Original- und Übersichtsarbeiten im Jahr 2016 und im Druck

Brenner H, Castro FA, Eberle A, Emrich K, Holleczek B, Katalinic A, Jansen L., for the GEKID Cancer Survival Workgroup.
Death certificate only proportions should be age adjusted in studies comparing cancer survival across populations and over time.
European Journal of Cancer 2016; 52:102-108.

Thompson DJ, O'Mara TA, Glubb DM, Painter JN, Cheng T, ..., Brenner H, ..., Tomlinson I, Dowsett M, Easton DF, Spurdle AB.
CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer.
Endocrine-Related Cancer 2016; 23:77-91.

Florath I, Butterbach K, Heiss JA, Bewerunge-Hudler M, Zhang Y, Schöttker B, Brenner H.
Type 2 diabetes and leucocyte DNA methylation: An epigenome-wide association study in over 1500 older adults.
Diabetologia 2016; 59:130-138.

Zhang Y, Schöttker B, Florath I, Stock C, Butterbach K, Holleczek B, Mons U, Brenner H.
Smoking-associated DNA methylation biomarkers and their predictive value for all-cause and cardiovascular mortality.
Environmental Health Perspectives 2016; 124:67-74.

Lei J, Rudolph A, Moysich KB, Behrens S, Goode EL, ..., Brenner, Arndt V, ..., Ambrosone CB, Swerdlow A, Jones M, Chang-Claude J.
Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium.
Human Genetics 2016; 135:137-154.

Carr PR, Jansen L, Walter V, Kloor M, Roth W, Bläker H, Chang-Claude J, Brenner H, Hoffmeister M.
Association of red and processed meat with survival after colorectal cancer and differences according to timing of dietary assessment.
American Journal of Clinical Nutrition 2016; 103:192-200.

Mons U, Muscat JE, Modesto J, Richie JP, Brenner H.
Effect of smoking reduction and cessation on the plasma levels of the oxidative stress biomarker glutathione - post-hoc analysis of data from a smoking cessation trial.
Free Radical Biology & Medicine 2016; 91:172-177.

Müezzinler A*, Mons U*, Dieffenbach AK, Butterbach K, Saum KU, Schick M, Stammer H, Boukamp P, Holleczek B, Stegmaier C, Brenner H.
Body mass index and leukocyte telomere length dynamics among older adults: Results from the ESTHER cohort.
Experimental Gerontology 2016; 74:1-8..
*=equal contribution.

Phipps A, Passarelli MN, Chan AT, Harrison TA, Jeon J, Hutter CM, Berndt SI, Brenner H, Caan BJ, Campbell PT, Chang-Claude J, Chanock SJ, Cheadle JP, Curtis KR, Duggan D, Fisher D, Fuchs CS, Gala M, Giovannucci EL, Hayes RB, Hoffmeister M, Hsu L, Jacobs EJ, Jansen L, Kaplan R, Kap L, Maughan TS, Potter JD, Schoen RE, Seminara D, Slattery ML, West H, White E, Peters U, Newcomb PA.
Common genetic variation and survival after colorectal cancer diagnosis: a genome-wide analysis.
Carciogenesis 2016; 37:87-95.

Carr P, Walter V, Brenner H, Hoffmeister M.
Meat subtypes and their association with colorectal cancer: systematic reveiw and meta-analysis.
International Journal of Cancer 2016; 138:293-302.

Schöttker B, Saum KU, Jansen EHJM, Holleczek B, Brenner H.
Associations of metabolic, inflammatory and oxidative stress markers with total morbidity and multi-morbidity in a large cohort of older German adults.
Age and Ageing 2016; 45:127-135.

Pattaro C, Teumer A, Gorski M, Chu AY, Li M, ..., Brenner H, ..., Butterbach K, ..., Köttgen A, Kao L, Fox CS.
Genetic association at 53 loci highlight cell types and biologic pathways for kidney function.
Nature Communications 2016; 7:10023.

Garcia-Albeniz X, Rudolph A, Hutter C, White E, Lin Y, ..., Brenner H, ..., Hoffmeister M, Butterbach K, ..., Hsu L, Chan A, Peters U, Chang-Claude J.
CYP24A1 variant modifies the association between use of estrogen plus progestogen therapy and colorectal cancer.
British Journal of Cancer 2016; 114:221-229.

Brenner H, Jansen L.
Timely disclosure of progress in long-term cancer survival: The boomerang method substantially improved estimates in a comparative study.
Journal of Clinical Epidemiology 2016;70:224-232.

Meeks HD, Song H, Michailidou K, Bolla MK, Dennis J, ..., Brenner H, Butterbach K, ..., Couch FJ, Spurdle AB, Goldgar DE.
BRCA2 polymorphic stop codon K3326X and the risk of breast, prostate and ovarian cancers.
Journal of the National Cancer Institute 2016; 108:djv315.

Zhang Y, Florath I, Saum KU, Brenner H.
Self-reported smoking, serum cotinine, and blood DNA methylation.
Environmental Research 2016; 146:395-403.

Horvat P, Gardiner J, Kubinova R, Pajak A, Tamosiunas, Schöttker B, Pikhart H, Peasey A, Jansen E, Bobak M.
Serum folate, vitamin B-12 and cognitive function in middle and older age: The HAPIEE study.
Experimental Gerontology 2016; 76:33-38.

