Press and Public Relations

Joint International Journal of Cancer and Klaus Tschira Stiftung Lecture at DKFZ

Wednesday, June 27, 2012 - Dr. Eugene Butcher

Eugene Butcher received his undergraduate degree in chemistry from MIT in Boston and his MD from Washington University in St. Louis. In 1976 he began his residency in pathology at Stanford University in California, where he developed his career. This has culminated in a professorship at Stanford in the Dept. of Pathology. He is also staff physician at the Veterans Administration Palo Alto Health Care System and Director of the Serology and Immunology Section there.

Dr. Butcher studies leukocyte trafficking, cellular and developmental immunology and mucosal immunobiology. He has a record of innovative advances in lymphocyte and dendritic cell biology including the discovery of L-selectin, MAdCAM-1, CLA, and PNAd; formulation of the multi-step paradigms of leukocyte-endothelial recognition and trafficking, and of chemotactic navigation;  first applications of fluorescent cell labeling to leukocyte tracer studies and of in situ video microscopy to lymphocyte homing mechanisms; discovery of chemokine mediators of lymphocyte integrin activation and their roles in lymphocyte recruitment, including T cell and IgA plasma cell homing to the GI tract; demonstration of tissue-specific T cell imprinting of trafficking programs, and of the role of dendritic cell processing of Vitamin D in epidermotropic imprinting of skin homing T cells; deorphaning of several chemoattractant receptors including the chemerin receptors CMKLR1 and CCRL2; and recent discovery of a potent tolerogenic endogenous DC population with therapeutic potential in GVHD and autoimmune disease.  He has also pioneered cell systems biology approaches for drug discovery.

Eugene Butcher is a dedicated mentor for young scientists and highly sought after as a speaker. A long list of publications in top journals documents his scientific success.

Interview

Dr. Eugene Butcher interviewed by Dr. Stefanie Seltmann

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