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Technology search

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Technology search by keyword

Results 1 - 48 of 48

Niehrs, Lee, Sun

Treatment of acute myeloid leukemia (AML) (P-1502)

Keywords: Diagnostics, Research Tools

Acute myeloid leukemia (AML) is a malignancy of the hematopoietic system and arises from uncontrolled proliferation and impaired differentiation of myeloid precursors. Current therapeutic approaches have shown limited success rates, stressing the urgency to identify genes as potential new AML biomarkers or for direct AML therapy. Novel WNT-independent functions of R-spondins (RSPOs) in inhibition of bone morphogenetic protein (BMP) signaling were investigated, identifying the role of RSPO2 in growth and differentiation of AML cells. High RSPO2 expression was also identified to associated with poor prognosis, highlighting its potential for identification of AML risk patients. The present invention relates to an inhibitor of R-spondin 2 mediated BMP receptor inhibition for use in treating and/or preventing AML more...

Brenner, Schrotz-King, Bhardwaj

Early stage colorectal cancer (CRC) diagnostic (P-1455)

Keywords: Diagnostics

Sigmoidoscopy and colonoscopy, the current gold standards for detection of CRC are limited by several disadvantages, such as high costs, limited resources and poor compliance. Therefore, other cost-effective and sensitive methods are urgently needed for the early detection of colorectal cancer. The need of an efficient and cheap test is very important from the health economic standpoint. Using blood samples this invention offers a set of proteins that can be used as a diagnostic tool for accurate diagnosis, and/or monitoring of therapy in colorectal cancer (CRC). The panel has the sensitivity of 83% for detecting early stage CRC at specificity 80% and the AUC of 0.86. For detecting all-stage CRC an AUC of s 0.82 is observed. more...

Krammer, Weyd, Bode

Therapeutic annexin composition of reduced off-target effects (P-1434)


DKFZ has patented a novel annexin-formulation of enhanced receptor-mediated effects.

Seco, Martins, Dal Bello, Seimetz

Detector and method for tracking an arrival time of single particle in an ionbeam (P-1428)


A detector fortracking the arrival time of single particles comprises a scintillating material in the form of scintillating fibers layers perpendicular to the direction of the beam. The scintillating materialis responsible for generating the radiation and further a detector element measures the signal from the radiation. After the interaction of the incident ion beam with the patient, prompt gamma radiation is measured.A processor is configured for the verification of the single particle range and dose delivered to the patient based on the prompt gamma radiation and the arrival time of the single particle. more...

Seco, Martins, Dal Bello

A device and a method for monitoring the treatment of a patient with particles (P-1427)

Keywords: Devices

The main goal of radiation therapy is to eradicate the tumor without causing significant damage to the surrounding normal tissues. The Ion beam therapy provides potential for increased dose conformation to the target volume and spares the normal tissues. The verification of the treatment is crucial for the accurate dose delivery, this new device comprises a delivery and a verification unit, particularly be used for the patient treatment with the ion beam therapy. The device offers real time tracking and several other advantages over the existing imaging  technologies for verifying the dose delivery and range of the particles. more...

Glinka, Melnik, Müller-Decker, Niehrs

Cancer cell specific treatment by simultaneous targeting metabolism and intracellular pH (P-1415)


Chemotherapy is the most effective treatment method for metastasis but it causes severe side effects such as organ toxicity and anaemia. We have invented a new approach for cancer specific therapy that is based on utilizing treatment with combination of two / three drugs. One drug must be an inhibitor mitochondrial complex I and another could have property of H+ ionophore. The third drug is optional and is either also mitochondrial complex I inhibitor with different properties compared to first one, or inhibitor of lactate transport. In addition to a cooperative effect on cancer cell eradication in vitro and in vivo, the suggested combinations work as a strong wnt-signaling inhibitors. Examples: Meformin + Fenofibrate + Monensin; Simvastatin + Papaverine. more...

