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Valinciute, G. (First author) ; Ecker, J. ; Selt, F. ; Hielscher, T. ; Sigaud, R. ; Ridinger, J. ; Thatikonda, V. ; Gatzweiler, C. ; Robinson, S. ; Talbot, J. ; Bernardi, F. ; Picard, D. ; Blattner-Johnson, M. ; Schmid, S. ; Jones, D. T. ; van Tilburg, C. M. ; Capper, D. ; Kool, M. ; Remke, M. ; Oehme, I. ; Pfister, S. M. ; Roussel, M. F. ; Ayrault, O. ; Witt, O. ; Milde, T. (Last author) Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells.
Journal of neuro-oncology nn , nn (2023 ) [10.1007/s11060-023-04319-1] 2023
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Korshunov, A. (First author) ; Okonechnikov, K. ; Schrimpf, D. ; Tonn, S. ; Mynarek, M. ; Koster, J. ; Sievers, P. ; Milde, T. ; Sahm, F. ; Jones, D. ; von Deimling, A. ; Pfister, S. ; Kool, M. (Last author) Transcriptome analysis stratifies second-generation non-WNT/non-SHH medulloblastoma subgroups into clinically tractable subtypes.
Acta neuropathologica 145 (6 ), 829-842 (2023 ) [10.1007/s00401-023-02575-z] 2023
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Okonechnikov, K. (First author) ; Camgöz, A. (First author) ; Chapman, O. ; et al 3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma.
Nature Communications 14 (1 ), 2300 (2023 ) [10.1038/s41467-023-38044-0] 2023
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Hardin, E. C. (First author) ; Schmid, S. ; Sommerkamp, A. ; Bodden, C. ; Heipertz, A.-E. ; Sievers, P. ; Wittmann, A. ; Milde, T. ; Pfister, S. ; von Deimling, A. ; Horn, S. ; Herz, N. A. ; Simon, M. ; Perera, A. A. ; Azizi, A. ; Cruz, O. ; Curry, S. ; Van Damme, A. ; Garami, M. ; Hargrave, D. ; Kattamis, A. ; Kotnik, B. F. ; Lähteenmäki, P. ; Scheinemann, K. ; Schouten-van Meeteren, A. Y. N. ; Sehested, A. ; Viscardi, E. ; Wormdal, O. M. ; Zapotocky, M. ; Ziegler, D. S. ; Koch, A. ; Driever, P. H. ; Witt, O. ; Capper, D. ; Sahm, F. ; Jones, D. ; van Tilburg, C. M. (Last author) LOGGIC Core BioClinical Data Bank: Added clinical value of RNA-Seq in an international molecular diagnostic registry for pediatric low-grade glioma patients.
Neuro-Oncology nn , nn (2023 ) [10.1093/neuonc/noad078] 2023
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Ecker, J. (First author) ; Selt, F. ; Sturm, D. ; Sill, M. ; Korshunov, A. ; Hirsch, S. ; Capper, D. ; Dikow, N. ; Sutter, C. ; Müller, C. ; Sigaud, R. ; Eggert, A. ; Simon, T. ; Niehues, T. ; von Deimling, A. ; Pajtler, K. ; van Tilburg, C. M. ; Jones, D. ; Sahm, F. ; Pfister, S. ; Witt, O. ; Milde, T. (Last author) Corrigendum to 'Molecular diagnostics enables detection of actionable targets: the Pediatric Targeted Therapy 2.0 registry' [Eur J Cancer 180 (2023) 71-84].
European journal of cancer nn , nn (2023 ) [10.1016/j.ejca.2023.02.024] 2023
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Bogumil, H. (First author) ; Sill, M. ; Schrimpf, D. ; et al Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions.
Acta neuropathologica nn , nn (2023 ) [10.1007/s00401-023-02558-0] 2023
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Sturm, D. (First author) ; Capper, D. ; Andreiuolo, F. ; et al Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology.