Brenner H, Schrotz-King P, Holleczek B, Katalinic A, Hoffmeister M.
Declining bowel cancer incidence and mortality in Germany - an analysis of time trends in the first ten years after the introduction of screening colonoscopy.
Deutsches Ärzteblatt International 2016; 113:101-106.

Jia M, Gao X, Zhang Y, Hoffmeister M, Brenner H.
Different definitions of CpG island methylator phenotype and outcomes of colorectal cancer: a systematic review.
Clinical Epigenetics 2016; 8:25.

Boehlen F, Herzog W, Maatouk I, Saum K-U, Brenner H, Wild B.
Behandlungswünsche von älteren Menschen mit psychischen Erkrankungen.
Zeitschrift für Gerontologie und Geriatrie 2016; 49:120-125.

Bock JO, Heider D, Matschinger H, Brenner H, Saum KU, Haefeli WE, König HH.
Willingness to pay for health insurance among the elderly population in Germany.
European Journal of Health Economics 2016; 17:149-158.

Teumer A, Tin A, Sorice R, Gorski M, Yeo NC, ..., Dieffenbach AK, ..., Brenner H, ..., Butterbach K, ..., Böger CA, Fox CS, Pattaro C, Köttgen A.
Genome-wide association studies identify genetic loci associated with albuminuria in diabetes.
Diabetes 2016; 65:803-817.

Petridis C, Brook MN, Shah V, Kohut K, Gorman P, ..., Brenner H, Arndt V, ..., Tomlinson I, Roylance R, Garcia-Closas M, Sawyer EJ.
Genetic predisposition to ductal carcinoma in situ of the breast.
Breast Cancer Research 2016; 18:22.

Logan CA, Thiel L, Striebel S, Reister F, Brenner H, Rothenbacher D, Genuneit J.
Delivery mode, duration of labor, and cord blood adiponectin, leptin, and C-reactive protein: Results of the population-based Ulm Birth Cohort Studies.
PLoS ONE 2016;11:e0149918.

Schöttker B, Rathmann W, Herder C, Thorand B, Wilsgaard T, Njølstad I, Siganos G, Mathiesen EB, Saum KU, Peasey A, Feskens E, Boffetta P, Trichopoulou A, Kuulasmaa KK, Kee F, Brenner H.
HbA1c levels in non-diabetic older adults - No J-shaped associations with primary cardovascular events, cardiovascular and all-cause mortality after adjustment for confounders. A meta-analysis of individual participant data from six cohort studies.
BMC Medicine 2016; 14:26.

Chen T, Fallah M, Brenner H, Jansen L, Mai E, Castro F, Katalinic A, Emrich K, Holleczek B, Geiss K, Eberle A, Sundquist K, Hemminki K, for the GEKID Cancer Survival Working Group.
Risk of second primary cancers in multiple myeloma survivors in German and Swedish cancer registries.
Scientific Reports 2016; 6:22084.

Breitling LP, Saum KU, Perna L, Schöttker B, Holleczek B, Brenner H.
Frailty is associated with the epigenetic clock but not with telomere length in a German cohort.
Clinical Epigenetics 2016; 8:21.

Gdynia G, Sauer SW, Kopitz J, Fuchs D, Duglova K, Ruppert T, Miller M, Pahl J, Cerwenka A, Enders M, Mairlbäurl H, Kaminski MM, Penzel R, Zhang C, Fuller JC, Wade R Benner A, Chang-Claude J, Brenner H, Hoffmeister M, Zentgraf H, Schirmacher P, Roth W.
The HMGB1 protein induces a metabolic type of tumor cell death by blocking aerobic respiration.
Nature Communication 2016; 7:10764.

Pulte D, Castro F, Jansen L, Luttmann S, Holleczek B Nennecke A, Ressing M, Katalinic A, Brenner H.
Trends in survival of chronic lymphocytic leukemia patients in Germany and the United States in the first decade of th 21st century.
Journal of Hematology & Oncology 2016; 9:28.

Dunning AM, Michailidou K, Kuchenbaecker KB, Thompson D, French JD, …, Arndt V, Brenner H, …, Chenevix-Trench G, Antoniou AC, Easton DF, Edwards SL.
Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.
Nature Genetics 2016; 48:374-86.

Ordóñez-Mena JM, Schöttker B, Mons U, Jenab M, Freisling H, Bueno-de-Mesquita B, O’Doherty MG, Scott A, Kee F, Stricker BH, Hofmann A, de Keyser CE, Ruiter R, Söderberg S, Jousilahti P, Kuulasmaa K, Freedman ND, Wilsgaard T, de Groot L, Kampman E, Håkansson N, Orsini N, Wolk A, Nilsson LM, Tjønneland A, Pająk A, Malyutina S, Kubínová R, Tamosiunas A, Bobak M, Katsoulis M, Oranos P, Boffetta P, Trichopoulou A, Brenner H.
Quantification of the smoking-associated cancer risk with rate advancement periods: meta-analysis of indivivual participant data from cohorts of the CHANCES consortium.
BMC Medicine 2016; 14:62.

Bonilla C, Lewis SJ, Martin RM, Donovan JL, Hamdy FC, Neal DE, Eeles R, Easton D, Kote-Jarai Z, Amin Al Olama A, Benlloch S, Muir K, Giles GG, Wiklund F, Gronberg H, Haiman CA, Schleutker J, Nordestgaard BG, Travis RC, Pashayan N, Khaw KT, Stanford JL, Blot WJ, Thibodeau S, Maier C, Kibel AS, Cybulski C, Cannon-Albright L, Brenner H, Park J, Kaneva R, Batra J, Teixeira MR, Pandha H, Lathrop M, Smith GD. The PRACTICAL consortium.
Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort.
BMC Medicine 2016; 14:66.

