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Hematological malignancies are a group of diseases affecting the blood, bone marrow and lymphoid system. Leukemias and lymphomas, are systemic malignancies originating from undifferentiated progenitor or lineage-committed cells of the hematopoietic system. As “tumors of the immune system”, leukemias and lymphomas form in the bone marrow or lymphoid organs, possess the potential to disseminate throughout the organism, but may also grow like solid tumors, even outside their regular homing compartments. Hence, studying pathogenetic mechanisms of hematological malignancies is not only of pivotal importance to improve therapeutic options against these entities, but will provide critical insights into oncogenic principles that apply to solid tumors as well.

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