MARIE / MARIEplus

Mammakarzinom-Risikofaktoren-Erhebung

Das Bild zeigt das Logo des Projekts "MARIE", das für "Mammakarzinom-Risikofaktoren-Erhebung" steht. Es enthält den Text "Mammakarzinom-Risikofaktoren-Erhebung" unter dem Namen "MARIE". Das Logo symbolisiert eine wissenschaftliche Initiative zur Erforschung von Krebsrisiken.

Kurzbeschreibung

MARIE ist eine bevölkerungsbezogene Fall-Kontroll-Studie mit über 10.000 Teilnehmerinnen, die in den Jahren 2002 bis 2005 durchgeführt wurde, um mögliche Risikofaktoren für die Entstehung von Brustkrebs nach den Wechseljahren zu ermitteln. Im Zeitraum 2009 – 2010 fand ein Follow-up der Krebspatientinnen statt (MARIEplus). Die gemeinsame Leitung der Studien liegt bei Prof. Dr. Jenny Chang-Claude und bei Prof. Dr. Dieter Flesch-Janys (bis 2018) und Prof. Dr. Heiko Becher (seit 2019).

Unsere Gruppe untersuchte unter Leitung von Prof. Dr. Karen Steindorf in MARIE und MARIEplus das körperliche Aktivitätsverhalten vor und nach der Diagnose der Teilnehmerinnen und dessen Auswirkung auf das Krebsrisiko, biologische Mechanismen, sowie das allgemeine und krankheitsfreie Überleben.

Darüber hinaus untersuchten wir in MARIEplus krebsbedingte Fatigue und die Lebensqualität. Ziel unserer Forschung ist ein besseres Verständnis der zugrundeliegenden Ursachen, der Einflussfaktoren und der verschiedenen Ausprägungen von Fatigue, um damit eine effektivere Behandlung zu ermöglichen.

Weitere Informationen zur MARIE-Studie:

MARIE und ihre Folgestudien

Publikationen

Obi N, Jung AY, Maurer T, Huebner M, Johnson T, Behrens S, Jaskulski S, Becher H, Chang-Claude J.
Association of circulating leptin, adiponectin, and resistin concentrations with long-term breast cancer prognosis in a German patient cohort. Sci Rep. 2021 Dec 7;11(1):23526.

Maurer T, Thöne K, Obi N, Jung AY, Behrens S, Becher H, Chang-Claude J.
Health-Related Quality of Life in a Cohort of Breast Cancer Survivors over More Than 10 Years Post-Diagnosis and in Comparison to a Control Cohort. Cancers (Basel). 2021 Apr 13;13(8):1854.

Maurer T, Jaskulski S, Behrens S, Jung AY, Obi N, Johnson T, Becher H, Chang-Claude J.
Tired of feeling tired - The role of circulating inflammatory biomarkers and long-term cancer related fatigue in breast cancer survivors. Breast. 2021 Apr;56:103-109.

Möhl A, Orban E, Jung AY, Behrens S, Obi N, Chang-Claude J, Becher H.
Comorbidity burden in long-term breast cancer survivors compared with a cohort of population-based controls from the MARIE study. Cancer. 2021 Apr 1;127(7):1154-1160.

Seiffert K, Thoene K, Eulenburg CZ, Behrens S, Schmalfeldt B, Becher H, Chang-Claude J, Witzel I.
The effect of family history on screening procedures and prognosis in breast cancer patients - Results of a large population-based case-control study. Breast. 2021 Feb;55:98-104.

Orban E, Jung AY, Möhl A, Behrens S, Becher H, Obi N, Chang-Claude J.
Changes in alcohol consumption, body weight and physical activity among breast cancer survivors and population-based unaffected women in a prospective study. Cancer Epidemiol. 2021 Feb;70:101852.

Jung AY, Hüsing A, Behrens S, Krzykalla J, Obi N, Becher H, Chang-Claude J.
Postdiagnosis weight change is associated with poorer survival in breast cancer survivors: A prospective population-based patient cohort study.  Int J Cancer. 2021 Jan 1;148(1):18-27.

Jaskulski S, Jung AY, Huebner M, Poschet G, Hell R, Hüsing A, Gonzalez-Maldonado S, Behrens S, Obi N, Becher H, Chang-Claude J.
Prognostic associations of circulating phytoestrogens and biomarker changes in long-term survivors of postmenopausal breast cancer.  Nutr Cancer. 2020;72(7):1155-1169.

Jung AY, Cai X, Thoene K, Obi N, Jaskulski S, Behrens S, Flesch-Janys D, Chang-Claude J.
Antioxidant supplementation and breast cancer prognosis in postmenopausal women undergoing chemotherapy and radiation therapy.Am J Clin Nutr. 2019 Jan 1;109(1):69-78.

