Cancer Core Europe (CCE) Lecture - A Computational Framework for Personalized Modeling of the Vascular Microenvironment to Predict Radiotherapy Outcomes in Head-and-Neck Cancer

This lecture explores the integration of clinical data with advanced biophysical models for microcirculation, presenting a framework that enables the creation of digital twins. These digital representations facilitate a bidirectional interaction between the model and the actual patient, offering a valuable tool for precision medicine. By modeling the microvasculature of individual patients, this approach allows for detailed analysis of the microvascular environment and provides a platform for forecasting personalized radiotherapy outcomes. Key aspects of the lecture include: The fundamental components of a biophysical model for microcirculation Methods for data collection and analysis to digitally represent patient-specific microvasculature Strategies for building personalized microvascular models This framework highlights the potential of merging biophysical modeling with clinical data to advance patient-specific therapeutic strategies. What is Cancer Core Europe (CCE)? Cancer Core Europe is a consortium of seven leading cancer centres (www.cancercoreeurope.eu). CCEs members are driven by a strong will to reshape the cancer research model to ultimately increase the European Union’s competitiveness as a place to conduct cutting-edge research that’s translated to the clinic to deliver more personalized medicine.