Augustin, Felcht, Hübers, Abdul Pari, Petkov

Inhibition of metastasis development by nANGPTL-4 (P-1412)

Keywords: Therapeutics, Research Tools

Cancer is responsible for the majority of deaths in high income countries. Most cancer patients die as a result of the formation of macro-metastases. Despite the clinical relevance, the patho-mechanisms of metastatic outgrowth are still poorly understood. Different studies indicate that primary tumors can inhibit secondary malignancy formation in mice and men. This phenomena has been termed ?concomitant tumor resistance? (CTR). Yet, up to now this could not be translated successfully into therapy. We identified in an unbiased in-silico meta-analyses of >5000 patient samples a protein which supports the concept of CTR in terms of contextuality, as it - depending on its proteolytic cleavage - enhances primary tumor growth and inhibits metastases formation. In a plethora of in vitro, ex vivo and in vivo studies the function of this fragment was unraveled and assessed as major inhibitor of meta-stasis formation. Further, we generated this peptide recombinantly and used it in different therapeutic settings in murine metastasis models. more...

Müller, Ottonello, Bettini, Bolchi, Spagnoli, Rossi

Dry-powder formulation of a thermostable HPV antigen for vaccine delivery to the lungs (P-1406)

Keywords: Vaccines

We patented a dry-powder vaccine, which can be filled into monodose capsules and administered via ready-to-use inhalers. The technology uses a new formulation for the manufacturing of a respirable, dry-powder vaccine (i.e., containing both a recombinant antigen and an immune-stimulant) suitable for pulmonary administration. In addition we achieve enhanced immunogenicity and ultimately the efficacy of vaccination. more...

Müller, Zhao, Ottonello

Combined prophylactic and therapeutic Vaccines of HPV (P-1382)

Keywords: Therapeutics, Vaccines

Cervical cancer is women?s second most frequent cancer worldwide. Clinical and molecular studies have shown that certain types of HPV, referred to as high-risk types, are the etiological agents of this disease. Two anti-HPV virus-like particles (VLPs) vaccines for the prophylaxis of cervical cancer are on the market (Merck: GardasilTM and GlaxoSmithKline: CervarixTM). We developed a vaccine which is composed of an immunogenic polypeptide comprising (i) a B-cell epitope of HPV, (ii) a T-cell epitope of HPV, and (iii) the scaffold polypeptide thioredoxine. The vaccine can be used in prophylactic and therapeutic approaches against infections with human papillomaviruses. more...

Kachelrieß, Berker

Deep Scatter Estimation in Positron Emission Tomography and other modalities (P-1375)

Keywords: Devices, Software

This invention is based on the assumption that large-angle, low-energy scatter (which is usually discarded) contains useful information about low-angle, high-energy scatter (which shall be estimated) that can be leveraged by machine learning. The invention therefore uses energy measurements to discern measured photons by energy bin. Multiple raw-data images can be formed from raw data acquired in multiple energy bins, and used for machine-learning approaches such as convolutional neural networks. more...

Seeber, da Graca

MLC Drive Concept - PLC new system control architecture/network topology (P-1365)


The control system comprises of a Programmable Logic Controller (PLC), acting as the main controller for the MLC, handling position commands, collision detection and error handling for the whole system, being a master for all the MLC high level decisions. All components are connected via a real-time fieldbus supporting a cycle rate of up to 8kHz, which enables MLC tumor tracking and compensating body and organ movements. more...

Hoppe-Seyler, Braun, Hoppe-Seyler

Iron Chelators in Tumor Therapy (P-1361)

Keywords: Therapeutics

We invented a pharmaceutically compatible iron chelator or a pro-drug thereof for use in treating and/or preventing cancer in a patient suspected or known to comprise hypoxic cancer cells, and use in treatment and/or prevention of a human papillomavirus (HPV) related lesion. The technology further allows the use of an iron chelator or prodrug thereof for inducing senescence in a cancer cell, preferably a hypoxic cancer cell; and to a method for inducing an irreversible proliferation arrest in cancer cells comprising a) contacting said cancer cells with an iron chelator or prodrug thereof and, thereby, b) inducing an irreversible proliferation arrest in said cancer cells. more...

Müller, Ottonello, Bolchi, Mariz, Balz, Zhao

Cutaneous human Papilloma Virus Vaccine (P-1358)

Keywords: Therapeutics, Vaccines

Infections with human papillomavirus (HPV) are a worldwide health challenge, particularly in resource-limited regions. HPV-related diseases are pre-malignancies or overt malignancies of the skin and mucosal surfaces and are an important personal and public health problem causing physical, mental, sexual and financial detriments. The World Health Organization estimates that there are approximately 14 million new HPV infections each year. We have developed an immunogenic polypeptide comprising a multitude of papilloma-virus (PV) L2 N-terminal peptides to protect against most cutaneous HPV types. more...

