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Seco, Martins, Dal Bello

A device and a method for monitoring the treatment of a patient with particles (P-1427)

Keywords: Devices

The main goal of radiation therapy is to eradicate the tumor without causing significant damage to the surrounding normal tissues. The Ion beam therapy provides potential for increased dose conformation to the target volume and spares the normal tissues. The verification of the treatment is crucial for the accurate dose delivery, this new device comprises a delivery and a verification unit, particularly be used for the patient treatment with the ion beam therapy. The device offers real time tracking and several other advantages over the existing imaging  technologies for verifying the dose delivery and range of the particles. more...

Kachelrieß, Berker

Deep Scatter Estimation in Positron Emission Tomography and other modalities (P-1375)

Keywords: Devices, Software

This invention is based on the assumption that large-angle, low-energy scatter (which is usually discarded) contains useful information about low-angle, high-energy scatter (which shall be estimated) that can be leveraged by machine learning. The invention therefore uses energy measurements to discern measured photons by energy bin. Multiple raw-data images can be formed from raw data acquired in multiple energy bins, and used for machine-learning approaches such as convolutional neural networks. more...

Engelhardt

Chromatic easySTED waveplate with wide excitation range (P-1312)

Keywords: Devices, 8

This EasySTED concept realizes STED microscopy with one source for excitation and inhibition light. The technology achieves a larger wavelength range for easySTED. Waveplates can be produced by standard methods e.g. from quartz.

Watanabe, Monyer

Pipette device for delicate transfer of tissue in immunohistochemistry staining procedures (P-1295)

Keywords: Research Tools, Devices, 8

Staining of tissue is a standard method in biological laboratories, but also in clinical environment for diagnostics such as immunohistochemistry (IHC). After a certain incubation period the protocol often requires the transfer of the tissue into another staining chamber. This transfer is a critical step since the thickness of the paraffin embedded slices is smaller than 10 micrometers. As a technical solution a disposable pipette is engineered to have a hole at a specified spot for pressure regulation. This ensures that no under pressure occurs, which might be able to damage the tissue mechanically and/or inhibits the tissue from being sucked into the pipette. more...

Maier-Hein, Kirchner, Gröhl

Machine learning-based quantitative photoacoustic tomography (P-1284)

Keywords: Devices, Software

The proprietary technology includes a method, a computer program and an apparatus for estimating an optical property of a tissue from a photoacoustic image in a fast, simple and accurate manner allowing real-time, in vivo application. Specifying the optical properties of a tissue is vital for interpreting diagnostic measurements, designing devices and planning therapeutic protocols (e.g. photodynamic therapy). more...

Maier-Hein, Stenau geb. Wild, Teber

System for fluorescence-guided surgery (P-1254)

Keywords: Devices

The technology enables the surgeon to place and navigate e.g. a laparoscope, within an organ in an extremely precise, safe, and reliable manner.

Engelhardt

Actively switched beam splitter (P-1216)

Keywords: Devices, 8

DKFZ researchers developed an actively switched beam splitter based on polarizing beam splitters in combination with a Pockels cell which can be used for all fluorescent microscopes using pulsed excitation light.

Wilkening

Device for sample purification by paramagnetic beads (P-1170)

Keywords: Devices

The invention discloses a device that enables bead purification and mixing of the sample without the need for moving the reaction plate from one deck position to the other and hence saving time and deck space.

Schaufler, Eipel, Bestvater, Schmidt

Temperature stabilisation of high-resolution microscopes (P-1115)

Keywords: Devices

Temperaturstabilisierung ist bei hochauflösenden Mikroskopen sehr wichtig. Die von DKFZ entwickelte Technologie ermöglicht mit Durchstrom von exakt temperierter Flüssigkeit durch die Temperiereinheiten die genaue Regulation der Temperatur und somit eine Wärmeaufnahme und -abgabe am Mikroskopaufbau.

Seeber, Schewiola

New MLC generation for radiotherapy: drive concept leaves by using linear servo motor (P-1044)

Keywords: Devices

The aim of radiation therapy is to eradicate a tumor without causing significant damage to contiguous normal tissue. For precise field shaping of the radiation beam multileaf collimators (MLC) have been broadly established. The linear servo MLC presented here provides various advantages over conventionally employed MLCs like reduced size and weight, dynamic leaf movements up to 4 m/s, direct fixation of the linear servo rod to the associated leaf and position sensors are implemented in the linear drives. more...

Engelhardt

4Pi STED Fluorescence Light Microscope with high three-Dimensional Spatial Resolution (P-1010)

Keywords: Devices

The here presented technology provides an apparatus for 4Pi STED which allows to generate a three-dimensional light intensity distribution comprising a very steep light intensity gradient between the areas of minimum and maximum light intensity.

Schewiola, Seeber

Control of radiation therapy devices via PLC technology (P-996)

Keywords: Devices

Synchronization and control of linear accelerator, multi-leaf collimator, gantry system, patient support system and x-ray beam generation system at the same time is difficult to establish, particularly with hard real-time requirements. The presented technology comprises a control unit consisting of standardized programmable logic controllers for real-time operation of all subsystems of a radiation therapy device. Thus, the technology allows precise and dynamic patient treatment with high time resolution. more...

