Mission and Scientific Goals

Overall PCCC Strategy
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The mission of the consortium is to improve cancer therapy by developing advanced mouse models which more clearly mirror tumor initiation and progression. The consortium will concentrate on most relevant and most promising mechanism-based genetically engineered as well as humanized preclinical mouse models, which are most suitable for relevant, human-disease mimicking intervention studies. The mission of the PCCC is to translate discoveries into the clinic: from bench to beside. This goal will be achieved by vertical integration of target discovery and target biology, novel target screens and validation and the development of novel preclinical models and therapeutic translation. The ultimate goal will thereby be to advance preclinical basic cancer research with translatable perspective and to establish for the selected tumor entities a new global standard of preclinical tumor models.

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