Research Program D: Tumor Immunology

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Below you will find DKFZ divisions and research groups of the Research Program Tumor Immunology who are interested in recruiting Postdocs within the 2018 DKFZ Postdoctoral Fellowships Selection.

Please note that this is not an exhaustive list and new groups are continously added.

You may also contact the principal investigator of the DKFZ research group of your choice directly to discuss about current possibilities. More information about hiring labs can be found below and descriptions of DKFZ research programs via the general topic locator.

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Cellular Immunology – Prof. Dr. Hans-Reimer Rodewald

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© Weike Pei ,Thorsten Feyerabend

RESEARCH PROFILE

The Division of Cellular Immunology investigates the development and function of immune cells and lymphoid organs under physiological and pathological conditions. We aim at understanding functional properties of hematopoietic stem cells (HSCs) and pathways of immune cell development (Höfer et al. Annu Rev Immunol 2016). Deciphering how the hematopoietic system is established and maintained by continuous replenishment from the stem- and progenitor compartments is one of our main interests.

We have developed a spontaneous mouse model for acute lymphoblastic T-cell leukemia (T-ALL) for which we could demonstrate that disturbed progenitor supply from the bone marrow abrogates normal cell competition in the thymus leading to T-ALL (Martins et al. JEM 2012, Martins et al. Nature 2104). Ongoing projects are set for further unraveling the molecular and cellular mechanisms of T-ALL induction.

Over the past years, we have devised a series of knock-in mice to enable lineage tracing and measuring hematopoietic turnover at steady state or responsiveness of HSCs towards physical and pathological stress (Busch et al. Nature 2015, Pei et al. Nature 2017). Our recently developed Polylox barcoding system allows introducing genetic tags to a target population of cells in vivo and tracing their fates down to the clonal level. Combined with single cell transcriptomics, this may for the first time allow linkage of gene expression profiling with clonal in vivo fate mapping. Future experiments will address questions on cellular heterogeneity of HSCs and the ontogeny of enigmatic immune cell types like tissue macrophages, innate lymphocytes or myeloid suppressor cells.

PROJECT TOPICS

We seek for candidates with a strong interest in basic immunology to address fundamental questions on mechanisms of leukemia induction, stem cell development, and clonal contribution of stem- and progenitor cells to regular or induced hematopoiesis. Projects are mainly based on laboratory bench work but would also offer the opportunity to work on bioinformatics analyses.

Please visit our website for further information on our research and recent publications, or contact the lab (office.rodewald (at) dkfz.de).

 

LINK: https://www.dkfz.de/en/zellimmunologie

B Cell Immunology – Prof. Dr. Hedda Wardemann

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RESEARCH PROFILE

The B Cell Immunology Department studies B cell and more recently also T cell responses in humans and mouse models. The long-term goal of the Division is to determine how differences in the antigen receptor repertoire are associated with protective vs. nonprotective adaptive immune responses. Our research aims at (I) understanding how the repertoire is shaped on a molecular and functional level by antigen-driven selection, (II) defining qualitative differences in the B cell and T cell repertoires in health and disease, (III) identifying protective antibodies and T cell receptors and exploring their therapeutic potential in cancer and infectious diseases and at (IV) developing strategies for the targeted manipulation of the adaptive immune system to induce protective responses. To characterize the quality of adaptive immune responses at single cell level, we developed a high-throughput antigen receptor gene sequencing and expression-cloning platform. The use of this platform provides full-length paired immunoglobulin or T cell receptor gene information that is stored in a database and linked to a bioinformatic analysis pipeline for in-depth analyses. The platform has enabled us to obtain detailed phenotypic, genotypic and functional insights in the quality, molecular features, and clonal evolution of human memory B cell antibody responses (Triller et al. Immunity 2017, Murugan et al. Sci. Immunol. 2018, Rollenske et al. Nat. Immunol. 2018, Imkeller et al. Science 2018).

 

PROJECT TOPICS

We welcome applicants with a strong interest in basic immunology to address fundamental questions with high relevance to human disease.

Please visit our website for further information on our research and recent publications.

LINK: https://www.dkfz.de/en/b-zell-immunologie

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