Clinical Investigations

In cooperation with radiation oncologists, our group analyzes clinical data to determine dose response curves and to derive tolerance doses in normal tissues. For ion beams, this allows analyzing the consistency of model-based RBE-predictions with clinical outcome. For photon treatments, it allows comparison of different treatment regimens and quantifying the tolerance of normal tissues.

Graph comparing the probability of post-CHM in relation to depth dose (Dmax) for different models: LEM IV (blue lines) and LEM I (red points). The graph illustrates how these models predict outcomes in medical radiation physics, with LEM IV demonstrating a smooth curve and LEM I showing discrete data points.
Figure 1. Dose response curves for late temporal lobe reactions in patients after carbon ion irradiation based on two versions of the local effect model (LEM). © Modified figure reprinted from Gillmann et al. 2014 with permission from Elsevier; Figure 2. Dose response curves for late temporal lobe reactions in patients after proton irradiation in comparison to carbon ions. © Reprinted from Gillmann et al. 2018 with permission from Elsevier

Selected publications ­(in chronological order)

  • Eichkorn T., Karger C.P., Brons S., Körber S.A., Mielke T., Haberer T., Debus J., Herfarth K.: Results of a prospective randomized trial on long-term effectiveness of protons and carbon ions in prostate cancer: LEM I and a/b=2Gy overestimates the RBE. Radiotherapy and Oncology 173, 223-230, 2022 https://www.sciencedirect.com/science/article/abs/pii/S0167814022041627?via%3Dihub
  • Gillmann C., Jäkel O., Karger C.P.: RBE-weighted doses in target volumes of chordoma and chondrosarcoma patients treated with carbon ion radiotherapy: comparison of local effect models I and IV. Radiotherapy and Oncology 141, 234-238, 2019 https://www.sciencedirect.com/science/article/pii/S0167814019330452?via%3Dihub
  • Gillmann C., Lomax A.J., Weber D.C., Jäkel O., Karger C.P.: Dose-response curves for MRI-detected radiation-induced temporal lobe reactions in patients after proton and carbon ion therapy: Does the same RBE-weighted dose lead to the same biological effect? Radiotherapy and Oncology 128, 109–114, 2018 https://www.sciencedirect.com/science/article/pii/S0167814018300446?via%3Dihub
  • Gillmann C., Jäkel O., Schlampp I., Karger C.P.: Temporal lobe reactions after carbon ion radiation therapy: comparison of relative biological effectiveness-weighted tolerance doses predicted by local effect models I and IV. International Journal of Radiation Oncology Biology Physics 88, 1136-1141, 2014 https://www.sciencedirect.com/science/article/pii/S0360301613037012?via%3Dihub
  • Schlampp I., Karger C.P., Jäkel O., Scholz M., Didinger B., Nikoghosyan A., Hoess A., Krämer M., Edler L., Debus J., Schulz-Ertner D.: Temporal lobe reactions after radiotherapy with carbon ions: incidence and estimation of the relative biological effectiveness (RBE) by the local effect model (LEM). International Journal of Radiation Oncology Biology Physics 80, 815-823, 2011 https://www.sciencedirect.com/science/article/pii/S0360301610003949?via%3Dihub
  • Kyas I., Hof H., Debus J., Schlegel W., Karger C.P.: Prediction of radiation-induced changes in the lung after stereotactic body radiation therapy of non-small-cell lung cancer. International Journal of Radiation Oncology Biology Physics 67, 768-774, 2007 https://www.redjournal.org/article/S0360-3016(06)02829-X/fulltext
  • Münter M.W., Hoffner S., Hof H., Herfarth K.K., Haberkorn U., Rudat V., Huber P., Debus J., Karger C.P.: Changes in salivary gland function after radiotherapy of head and neck tumors measured by quantitative pertechnetate scintigraphy: Comparison of intensity-modulated radiotherapy and conventional radiation therapy with and without Amifostine. International Journal of Radiation Oncology Biology Physics 67, 651-659, 2007 https://www.sciencedirect.com/science/article/pii/S0360301606031294?via%3Dihub
  • Münter M.W., Karger C.P., Hoffner S.G., Hof H., Thilmann C., Rudat V., Nill S., Wannenmacher M., Debus J.: Evaluation of salivary gland function after treatment of head-and-neck tumors with intensity-modulated radiotherapy by quantitative pertechnetate scintigraphy. International Journal of Radiation Oncology Biology Physics 58, 175-184, 2004 https://www.sciencedirect.com/science/article/pii/S0360301603014378?via%3Dihub

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Prof. Dr. Christian Karger

Research Group Leader
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