Immune Regulation in Cancer
Dr. Chong Sun
Our lab investigates the interplay between T cells and tumors, with a particular focus on the molecular mechanisms that impair T cell-mediated immune responses against tumors.
Our Research
Research focus
The (neo) antigen-specific T cell response to tumors is a crucial component of antitumor immunity, but it is frequently compromised by various inhibitory factors within the tumor microenvironment or inherent to T cells. Among them, three interconnected events i) insufficient T cell trafficking into tumors, ii) compromised T cell activities, and iii) resistance of tumor cells to cytotoxicity of T cells, largely contribute to the immune evasion of cancer and render T cell-based immunotherapies futile in the majority of cancer patients. These three areas form our research focus.
Approach
We begin by constructing physiologically or clinically relevant cell and mouse models to recapitulate the aforementioned events within the antitumor T cell response. Subsequently, we use or develop function-based genomics techniques, including genetic and chemical screening, in conjunction with molecular, biochemical, and cell biological assays, to systematically dissect these individual processes. Finally, we assess the translational potential of our findings in both in vivo and ex vivo tumor models.
Objective
We aim to 1) elaborate on the molecular and cellular basis of immune suppressive mechanisms in antitumor T cell immunity; 2) Identify novel therapeutic targets and develop more effective therapeutic strategies for cancer immunotherapy.
Live cell imaging of T cell – Tumor cell interactions
Team
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Dr. Chong Sun
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Dr. med. Shangce Du
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Helena Engel
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Annika Fitz
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Zhaoqing Hu
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Irem Sena Karagözler
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Elke Laport
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Mohamed Abdalla Abdelaziz Mahmoud
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Hitoshi Matsuo
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Beiping Miao
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Dr. Patrick Johannes Partscht
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Melanie Sator-Schmitt
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Raphael Warchalowski
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Xiyue Zhao
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Cheng Zu
Selected Publications
Cansu Eris*, Cheng Zu*, Yanling Xiao, Michael Platten#, Chong Sun#
Lena Jassowicz#*, Fangyoumin Feng*, Rolf Warta*, Fatima Heinicke, Amélie Wöllner, Hannah Briesch, Furkan Sor, Julia Soller, Catharina Lotsch, John KL Wong, Chang-Gyun Park, Nicolas Aubert, Maximilian Scheer, Zhaoqing Hu, Maximilian Knoll, Julian Schlegel, Lukas Frank, Philip Dao Trong, Gerhard Jungwirth, Amin I Nohman, Kendra Maaß, Niels Grabe, Mandy Barthel, Simone Butz, Christina Lulay, Manuela Zucknick, Michele Bortolomeazzi, Pooja Sant, Verena Thewes, Laura Michel, Carlo Fremd, Andreas Schneeweiss, Chong Sun, Karsten Rippe, Amir Abdollahi, Andreas von Deimling, Andreas Unterberg, Sandro M Krieg, Jan-Philipp Mallm, Peter Lichter, Marc Zapatka, Martina Seiffert#, Christel Herold-Mende#