Turchinovich, Burwinkel

A method to prevent incorporation of DNA molecules into DNA libraries for massive parallel sequencing of RNA: DNA lock off (DLoff) (P-1357)

Keywords: Diagnostics, Research Tools

A method to prevent incorporation of DNA molecules into DNA libraries for massive parallel sequencing of RNA.

Brenner, Zhang

Mortality prediction through DNA methylation biomarkers (P-1333)

Keywords: Diagnostics

Getting to know you chances of dying can be daunting but also can be rather useful and fascinating. The kit predicts all-cause mortality independent of underlying diseases or the ?epigenetic clock?. It has been validated through a 14 year long patient study.


Chromatic easySTED waveplate with wide excitation range (P-1312)

Keywords: Devices, 8

This EasySTED concept realizes STED microscopy with one source for excitation and inhibition light. The technology achieves a larger wavelength range for easySTED. Waveplates can be produced by standard methods e.g. from quartz.

Delecluse, Tsai, Shumilov

Improved EBV Vaccine: BNRF1 inducing chromosomal instability (P-1309)

Keywords: Vaccines

This invention provides a safe Epstein-Barr Virus vaccine, which does not introduce chromosomal instabilities associated with cancer development.

Amtmann, Gunkel, Miller, Morgen

Treatment of chemotherapy-resistant Small Cell Lung Cancer (P-1306)

Keywords: Therapeutics

Lung cancer is the leading cause of death among men and women in North America and attracts substantial pharmaceutical investment. However, in contrast to non-small cell lung cancer (NSCLC) therapies, where significant progress has been made with targeted agents and immunotherapies, the small cell lung cancer (SCLC) landscape has remained static for more than 30 years. However, we have shown that cyclodextrin stimulates the anti-tumor effect of combinations of disulfiram with various heavy metal salts. Surprisingly, the tested T-cell lymphoma/leukemia, carcinoma, non-T-cell leukemia and SCLC cells are hypersensitive to the combination treatment in cyclodextrin formulation. more...

Heikenwälder, Zender, Weber

Treatments of Non-Alcoholic Steatohepatitis (NASH) and HCC (P-1305)

Keywords: Therapeutics

Non-alcoholic fatty liver disease (NAFLD), comprising several liver diseases including NAFL and NASH, which is the most frequent liver disease world-wide, is a clinical manifestation of overweight and metabolic syndrome. The prevalence of NAFL is increasing globally. We have identified compounds that are effective for treating non-alcoholic steatohepatitis (NASH), an advanced stage of NAFL (non-alcoholic fatty liver), in order to avoid the development of liver cirrhosis and hepatocellular carcinoma (HCC). more...

Watanabe, Monyer

Pipette device for delicate transfer of tissue in immunohistochemistry staining procedures (P-1295)

Keywords: Research Tools, Devices, 8

Staining of tissue is a standard method in biological laboratories, but also in clinical environment for diagnostics such as immunohistochemistry (IHC). After a certain incubation period the protocol often requires the transfer of the tissue into another staining chamber. This transfer is a critical step since the thickness of the paraffin embedded slices is smaller than 10 micrometers. As a technical solution a disposable pipette is engineered to have a hole at a specified spot for pressure regulation. This ensures that no under pressure occurs, which might be able to damage the tissue mechanically and/or inhibits the tissue from being sucked into the pipette. more...

Maier-Hein, Kirchner, Gröhl

Machine learning-based quantitative photoacoustic tomography (P-1284)

Keywords: Devices, Software

The proprietary technology includes a method, a computer program and an apparatus for estimating an optical property of a tissue from a photoacoustic image in a fast, simple and accurate manner allowing real-time, in vivo application. Specifying the optical properties of a tissue is vital for interpreting diagnostic measurements, designing devices and planning therapeutic protocols (e.g. photodynamic therapy). more...


