Publications
for all publications: [pubmed] [google scholar]
Selected Research Articles (Kutscher Lab members in bold)
13. Akçay V*, Spänig LM*, Vierdag W-MAM*, Joshi P, da Silva PBG, Sanderson A, Reinhardt R, Sieber L, Hofmann N, Nolle J, Schelb F, Zuckermann M, Kaessmann H, Pfister SM, Sanchez Danes A, Sepp M, Saka S, Kutscher LM (2026) Conserved cerebellar rhombic lip compartmentalization and Eomes regulatory networks govern unipolar brush cell development. [bioRxiv] *co-first authors
12. Joshi P*, da Silva PBG*, Okonechnikov K*, Stelzer T, Sarropoulos I, Nolle J, Sepp M, Leiss K, Rademacher A, Yamada T, Bortolomeazzi M, Mallm J-P, Statz B, Wittmann A, Schramm K, Blattner-Johnson M, Fiesel P, Jones B, Milde T, Pajtler KW, van Tilburg CM, Witt O, Rippe K, Korshunov A, Jones DTW, Thongjuea S, Jäger N, Kaessmann H, Pfister SM§, Kutscher LM§ (2024) Cell-state plasticity drives heterogeneity in Group 3/4 medulloblastoma. [bioRxiv] *co-first authors, §co-corresponding authors
11. Bianchini L*, Xu R*, Filipovic D*, da Silva PBG, Sieber L, Akçay V, Arnskötter F, Joshi P, Nolle J, Soliman T, Tao R, Scheuing A, Okonechnikov K, Atamian A, Zuckermann M, Robinson GW, Quadrato G, Northcott PA§, Kutscher LM§. (2026) Developmental determinants of male bias in medulloblastoma. [bioRxiv]. §co-corresponding authors
10. Joshi P, Sepp M, Sarropoulos I, Trost N, Okonechnikov K, Yamada T, Schneider C, Schmidt J, Perera AA, Wittmann A, Blattner-Johnson M, Jones B, van Tilburg CM, Witt O, Jones DTW, Thongjuea S, Kaessmann H§, Pfister SM§, Kutscher LM§ (2026). A multi-omic view of human hindbrain development. [bioRxiv] §co-senior authors
9. Vaillant J, Pal S, Müller J, Wittmann A, Boakye-Yiadom A, Sievers P, Zimmer P, Schoof M, Schelb F, Hofmann N, Keck M-K, Fabian T, Schüller U, Zuckermann M, Beroukhim R, Bandopadhayay P, Jones DTW§, Kutscher LM§ (2025) A Cre-mediated copy number variant compromises the reliability of a LoxP-STOP-LoxP-PLAG1 driven brain tumor model. Neuro Onc Adv [pubmed] §co-corresponding authors
8. Yarychkivska O*, Kutscher LM*, Mamriev D, Bido BO, Lu Y, Puscher E, Keil W, Larisch S, Shaham S (2025). CED-3 caspase promotes dismantling but not onset of non-apoptotic linker cell death in C. elegans. [bioRxiv] *co-first authors
7. Arnskötter M, da Silva PBG, Schouw ME, Lukasch C, Bianchini L, Sieber L, Garcia-Lopez J, Ahmad ST, Li Y, Lin H, Joshi P, Spänig L, Radoš M, Roiuk M, Sepp M, Zuckermann M, Northcott PA, Patrizi A, Kutscher LM (2024) Loss of Elp1 in cerebellar granule cell progenitors models ataxia phenotype of Familial Dysautonomia. Neurobiol Dis.199:106600 [pubmed]
6. Okonechnikov K*, Joshi P*, Körber V*, Rademacher A, Bortolomeazzi M, Mallm J-P, da Silva PBG, Statz B, Wittmann A, Sepp M, Sarropoulos I, Yamada-Saito T, Vaillant J, Schramm K, Blattner-Johnson M, Fiesel P, Jones B, Milde T, Pajtler K, van Tilburg CM, Witt O, Schüller U, Mynarek M, Rutkowski S, Jones DTW, Rippe K, Korshunov A, Westermann F, Thongjuea S, Höfer T, Kaessmann H, Kutscher LM§, Pfister SM§ (2024) Medulloblastoma oncogene aberrations are not involved in tumor initiation, but essential for disease progression and therapy resistance. Nature [pubmed] *co-first authors, §co-senior authors
