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Waterboer, Hufnagel, Lueong Smiths, Pawlita, Hoheisel, Willhauck-Fleckenstein

Peptide array for Chlamydia trachomatis diagnosis (P-1391)

Keywords: Diagnostics, Research Tools

We have developped a peptide array comprising at least 100 polypeptides expressed or expressible from a Chlamydia trachomatis genome or epitopes fragment thereof. The technology can be used for diagnosing cervical carcinoma or for diagnosing a Chlamydia spp. infection in a patient.

Eisenbach, Tzehoval, Cafri, Yunger, Grees

A universal vaccine platform (P-1367)

Keywords: Therapeutics, Research Tools, Vaccines

While cancer vaccines have been investigated for many decades, to date only one has been approved in the USA as a treatment for existing cancer, and most have failed. Recent clinical studies demonstrate the beneficial effect of immunization with several peptide combinations. However, immunotherapy using a several peptides is expensive and laborious. The invention addresses this issue through a novel genetic platform capable of universal application. The technology is a cell based vaccine that has been shown to be effective against metastatic melanoma, which is one of the most lethal malignancies, with median survival of less than a year. The vaccine platform is very effective in generating a potent anti-tumor effect due to multiple antigenic presentations and can potentially be applied to all proliferative diseases. more...

Watanabe, Monyer

Pipette device for delicate transfer of tissue in immunohistochemistry staining procedures (P-1295)

Keywords: Research Tools, Devices, 8

Staining of tissue is a standard method in biological laboratories, but also in clinical environment for diagnostics such as immunohistochemistry (IHC). After a certain incubation period the protocol often requires the transfer of the tissue into another staining chamber. This transfer is a critical step since the thickness of the paraffin embedded slices is smaller than 10 micrometers. As a technical solution a disposable pipette is engineered to have a hole at a specified spot for pressure regulation. This ensures that no under pressure occurs, which might be able to damage the tissue mechanically and/or inhibits the tissue from being sucked into the pipette. more...

Arnold

A unique inducible mouse model of hepatocellular carcinoma (HCC) (P-1245)

Keywords: Research Tools

The mouse model faithfully mimics clinical conditions in HCC and allows evaluation of novel therapeutic strategies like immunotherapy or antiangiogenic therapy or vaccination. The tumor induction is tightly controlled by cre/loxP-system in a dose-dependent manner.

Melchior

New Antibody against SUMO1 protein (P-1193)

Keywords: Therapeutics, Research Tools

The antibody of this invention is a mouse monoclonal antibody directed against SUMO176-86 recognizing SUMO1 of human, mouse, chicken and X. laevis. It is suitable for western blot and immune precipitation as well as for large-scale enrichment of SUMOylated species by IP / peptide elution.

Rösl

Know-How: A natural rodent model system for papilloma-virus (PV) - induced cancer (P-1168)

Keywords: Research Tools

The Mastomys mouse model is the only existing natural laboratory model to investigate PV pathogenesis and tumor development in the skin, ear, eye and tongue and could help to develop prophylactic or therapeutic approaches to prevent those lesions.

Burwinkel, Yang, Peng, Cike, Schneeweiss

Plasma S100P and hyaluronic acid level as prognostic and treatment monitoring markers for metastatic breast cancer (P-1157)

Keywords: Diagnostics, Research Tools

The present invention comprises the use of two serum/plasma markers for stage discrimination and prediction of survival as well as treatment response in breast cancer patients. Test statistics show that these markers outperform established ones like the number of circulating tumor cells (CTCs).

Allgayer, Leupold

A Fast and Cost-Efficient In Vivo Model to Investigate Tumor Metastasis (P-1148)

Keywords: Research Tools

The invention discloses an improved version of the chorionallantic membrane, for accurate quantification of metastatic cells in different organs of the chicken embryo at a high sensitivity.

Schmidt, Oakes, Plass

Cell line for screening demethylating agents using an endogenous epigenetically silenced reporter (P-1045)

Keywords: Research Tools

The invention provides a cell based high-throughput screening system for agents that influence DNA methylation by determining the methylation status of an internal promoter.

Becker geb. Schoch, Jäschke, Samanta, Wießler

Multiple orthogonal labelling of oligonucleotides (P-1007)

Keywords: Research Tools

Labeled oligonucleotides are used in research and for diagnostic, therapeutic and industrial applications. Researchers from the DKFZ and the Heidelberg University developed a fast method for post-synthetic multiple orthogonal labeling of oligonucleotides by combining the inverse Diels-Alder reaction with the well-known copper-catalyzed azide-alkyne cycloaddition. more...

Kliem, Wießler, Lorenz, Fleischhacker, Jäschke, Becker geb. Schoch

Post-synthetic modification of nucleic acids by inverse Diels-Alder reaction (P-870)

Keywords: Research Tools

This invention provides a method for an easy, economical and reliable post-synthetic modification of nucleic acids. The key facts are: ? Variety of application: labelling, drug discovery, material studies, biomolecule research ? Attractive for conjugation of expensive and sensitive compounds ? Suitable for simple and complex molecules ? High yielding, easy to monitor, non-toxic reactions more...

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