Selected publications

Iyer A and Grummt I (2017) Ribosomes Dance to a Daily Rhythm. Trends Biochem Sci. 42(8):585-587. doi: 10.1016/j.tibs.2017.06.001. Epub 2017 Jun 17.

Song C, Hotz-Wagenblatt A, Voit R, Grummt I (2017) SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R-loops and safeguard genome stability. Genes Dev (in press).

Blank MF, Chen S, Poetz F, Schnölzer M, Voit R, Grummt I (2017) SIRT-dependent deacetylation of CDK9 activates RNA polymerase II transcription. Nucleic Acids Res 45(5), 2675-2686, doi: 10.1093/nar/gjx053.i

Blank MF and Grummt I (2017) The seven faces of SIRT7. Transcription 8(2), 67-74, doi: 10.1080/21541264.2016.1276658.

Zhao Z, Dammert MA, Hoppe S, Bierhoff H, Grummt I (2016) Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning. Nucleic Acids Res, doi: 10.1093/nar/gkw496

Zhao Z, Dammert MA, Grummt I, Bierhoff H (2016) LncRNA-induced nucleosome repositioning reinforces transcriptional repression of rRNA genes upon hypotonic stress. Cell Rep,

Chen S, Blank MF, Iyer A, Huang B, Wang L, Grummt I, Voit R (2016) SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing. Nat Commun 7, 10734 doi: 10.1038/ncomms10734.

Chen N-P, Uddin B, Voit R, Schiebel E (2016) Human phosphatase CDC14A is recruited to the cell leading edge to regulate cell migration and adhesion. Proc Natl Acad Sci USA 113, 990-995.

Postepska-Igielska A, Giwojna A, Gasri-Plotnitsky L, Schmitt N, Dold A, Ginsberg D, Grummt I (2015) LncRNA Khps1 regulates expression of the proto-oncogene SPHK1 via triplex-mediated changes in chromatin structure. Mol Cell 60, 626-636.

Caudron-Herger M, Pankert T, Seiler J, Nemeth A, Voit R, Grummt I, Rippe K (2015) Alu element-containing RNAs maintain nucleolar structure and function. EMBO J 34, 2735-2757.

Highlighted by: Carmo-Fonseca M (2015) Assembly of the nucleolus: in need of revision. EMBO J 34, 2731-2732.

Voit R, Seiler J, Grummt I (2015) Cooperative action of Cdk1/cyclin B and SIRT1 is required for mitotic repression of rRNA synthesis. PLoS Genet 11, e1005246. doi: 10.1371/journal.pgen.1005246.

Anosova I, Melnik S, Tripsianes K, Kateb F, Grummt I, Sattler M (2015) A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes. Nucleic Acids Res 43, 5208-5220.

Postepska-Igielska A, Grummt I (2014) NoRC silences rRNA genes, telomeres, and centromeres. Cell Cycle 13, 493-494. Comment.

Arab K, Park YJ, Lindroth AM, Schäfer A, Oakes C, Weichenhan D, Lukanova A, Lundin E, Risch A, Meister M, Dienemann H, Dyckhoff G, Herold-Mende C, Grummt I, Niehrs C, Plass C (2014) Long noncoding RNA TARID directs demthylation and activation of the tumor suppressor TCF21 via GADD45a. Mol Cell 55, 604-614.

Bierhoff H, Dammert MA, Brocks D, Dambacher S, Schotta G, Grummt I (2014) Quiescence-induced LncRNAs triggger H4K20 trimethylation and transcriptional silencing. Mol Cell 54, 675-682.

Chen S, Seiler J, Santiago-Reichelt M, Felbel K, Grummt I, Voit R (2013) Repression of RNA Polymerase I upon stress is caused by inhibition of RNA-dependent deacetylation of PAF53 by SIRT7. Mol Cell 52, 303-313.

Highlighted by: Laitem C, Murphy S (2013) Ac/D(eA)C rocks the polymerases. Mol Cell 52, 287-288.

