aging 2018; 10:339-357.

Colombo M, Lòpez-Perolio I, Meeks HD, Caleca L, Parsons M,…, Arndt V,…, Brenner H,…, Spurdle AB, Goldgar DE, de la Hoya M, Radice P.
The BRCA2 c.68-7T>A variant is not pathogenic: a model for clinical calibration of spliceogenicity.
Human Mutation 2018; 39:729-741.

Pulte D, Jansen L, Brenner H.
Disparities in colon cancer survival by insurance type: a population based analysis.
Diseases of the Colon & Rectum 2018; 61:538-546.

Krilaviciute A, Stock C, Leja M, Brenner H.
Potential for non-invasive breath tests for preselecting individuals for invasive gastric cancer screening endoscopy.
Journal of Breath Research 2018; 12:036009.

Niedermaier T, Weigl K, Hoffmeister M, Brenner H.
Diagnostic performance in one-off flexible sigmoidoscopy with fecal immunochemical test in a large screening population.
Epidemiology 2018; 29:397-406.

Maalmi H, Walter V, Jansen L, Owen RW, Ulrich A, Schöttker B, Chang-Claude J, Hoffmeister M, Brenner H.
Dose-response relationship between serum retinol levels and survival in patients with colorectal cancer: results from the DACHS study.
Nutrients 2018; 10:510.

Su YR, Di C, Bien S, Huang L, Dong X, Abecasis G, Berndt S, Bezieau S, Brenner H, Caan B, Casey G, Chang-Claude J, Chanock S, Chen S, Connolly C, Curtis K, Figueiredo J, Gala M, Gallinger S, Harrison T, Hoffmeister M, Hopper J, Huyghe JR, Jenkins M, Joshi A, Le Marchand L, Newcomb P, Nickerson D, Potter J, Schoen R, Slattery M, White E, Zanke B, Peters U, Hsu L.
A mixed-effects model for powerful association tests in integrative functional genomics.
American Journal of Human Genetics 2018; 102:904-919.

Horne HN, Oh H, Sherman ME, Palakal M, Hewitt SM,…, Brenner H,…, Van Leeuwen FF, Van’t Veer LJ, Garcia-Closas M, Figueroa JD.
E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium.
Scientific Reports 2018; 8:6574.

Nabers A*, Perna L*, Lange J, Mons U, Schartner J, Güldenhaupt J, Saum KU, Janelidze S, Holleczek B, Rujescu D, Hansson O, Gerwert K, Brenner H.
Amyloid blood biomarker detects alzheimer’s disease.
EMBO Molecular Medicine 2018; 10:e8763.
*shared first authorship

Painter J, O’Mara T, Morris A, Cheng T, Gorman M,…, Brenner H,…, Tomlinson I, Easton D, Thompson D, Spurdle A.
Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses.
Cancer Medicine 2018; 7:1978-1987.

Rudolph A, Song M, Brook MN, Milne RL, Mavaddat N,…, Brenner H, Arndt V,…, Easton DF, Chatterjee N, Chang-Claude J, Garcia-Closas M.
Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium.
International Journal of Epidemiology 2018; 47:526-536.

Niedermaier T, Weigl K, Hoffmeister M, Brenner H.
Flexible sigmoidoscopy in colorectal cancer screening: implications of different colonoscopy referral strategies.
European Journal of Epidemiology 2018; 33:473-484.

Gao X, Zhang Y, Schöttker B, Brenner H.
Vitamin D status and epigenetic-based mortality risk score: strong independent and joint prediction of all-cause mortality in a population-based cohort study.
Clinical Epigenetics 2018; 10:84.

GBD 2016 Healthcare Access and Quality Collaborators*.
Measuring performance on the healthcare access and quality index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016.
Lancet 2018; 391:2236-2271.
*Collaborator from DKFZ: Brenner H

Dadaev T, Saunders E, Newcombe P, Anokian E, Leongamornlert D,…, Brenner H,…, Haiman C, Eeles R, Conti D, Kote-Jarai Z.
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.
Nature Communications 2018; 9:2256.

Gào X, Brenner H, Holleczek B, Cuk K, Zhang Y, Anusruti A, Xuan Y, Xu Y, Schöttker B.
Urinary 8-isoprostane levels and occurrence of lung, colorectal, prostate, breast and overall cancer: Results from a large, population-based cohort study with 14 years of follow-up.
Free Radical Biology & Medicine 2018; 123:20-26.