Nature medicine nn , nn (2023 ) [10.1038/s41591-023-02255-1] 2023
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Keck, M.-K. (First author) ; Sill, M. ; Wittmann, A. ; et al Correction to: Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification.
Acta neuropathologica 145 (4 ), 511-514 (2023 ) [10.1007/s00401-023-02538-4] 2023
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Tonn, S. ; Korshunov, A. ; Obrecht, D. ; Sill, M. ; Spohn, M. ; von Hoff, K. ; Milde, T. ; Pietsch, T. ; Goschzik, T. ; Bison, B. ; Juhnke, B.-O. ; Struve, N. ; Sturm, D. ; Sahm, F. ; Bockmayr, M. ; Friedrich, C. ; von Bueren, A. O. ; Gerber, N. U. ; Benesch, M. ; Jones, D. ; Kool, M. ; Wefers, A. K. ; Schüller, U. ; Pfister, S. ; Rutkowski, S. ; Mynarek, M. Risk prediction in early childhood SHH medulloblastoma treated with radiation-avoiding chemotherapy: Evidence for more than two subgroups.
Neuro-Oncology nn , nn (2023 ) [10.1093/neuonc/noad027] 2023
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Marquardt, V. ; Theruvath, J. ; Pauck, D. ; Picard, D. J. ; Qin, N. ; Blümel, L. ; Maue, M. ; Bartl, J. ; Ahmadov, U. ; Langini, M. ; Meyer, F.-D. ; Cole, A. ; Cruz-Cruz, J. ; Graef, C. M. ; Wölfl, M. ; Milde, T. ; Witt, O. ; Erdreich-Epstein, A. ; Leprivier, G. ; Kahlert, U. ; Stefanski, A. ; Stühler, K. ; Keir, S. T. ; Bigner, D. D. ; Hauer, J. ; Beez, T. ; Knobbe-Thomsen, C. B. ; Fischer, U. ; Felsberg, J. ; Hansen, F. K. ; Vibhakar, R. ; Venkatraman, S. ; Cheshier, S. H. ; Reifenberger, G. ; Borkhardt, A. ; Kurz, T. ; Remke, M. ; Mitra, S. Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation.
Journal for ImmunoTherapy of Cancer 11 (1 ), e005871 (2023 ) [10.1136/jitc-2022-005871] 2023
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Maatman, I. T. ; Ypma, S. ; Kachelriess, M. ; Berker, Y. ; van der Bijl, E. ; Block, K. T. ; Hermans, J. J. ; Maas, M. C. ; Scheenen, T. W. J. Single-spoke binning: Reducing motion artifacts in abdominal radial stack-of-stars imaging.
Magnetic resonance in medicine 89 (5 ), 1931-1944 (2023 ) [10.1002/mrm.29576] 2023
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Ecker, J. (First author) ; Selt, F. ; Sturm, D. ; Sill, M. ; Korshunov, A. ; Hirsch, S. ; Capper, D. ; Dikow, N. ; Sutter, C. ; Müller, C. ; Sigaud, R. ; Eggert, A. ; Simon, T. ; Niehues, T. ; von Deimling, A. ; Pajtler, K. W. ; van Tilburg, C. M. ; Jones, D. T. W. ; Sahm, F. ; Pfister, S. M. ; Witt, O. ; Milde, T. (Last author) Molecular diagnostics enables detection of actionable targets: the Pediatric Targeted Therapy 2.0 registry.
European journal of cancer 180 , 71 - 84 (2023 ) [10.1016/j.ejca.2022.11.015] 2023
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Mynarek, M. ; Obrecht, D. ; Sill, M. ; Sturm, D. ; Kloth-Stachnau, K. ; Selt, F. ; Ecker, J. ; von Hoff, K. ; Juhnke, B.-O. ; Goschzik, T. ; Pietsch, T. ; Bockmayr, M. ; Kool, M. ; von Deimling, A. ; Witt, O. ; Schüller, U. ; Benesch, M. ; Gerber, N. U. ; Sahm, F. ; Jones, D. ; Korshunov, A. ; Pfister, S. ; Rutkowski, S. ; Milde, T. (Last author) Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts.