JuanFei Peng*, JiaJin Yang*, Georgia Antonopoulou*, Rui Fang, Bikash Adhikari, Markus Vogt, Elmar Wolf, Chong Sun, Shangce Du, Laura Godfrey, Aayush Gupta, Marija Trajkovic-Arsic, Nicole Teichmann, Barbara T Grünwald, Niklas Krebs, Katja Steiger, Carolin Mogler, Kristina Althoff, Xin Wang, Giovanni Giglio, Sven-Thorsten Liffers, Konstantinos Savvatakis, Rickmer Braren, Rita T Lawlor, Aldo Scarpa, Diana Behrens, Karl S Lang, Phyllis F Cheung#, Jens T Siveke#
Zhaoqing Hu, Hitoshi Matsuo, Shangce Du, Cecilia Berzain Battioni, Lena Jassowicz, Rafael Carretero, Melanie Sator-Schmitt, Xiyue Zhao, Beiping Miao, Cansu Eris, Helena Engel, Mohamed A.A. Mahmoud, Elke Laport, Yanling Xiao, Ilse Hofmann, Christel Herold-Mende, Chong Sun
Beiping Miao*, Zhaoqing Hu*, Riccardo Mezzadra*, Lotte Hoeijmakers*, Astrid Fauster, Shangce Du, Zhi Yang, Melanie Sator-Schmitt, Helena Engel, Xueshen Li, Caroline Broderick, Guangzhi Jin, Raquel Gomez-Eerland, Lisette Rozeman, Xin Lei, Hitoshi Matsuo, Chen Yang, Ingrid Hofland, Dennis Peters, Annegien Broeks, Elke Laport, Annika Fitz, Xiyue Zhao, Mohamed A A Mahmoud, Xiujian Ma, Sandrine Sander, Hai-Kun Liu, Guoliang Cui, Yu Gan, Wei Wu, Yanling Xiao, Albert J R Heck, Wenxian Guan, Scott W Lowe, Hugo M Horlings, Cun Wang, Thijn R Brummelkamp, Christian U Blank#, Ton N M Schumacher#, Chong Sun#
CD4(+) helper T cells endow cDC1 with cancer-impeding functions in the human tumor micro-environment
Xin Lei, Indu Khatri, Tom de Wit, Iris de Rink, Marja Nieuwland, Ron Kerkhoven, Hans van Eenennaam, Chong Sun, Abhishek D Garg, Jannie Borst, Yanling Xiao
Chen Yang*, Haigang Geng*, Xupeng Yang*, Shuyi Ji*, Zhicheng Liu*, Hao Feng*, Qian Li, Tangansu Zhang, Sisi Zhang, Xuhui Ma, Chuchen Zhu, Nuo Xu, Yuhan Xia, Yan Li, Hongye Wang, Chune Yu, Shangce Du, Beiping Miao, Lei Xu, Hui Wang, Ying Cao, Botai Li, Lili Zhu, Xiangyu Tang, Haoyu Zhang, Chunchao Zhu, Zhao Huang, Chao Leng, Haiyan Hu, Xiaoping Chen, Shengxian Yuan, Guangzhi Jin, René Bernards, Chong Sun#, Quan Zheng#, Wenxin Qin#, Qiang Gao#, Cun Wang#
Sun, C.*, Mezzadra, R.* & Schumacher, T. N.*
Mezzadra, R.*, Sun, C.*, Jae, L. T.*, Gomez-Eerland, R., de Vries, E., Wu, W., Logtenberg, M. E. W., Slagter, M., Rozeman, E. A., Hofland, I., Broeks, A., Horlings, H. M., Wessels, L. F. A., Blank, C. U., Xiao, Y., Heck, A. J. R., Borst, J., Brummelkamp, T. R.# & Schumacher, T. N. M.#
Sun, C.*, Wang, L.*, Huang, S.*, Heynen, G. J., Prahallad, A., Robert, C., Haanen, J., Blank, C., Wesseling, J., Willems, S. M., Zecchin, D., Hobor, S., Bajpe, P. K., Lieftink, C., Mateus, C., Vagner, S., Grernrum, W., Hofland, I., Schlicker, A., Wessels, L. F., Beijersbergen, R. L., Bardelli, A., Di Nicolantonio, F., Eggermont, A. M. & Bernards, R.
Prahallad, A.*, Sun, C.*, Huang, S.*, Di Nicolantonio, F.*, Salazar, R., Zecchin, D., Beijersbergen, R. L., Bardelli, A. & Bernards, R.
Jin, H., Shi, Y., Lv, Y., Yuan, S., Ramirez, C. F. A., Lieftink, C., Wang, L., Wang, S., Wang, C., Dias, M. H., Jochems, F., Yang, Y., Bosma, A., Hijmans, E. M., de Groot, M. H. P., Vegna, S., Cui, D., Zhou, Y., Ling, J., Wang, H., Guo, Y., Zheng, X., Isima, N., Wu, H., Sun, C., Beijersbergen, R. L., Akkari, L., Zhou, W., Zhai, B., Qin, W. & Bernards, R.
Huang, S., Holzel, M., Knijnenburg, T., Schlicker, A., Roepman, P., McDermott, U., Garnett, M., Grernrum, W., Sun, C., Prahallad, A., Groenendijk, F. H., Mittempergher, L., Nijkamp, W., Neefjes, J., Salazar, R., Ten Dijke, P., Uramoto, H., Tanaka, F., Beijersbergen, R. L., Wessels, L. F. & Bernards, R.
Carette, J. E., Guimaraes, C. P., Wuethrich, I., Blomen, V. A., Varadarajan, M., Sun, C., Bell, G., Yuan, B., Muellner, M. K., Nijman, S. M., Ploegh, H. L. & Brummelkamp, T. R.
Funding sources
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