Hoppe LK, Muhlack DC, König W, Carr PR, Brenner H, Schöttker B.
Association of abnormal serum potassium levels with arrhythmias and cardiovascular mortality: a systematic review and meta-analysis of observational studies.
Cardiovascular Drugs and Therapy 2018; 32:197-212.

Brück K, Jager KJ, Zoccali C, Bello A, Minutolo R,…, Brenner H,…, De Nicola L, Heinze G, Van Biesen W, Stel VS on behalf of the European CKD Burden Consortium.
Different rates of progression and mortality in patients with chronic kidney disease at outpatient nephrology clinics across Europe.
Kidney International 2018; 93:1432-1441.

Pulte D, Weberpals J, Schröder CC, Emrich K, Holleczek B, Katalinic A, Luttmann S, Sirri E, Jansen L, Brenner H for the GEKID Cancer Survival Working Group.
Survival of patients with hepatobiliary tract and duodenal cancer sites in Germany and the United States in the early 21st century.
International Journal of Cancer 2018; 143:324-332.

Jeon J, Du M, Schoen RE, Hoffmeister M, Newcomb PA,..., Brenner H, Hayes RB, White E, Peters U, Hsu L, on behalf of the Colorectal Transdisciplinary (CORECT) Study and Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO).
Determining risk of colorectal cancer and starting age of screening based on lifestyle, environmental, and genetic factors.
Gastroenterology 2018; 154:2152-2164.

Carr PR, Alwers E, Bienert S, Weberpals J, Kloor M, Brenner H, Hoffmeister M.
Lifestyle factors and risk of sporadic colorectal cancer by microsatellite instability status: a systematic review and meta-analyses.
Annals of Oncology 2018; 29:825-834.

Eyl RE, Xie K, Koch-Gallenkamp L, Brenner H, Arndt V.
Quality of life and physical activity in long-term (>5 years post-diagnosis) colorectal cancer survivors – systematic review.
Health and Quality of Life Outcomes 2018; 16:112.

Gies A, Bhardwaj M, Stock C, Schrotz-King P, Brenner H.
Quantitative fecal immunochemical tests for colorectal cancer screening.
International Journal of Cancer 2018; 143:234-244.

Maalmi H, Walter V, Jansen L, Boakye D, Schöttker B, Hoffmeister M, Brenner H.
Association between blood 25-hydroxyvitamin D levels and survival in colorectal cancer patients: an updated systematic review and meta-analysis.
Nutrients 2018; 10:896.

Gies A, Cuk K, Schrotz-King P, Brenner H.
Direct comparison of ten quantitative fecal immunochemical tests for hemoglobin stability in colorectal cancer screening.
Clinical and Translational Gastroenterology 2018; 9:168.

Braig S, Berger S, Rothenbacher D, Schmid S, Seufferlein T, Brenner H, Rothenbacher D, Gündel H.
Time trends in dyspepsia and association with H. pylori and work-related stress – an observational study in white collar employees in 1996 and 2015.
PLoS ONE 2018; 13:e0199533.

Huhn S, da Silva Filho MI, Sanmuganantham T, Pichulik T, Catalano C, Pardini B, Naccarati A, Polakova-Vymetálkova V, Jiraskova K, Vodickova L, Vodicka P, Löffler MW, Courth L, Wehkamp J, Din FVN, Timofeeva M, Farrington SM, Jansen L, Hemminki K, Chang-Claude J, Brenner H, Hoffmeister M, Dunlop MG, Weber ANR, Försti A.
Coding variants in NOD-like receptors: an association study on risk and survival of colorectal cancer.
PLoS ONE 2018; 13:e0199350.

Braig S, Genuneit J, Walter V, Brandt S, Wabitsch M, Goldbeck L, Brenner H, Rothenbacher D.
Screen time, physical activity and self-esteem in children: the Ulm Birth Cohort Study.
International Journal of Environmental Research and Public Health 2018; 15: 1275.

Neumeyer S, Banbury BL, Arndt V, Berndt SI, Bezieau S, Bien SA, Buchanan DD, Butterbach K, Caan BJ, Campbell PT, Casey G, Chan AT, Chanock SJ, Dai JY, Gallinger S, Giovannucci EL, Giles GG, Grady WM, Hampe J, Hoffmeister M, Hopper JL, Hsu L, Jenkins MA, Joshi A, Larsson SC, Le Marchand L, Lindblom A, Moreno V, Lemire M, Li L, Lin Y, Offit K, Newcomb PA, Pharaoh PD, Potter JD, Qi L, Rennert G, Schafmayer C, Schoen RE, Slattery ML, Song M, Ulrich CM, Win AK, White E, Wolk A, Woods MO, Wu AH, Gruber SB, Brenner H, Peters U, Chang-Claude J.
Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer.
British Journal of Cancer 2018; 118:1639-1647.

