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The main goal of radiation therapy is to eradicate the tumor without causing significant damage to the surrounding normal tissues. The Ion beam therapy provides potential for increased dose conformation to the target volume and spares the normal tissues. The verification of the treatment is crucial for the accurate dose delivery, this new device comprises a delivery and a verification unit, particularly be used for the patient treatment with the ion beam therapy. The device offers real time tracking and several other advantages over the existing imaging  technologies for verifying the dose delivery and range of the particles. more...

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Keywords: Devices, Software

This invention is based on the assumption that large-angle, low-energy scatter (which is usually discarded) contains useful information about low-angle, high-energy scatter (which shall be estimated) that can be leveraged by machine learning. The invention therefore uses energy measurements to discern measured photons by energy bin. Multiple raw-data images can be formed from raw data acquired in multiple energy bins, and used for machine-learning approaches such as convolutional neural networks. more...

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Keywords: Devices, 8

This EasySTED concept realizes STED microscopy with one source for excitation and inhibition light. The technology achieves a larger wavelength range for easySTED. Waveplates can be produced by standard methods e.g. from quartz.

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Keywords: Research Tools, Devices, 8

Staining of tissue is a standard method in biological laboratories, but also in clinical environment for diagnostics such as immunohistochemistry (IHC). After a certain incubation period the protocol often requires the transfer of the tissue into another staining chamber. This transfer is a critical step since the thickness of the paraffin embedded slices is smaller than 10 micrometers. As a technical solution a disposable pipette is engineered to have a hole at a specified spot for pressure regulation. This ensures that no under pressure occurs, which might be able to damage the tissue mechanically and/or inhibits the tissue from being sucked into the pipette. more...

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The proprietary technology includes a method, a computer program and an apparatus for estimating an optical property of a tissue from a photoacoustic image in a fast, simple and accurate manner allowing real-time, in vivo application. Specifying the optical properties of a tissue is vital for interpreting diagnostic measurements, designing devices and planning therapeutic protocols (e.g. photodynamic therapy). more...

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Keywords: Devices

The technology enables the surgeon to place and navigate e.g. a laparoscope, within an organ in an extremely precise, safe, and reliable manner.

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Keywords: Devices, 8

DKFZ researchers developed an actively switched beam splitter based on polarizing beam splitters in combination with a Pockels cell which can be used for all fluorescent microscopes using pulsed excitation light.

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Keywords: Devices

The aim of radiation therapy is to eradicate a tumor without causing significant damage to contiguous normal tissue. For precise field shaping of the radiation beam multileaf collimators (MLC) have been broadly established. The linear servo MLC presented here provides various advantages over conventionally employed MLCs like reduced size and weight, dynamic leaf movements up to 4 m/s, direct fixation of the linear servo rod to the associated leaf and position sensors are implemented in the linear drives. more...

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Keywords: Devices

The here presented technology provides an apparatus for 4Pi STED which allows to generate a three-dimensional light intensity distribution comprising a very steep light intensity gradient between the areas of minimum and maximum light intensity.

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Keywords: Devices

Synchronization and control of linear accelerator, multi-leaf collimator, gantry system, patient support system and x-ray beam generation system at the same time is difficult to establish, particularly with hard real-time requirements. The presented technology comprises a control unit consisting of standardized programmable logic controllers for real-time operation of all subsystems of a radiation therapy device. Thus, the technology allows precise and dynamic patient treatment with high time resolution. more...

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Keywords: Devices

Currently, multi leaf collimators (MLC) are established and state of the art in numerous devices for radiotherapy used for cancer treatment. However, the established MLC comprising 80 and more leafs require an enormous space at the level of the leaves for corresponding drive and controlling elements if realized with normal electric motors. Since space is very limited within the head of linear accelerators the invention proposes a new small and convenient driving/controlling device based on piezoelectricity, which is directly coupled to the leaves and their driving rods. more...

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We developed a new concept for on-patient visualization of anatomical data acquired with an arbitrary modality (typically CT or MRI). The method is based on a mobile device consisting of a flat display and a Time-of-Flight (ToF) camera which can be moved along the patient to provide a view on internal anatomical structures via augmented reality. For this purpose, the pose of the mobile device, which represents the viewing direction of the user, is continuously estimated by registering (i.e., aligning) the ToF data acquired during the visualization process with the patient surface extracted from the 3D medical data set. During camera pose estimation, a custom-designed algorithm accounts for the camera specific localization errors. more...

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Keywords: Devices

Currently, Multileaf Collimators (MLC) are established and state of the art in numerous devices for radiotherapy used for cancer treatment. However, the established MLC comprising 80 and more leafs require an enormous space at the level of the leaves together with corresponding drive elements and position measuring/ acquisi-tion. Since space is very limited within the head of linear accelerators DKFZ developed a smaller sized Compact MLC, which prototype was tested successfully. more...

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Quadscanner for High Resolution Scanning Microscopes and Array Readers. The key facts are: (1) Fast, adaptive optical scanning device; (2) Completely free positioning of the scanning mirrors regarding the conjugated back focal plane; (3) Calibration with 4 galvanometers; (4) Application in high resolution microscopes (fluorescence, Raman, STED, localization), but also in Array Readers. more...

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Optical techniques, such as bioluminescence and fluorescence, are emerging as powerful new modalities for molecular imaging in disease and therapy. Combining innovative molecular biology and chemistry, researchers have developed optical methods for imaging a variety of cellular and molecular processes in vivo, including protein interactions, protein degradation, and protease activity. DKFZ developed an optical imaging detector regarding fluorescence and bioluminescence for small animal imaging, which is compatible for magnetic resonance imaging (MRI). This technology provides the possibility to study simultaneously tracer/marker kinetics of optical (OT) as well as NMR induced signals. more...

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Keywords: Devices

DKFZ developed an optical imaging detector (25 mm x 100 mm photon sensor) for fluorescence and bioluminescence in small animal imaging, which is compatible for magnetic resonance imaging (MRI), computer tomography (CT), positron electron tomography (PET) and Single-photon emission computed tomography (SPECT). The instrument has been evaluated regarding ist optical performance including radiation durability using various phantoms and measurement setups and was successfully used in a number of preclinical studies such as simultaneous positron (18F-FDG, 68Ga-RGD) - bioluminescence (PC-3-hVEGF-Luc) imaging of reporter gene expression and receptor targeting in mice or simultaneous imaging of fluorescent XenoLight-RediJect-2-DG-750 and radiolabeled FDG probes. more...

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