Stabilization of focus in high resolution microscopy (P-1260)

Keywords: 8

The relative position of a microscope objective with regard to a sample is essential in imaging the sample using the microscope objective. The invention describes a method in which monitoring and correcting of a relative position of a microscope objective with regard to a sample is easily realized and does not disturb the primary use of the microscope objective. The procedure is carried out using a test beam directed onto a reflective surface connected to the sample and on the other hand using a test beam directed onto a reflective surface connected to the objective. Both results are registered, evaluated and used for correction. more...

Maier-Hein, Stenau geb. Wild, Teber

System for fluorescence-guided surgery (P-1254)

Keywords: Devices

The technology enables the surgeon to place and navigate e.g. a laparoscope, within an organ in an extremely precise, safe, and reliable manner.


A unique inducible mouse model of hepatocellular carcinoma (HCC) (P-1245)

Keywords: Research Tools

The mouse model faithfully mimics clinical conditions in HCC and allows evaluation of novel therapeutic strategies like immunotherapy or antiangiogenic therapy or vaccination. The tumor induction is tightly controlled by cre/loxP-system in a dose-dependent manner.


Actively switched beam splitter (P-1216)

Keywords: Devices, 8

DKFZ researchers developed an actively switched beam splitter based on polarizing beam splitters in combination with a Pockels cell which can be used for all fluorescent microscopes using pulsed excitation light.


New Antibody against SUMO1 protein (P-1193)

Keywords: Therapeutics, Research Tools

The antibody of this invention is a mouse monoclonal antibody directed against SUMO176-86 recognizing SUMO1 of human, mouse, chicken and X. laevis. It is suitable for western blot and immune precipitation as well as for large-scale enrichment of SUMOylated species by IP / peptide elution.


Know-How: A natural rodent model system for papilloma-virus (PV) - induced cancer (P-1168)

Keywords: Research Tools

The Mastomys mouse model is the only existing natural laboratory model to investigate PV pathogenesis and tumor development in the skin, ear, eye and tongue and could help to develop prophylactic or therapeutic approaches to prevent those lesions.

Allgayer, Leupold

A Fast and Cost-Efficient In Vivo Model to Investigate Tumor Metastasis (P-1148)

Keywords: Research Tools

The invention discloses an improved version of the chorionallantic membrane, for accurate quantification of metastatic cells in different organs of the chicken embryo at a high sensitivity.


Chromatic phase plate (P-1146)

Keywords: 8

Novel chromatic phase plate designed for STED or RESOLFT fluorescence light microscopy

Schmidt, Oakes, Plass

Cell line for screening demethylating agents using an endogenous epigenetically silenced reporter (P-1045)

Keywords: Research Tools

The invention provides a cell based high-throughput screening system for agents that influence DNA methylation by determining the methylation status of an internal promoter.

Seeber, Schewiola

New MLC generation for radiotherapy: drive concept leaves by using linear servo motor (P-1044)

Keywords: Devices

The aim of radiation therapy is to eradicate a tumor without causing significant damage to contiguous normal tissue. For precise field shaping of the radiation beam multileaf collimators (MLC) have been broadly established. The linear servo MLC presented here provides various advantages over conventionally employed MLCs like reduced size and weight, dynamic leaf movements up to 4 m/s, direct fixation of the linear servo rod to the associated leaf and position sensors are implemented in the linear drives. more...

Lichter, Pfister, Witt, Jones, Sturm, Plass, Korshunov, Pfaff, Jabado

Histone mutations as marker for Glioblastoma (P-1012)

Keywords: Diagnostics

This technology was achieved by a cooperation between McGill University and DKFZ. Brain tumours, such as the highly aggressive glioblastoma multiforme (GBM), are currently the leading cause of cancer-related mortality and morbidity in children. Current diagnosis of brain cancers involve MRI, PET and CT scans, angiographies, followed by biopsies performed either during the resection of the tumor or as a separate procedure via a burr hole. A blood-based test would provide a more economical, i.e accessible and less invasive diagnostic tool. The GBM specific biomarker has been patented and is available for licensing i.e. for companion diagnostics. more...


4Pi STED Fluorescence Light Microscope with high three-Dimensional Spatial Resolution (P-1010)

Keywords: Devices

The here presented technology provides an apparatus for 4Pi STED which allows to generate a three-dimensional light intensity distribution comprising a very steep light intensity gradient between the areas of minimum and maximum light intensity.

