Dr. Siao-Han Wong

Affiliation

Co-affiliated with the Division of Personalized Medical Oncology at the DKFZ and the DKFZ-Hector Cancer Institute at the University Medical Center Mannheim

Research interests

Cancer research and its translation into practice has been the center of my research. Specifically, this is to address clinical questions by applying computational or statistical methods to complex biomedical data and interpret its biological underpinnings. I'm also enthusiastic about learning new concepts and technologies that can be integrated into our research, e.g. spatial omics, multi-omics integration and deep learning.
Through specific projects conducted in Prof. Brors' group, I've accumulated domain knowledge in personalized oncology and cancer genomics.

1. Tumor Evolution and Heterogeneity in Ovarian Cancer
2. Structure-Informed Variant Prioritization in Personalized Oncology
3. Integration of Omics Data in Personalized Oncology Scenario

During the postdoctoral training, my research interest is extended to the microenvironment surrounding tumor cells (in acute myeloid leukemia and lung cancer setting). Here the focus is to study the heterogeneity within specific normal cell types, in particular the myeloid cells and endothelial cells that have immune suppressive function.
Putting together, with ongoing research activities focusing on the tumor developmental process and the tumor microenvironment heterogeneity, I would like to go further into the direction of studying the co-evolution of tumor and its microenvironment using spatial omics technologies.
Other past research activities: microbial etiology of cancers, genetic testing of common diseases, to name but a few.

Curriculum vitae

Research positions:
11/2021 – present Postdoctoral Researcher, Department of Applied Bioinformatics (jointly affiliated), German Cancer Research Center, Heidelberg, Germany

11/2010 – 05/2014 Bioinformatician, YongLin Healthcare Foundation, Taiwan

07/2009 – 10/2010 Research Assistant, Division of Cancer Research, Institute of Biomedical Sciences, Academia Sinica, Taiwan

Education:
09/2014 – 07/2021 Ph.D. (Dr rer. Nat.), The Helmholtz International Graduate School for Cancer Research at the German Cancer Research Center (DKFZ); Faculty of Biosciences, Heidelberg University, Heidelberg, Germany

09/2007 – 06/2009 M.S., Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University (NTU), Taipei, Taiwan

09/2003 – 07/2007 B.S., Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University (NTHU), Hsinchu, Taiwan

Selected publications

(abstract) S.H. Wong et al., A multi-sample study reveals the evolution and heterogeneity in high-grade serous ovarian cancer. Cancer Res 83 (7 Suppl): Abstract nr 1513 (2023).
https://doi.org/10.1158/1538-7445.AM2023-1513

(abstract) S.H. Wong, B. Brors, A structural approach for prioritizing variants in personalized Oncology. Cancer Res 79 (13 Suppl): Abstract nr 1655 (2019).
https://doi.org/10.1158/1538-7445.AM2019-1655

(co-author) Lin, E. P. et al., Translating gene signatures into a pathologic feature: tumor necrosis predicts disease relapse in operable and stage I lung adenocarcinoma. JCO Precis Oncol 2018, 2, 1-13.
https://doi.org/10.1200/PO.18.00043

(co-author) P. Chudasama et al., Integrative genomic and transcriptomic analysis of leiomyosarcoma. Nat Commun 9, 144 (2018)
https://doi.org/10.1038/s41467-017-02602-0

(co-author) H. L. Wu et al., Liver gene expression profiles correlate with virus infection and response to interferon therapy in chronic hepatitis B patients. Sci Rep 6, 31349 (2016)
https://doi.org/10.1038/srep31349