Gusev A, Shi H, Kichaev G, Pomerantz M, Li F,…, Brenner H,…, Volker Arndt,…, Price AL, Freedman ML, Haiman CA, Pasaniuc B.
Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.
Nature Communications 2016; 7:10979.

Werner S, Krause F, Rolny V, Strobl M, Morgenstern D, Datz C, Chen H, Brenner H.
Evaluation of a 5-marker blood test for colorectal cancer early detection in a colorectal cancer screening setting.
Clinical Cancer Research 2016; 22:1725-1733.

Ordóñez-Mena JM, Schöttker B, Fedirko V, Jenab M, Olsen A, Halkjær J, Kampman E, de Groot L, Jansen E, Bas Bueno-de-Mesquita H, Peeters PH, Siganos G, Wilsgaard T, Perna L, Holleczek B, Pettersson-Kymmer U, Orfanos P, Trichopoulou A, Boffetta P, Brenner H.
Pre-diagnostic vitamin D concentrations and cancer risks in older individuals: an analysis of cohorts participating in the CHANCES consortium.
European Journal of Epidemiology 2016; 31:311-323.

Holleczek B, Brenner H.
Implications from under-reporting, death certificate notifications and trace-back on the recorded incidence of a newly established population-based cancer registry.
Methods of Information in Medicine 2016; 55:182-192.

Bock JO, Konig HH, Brenner H, Haefeli WE, Quinzler R, Matschinger H, Saum KU, Schöttker B, Heider D.
Associations of frailty with health care costs? Results of the ESTHER cohort study.
BMC Health Services Research 2016; 16:128.

Lüthgens K, Albert S, Brenner H.
Unterschiedliche Nachweisgrenzen immunologischer Tests auf Blut im Stuhl unterstreichen die Notwendigkeit der Standardisierung und Qualitätssicherung.
Zeitschrift für Gastroenterologie 2016; 54:299-303.

Kap EJ, Seibold P, Scherer D, Habermann N, Balavarca Y, Jansen L, Zucknick M, Becker N, Hoffmeister M, Ulrich A, Benner A, Ulrich CM, Burwinkel B, Brenner H, Chang-Claude J.
SNPs in transporter and metabolizing genes as predictive markers for oxaliplatin treatment in colorectal cancer patients.
International Journal of Cancer 2016; 138:2993-3001.

Florath I, Schöttker B, Butterbach K, Bewerunge-Hudler M, Brenner H.
Epigenome-wide search for association of serum 25-hydroxyvitamin D concentration with leukocyte DNA methylation in a large cohort of older men.
Epigenomics 2016; 8:487-499.

Zhao Z, Wen W, Michailidou K, Bolla MK, Wang Q,…, Arndt V,…, Brenner H,…, Pharoah P, Hunter D, Easton DF, Zheng W.
Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry.
Cancer Causes Control 2016; 27:679-693.

Merz M, Jansen L, Castro FA, Hillengass J, Salwender H, Weisel K, Scheid C, Luttmann S, Emrich K, Holleczek B, Katalinic A, Nennecke A, Straka C, Langer C, Engelhardt M, Einsele H, Kröger N, Beelen D, Dreger P, Brenner H, Goldschmidt H for the GEKID Cancer Survival Working Group.
Survival of elderly patients with multiple myeloma – Effect of upfront autologous stem cell transplantation.
European Journal of Cancer 2016; 62:1-8.

Weberpals J, Jansen L, Carr P, Hoffmeister M, Brenner H.
Beta blockers and cancer prognosis – the role of immortal time bias: A systematic review and meta-analysis.
Cancer Treatment Reviews 2016; 47:1-11.

Tsilidis KK, Papadimitriou N, Capothanassi D, Bamia C, Benetou V, Jenab M, Freisling H, Kee F, Nelen A, O’Doherty MG, Scott A, Soerjomataram I, Tjonneland A, May AM, Quirós JR, Pettersson-Kymmer U, Brenner H, Schöttker B, Ordónez-Mena J, Dieffenbach AK, Eriksson S, Bogeberg Mathiesen E, Njolstad I, Siganos G, Wilsgaard T, Boffetta P, Trichopoulos D, Trichopoulou A.
Burden of cancer in a large consortium of prospective cohorts in Europe.
Journal of the National Cancer Institute 2016; 108:djw127.

Pelttari LM, Khan S, Vuorela M, Kiiski JI, Vilske S,…, Brenner H, Arndt V,…, Mattson J, Blomqvist C, Aittomäki K, Nevanlinna H.
RAD51B in Familial Breast Cancer.
PLOS ONE 2016; 11:e0153788.

Werner S, Chen H, Butt J, Michel A, Knebel P, Holleczek B, Zornig I, Eichmüller SB, Jäger D, Pawlita M, Waterboer T, Brenner H.
Evaluation of the diagnostic value of 64 simultaneously measured autoantibodies for early detection of gastric cancer.
Scientific Reports 2016; 6:25467.

Couch F, Kuchenbaecker K, Michailidou K, Mendoza-Fandino G, Nord S,..., Brenner H,..., Monteiro A, Garcia-Closas M, Easton D, Antoniou A.
Identification of four novel susceptibility loci for estrogen receptor negative breast cancer.
Nature Communications 2016; 7:11375.

