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BEGIN:VEVENT
UID:entry-297@www.dkfz.de
DTSTAMP:20260929T171433Z
DTSTART:20250410T110000Z
DTEND:20250410T120000Z
SUMMARY:Cancer Core Europe (CCE) Lecture - Dissecting the function of copy 
 number alterations in cancer
DESCRIPTION:Welcome to the next lecture\, hosted by Vall Hebron Institute o
 f Oncology (VHIO): Speaker: Francisco Barriga\, Group Leader\, VHIO\, Barc
 elona Spain Thursday\, April 10 ‒ Time 15:00 - 16. 00 CET Join Zoom Meet
 ing https://us06web.zoom.us/j/88644457350?pwd=y9ZcmrY6mWlIkhPKzLa4fqIi310F
 UF.1 Meeting ID: 886 4445 7350 Abstract Chromosomal deletions are prevalen
 t in cancer\, yet their function remains ill-defined. One of the most freq
 uent losses affects chromosome 9p21.3\, which disables the CDKN2A/B tumor 
 suppressor genes. Intriguingly\, half of 9p21.3 deletions encompass a clus
 ter of 16 type I interferons (IFNs) whose co-deletions have not been funct
 ionally characterized. To dissect this biology we developed MACHETE (Molec
 ular Alteration of Chromosomes with Engineered Tandem Elements)\, a genome
  engineering strategy to create megabase-sized deletions. 9p21.3-syntenic 
 deletions in a mouse model of pancreatic cancer revealed that concomitant 
 loss of Cdkn2a/b and IFNs led to immune evasion and metastasis. Mechanisti
 cally\, IFN co-deletion disrupted antigen-presenting cells and facilitated
  escape from CD8+ T cell surveillance in a cell extrinsic manner. Our resu
 lts establish co-deletions of the IFN cluster as a pervasive route to tumo
 r immune evasion and metastasis. This study establishes a framework to dis
 sect the functions of genomic deletions in cancer and beyond. What is Canc
 er Core Europe (CCE)? Cancer Core Europe is a consortium of seven leading 
 cancer centres (www.cancercoreeurope.eu). CCEs members are driven by a str
 ong will to reshape the cancer research model to ultimately increase the E
 uropean Union’s competitiveness as a place to conduct cutting-edge resea
 rch that’s translated to the clinic to deliver more personalized medicin
 e. What is the content and aim of the CCE Lecture? The CCE Lecture serie i
 s a CCE-internal event\, which educates and informs about state of the art
  research within the seven centers and is aimed to increase awareness amon
 g partners about each other’s activities and potential for collaboration
 .
LOCATION:Online
URL:https://www.dkfz.de/en/news/events/details/58-cancer-core-europe-cce-le
 cture-dissecting-the-function-of-copy-number-alterations-in-cancer/a297
CATEGORIES:Vorträge und Seminare
STATUS:CONFIRMED
SEQUENCE:1790690401
LAST-MODIFIED:20260929T140001Z
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