Grummt I (2013) The nucleolus - guardian of cellular homeostasis and genome integrity. Chromosoma 122, 487-497. Review

Diermeier SD, Nemeth A, Rehli M, Grummt I, Längst G (2013) Chromatin-specific regulation of mammalian rDNA transcription by clustered TTF-I binding sites. PLoS Genet 9, e1003786.

Postepska-Igielska A, Krunic D, Schmitt N, Greulich-Bode KM, Boukamp P, Grummt I (2013) The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres. EMBO Rep 14, 704-710.

Luo M, Ling T, Xie W, Sun H, Zhou Y, Zhu Q, Shen M, Zong L, Lyu G, Zhao Y, Ye T, Gu J, Tao W, Lu Z, Grummt I (2013) NuRD block reprogramming of mouse somatic cells into pluripotent stem cells. Stem Cells 31, 1278-1286.

Xie W, Ling T, Zhou Y, Feng W, Zhu Q, Stunnenberg HG, Grummt I, Tao W (2012) The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions. Proc Natl Acad Sci U S A 109, 8161-8166.

Tumurbaatar I, Cizmecioglu O, Hoffmann I, Grummt I, Voit R (2011) Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity. PLoS ONE 6:e14711.

Bierhoff H, Schmitz K, Maass F, Ye J, Grummt I (2010) Noncoding transcripts in sense and antisense orientation regulate the epigenetic state of ribosomal RNA genes. Cold Spring Harb Symp Quant Biol 75, 357-364.

Grummt I (2010) Wisely chosen paths-regulation of rRNA synthesis. FEBS J 277, 4626-4639. Review.

Schmitz KM, Mayer C, Postepska A, Grummt I (2010) Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes. Genes Dev 24, 2264-2269.

Felle M, Exler JH, Merkl R, Dachauer K, Brehm A, Grummt I, Längst G (2010) DNA sequence encoded repression of rRMA gene transcription in chromatin. Nucleic Acids Res 38, 5304-5314.

Guetg C, Lienemann P, Sirri V, Grummt I, Hernandez-Verdun D, Hottiger MO, Fussenegger M, Santoro R (2010) The NoRC complex mediates heterochromatin formation and stability of silent rRNA genes and centromeric repeats. EMBO J 29, 2253-2146.

Feng W, Yonezawa M, Ye J, Jenuwein T, Grummt I (2010) PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Nat Struct Mol Biol. 17, 445-450.

Drygin D, Rice WG, Grummt I (2010) The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer. Annu Rev Pharmacol Toxicol 50, 131-156. Review.

Grummt I, Voit R (2010) Linking rDNA transcription to the cellular energy supply. Cell Cycle 9, 225-226.

Santoro R, Schmitz KM, Sandoval J, Grummt I (2010) Intergenic transcripts originating from a subclass of ribosomal DNA repeats silence ribosomal RNA genes in trans. EMBO Rep 11, 52-58.

Hoppe S, Bierhoff H, Cado I, Weber A, Tiebe M, Grummt I, Voit R (2009) AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply. Proc Natl Acad Sci USA 106, 17781-17786.

Zhou Y, Schmitz KM, Mayer C, Yuan X, Akhtar A, Grummt I (2009) Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing. Nat Cell Biol 11, 1010-1016.

Schmitz KM, Schmitt N, Hoffmann-Rohrer U, Schäfer A, Grummt I, Mayer C (2009) TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation. Mol Cell 33, 344-353.

Szymanski J, Mayer C, Hoffmann-Rohrer U, Kalla C, Grummt I, Weiss M (2009) Dynamic subcellular partitioning of the nucleolar transcription factor TIF-IA under ribotoxic stress. Biochim Biophys Acta 1793, 1191-1198.

Parlato R, Kreiner G, Erdmann G, Rieker C, Stotz S, Savenkova E, Berger S, Grummt I, Schütz G (2008) Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice. J Neurosci 28, 12759-12764.

Fátyol K, Grummt I (2008) Proteasomal ATPases are associated with rDNA: The ubiquitin proteasome system plays a direct role in RNA polymerase I transcription. Biochim Biophys Acta 1779, 850-859.