5. Sepp M, Leiss K, Murat F, Okonechnikov K, Joshi P, Leushkin E, Spänig L, Mbengue N, Schneider C, Schmidt J, Trost N, Schauer M, Khaitovich P, Lisgo S, Palkovits M, Giere P, Kutscher LM, Anders S, Cardoso-Moreira M, Sarropoulos I, Pfister SM, Kaessmann H. (2024) Cellular development and evolution of the mammalian cerebellum. Nature. 625(7996):788-796 [pubmed]
4. Okonechnikov K*, Joshi P*, Sepp M*, Leiss K*, Sarropoulos I, Murat F, Sill M, Beck P, Chan KC-H, Korshunov A, Sahm F, Deng MY, Sturm D, DeSisto J, Donson AM, Foreman NK, Green AL, Robinson G, Orr BA, Gao Q, Darrow E, Hadley JL, Northcott PA, Gojo J, Ryzhova M, Kawauchi D, Hovestadt V, Filbin MG, von Deimling A, Zuckermann M, Pajtler KW, Kool M, Jones DTW, Jäger N, Kutscher LM^, Kaessmann H^, Pfister SM^ (2023) Mapping pediatric brain tumors to their origins in the developing cerebellum. Neuro-Oncology 25(10):1895-1909 [pubmed] *equal contribution ^co-corresponding
3. Sarropoulos I*, Sepp M*, Frömel R, Leiss K, Trost N, Leushkin E, Okonechnikov K, Joshi P, Giere P, Kutscher LM, Cardoso-Moreira M, Pfister SM^, Kaessmann H^ (2021) Developmental and evolutionary dynamics of cis-regulatory elements in mouse cerebellar cells. Science 373(6558). [pubmed]
2. Kutscher LM*, Okonechnikov K*, Batora NV*, Clark J, Silva PBG, Vouri M, van Rijn S, Sieber L, Statz B, Gearhart MD, Shiraishi R, Mack N, Orr BA, Korshunov A, Gudenas BL, Smith KS, Mercier AL, Ayrault O, Hoshino M, Kool M, von Hoff K, Graf N, Fleischhack G, Bardwell VJ, Pfister SM, Northcott PA^, Kawauchi D^ (2020) Functional loss of a non-canonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation. Genes Dev 34:1161–1176. [pubmed] *equal contribution
1. Kutscher LM, Keil W, Shaham S (2018) RAB-35 and ARF-6 GTPases Mediate Engulfment and Clearance Following Linker Cell-Type Death. Dev. Cell 47: 222–238.e6. [pubmed]
Selected Resources, Reviews and Commentaries
6. Becker EBE§, Mayer S§, Kutscher LM§ (2026) Generating cerebellar organoids from pluripotent stem cells. Dis Models Mech 19. [pubmed] §co-corresponding authors
5. Kutscher LM§, Aprile D, Bayin NS, Becker EBE, Cerrato V, Turrini G, Coolen M, Vantagrel V, Burand BC, Evans MK, Haldipur P, Millen KJ, Yeung J, Goldowitz D, Hatten ME, Joyner AL, Kebschull JM, Li JYH, Quadrato G, Schmidt C, Sepp M, Silva TP, Testa. G, Tiberi L, Mayer S§ (2025) Conference report: Cerebellar development and disease at single-cell resolution. Cerebellum.[pubmed] §co-corresponding authors
4. Bianchini L, Sieber L, Hammad R, Schäfer R, Kutscher LM (2024) Generation of two patient-derived human-induced pluripotent stem cell lines with 6q27 deletion. Stem Cell Res. 80: 103524 [pubmed]
3. Schloo C and Kutscher LM (2023) Modeling brain and neural crest neoplasms with human pluripotent stem cells. Neuro-oncology [pubmed]
2. Kutscher LM and Shaham S (2017) Non-apoptotic cell death in animal development. Cell Death Differ. 24: 1326–1336. [pubmed]
1. Kutscher LM and Shaham S (2014) Forward and reverse mutagenesis in C. elegans. WormBook: 1–26. [pubmed]