NCD Risk Factor Collaboration (NCD-RisC).*
The weight of the world - trends in adult body mass index in 200 countries since 1975: pooled analysis of 1,698 population-based measurement studies with 19.2 million participants.
The Lancet 2016; 387:1377-1396.
*Collaborators on behalf of the ESTHER study: Brenner H, Saum KU.

Perna L, Mons U, Schöttker B, Brenner H.
Association of cognitive function and serum uric acid: Are cardiovascular diseases a mediator among women?
Experimental Gerontology 2016; 81:37-41.

Eisemann N, Jansen L, Castro FA, Chen T, Eberle A, Nennecke A, Zeissig SR, Brenner H, Katalinic A, for the GEKID Cancer Survival Working Group.
Survival from non-melanoma skin cancer in Germany.
British Journal of Dermatology 2016; 174:713-714.

Chen H, Werner S, Butt J, Zörnig I, Knebel P, Michel A, Eichmüller SB, Jäger D, Waterboer T, Pawlita M, Brenner H.
Prospective evaluation of 64 serum autoantibodies as biomarkers for early detection of colorectal cancer in a true screening setting.
Oncotarget 2016; 7:16420-16432.

Chen X*, Schöttker B*, Castro F, Chen H, Zhang Y, Holleczek B, Brenner H.
Association of Helicobacter pylori infection and chronic athrophic gastritis with risk of colonic, pancreatic and gastric cancer: a ten-year follow-up of the ESTHER cohort study.
Oncotarget 2016; 7:17182-17193.
*shared first authorship

NCD Risk Factor Collaboration (NCD-RisC)*
Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants.
The Lancet 2016; 387:1513-1530.
*Collaborators on behalf of the ESTHER study: Brenner H, Saum KU.

Lechner S, Herzog W, Boehlen F, Maatouk I, Saum KU, Brenner H, Wild B.
Control preferences in treatment decisions among older adults – results of a large population-based study.
Journal of Psychosomatic Research 2016; 86:28-33.

Niedermaier T, Weigl K, Hoffmeister M, Brenner H.
Fecal immunochemical tests combined with other stool tests for colorectal cancer and advanced adenoma detection. A systematic review.
Clinical and Translational Gastroenterology 2016; 7:e175.

Babaei M, Balavarca Y, Jansen L, Gondos A, Lemmens V,…, Ulrich A, Ulrich CM, Schrotz-King P, Brenner H.
Minimally invasive colorectal cancer surgery in Europe: Implementation and outcomes.
Medicine 2016; 95:e3812.

Logan C, Zittel T, Striebel S, Reister F, Brenner H, Rothenbacher D, Genuneit J.
Changing societal and lifestyle factors and breastfeeding patterns over time.
Pediatrics 2016; 137:e20154473.

Khodadost M, Yavari P, Khodadost B, Babaei M, Sarvi F, Khatibi SR, Barzegari S.
Estimating the esophagus cancer incidence rate in Ardabil, Iran: A capture-recapture method.
Iran Journal of Cancer Prevention 2016; 9:e3972.

Walter V, Jansen L, Ulrich A, Roth W, Bläker H, Chang-Claude J, Hoffmeister M, Brenner H.
Alcohol consumption and survival of colorectal cancer patients: population-based study from Germany.
The American Journal of Clinical Nutrition 2016; 103:1497-1506.

Cheng THT, Thompson DJ, O’Mara TA, Painter JN, Glubb DM,…, Burwinkel B, Brenner H,…, Chang-Claude J,…, Edwards SL, Easton DF, Tomlinson I, Spurdle AB.
Five endometrial cancer risk loci identified through genomewide association analysis.
Nature Genetics 2016; 48:667-674.

Easton DF, Lesueur F, Decker B, Michailidou K, Li J, ..., Arndt V, ..., Brenner H, ..., Le Calvez-Kelm F, Goldgar DE, Tavtigian SV, Chenevix-Trenche G.
No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing.
Journal of Medical Genetics 2016; 53:298-309.

Gondos A, Jansen L, Heil J, Schneeweiss A, Voogd AC, Frisell J, Fredriksson I, Johannsson U, Tvedskof TF, Jensen MB, Balslev E, Hartmann-Johnsen OJ, Sant M, Baili P, Agresti R, van de Velde T, Broeks A, Nogaret JM, Bourgois P, Moreau M, Mátrai Z, Sávolt A, Nagy P, Kásler M, Schrotz-King P, Ulrich C, Brenner H.
Time trends in axilla management among early breast cancer patients: persisting major variation in clinical practice across European centers.
Acta Oncologica2016; 55:712-719.

Ovarian Cancer Association Consortium, Breast Cancer Association Consortium and Consortium of Modifiers of BRCA1 and BRCA2, Hollestelle A, van der Baan F, Berchuck A, Johnatty SE, Aben KK, Agnarsson BA, …, Arndt V, …, Brenner H, …, Pharoah PDP, Rookus MA, Hooning MJ, Goode EL.
No clinical utility of KRAS Variant rs61764370 for ovarian or breast cancer.
Gynecologic Oncology 2016; 141:386-401.

Meid AD, Quinzler R, Groll A, Wild B, Saum K-U, Schöttker B, Heider D, König H-H, Brenner H, Haefeli WE.
Longitudinal evaluation of medication underuse in older outpatients and its association with quality of life.
European Journal of Clinical Pharmacology 2016; 72:877-885.