Becker geb. Schoch, Jäschke, Samanta, Wießler

Multiple orthogonal labelling of oligonucleotides (P-1007)

Keywords: Research Tools

Labeled oligonucleotides are used in research and for diagnostic, therapeutic and industrial applications. Researchers from the DKFZ and the Heidelberg University developed a fast method for post-synthetic multiple orthogonal labeling of oligonucleotides by combining the inverse Diels-Alder reaction with the well-known copper-catalyzed azide-alkyne cycloaddition. more...

Abdollahi, Lee, Javaherian

Oligomerization improves endostatin as antiangiogenic and anticancer drug (P-1000)

Keywords: Therapeutics

Endostatin is an antiangiogenic protein first discovered in Folkman’s laboratory at Childrens Hospital, Harvard Medical School, and Boston. The antitumor properties of this protein are well established. However, the amount of protein required for injection in patients was beyond production feasibility due to the poor pharmacokinetics of endostatin monomer. We have shown that the problem of poor pharmacokinetics can be solved by using the Fc domain of IgG being conjugated to endostatin, a component of all monoclonal antibodies approved for patients with a number of diseases including cancer. As a result of employing Fc-endostatin, the half-life in mice was increased to 2 weeks instead of 2 hours for endostatin alone, consistent with pharmacokinetics of monoclonal antibodies. more...

Schewiola, Seeber

Control of radiation therapy devices via PLC technology (P-996)

Keywords: Devices

Synchronization and control of linear accelerator, multi-leaf collimator, gantry system, patient support system and x-ray beam generation system at the same time is difficult to establish, particularly with hard real-time requirements. The presented technology comprises a control unit consisting of standardized programmable logic controllers for real-time operation of all subsystems of a radiation therapy device. Thus, the technology allows precise and dynamic patient treatment with high time resolution. more...

Delecluse, Feederle, Hundt

Promising effective and safe Epstein-Barr virus (EBV) vaccine based on VLPs (P-989)

Keywords: Vaccines

Virus-like particles (VLPs) of EBV, completely devoid of viral DNA, for the prevention of infectious mononucleosis (IM) and EBV-associated diseases like lymphomas often developed in patients with immunosuppression.

Platten, Bunse, Wick

Method for immunodiagnostic und immunotherapy of astrozytomes having IDH1R132H-mutation (P-987)

Keywords: Therapeutics

The technology can be used to detect cancer types with IDH1 R132H mutation in blood samples of patients. Furthermore, T-cells obtained from patients suffering from tumors accompanied by IDH1 R132H mutation can be stimulated using the peptide, which initiates via the peptide vaccine immune response against tumor cells. more...

von Deimling, Buckel, Balss, Pusch

Diagnosis of glioblastoma and acute myeloid leukaemia by (D)-2-hydroxyglutarate test (P-977)

Keywords: Diagnostics

Diagnosis and monitoring of IDH1/IDH2/IDH3 dependent diseases such as: Glioblastomas, astrocytoma, oligodendrogliomas, oligoastrocytoma, acute myeloid leukaemia (AML), chondrosarcoma, intrahepatic cholangiocarcinoma, angioimmunoblastic T cell lymphoma. The technolgy describes a patented test, which is a simple and robust enzymatic assay with a readout in 3 hours. The test is suitable for 96-/384-well format, less expensive/time-consuming and high-throughput possible in opposite to established GC-MS test. more...

Echner, Seeber, Schewiola

Piezo elements as driving units for leafs of multi-leaf collimators (MLC) (P-973)

Keywords: Devices

Currently, multi leaf collimators (MLC) are established and state of the art in numerous devices for radiotherapy used for cancer treatment. However, the established MLC comprising 80 and more leafs require an enormous space at the level of the leaves for corresponding drive and controlling elements if realized with normal electric motors. Since space is very limited within the head of linear accelerators the invention proposes a new small and convenient driving/controlling device based on piezoelectricity, which is directly coupled to the leaves and their driving rods. more...

Maier-Hein, Meinzer, Fangerau, Seitel

Mobile On-patient visualization device of medical images (P-952)

Keywords: Devices, Software

We developed a new concept for on-patient visualization of anatomical data acquired with an arbitrary modality (typically CT or MRI). The method is based on a mobile device consisting of a flat display and a Time-of-Flight (ToF) camera which can be moved along the patient to provide a view on internal anatomical structures via augmented reality. For this purpose, the pose of the mobile device, which represents the viewing direction of the user, is continuously estimated by registering (i.e., aligning) the ToF data acquired during the visualization process with the patient surface extracted from the 3D medical data set. During camera pose estimation, a custom-designed algorithm accounts for the camera specific localization errors. more...


