Dr. Maria Llamazares Prada

11.2020 – present           DKFZ, German Cancer Research Center, Heidelberg. Division of Cancer Epigenomics, Prof. Christoph Plass. Human Lung Cell Multi-omic Atlas, TLRC PI

• PROJECTS: Generation of multi-omic atlas with cellular and spatial resolution of lung tissue and lung tumors. Epigenetic deregulation in Lung Cancer. Generation of Lung Cancer Organoids to study non-genetic mechanisms of drug resistance. Loss of Y in lung cancer and epigenetic heterogeneity.

07.2016 – 10.2020           BioMed X Innovation Center, sponsored by Boehringer Ingelheim

                                                Epigenetics and COPD

• PROJECT: Isolation and epigenetic characterization of human primary lung cells in COPD. Target identification and validation in patient-derived lung organoids. Establishment and management of lung bioarchive.

01.2016 – 03.2016           BioMed X Innovation Center, sponsored by Merck

                                                Immunosuppressive Microenvironment of Tumors

• PROJECT: New strategies aiming for immunosuppression relieve in cancer. Hypoxia effects on human PBMCs and phage display to identify novel MDSC targets in tumors with immunosuppressive stroma.

04.2013 – 10.2015           DKFZ, German Cancer Research Center, Heidelberg

                                                Signal Transduction and Growth Control, Prof. Peter Angel.

• PROJECT: Regulatory networks governing transitions between proliferation and differentiation in primary human keratinocytes. 3D skin models to characterize the role of novel regulators of skin homeostasis and cancer.

02.2010 – 07.2012           University Hospital, Marburg

Clinic for Dermatology and Allergology, Prof. Michael Hertl.

• PROJECT: Molecular mechanisms behind epidermal autoimmune diseases. Humanized mouse models of pemphigus vulgaris, ex vivo and in vitro assays.

10.2006 – 01.2010           University of Marburg and Würzburg Biozentrum, Prof. Martin Eilers.

Institute for Molecular Biology and Tumor Research

• PROJECT: Stability of the oncogene c-myc. siRNA screenings to identify novel E3 ligases. Experimental validation of the screen and generation of hypothesis.

10. 2005 – 09.2006          University of Oviedo, Spain

Institute of Biochemistry and Molecular Biology, Prof. Carlos López-Otín.

• PROJECT: ADAMTS-12 role in tumorigenesis. Generation of clonal cell lines and loss-of-function mouse model to study ADAMTS-12 functions.

05.2001 – 09.2005           PhD in Biochemistry and Molecular Biology, University of Oviedo, Spain

• “Analysis of the Human Degradome: Definition of the Polyserase group of serine-proteases and identification of new metalloproteases of the ADAMTS family”.

  • Supervisors/ Mentors: Prof. Carlos López-Otín and PD Dr Cal.

    • Final Grade: Summa cum laude (Honors).

03.2004 – 07.2004           Visiting scientist, University of British Columbia, Vancouver, Canada

• Supervisor: Prof. Chris Overall. 

  • international PhD student fellow from the program „Training and Mobility of Researchers (TMR)” from Ministerio de Ciencia y Tecnología, Spain.

09.1995 – 12.2000           MSc & BSc in Biochemistry and Molecular Biology, University of Oviedo, Spain

• Subjects of interest: Cellular and Molecular Biology, Immunology, Genetics, Biochemistry, Recombinant Technologies, Physiology and Pathology. 

2021                   EACR & NanoString WTA Grant: Spatial whole-transcriptome profiling in giant cell tumor of bone

2006 - 2008       Alfonso Martín Escudero postdoctoral fellowship (www.fundame.org)

2007                   MEC/Fulbright postdoctoral fellowship. Rejected to avoid conflicts with fellowship previously obtained

2004                   Training and Mobility of Researchers (TMR) at Prof. Dr Chris Overall laboratory in British Columbia University, Vancouver, Canada

2001 - 2005       Ministerio de Ciencia y Tecnología PhD fellowship, Spain

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