McStay B, Grummt I (2008) The Epigenetics of rRNA Genes: From Molecular to Chromosome Biology. Annu Rev Cell Dev Biol 24, 131-157. Review.

Mayer C, Neubert, M, Grummt I (2008) The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus. EMBO Rep 9, 774-780.

Bierhoff H, Dundr M, Michels A, Grummt I (2008) Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I. Mol Cell Biol 28, 4988-4998.

Grummt I, Ladurner AG (2008) A metabolic throttle regulates the epigenetic state of rDNA. Cell 133, 577-580. Review.

Ye J, Zhao J, Hoffmann-Rohrer U, Grummt I (2008) Nuclear myosin I acts in concert with polymeric actin to drive RNA polymerase I transcription. Genes Dev 22, 322-330.

Grummt I (2007) Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes. Hum Mol Genet 16, R21-27. Review.

Yuan X, Feng W, Imhof A, Grummt I, Zhou Y (2007) Activation of RNA polymerase I transcription by Cockayne Syndrome group B (CSB) protein and histone methyltransferase G9a. Mol Cell 27, 585-595.

Denissov S, van Driel M, Voit R, Hekkelman M, Hulsen T, Hernandez N, Grummt I, Wehrens R, Stunnenberg H (2007) Identification of novel TBP-binding sites and general factor repertoires. EMBO J 26, 944-954.

Arai S, Miyake K, Voit R, Nemoto S, Wakeland EK, Grummt I, Miyazaki T (2007) Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B. Proc Natl Acad Sci USA 104, 2289-2294.

Brenz-Verca MS, Weber P, Mayer C, Graf C, Refojo D, Kuhn R, Grummt I, Lutz B (2007) Development of a species-specific RNA polymerase I-based shRNA expression vector. Nucleic Acids Res 35, e10.

Li J, Laengst G, Grummt I (2006) NoRC-dependent nucleosome positioning silences rRNA genes. EMBO J 13, 5735-5741.

Mayer C, Grummt I (2006) Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases. Oncogene 25, 6384-6391. Review.

Mayer C, Schmitz K, Li J, Grummt I, Santoro R (2006) Intergenic transcripts regulate the epigenetic state of rRNA genes. Mol Cell 22, 351-361.

Meraner J, Lechner M, Loidl A, Goralik-Schramel M, Voit R, Grummt I, Loidl P (2006) Acetylation of UBF changes during the cell cycle and regulates the interaction of UBF with RNA polymerase I. Nucleic Acids Res 34, 1798-1806.

Ford E, Voit R, Liszt G, Magin C, Grummt I, Guarente L (2006) Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev 20, 1075-1080.

Percipalle P, Fomproix N, Cavellan E, Voit R, Reimer G, Krueger T, Thyberg J, Scheer U, Grummt I, Ostlund-Farrants AK (2006) The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription. EMBO Rep 7, 525-530.

Zhou Y, Grummt I (2005) The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing. Curr Biol 15, 1434-1438.

Yuan X, Zhou Y, Casanova E, Chai M, Kiss E, Gröne HJ, Schütz G, Grummt I (2005) Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell 19, 77-87.

Mayer C, Bierhoff H, Grummt I (2005) The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. Genes Dev 19, 933-941.

Santoro R, Grummt I (2005) Epigenetic mechanism of rRNA gene silencing: temporal order of NoRC-mediated histone modification, chromatin remodeling, and DNA methylation. Mol Cell Biol 25, 2539-2546.

Arabi A, Wu S, Ridderstrale K, Bierhoff H, Shiue C, Fatyol K, Fahlen S, Hydbring P, Soderberg O, Grummt I, Larsson LG, Wright AP (2005) Myc associates with ribosomal DNA and activates RNA polymerase I transcription. Nat Cell Biol 7, 303-310.

Li J, Santoro R, Koberna K, Grummt I (2005) The chromatin remodeling complex NoRC controls replication timing of rRNA genes. EMBO J 24, 120-127.