Acta neuropathologica 145 (1 ), 97-112 (2023 ) [10.1007/s00401-022-02522-4] 2023
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Keck, M.-K. (First author) ; Sill, M. ; Wittmann, A. ; et al Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification.
Acta neuropathologica 145 (1 ), 49-69 (2023 ) [10.1007/s00401-022-02516-2] 2023
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Berker, Y. (First author) ; Muti, I. H. ; Cheng, L. L. Visualizing metabolomics data with R.
NMR in biomedicine 36 (4 ), e4865 (2023 ) [10.1002/nbm.4865] 2023
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Gatzweiler, C. (First author) ; Ridinger, J. ; Ayhan, S. ; Najafi, S. ; Peterziel, H. ; Witt, O. ; Oehme, I. (Last author) Evaluation of Antitumor and On-Target Activity of HDAC Inhibitors with the Zebrafish Embryo Xenograft Model.
Methods in molecular biology 2589 , 75-85 (2023 ) [10.1007/978-1-0716-2788-4_5] 2023
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Darwish, S. ; Heimburg, T. ; Ridinger, J. ; Herp, D. ; Schmidt, M. ; Romier, C. ; Jung, M. ; Oehme, I. ; Sippl, W. Synthesis, Biochemical, and Cellular Evaluation of HDAC6 Targeting Proteolysis Targeting Chimeras.
Methods in molecular biology 2589 , 179-193 (2023 ) [10.1007/978-1-0716-2788-4_12] 2023
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Rösch, L. (First author) ; Herter, S. ; Najafi, S. ; Ridinger, J. ; Peterziel, H. ; Cinatl, J. ; Jones, D. T. W. ; Michaelis, M. ; Witt, O. ; Oehme, I. (Last author) ERBB and P-glycoprotein inhibitors break resistance in relapsed neuroblastoma models through P-glycoprotein.
Molecular oncology 17 (1 ), 37-58 (2023 ) [10.1002/1878-0261.13318] 2023
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Selt, F. (First author) ; Sigaud, R. ; Valinciute, G. ; Sievers, P. ; Zaman, J. ; Alco, C. ; Schmid, S. ; Peterziel, H. ; Tsai, J. W. ; Guiho, R. ; Martínez-Barbera, J. P. ; Pusch, S. ; Deng, J. ; Zhai, Y. ; van Tilburg, C. M. ; Schuhman, M. U. ; Damaty, A. E. L. ; Bandopadhayay, P. ; Herold-Mende, C. ; von Deimling, A. ; Pfister, S. ; Montero, J. ; Capper, D. ; Oehme, I. ; Sahm, F. ; Jones, D. ; Witt, O. ; Milde, T. (Last author) BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma.
Neuro-Oncology 25 (4 ), 735-747 (2023 ) [10.1093/neuonc/noac199] 2023
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Sigaud, R. (First author) ; Rösch, L. (First author) ; Gatzweiler, C. (First author) ; Benzel, J. (First author) ; von Soosten, L. (First author) ; Peterziel, H. ; Selt, F. ; Najafi, S. ; Ayhan, S. ; Gerloff, X. ; Hofmann, N. ; Büdenbender, I. ; Schmitt, L. ; Foerster, K. I. ; Burhenne, J. ; Haefeli, W. E. ; Korshunov, A. ; Sahm, F. ; van Tilburg, C. M. ; Jones, D. ; Pfister, S. ; Knoerzer, D. ; Kreider, B. L. ; Sauter, M. ; Pajtler, K. (Last author) ; Zuckermann, M. (Last author) ; Oehme, I. (Last author) ; Witt, O. (Last author) ; Milde, T. (Last author) The first-in-class ERK inhibitor ulixertinib shows promising activity in MAPK-driven pediatric low-grade glioma models.
Neuro-Oncology 25 (3 ), 566-579 (2023 ) [10.1093/neuonc/noac183] 2023
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