Brenner H.
Darmkrebs-Prävention: Möglichkeiten – Grenzen – Akzeptanz
Onkologie heute 2016; 15 (4):19-21.

Chen H, Knebel P, Brenner H.
Empirical evaluation demonstrated importance of validating biomarkers for early detection of cancer in screening settings to limit the number of false positive findings.
Journal of Clinical Epidemiology 2016; 75:108-114.

Perna L, Zhang Y, Mons U, Holleczek B, Saum KU, Brenner H.
Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a german case cohort.
Clinical Epigenetics 2016; 8:64.

Pulte D, Jansen L, Castro F, Brenner H.
Changes in survival of older patients with hematologic malignancies in the early 21st century.
Cancer 2016; 122:2031-2040.

Zeng C, Matsuda K, Jia WH, Chang J, Kweon SS,…, Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Brenner H,…, Shu XO, Lin D, Zeng YX, Zheng W.
Identification of susceptibility loci and genes for colorectal cancer risk.
Gastroenterology 2016; 150:1633-1645.

Sirri E, Castro F, Kieschke J, Jansen L, Emrich K, Gondos A, Holleczek B, Katalinic A, Urbschat I, Vohmann C, Brenner H for the GEKID Cancer Survival Group.
Recent trends in survival of patients with pancreas cancer in Germany and the United States.
Pancreas 2016; 45:908-914.

Du M, Jiao S, Bien SA, Gala M, Abecasis G,…, Brenner H,…, Hoffmeister M,…, Chan AT, White E, Berndt SI, Peters U.
Fine-Mapping of common genetic variants associated with colorectal tumor risk identified potential functional variants.
PLoS One 2016; 11(7):e0157521.

Dallmeier D, Brenner H, Mons U, Rottbauer W, Koenig W, Rothenbacher D.
Growth Differentiation Factor 15, its 12-month relative change, and risk of cardiovascular events and total mortality in patients with stable coronary heart disease: 10-year follow-up of the KAROLA Study.
Clinical Chemistry 2016; 62:982-992.

Pulte D, Jansen L, Castro FA, Krilaviciute A, Katalinic A, Barnes B, Ressing M, Holleczek B, Luttmann S, Brenner H, for the GEKID Cancer Survival Working Group.
Survival in patients with acute myeloblastic leukemia in Germany and the United States: Major differences in survival in young adults.
International Journal of Cancer 2016; 139:1289-1296.

Shi J, Zhang Y, Zheng W, Michailidou K, Ghoussaini M, …, Arndt V, …, Brenner H, …, Antoniou AC, Easton DE, Cai Q, Long J.
Fine-scale mapping of 8q24 locus identifies multiple risk variants for breast cancer.
International Journal of Cancer 2016; 139:1303-1317.

Bull CJ, Bonilla C, Holly JMP, Perks CM, Davies N, Haycock P, Yu OHYY, Richards B, Eeles R, Easton D, Kote-Jarai Z, Al Olama AA, Benlloch S, Muir K, Giles GG, MacInnis RJ, Wiklund F, Gronberg H, Haiman CA, Schleutker J, Nordestgaard BG, Travis RC, Neal D, Pashayan N, Khaw KT, Stanford JL, Blot WJ, Thibodeau S, Maier C, Kibel AS, Cybulski C, Cannon-Albright L, Brenner H, Park J, Kaneva R, Batra J, Teixeira MR, Michael A, Pandha H, and the PRACTICAL Consortium, Smith GD, Lewis SJ, Martin RM.
Blood lipids and prostate cancer: a Mendelian randomization analysis.
Cancer Medicine 2016; 5:1125-1136.

Bonilla C, Lewis SJ, Rowlands MA, Gaunt TR, Smith GD,…, Brenner H,…, the PRACTIAL consortium, Lathrop M, Martin RM, Holly JMP.
Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: genetic variants as instruments for circulating levels.
International Journal of Cancer 2016; 139:1520-1533.

Brück K, Stel VS, Gambaro G, Hallan S, Völzke H, Ärnlöv J, Kastarinen M, Guessous I, Vinhas J, Stengel B, Brenner H, Chudek J, Romundstad S, Tomson C, Gonzalez AO, Bello AK, Ferrieres J, Palmieri L, Browne G, Capuano V, Van Biesen W, Zoccali C, Gansevoort R, Navis G, Rothenbacher D, Ferraro PM, Nitsch D, Wanner C, Jager KJ.
Chronic kidney disease prevalence varies across European general population.
Journal of the American Society of Nephrology 2016; 27:2135-2147.

O'Doherty MG, Cairns K, O'Neill V, Lamrock F, Jørgensen T, Brenner H, Schöttker B, Wilsgaard T, Siganos G, Kuulasmaa K, Boffetta P, Trichopoulou A, Kee F, on behalf of the CHANCES consortium.
Effect of major lifestyle risk factors, independent and jointly, on life expectancy with and without cardiovascular disease: results from the Consortium on Health and Ageing Network of Cohorts in Europe and the United States (CHANCES).
European Journal of Epidemiology 2016; 31:455-468.

Maatouk I, Herzog W, Böhlen F, Quinzler R, Löwe B, Saum KU, Brenner H, Wild B.
Association of hypertension with depression and generalized anxiety symptoms in a large population-based sample of older adults.
Journal of Hypertension 2016; 34:1711-1720.