Compact Multileaf-Collimator with small diameter (P-901)

Keywords: Devices

Currently, Multileaf Collimators (MLC) are established and state of the art in numerous devices for radiotherapy used for cancer treatment. However, the established MLC comprising 80 and more leafs require an enormous space at the level of the leaves together with corresponding drive elements and position measuring/ acquisi-tion. Since space is very limited within the head of linear accelerators DKFZ developed a smaller sized Compact MLC, which prototype was tested successfully. more...

Moldenhauer, Scheffzek, Parret

Monoclonal Antibody against Neurofibromin: Diagnostic and Prognostic Marker for Glioma Treatment (N terminal antibody: mAb NF1-5.16) (P-897)

Keywords: Diagnostics

Monoclonal Antibody against Neurofibromin as a diagnostic and prognostic Marker for Glioma Treatment. The proof of concept is established with Biopsy Material. The antibody is fast, reliable & ready to use.

Rubio, Müller, Tommasino, Ottonello, Bolchi

Presentation of HPV L2 Epitopes by using thioredoxin scaffold (P-824)

Keywords: Vaccines

The current invention provides a prophylactic HPV vaccine. Immunization against peptides from the HPV L2 protein gives a robust immune reaction that provides cross-protection against a variety of other high-risk HPV strains. The vaccine is based on a thioredoxin-L2 construct and can be produced in standard E. coli bacteria, which makes a cost-effective production feasible. more...


Quadscanner for High Resolution Microscopy (P-750)

Keywords: Devices

Quadscanner for High Resolution Scanning Microscopes and Array Readers. The key facts are: (1) Fast, adaptive optical scanning device; (2) Completely free positioning of the scanning mirrors regarding the conjugated back focal plane; (3) Calibration with 4 galvanometers; (4) Application in high resolution microscopes (fluorescence, Raman, STED, localization), but also in Array Readers. more...

Peter, Bock, Umathum

Optical Tomography (OT) and MR combination for dual-modality imaging (P-734)

Keywords: Devices

Optical techniques, such as bioluminescence and fluorescence, are emerging as powerful new modalities for molecular imaging in disease and therapy. Combining innovative molecular biology and chemistry, researchers have developed optical methods for imaging a variety of cellular and molecular processes in vivo, including protein interactions, protein degradation, and protease activity. DKFZ developed an optical imaging detector regarding fluorescence and bioluminescence for small animal imaging, which is compatible for magnetic resonance imaging (MRI). This technology provides the possibility to study simultaneously tracer/marker kinetics of optical (OT) as well as NMR induced signals. more...

Schulz, Peter, Unholtz

Optical Tomography (OT) for multi-modality imaging (P-706)

Keywords: Devices

DKFZ developed an optical imaging detector (25 mm x 100 mm photon sensor) for fluorescence and bioluminescence in small animal imaging, which is compatible for magnetic resonance imaging (MRI), computer tomography (CT), positron electron tomography (PET) and Single-photon emission computed tomography (SPECT). The instrument has been evaluated regarding ist optical performance including radiation durability using various phantoms and measurement setups and was successfully used in a number of preclinical studies such as simultaneous positron (18F-FDG, 68Ga-RGD) - bioluminescence (PC-3-hVEGF-Luc) imaging of reporter gene expression and receptor targeting in mice or simultaneous imaging of fluorescent XenoLight-RediJect-2-DG-750 and radiolabeled FDG probes. more...

Peter, Schulz

Optical Tomography (OT) and PET combination for dual-modality imaging (P-655)

Keywords: Devices

DKFZ developed an optical imaging detector for fluorescence and bioluminescence in small animal imaging, which is compatible for positron electron tomography (PET). Compatibility of light detection with PET has been accomplished by developing an optical detector that consists of a 25 mm x 100 mm photon sensor (liquid cooled) for light detection, a microlens array for field-of-view definition, a septum masks for cross-talk suppression, and a transferable filter for wavelength selection. more...

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