Weigl K, Thomsen H, Balavarca Y, Hellwege J, Shrubsole M, Brenner H.
Genetic risk score is associated with prevalence of advanced neoplasms in a colorectal cancer screening population.
Gastroenterology 2018; 155:88-98.

Abubakar M, Chang-Claude J, Raza Ali H, Chatterjee N, Coulson P, Daley F, Blows F, Benitez J, Milne R, Brenner H, Stegmaier C, Mannermaa A, Rudolph A, Sinn P, Couch FJ, Devilee P, Tollenaar RAEM, Seynaeve C, Figueroa J, Lissowska J, Hewitt S, Hooning MJ, Hollestelle A, Foekens R, Koppert LB, kConFab Investigators, Bolla MK, Wang Q, Jones ME, Schoemaker MJ, Keeman R, Easton DF, Swerdlow AJ, Sherman ME, Schmidt MK, Pharoah PD, Garcia-Closas M.
Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation.
International Journal of Cancer 2018; 143:746-757.

Hajek A, Bock JO, Saum KU, Schöttker B, Brenner H, Heider D, König HH.
Unterschiede in der Morbidität nach Krankenversichertenstatus im Alter.
Das Gesundheitswesen 2018; 80:551-556.

Ose J, Botma A, Balavarca Y, Buck K, Scherer D, Habermann N, Beyerle J, Pfütze K, Seibold P, Kap EJ, Benner A, Jansen L, Butterbach K, Hoffmeister M, Brenner H, Ulrich A, Schneider M, Chang-Claude J, Burwinkel B, Ulrich CM.
Pathway analysis of genetic variants in folate-mediated one-carbon metabolism-related genes and survival in a prospectively followed cohort of colorectal cancer patients.
Cancer Medicine 2018; 7:2797-2807.

Erben V, Bhardwaj M, Schrotz-King P, Brenner H.
Metabolomics biomarkers for detection of colorectal neoplasms: A systematic review.
Cancers 2018; 10:246.

Tikk K, Weigl K, Hoffmeister M, Igel S, Schwab M, Hampe J, Klug SJ, Mansmann U, Kolligs F, Brenner H.
Study protocol of the RaPS Study: Novel risk adapted prevention strategies for people with a family history of colorectal cancer.
BMC Cancer 2018; 18:720.

O’Mara TA, Glubb DM, Amant F, Annibali D, Ashton K,…, Brenner H,…, Tomlinson I, Easton DF, Spurdle AB, Thompson DJ.
Identification of nine new susceptibility loci for endometrial cancer.
Nature Communications 2018; 9:3166.

Shi J, Wu L, Zheng W, Wen W, Wang S, Shu X, Long J, Shen CY, Wu PE, Saloustros E, Chang-Claude J, Brenner H, Shu XO, Cai Q.
Genetic evidence for the association between schizophrenia and breast cancer.
Journal of Psychiatry and Brain Science 2018; 3:7.

Qian J, Tikk K, Werner S, Balavarca Y, Saadati M, Hechtner M, Brenner H.
Biomarker discovery study of inflammatory proteins for colorectal cancer early detection demonstrated importance of screening setting validation.
Journal of Clinical Epidemiology 2018; 104:24-34.

Stocker H, Möllers T, Perna L, Brenner H.
The genetic risk of Alzheimer’s disease beyond APOE ε4: A systematic review of Alzheimer’s genetic risk scores.
Translational Psychiatry 2018; 8:166.

Klett H, Balavarca Y, Toth R, Gigic B, Habermann N, Scherer D, Schrotz-King P, Ulrich A, Schirmacher P, Herpel E, Brenner H, Ulrich C, Michels KB, Busch H, Boerries M.
Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles.
Epigenetics 2018; 13:386-397.

Eyl RE, Koch-Gallenkamp L, Jansen L, Walter V, Carr PR, Hoffmeister M, Chang-Claude J, Brenner H, Arndt V.
Potential determinants of physical inactivity among long-term colorectal cancer survivors.
Journal of Cancer Survivorship 2018; 12:679-690.