Mayer C, Zhao J, Yuan X, Grummt I (2004) mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. Genes Dev 18, 423-434.

Philimonenko VV, Zhao J, Iben S, Dingová H, Kyselá K, Zentgraf H, Hofmann W, de Lanerolle P, Hozák P, Grummt I (2004) Nuclear myosin I and actin are required for RNA polymerase I transcription. Nat Cell Biol 6, 1165-1172.

Prisco M, Maiorana A, Guerzoni C, Calin G, Calabretta B, Voit R, Grummt I, Baserga R (2004) Role of pescadillo and upstream binding factor in the proliferation and differentiation of murine myeloid cells. Mol Cell Biol 24, 5421-5433.

Grummt I (2003) Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus. Genes Dev 17, 1691-1702. Review.

Grummt I, Pikaard CS (2003) Epigenetic control of ribosomal RNA gene transcription. Nat Rev Mol Cell Biol 4, 641-649. Review.

Zhao J, Yuan Y, Frödin M, Grummt I (2003) The activity of TIF-IA, a basal RNA polymerase I transcription factor, is regulated by MAP kinase-mediated signaling. Mol Cell 11, 405-413.

Bradsher J, Auriol J, Proietti de Santis L, Iben S, Vonesch J-L, Grummt I, Egly J-M (2002) CSB is a component of RNA pol I transcription. Mol Cell 10, 819-829.

Dundr M, Hoffmann-Rohrer U, Hu Q, Grummt I, Rothblum LI, Phair RD, Misteli T (2002) A kinetic framework for a mammalian RNA polymerase in vivo. Science 298, 1623-1626.

Iben S, Tschochner H, Hoogstraten D, Hozak P, Egly JM, Grummt I (2002) TFIIH plays a role in RNA polymerase I transcription. Cell 109, 297-306.

Santoro R, Li J, Grummt I (2002) The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Nat Genet 32, 393-396.

Zhou Y, Santoro R, Grummt I (2002) NoRC, a SNF2h-containing chromatin remodeling complex, represses RNA polymerase I transcription by recruiting a histone deacetylase complex to the ribosomal gene promoter. EMBO J 21, 4632-4660.

Ciarmatori S, Scott PH, Sutcliff JE, McLees A, Alzuherri HM, Dannenberg J-H, te Riele H, Grummt I, Voit R, White RJ (2001). Overlapping functions of the pRb family in the regulation of rRNA synthesis. Mol Cell Biol 21, 5806-5814.

Muth V, Nadaud S, Grummt I, Voit R (2001) Acetylation of TAFI68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. EMBO J 20, 1353-1362.

Santoro R, Grummt I (2001) Molecular mechanisms mediating methylation-dependent silencing of ribosomal gene transcription. Mol Cell 8, 719-725.

Strohner R, Nemeth A, Jansa P, Hofmann-Rohrer U, Santoro R, Grummt I (2001) NoRC - a novel member of mammalian ISWI-containing chromatin remodeling complexes. EMBO J 20, 4892-4900.

Voit R, Grummt I (2001) Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription. Proc Natl Acad Sci USA 98, 13631-13636.

Bodem J, Dobreva G, Hoffmann-Rohrer U, Iben S, Zentgraf H, Delius H,Vingron M, Grummt I (2000) TIF–IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p. EMBO Rep 1, 171-175.

Voit R, Hoffmann M, Grummt I (1999) Phosphorylation by G1-specific cdk/cyclin complexes activates the nucleolar transcription factor UBF. EMBO J 18, 1891-1899.

Heix J, Vente A, Voit R, Budde A, Michaelidis T, Grummt I (1998) Mitotic silencing of human rRNA synthesis: inactivation of the promoter selectivity factor SL1 by cdc2/cyclin B-mediated phosphorylation. EMBO J 17, 7373-7381.

Längst G, Becker P, Grummt I. (1998) TTF-I determines the chromatin architecture of the active rDNA promoter. EMBO J 17, 3135-3145.

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