Abubakar M, Orr N, Howat WJ, Daley F, Coulson P, Blows F, Ali HR, Benitez J, Milne R, Brenner H, Stegmaier C, Mannermaa A, Chang-Claude J, Rudolph A, Sinn P, Couch FJ, Devilee P, Figueroa J, Sherman ME, Lissowska J, Hewitt S, Eccles D, Hooning MJ, Hollestelle A, Martens JWM, Van Deurzen CHM, kConFab Investigators, Bolla MK, Wang Q, Jones M, Schoemaker M, Broeks A, Van Leeuwen FE, Van ´t Veer L, Easton D, Swerdlow AJ, Dowsett M, Pharoah PD, Schmidt MK, Garcia-Closas M.
High-throughput automated scoring of Ki67 in breast cancer tissue microarrays in the Breast Cancer Association Consortium (BCAC).
Journal of Pathology: Clinical Research 2016; 2:138-153.

Schmidt M, Hogervorst F, van Hien R, Cornelissen S, Broeks A,..., Arndt V,..., Brenner H,..., Nevanlinna H, Dörk T, Bojesen S, Easton D.
Age- and tumor subtype-specific breast cancer risk estimates for CHEK2*1100delC carriers.
Journal of Clinical Oncology 2016; 34:2750-2760.

Brenner H, Jansen L, Ulrich A, Chang-Claude J, Hoffmeister M.
Survival of patients with symptom- and screening-detected colorectal cancer.
Oncotarget 2016; 7:44695-44704.

Yang B, Thrift AP, Figueiredo JC, Jenkins MA, Schumacher FR, Lin Y, Win AK, Limburg PJ, Berndt SI, Brenner H, Chan AT, Chang-Claude J, Hoffmeister M, Hudson TJ, Le Marchand L, Newcomb PA, Slattery ML, White E, Peters U, Casey G, Campbell PT.
Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer.
Cancer Epidemiology 2016; 44:1-4.

Zeng C, Guo X, Long J, Kuchenbaecker KB, Droit A,…, Arndt V,…, Brenner H,..., Couch FJ, Antoniou AC, Easton DF, Zheng W.
Identification of independent association signals and putative functional variants for breast cancer risk though fine-scale mapping of the 12p11 locus.
Breast Cancer Research 2016; 18:64.

NCD Risk Factor Collaboration (NCD-RisC).
A century of trends in adult human height.
eLife 2016; 5:e13410.

Brenner H, Kretschmann J, Stock C, Hoffmeister M.
Expected long-term impact of screening endoscopy on colorectal cancer incidence: A modelling study.
Oncotarget 2016; 7:48168-48179.

Guo Y, Andersen SW, Shu XO, Michailidou K, Bolla MK,…, Arndt V,…, Brenner H,…, Pharoah P, Hunter D, Easton DF, Zheng W.
Genetically predicted body mass index and breast cancer risk: Mendelian randomization analyses of data from 145,000 women of european descent.
PLOS Medicine 2016; 13:e1002105.

Horne HN, Chung CE, Zhang H, Yu K, Prokunina-Olsson L,…, Brenner H, Arndt V,…, Easton DF, Chanock SJ, Dunning AM, Figueroa J.
Fine-mapping of the 1p11.2 breast cancer susceptibility locus.
PLOS ONE 2016; 11:e0160316.

Leja M, Axon A, Brenner H.
Epidemiology of Helicobacter pylori infection.
Helicobacter 2016; 21 (Suppl 1):3-7.

Dumstrei K, Chen H, Brenner H.
A systematic review of serum autoantibodies as biomarkers for pancreatic cancer detection.
Oncotarget 2016; 7:11151-11164.

Lawrenson K, Kar S, McCue K, Kuchenbaeker K, Michailidou K,…, Arndt V,…, Brenner H,…, Edwards SL, Chenevix-Trench G, Antoniou AC, Gayther SA.
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.
Nature Communications 2016; 7:12675.

Darabi H, Beesley J, Droit A, Kar S, Nord S,…, Arndt V,…, Brenner H,…, Simard J, French JD, Chenevix-Trench G, Dunning AM.
Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs).
Scientific Reports 2016; 6:32512.

Southey MC, Goldgar DE, Winqvist R, Pylkäs K, Couch F,…, Brenner H, Arndt V, Stegmaier C,…, Giles GG, Tavtigian SV, Easton DF, Milne RL.
PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
Journal of Medical Genetics 2016; 53:800-811.

Fehringer G, Kraft P, Pharoah PD, on behalf of Ovarian Cancer Association Consortium (OCAC); Eeles RA, on behalf of The PRACTICAL Consortium; Chatterjee N,…, Brenner H,…, Kaaks R,…, Hunter DJ, Haiman CA, on behalf of African American Breast Cancer Consortium (AABC) and African Ancestry Prostate Cancer Consortium (AAPC); Henderson BE, Hung RJ.
Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations.
Cancer Research 2016; 76:5103-5114.

Kar SP, Beesley J, Al Olama AA, Michailidou K, Tyrer J,..., Brenner H,…, Arndt V,…, Chenevix-Trench G, Eeles R, Pharoah PDP, Lambrechts D.
Genome-wide meta-analyses of breast, ovarian and prostate cancer association studies identify multiple new susceptibility loci shared by at least two cancer types.
Cancer Discovery 2016; 6:1052-1067.

Weigl K, Jansen L, Chang-Claude J, Knebel P, Hoffmeister M, Brenner H.
Family history and the risk of colorectal cancer: the importance of patients’ history of colonoscopy.
International Journal of Cancer 2016; 139:2213-2220.