Went M, Sud A, Försti A, Halvarsson BM, Weinhold N,…, the PRACTICAL consortium*,…, Morgan GJ, Hemminki K, Nilsson B, Houlston RS.
Identification of multiple risk loci and regulatory mechnisms influencing susceptibility to multiple myeloma.
Nature Communications 2018; 9:3707.
*Collaborator from DKFZ: Brenner H

Niedermaier T, Weigl K, Gies A, Hoffmeister M, Brenner H.
Accuracy of a fecal immunochemical test according to outside temperature and travel time.
Clinical Epidemiology 2018; 10:1203-1213.

Mons U, Gredner T, Behrens G, Stock C, Brenner H.
Cancers due to smoking and high alcohol consumption.
Deutsches Ärzteblatt International 2018; 115:571-577.

Behrens G, Gredner T, Stock C, Leitzmann MF, Brenner H, Mons U.
Cancers due to excess weight, low physical activity, and unhealthy diet.
Deutsches Ärzteblatt International 2018; 115:578-585.

Gredner T, Behrens G, Stock C, Brenner H, Mons U.
Cancers due to infection and selected environmental factors.
Deutsches Ärzteblatt International 2018; 115:586-593.

Weberpals J, Jansen L, Silversmit G, Verbeeck J, van der Geest L, Vissers PAJ, Zadnik V, Brenner H.
Comparative performance of a modified landmark approach when no time of treatment data are available within oncological databases: exemplary cohort study among resected pancreatic cancer patients.
Clinical Epidemiology 2018; 10:1109-1125.

Kather JN, Suarez-Carmona M, Charoentong P, Weis CA, Hirsch D, Bankhead P, Horning M, Ferber D, Kel I, Herpel E, Schott S, Zörnig I, Utikal J, Marx A, Gaiser T, Brenner H, Chang-Claude J, Hoffmeister M, Jäger D, Halama N.
Topography of cancer-associated immune cells in human solid tumors.
eLife 2018; 7:e36967.

Tikk K, Czock D, Haefeli WE, Kopp-Schneider A, Brenner H.
Clinical trial protocol of the ASTER trial: a double-blind, randomized, placebo-controlled phase III trial evaluating the use of acetylsalicylic acid (ASA) for enhanced early detection of colorectal neoplasms.
BMC Cancer 2018; 18:914.

Forman D, Bauld L, Bonanni B, Brenner H, Brown K, Dillner J, Kampman E, Manczuk M, Riboli E, Steindorf K, Storm H, Espina C, Wild CP.
Time for a European initiative for research to prevent cancer: A manifesto for Cancer Prevention Europe (CPE).
Journal of Cancer Policy 2018; 17:15-23.

Schumacher FR, Al Olama AA, Berndt SI, Benlloch S, Ahmed M,…, Brenner H,…, Henderson BE, Kote-Jarai Z, Haiman CA, Eeles RA.
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
Nature Genetics 2018; 50:928-936.

Wu L, Shi W, Long J, Guo X, Michailidou K,..., Arndt V,…, Brenner H,…, Kraft P, Easton DF, Chenevix-Trench G, Zheng W.
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.
Nature Genetics 2018; 50:968-978.

Gies A, Cuk K, Schrotz-King P, Brenner H.
Fecal immunochemical test for hemoglobin in combination with fecal transferrin in colorectal cancer screening.
United European Gastroenterology Journal 2018; 6:1223-1231.

Rösch T, Altenhofen L, Kretschmann J, Hagen B, Brenner H, Pox C, Schmiegel W, Theilmeier A, Aschenbeck J, Tannapfel A, von Stillfried D, Zimmermann-Fraedrich K, Wegscheider K.
Risk of malignancy in adenomas detected during screening colonoscopy.
Clinical Gastroenterology and Hepatology 2018; 16:1754-1761.

Huang L, Jansen L, Balavarca Y, Babaei M, van der Geest L, Lemmens V, Van Eycken L, De Schutter H, Johannesen TB, Primic-Zakelj M, Zadnik V, Besselink MG, Schrotz-King P, Brenner H.
Stratified survival of resected and overall pancreatic cancer patients in Europe and USA in the early 21st century: a large international population-based study.
BMC Medicine 2018; 16:125.

