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BEGIN:VEVENT
UID:entry-121@www.dkfz.de
DTSTAMP:20260929T162907Z
DTSTART:20260505T053000Z
DTEND:20260505T063000Z
SUMMARY:DDLSS: Maria Rescigno "The microbiota in cancer progression and tre
 atment"
DESCRIPTION:The involvement of the microbiota in cancer progression and tre
 atment has for long been proposed. The microbiota can affect tumor cell pr
 oliferation and death\, the immune system and the tumor microenvironment. 
 We have observed a reduction in one particular strain capable of controlli
 ng tumor cell proliferation 1. Further\, Immune checkpoint blockade (ICB)\
 , has drastically improved treatment of metastatic cancer patients. Microb
 iota composition has been proposed to be one of the reasons for failure or
  success. ICB works via the activation or reactivation of T cells that are
  ‘switched off’ by tumor cells or by the tumor microenvironment. Even 
 advanced metastatic disease\, previously considered as untreatable\, can b
 enefit from cancer immunotherapy. However\, still a good proportion of pat
 ients does not respond to therapy or acquires resistance during treatment.
  Some genera or species of bacteria have been associated with treatment re
 sponse or toxicity\, but as the composition of the microbiota is not stati
 c\, rather\, it is very dynamic there is promise that by changing the micr
 obiota composition\, or by harnessing the microbiota ‘secrete’ tricks\
 , one can improve treatment efficacy or reduce toxicity. Several players\,
  including diet\, prebiotics\, probiotics and postbiotics have been propos
 ed to shape the microbiota. We found that it is possible to train the micr
 obiota to increase ICB efficacy and to reduce toxicity via the use of post
 biotics 2\, but we also know that the microbiota can influence cancer trea
 tment by metabolizing chemotherapeutic drugs. We will discuss both possibi
 lities.
LOCATION:BioQuant - Seminar Room SR041
URL:https://www.dkfz.de/en/news/events/details/212-ddlss-maria-rescigno-the
 -microbiota-in-cancer-progression-and-treatment/a121
CATEGORIES:Vorträge und Seminare
ORGANIZER;CN="Martina Jochim":mailto:m.jochim@dkfz-heidelberg.de
STATUS:CONFIRMED
SEQUENCE:1790690401
LAST-MODIFIED:20260929T140001Z
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