Saunders EJ, Dadaev T, Leongamornlert DA, Al Olama AA, Benlloch S, Giles GG, Wiklund f, Gronberg H, Haiman CA, Schleutker J, Nordestgaard B, Travis RC, Neal D, Pasayan N, Khaw KT, Stanford JL, Blot WJ, Thibodeau SN, Maier C, Kibel AS, Cybulski C, Canon-Albright L, Brenner H, Park JY, Kaneva R, Batra J, Teixeira MR, Panda H, Govindasami K, Muir K, COGS-CRUK GWAS-ELLIPSE (Part of GAME-ON) Initiative, The UK Genetic Prostate Cancer Study Collaborators, The PRACTICAL Consortium, Easton DF, Eeles RA, Kote-Jarai Z.
Gene and pathway level analyses of germline DNA repair gene variants and prostate cancer susceptibility using the iCOGS genotyping array.
British Journal of Cancer 2016; 114:945-952.

Breitling LP, Saum KU, Schöttker B, Holleczek B, Herth FJ, Brenner H.
Pneumonien in der nicht-institutionalisierten älteren Allgemeinbevölkerung: prospektive Beobachtungsstudie über 11 Jahre.
Deutsches Ärzteblatt 2016; 113:607-614.

Walter V, Jansen L, Hoffmeister M, Ulrich A, Roth W, Bläker H, Chang-Claude J,  Brenner H.
Prognostic relevance of prediagnostic weight loss and overweight at diagnosis in patients with colorectal cancer.
The American Journal of Clinical Nutrition 2016; 104:1110-1120.

Chen LS, Baker T, Hung RJ, Horton A, Culverhouse R,…, Saum KU,…, Brenner H,…, Zhang ZF, Spitz MR, Amos CI, Bierut LJ.
Genetic risk can be decreased: Quitting smoking decreases and delays lung cancer for smokers with high and low CHRNA5 risk genotypes – A meta-analysis.
EBiomedicine 2016; 11:219-226.

Jansen H, König W, Jaensch A, Mons U, Breitling L, Scharnagl H, Stojakovic T, Schunkert H, Brenner H, Rothenbacher D.
Prognostic utility of Galectin-3 for recurrent cardiovascular events during long-term follow-up in patients with stable coronary heart disease. Results of the KAROLA study.
Clinical Chemistry 2016; 62:1372-1379.

Zhang Y, Breitling LP, Balavarca Y, Holleczek B, Schöttker B, Brenner H.
Comparison and combination of blood DNA methylation at smoking-associated genes and at lung cancer related genes in prediction of lung cancer mortality.
International Journal of Cancer 2016; 139:2482-2492.

Gao X, Zhang Y, Breitling L, Brenner H.
Tobacco smoking and methylation of genes related to lung cancer development.
Oncotarget 2016; 7:59017-59028.

Gao X, Zhang Y, Breitling LP, Brenner H.
Relationship of tobacco smoking and smoking-related DNA methylation with epigenetic age acceleration.
Oncotarget 2016; 7:46878-46889.

GBD 2015 Risk Factors Collaborators.*
Global, regional and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 195 countries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.
The Lancet 2016; 388:1659-1724.
*Collaborators from DKFZ: Brenner H, Schöttker B

GBD 2015 Mortality and Causes of Death Collaborators.*
Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015.
The Lancet 2016; 388:1459-1544.
*Collaborators from DKFZ: Brenner H, Schöttker B

Gong J, Hutter CM, Newcomb PA, Ulrich CM, Bien SA, Campbell PT, Baron JA, Berndt SI, Bezieau S, Brenner H, Casey G, Chan AT, Chang-Claude J, Du M, Duggan D, Figueiredo JC, Gallinger S, Giovannucci EL, Haile RW, Harrison TA, Hayes RB, Hoffmeister M, Hopper JL, Hudson TJ, Jeon J, Jenkins MA, Kocarnik J, Küry S, Le Marchand L, Lin Y, Lindor NM, Nishihara R, Ogino S, Potter JD, Rudoph A, Schoen RE, Schrotz-King P, Seminara D, Slattery ML, Thibodeau SN, Thornquist M, Toth R, Wallace R, White E, Jiao S, Lemire M, Hsu L, Peters U, CCFR and GECCO.
Genome-wide interaction analyses between genetic variants and alcohol consumption and smoking for risk of colorectal cancer.
PLOS Genetics 2016; 12:e1006296.

Ghoussaini M, French JD, Michailidou K, Nord S, Beesley J,…, Brenner H, Arndt V,…, Chenevix-Trench G, Easton DF, Dunning AM, Edwards SL.
Evidence that the 5p12 variant rs10941679 confers susceptibility to estrogen receptor positive breast cancer through FGF10 and MRPS30 regulation.
The American Journal of Human Genetics 2016; 99:903-911.

Karami S, Han Y, Pande M, Cheng I, Rudd J,…, Brenner H,…, Zheng W, Chatterjee N, Amos CI, Doherty JA, on behalf of GECCO and the GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, and TRICL.
Telomere structure and maintenance gene variants and risk of five cancer types.
International Journal of Cancer 2016; 139:2655-2670.

Jia M, Jansen L, Walter V, Tagscherer K, Roth W, Herpel E, Kloor M, Bläker H, Chang-Claude J, Brenner H, Hoffmeister M.
No association of CpG island methylator phenotype and colorectal cancer survival: population-based study.
British Journal of Cancer 2016; 115:1359-1366.