Echner, Seeber, Schewiola

Piezo elements as driving units for leafs of multi-leaf collimators (MLC) (P-973)

Keywords: Devices

Currently, multi leaf collimators (MLC) are established and state of the art in numerous devices for radiotherapy used for cancer treatment. However, the established MLC comprising 80 and more leafs require an enormous space at the level of the leaves for corresponding drive and controlling elements if realized with normal electric motors. Since space is very limited within the head of linear accelerators the invention proposes a new small and convenient driving/controlling device based on piezoelectricity, which is directly coupled to the leaves and their driving rods. more...

Maier-Hein, Meinzer, Fangerau, Seitel

Mobile On-patient visualization device of medical images (P-952)

Keywords: Devices, Software

We developed a new concept for on-patient visualization of anatomical data acquired with an arbitrary modality (typically CT or MRI). The method is based on a mobile device consisting of a flat display and a Time-of-Flight (ToF) camera which can be moved along the patient to provide a view on internal anatomical structures via augmented reality. For this purpose, the pose of the mobile device, which represents the viewing direction of the user, is continuously estimated by registering (i.e., aligning) the ToF data acquired during the visualization process with the patient surface extracted from the 3D medical data set. During camera pose estimation, a custom-designed algorithm accounts for the camera specific localization errors. more...

Echner

Compact Multileaf-Collimator with small diameter (P-901)

Keywords: Devices

Currently, Multileaf Collimators (MLC) are established and state of the art in numerous devices for radiotherapy used for cancer treatment. However, the established MLC comprising 80 and more leafs require an enormous space at the level of the leaves together with corresponding drive elements and position measuring/ acquisi-tion. Since space is very limited within the head of linear accelerators DKFZ developed a smaller sized Compact MLC, which prototype was tested successfully. more...

Engelhardt, Hell, Keller

Localization Light Emitting Molecules of Unknown Orientation (P-899)

Keywords: Devices

Many light emitting entities routinely used, in cell biological settings show a dipole orientation. If the exact z position of the light emitting entity is unknown, using simple two-dimensional Gaussian fit algorithms to the light intensity distribution of a range of emitted light, may lead to calculation errors of the x- and y-position of several 10nm. The invention discloses a method for calculation of the exact spatial position and orientation of a light emitting in a sample. more...

Giesel, Zechmann, von Tengg-Kobligk, Münter, Neumann, Debus

Manufacturing patient mask for positioning patients in radiotherapy by rapid prototyping (P-806)

Keywords: Devices, Software

Radiotherapy is a well-established method to treat certain tumor types in particular brain tumors. For fixation of the patient’s head a ?mask? is used, with is connected to the plate where the patient is located on. The novel technology describes a non-invasive procedure, where the patient mask is produced by rapid prototyping based on CT/MR data. more...

Engelhardt

Quadscanner for High Resolution Microscopy (P-750)

Keywords: Devices

Quadscanner for High Resolution Scanning Microscopes and Array Readers. The key facts are: (1) Fast, adaptive optical scanning device; (2) Completely free positioning of the scanning mirrors regarding the conjugated back focal plane; (3) Calibration with 4 galvanometers; (4) Application in high resolution microscopes (fluorescence, Raman, STED, localization), but also in Array Readers. more...

Engelhardt

Stabilisation of images in microscopy (P-743)

Keywords: Devices

The technology specifies a novel device which allows to stabilize images of optical microscopes with high resolutions against externally induced oscillations and drift effects. In particular for optical microscopes, which achieve a higher resolution, it is important to ensure a high mechanical stability of the structure of microscope for a good image quality. It improves the performance of instruments such as laser scanners, fluorescence microscopes, Raman systems, STED- or localization-microscopes. more...

Peter, Bock, Umathum

Optical Tomography (OT) and MR combination for dual-modality imaging (P-734)

Keywords: Devices

Optical techniques, such as bioluminescence and fluorescence, are emerging as powerful new modalities for molecular imaging in disease and therapy. Combining innovative molecular biology and chemistry, researchers have developed optical methods for imaging a variety of cellular and molecular processes in vivo, including protein interactions, protein degradation, and protease activity. DKFZ developed an optical imaging detector regarding fluorescence and bioluminescence for small animal imaging, which is compatible for magnetic resonance imaging (MRI). This technology provides the possibility to study simultaneously tracer/marker kinetics of optical (OT) as well as NMR induced signals. more...

Schulz, Peter, Unholtz

Optical Tomography (OT) for multi-modality imaging (P-706)

Keywords: Devices

DKFZ developed an optical imaging detector (25 mm x 100 mm photon sensor) for fluorescence and bioluminescence in small animal imaging, which is compatible for magnetic resonance imaging (MRI), computer tomography (CT), positron electron tomography (PET) and Single-photon emission computed tomography (SPECT). The instrument has been evaluated regarding ist optical performance including radiation durability using various phantoms and measurement setups and was successfully used in a number of preclinical studies such as simultaneous positron (18F-FDG, 68Ga-RGD) - bioluminescence (PC-3-hVEGF-Luc) imaging of reporter gene expression and receptor targeting in mice or simultaneous imaging of fluorescent XenoLight-RediJect-2-DG-750 and radiolabeled FDG probes. more...

Peter, Schulz

Optical Tomography (OT) and PET combination for dual-modality imaging (P-655)

Keywords: Devices

DKFZ developed an optical imaging detector for fluorescence and bioluminescence in small animal imaging, which is compatible for positron electron tomography (PET). Compatibility of light detection with PET has been accomplished by developing an optical detector that consists of a 25 mm x 100 mm photon sensor (liquid cooled) for light detection, a microlens array for field-of-view definition, a septum masks for cross-talk suppression, and a transferable filter for wavelength selection. more...

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