Jung A, Behrens S, Schmidt M, Thoene K, Obi N, Hüsing A, Benner A, Steindorf K, Chang-Claude J. 
Pre- to postdiagnosis leisure-time physical activity and prognosis in postmenopausal breast cancer survivors. Breast Cancer Res 21, 117 (2019).

Jaskulski S, Jung AY, Behrens S, Johnson T, Kaaks R, Thöne K, Flesch-Janys D, Sookthai D, Chang-Claude J.
Circulating enterolactone concentrations and prognosis of postmenopausal breast cancer: assessment of mediation by inflammatory markers. Int J Cancer. 2018 Dec 1;143(11):2698-2708

Kühl T, Behrens S, Jung AY, Obi N, Thöne K, Schmidt ME, Becher H, Chang-Claude J.
Validation of inflammatory genetic variants associated with long-term cancer related fatigue in a large breast cancer cohort. Brain Behav Immun. 2018 Oct;73:252-260.

Obi N, Eulenburg C, Seibold P, Eilber U, Thöne K, Behrens S, Chang-Claude J, Flesch-Janys D.
Associations between adjuvant radiotherapy and different causes of death in a German breast cancer cohort. Breast. 2018 Apr;38:75-80.

Schmidt, M. E., Chang-Claude, J., Seibold, P., Vrieling, A., Heinz, J., Flesch-Janys, D., and Steindorf, K.
Determinants of long-term fatigue in breast cancer survivors: results of a prospective patient cohort study. Psychooncology. 2014.

Nickels S, Truong S, Hein R, Stevens K, Buck K, Behrens S, Eilber U, Schmidt ME, et al. Evidence of Gene-Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors. PLOS genetics, 2013, 9(3):e1003284

Schmidt, M. E., Chang-Claude, J., Vrieling, A., Seibold, P., Heinz, J., Obi, N., Flesch-Janys, D., and Steindorf, K.
Association of pre-diagnosis physical activity with recurrence and mortality among women with breast cancer. Int J Cancer 2013; 133:1431-1440.

Bock C, Schmidt ME, Vrieling A, Chang-Claude J, Steindorf K (2013) Walking, bicycling, and sports in postmenopausal breast cancer survivors-results from a German patient cohort study. Psychooncology, 22, 1291-8. doi: 10.1002/pon.3134. Epub 2012 Jul 16.

Schmidt, M. E., Chang-Claude, J., Vrieling, A., Heinz, J., Flesch-Janys, D., and Steindorf, K. Fatigue and quality of life in breast cancer survivors: temporal courses and long-term pattern. J Cancer Surviv. 2012; 6:11-19.

Huy C, Schmidt ME, Vrieling A, Chang-Claude J, Steindorf K (2012): Physical activity in a German breast cancer patient cohort: one-year trends and characteristics associated with change in activity level. European Journal of Cancer, 48(3):297-304. Epub 2011 Sep 14.

Barnes, B. B., Steindorf, K., Hein, R., Flesch-Janys, D., and Chang-Claude, J. 
Population attributable risk of invasive postmenopausal breast cancer and breast cancer subtypes for modifiable and non-modifiable risk factors. Cancer Epidemiol 2011; 35:345-352.

Liedtke S, Schmidt M, Becker S, Kaaks R, Zaineddin KA, Buck K, Flesch-Janys D, Wahrendorf J, Chang-Claude J, Steindorf K (2011): Physical Activity and Endogenous Sex Hormones in Postmenopausal Women: To what extent are observed associations confounded or modified by BMI? Cancer Causes and Control, 22, 81-89.

Schmidt ME, Chang-Claude J, Slanger T, Obi N, Flesch-Janys D, Steindorf K.
Physical activity and postmenopausal breast cancer: effect modification by other breast cancer risk factors. Methods Inf Med. 2009;48(5):444-50.

Barnes BB, Chang-Claude J, Flesch-Janys D, Kinscherf R, Schmidt M, Slanger T, Bonaterra G, Steindorf K.
Cancer risk factors associated with insulin-like growth factor (IGF)-I and IGF-binding protein-3 levels in healthy women: effect modification by menopausal status. Cancer Causes Control. 2009 Jul 12.

Schmidt ME, Steindorf K, Mutschelknauss E, Slanger T, Kropp S, Obi N, Flesch-Janys D, Chang-Claude J.

Physical activity and postmenopausal breast cancer: effect modification by breast cancer subtypes and effective periods in life. Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3402-10. Epub 2008 Nov 24.

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