Abubakar M, Orr N, Daley F, Coulson P, Raza Ali H, Blows F, Benitez J, Milne R, Brenner H, Stegmaier C, Mannermaa A, Chang-Claude J, Rudolph A, Sinn P, Couch FJ, Devilee P, Tollenaar RAEM, Seynaeve C, Figueroa J, Sherman ME, Lissowska J, Hewitt S, Eccles D, Hooning MJ, Hollestelle A, Martens JWM, van Deurzen CHM, kConFab Investigators, Bolla MK, Wang Q, Jones M, Schoemaker M, Wesseling J, van Leeuwen FE, Van ‘t Veer L, Easton D, Swerdlow AJ, Dowsett M, Pharoah PD, Schmidt MK, Garcia-Closas M.
Prognostic value of automated KI67 scoring in breast cancer: a centralised evaluation of 8088 patients from 10 study groups.
Breast Cancer Research 2016; 18:104.

Liu J, Loncar I, Collée JM, Bolla MK, Dennis J,…, Brenner H,…, Cuk K,…, Hooning MJ, van den Ouweland AMW, Martens JWM, Hollestelle A.
rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk.
Scientific Reports 2016; 6:36874.

Painter JN, O’Mara TA, Marquart L, Webb PM on behalf of the AOCS Group, Attia J,…, Brenner H,…, Dunning AM, Easton DF, Thompson DJ, Spurdle AB on behalf of The Australian National Endometrial Cancer Study Group (ANECS).
Genetic risk score Mendelian randomization shows obesity measured as body mass index, but not waist: hip ratio, is causal for endometrial cancer.
Cancer Epidemiology, Biomarkers & Prevention 2016; 25:1503-1510.

Khankari NK, Murff HJ, Zeng C, Wen W, Eeles RA,..., Brenner H,..., Teixeira MR, Pandha H, Zheng W, PRACTICAL Consortium
Polyunsaturated fatty acids and prostate cancer risk: a Mendelian randomisation analysis from the PRACTICAL consortium.
British Journal of Cancer 2016; 115:624-631.

Kovesdy CP, Coresh J, Ballew SH, Woodward M, Levin A, Naimark DMJ, Nally J, Rothenbacher D, Stengel B, Iseki K, Matsushita K, Levey AS, the CKD Prognosis Consortium*.
Past decline versus current eGFR and subsequent ESRD risk.
Journal of the American Society of Nephrology 2016; 27:2447-2455.
*Investigators and collaborators on behalf of the ESTHER study: Rothenbacher D, Brenner H, Müller H, Schöttker B.

Naimark DMJ, Grams ME, Matsushita K, Black C, Drion I, Fox CS, Inker LA, Ishani A, Jee SH, Kitajura A, Lea JP, Nally J, Peralta CA, Rothenbacher D, Ryu S, Tonelli M, Yatsuya H, Coresh J, Gansevoort RT, Warnock DG, Woodward M, de Jong PE, the CKD Prognosis Consorstium*.
Past decline versus current eGFR and subsequent mortality risk.
Journal of the American Society of Nephrology 2016; 27:2456-2466.
*Investigators and collaborators on behalf of the ESTHER study: Rothenbacher D, Brenner H, Müller H, Schöttker B.

Zhang Y, Elgizouli M, Schöttker B, Holleczek B, Nieters A, Brenner H.
Smoking-associated DNA methylation markers predict lung cancer incidence.
Clinical Epigenetics 2016; 8:127.

Meid AD, Heider D, Adler JB, Quinzler R, Brenner H, Günster C, König HH, Haefeli WE.
Comparative evaluation of methods approximating drug prescription durations in claims data: Modeling, simulation, and application to real data.
Pharmacoepidemiology and Drug Safety 2016; 25:1434-1442.

Koch-Gallenkamp L, Betram H, Eberle A, Holleczek B, Schmid-Höpfner S, Waldmann A, Zeissig SR, Brenner H, Arndt V.
Fear of recurrence in long-term cancer survivors - do cancer-type, sex, time since diagnosis, and social support matter?
Health Psychology 2016; 35:1329-1333.

Shi J, Park JH, Duan J, Berndt S, Moy W,..., Brenner H,…, Landi MT, Levinson DF, Chanock SJ, Chatterjee N.
Winner’s curse correction and variable thresholding improve performance of polygenic risk modeling based on genome-wide association study summary-level data.
PLOS Genetics 2016; 12:e1006493.

Gao X, Mons U, Zhang Y, Breitling LP, Brenner H.
DNA methylation changes in response to active smoking exposure are associated with leukocyte telomere length among older adults.
European Journal of Epidemiology 2016; 31:1231-1241.

Hamdi Y, Soucy P, Adoue V, Michailidou K, Canisius S,…, Arndt V,…, Brenner H,…, Hall P, Easton DF, Pastinen T, Nord S.
Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.
Oncotarget 2016; 7:80140-80163.

Wyszynski A, Hong CC, Lam K, Michailidou K, Lytle C,…, Brenner H,…, Amos C, Ambrosone C, Easton DF, Cole MD.
An intergenetic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression.
Human Molecular Genetics 2016; 25:3863-3876.

Zhang M, Wang Z, Obazee O, Jia J, Childs E,…, Brenner H,..., Kaaks R,...,Kraft P, Klein AP, Canzian F, Amundadottir LT.
Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21.
Oncotarget 2016; 7:66328-66343.

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