Heinrichs SKM, Hess T, Becker J, Hamann L, Vashist YK, Butterbach K, Schmidt T, Alakus H, Krasniuk I, Höblinger A, Lingohr P, Ludwig M, Hagel AF, Schildberg CW, Veits L, Gyvyte U, Weise K, Schüller V, Böhmer A, Schröder J, Gehlen J, Kreuser N, Hofer S, Lang H, Lordick F, Malfertheiner P, Moehler M, Pech O, Vassos N, Rodermann E, Izbicki JR, Kruschewski M, Ott K, Schumann RR, Vieth M, Mangold E, Gasenko E, Kupcinskas L, Brenner H, Grimminger P, Bujanda L, Sopena F, Espinel J, Thomson C, Perez-Aisa A, Campo R, Geijo F, Collette D, Bruns C, Messerle K, Gockel I, Nöthen MM, Lippert H, Ridwelski K, Lanas A, Keller G, Knapp M, Leja M, Kupcinskas J, Garcia-Gonzalez MA, Venerito M, Schumacher J.
Evidence for PTGER4, PSCA and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level.
Cancer Medicine 2018; 7:5057-5065.

Gao X, Zhang Y, Mons U, Brenner H.
Leukocyte telomere length and epigenetic-based mortality risk score: associations with all-cause mortality among older adults.
Epigenetics 2018; 13:846-857.

Matejcic M, Saunders E, Dadaev T, Brook M, Wang K,…, Brenner H,…, Eeles R, Kote-Jarai Z, Conti D, Haiman C.
Germline variation at 8q24 and prostate cancer risk in men of European ancestry.
Nature Communications 2018; 9:4616.

Stock C, Mons U, Brenner H.
Projection of cancer incidence rates and case numbers until 2030: a probabilistic approach applied to German cancer registry data (1999-2013).
Cancer Epidemiology 2018; 57:110-119.

GBD 2016 Alcohol Collaborators.*
Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.
Lancet 2018; 392:1015-1035.
*Collaborator from DKFZ: Brenner H

GBD 2017 Mortality Collaborators.*
Global, regional, and national age-sex-specific mortality and life expectancy, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017.
Lancet 2018; 392:1684-1735.
*Collaborator from DKFZ: Brenner H

GBD 2017 Causes of Death Collaborators.*
Global, regional, and national age-sex-specific mortality for 282 causes of death, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017.
Lancet 2018; 392:1736-1788.
*Collaborator from DKFZ: Brenner H

GBD 2017 Disease and Injury Incidence and Prevalence Collaborators.*
Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.
Lancet 2018; 392:1789-1858.
*Collaborators from DKFZ: Brenner H

GBD 2017 DALYs and HALE Collaborators.*
Global, regional, and national disability-adjusted life years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.
Lancet 2018; 392:1859-1922.
*Collaborators from DKFZ: Brenner H

GBD 2017 Risk Factor Collaborators.*
Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.
Lancet 2018; 392:1923-1994.
*Collaborator from DKFZ: Brenner H

GBD 2017 Population and Fertility Collaborators.*
Population and fertility by age and sex for 195 countries and territories, 1950-2017: a systematic analysis for the Global Burden of Disease 2017.
Lancet 2018; 392:1995-2051.
*Collaborator from DKFZ: Brenner H

Wang X, Chan AT, Slattery ML, Chang-Claude J, Potter JD, Gallinger S, Caan B, Lampe JW, Newcomb PA, Zubair N, Hsu L, Schoen RE, Hoffmeister M, Brenner H, Le Marchand L, Peters U, White E.
Influence of smoking, body mass index, and other factors on the preventive effect of nonsteroidal anti-inflammatory drugs on colorectal cancer risk.
Cancer Research 2018; 78:4790-4799.

NCD Risk Factor Collaboration (NCD-RisC)*.
Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants.
International Journal of Epidemiology 2018; 47:872-883i.
*Collaborators on behalf of the ESTHER study: Brenner H, Saum KU, Schöttker B

Chen C, Stock C, Hoffmeister M, Brenner H.
How long does it take until the effects of endoscopic screening on colorectal cancer mortality are fully disclosed? : A Markov model study.
International Journal of Cancer 2018; 143:2718-2724.

Huang L, Jansen L, Balavarca Y, van der Geest L, Lemmens V, van Eycken L, De Schutter H, Johannesen TB, Primic-Zakelj M, Zadnik V, Mägi M, Pulte D, Schrotz-King P, Brenner H.
Non-surgical therapies for resected and unresected pancreatic cancer in Europe and USA in 2003-2014: a large international population-based study.
International Journal of Cancer 2018; 143:3227-3239.

Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Akinyemiju TF, Al Lami FH, Alam T,…, Brenner H,…, Yonemoto N, Younis MZ, Murray CJL, Naghavi M.
Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2016: a systematic analysis for the Global Burden of Disease Study.
JAMA Oncology 2018; 4:1553-1568.

Muhlack DC, Hoppe LK, Stock C, Haefeli WE, Brenner H, Schöttker B.
The associations of geriatric syndromes and other patient characteristics with the current and future use of potentially inappropriate medications in a large cohort study.
European Journal of Clinical Pharmacology 2018; 74:1633-1644.

Finke I, Behrens G, Weißer L, Brenner H, Jansen L.
Socioeconomic differences and lung cancer survival – systematic review and meta-analysis.
Frontiers in Oncology 2018; 8:536.

Xuan Y, Gào X, Holleczek B, Brenner H, Schöttker B.
Prediction of myocardial infarction, stroke and cardiovascular mortality with urinary biomarkers of oxidative stress: Results from a large cohort study.
International Journal of Cardiology 2018; 273:223-229.

Weberpals J, Jansen L, Müller OJ, Brenner H.
Long term heart-specific mortality among 347,476 breast cancer patients treated with radiotherapy or chemotherapy: A registry-based cohort study.
European Heart Journal 2018; 39:3896-3903.

Dai JY, Peters U, Wang X, Kocarnik J, Chang-Claude J, Slattery ML, Chan A, Lemire M, Berndt SI, Casey G, Song M, Jenkins MA, Brenner H, Thrift A, White E, Hsu L.
Diagnostics of pleiotropy in Mendelian randomization studies: Global and individual tests for direct effects.
American Journal of Epidemiology 2018; 187:2672-2680.

Lin HY, Huang PY, Chen DT, Sellers TA, Pow-Sang J, Eeles R, Easton D, Kote-Jarai Z, Al Olama AA, Benlloch S, Muir K, Giles GG, Wiklund F, Gronberg H, Haiman CA, Schleutker J, Nordestgaard BG, Travis RC, Hamdy F, Neal DE, Pashayan N, Khaw KT, Stanford JL, Blot WJ, Thibodeau SN, Maier C, Kibel AS, Cybulski C, Cannon-Albright L, Brenner H, Kaneva R, Batra J, Teixeira MR, Pandha H, Lu YJ, the PRACTICAL consortium, Park JY.
AA9int: SNP interaction pattern search using non-hierarchical additive model set.
Bioinformatics 2018; 34:4141-4150.

Peng L, Weigl K, Boakye D, Brenner H.
Risk scores for predicting advanced colorectal neoplasia in the average-risk population: A systematic review and meta-analysis.
American Journal of Gastroenterology 2018; 113:1788-1800.

Qian J, Tikk K, Weigl K, Balavarca Y, Brenner H.
Fibroblast growth factor 21 as a circulating biomarker at various stages of colorectal carcinogenesis.
British Journal of Cancer 2018; 119:1374-1382.

Carr PR, Weigl K, Jansen L, Walter V, Erben V, Chang-Claude J, Brenner H, Hoffmeister M.
Healthy lifestyle factors associated with lower risk of colorectal cancer irrespective of genetic risk.
Gastroenterology 2018; 155:1805-1815.

Parmar P, Lowry E, Cugliari G, Sudermann M, Wilson R,…, Zhang Y,…, Schöttker B,…, Brenner H, Verweij N, Li S, Chambers JC, Järvelin MR, Sebert S, for the GLOBAL Meth QTL consortium.
Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults.
EBioMedicine 2018; 38:206-216.

Brenner H, Chen C.
The colorectal cancer epidemic: challenges and opportunities for primary, secondary and tertiary prevention.
British Journal of Cancer 2018; 119:785-792.

Amitay EL, Krilaviciute A, Brenner H.
Systematic review: Gut microbiota in fecal samples and detection of colorectal neoplasms.
Gut Microbes 2018; 9:293-307.

Yu H, Guan Z, Cuk K, Brenner H, Zhang Y.
Circulating MicroRNA biomarkers for lung cancer detection in Western populations.
Cancer Medicine 2018; 7:4849-4862.

Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for the International Agency for Research on Cancer Handbook Working Group*.
The IARC perspective on colorectal cancer screening.
The New England Journal of Medicine 2018; 378:1734-1740.
*Collaborator from DKFZ: Hoffmeister M

Stock C, Mons U, Brenner H.
Projection of cancer incidence rates and case numbers until 2030: a probabilistic approach applied to German cancer registry data (1999-2013).
Cancer Epidemiology 2018; 57:110-119.



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