Mohsen Abolfathi, M.Sc.
Mohsen Abolfathi, M.Sc.
Position:
Ph.D. student
Affiliation:
Molecular Hematology/Oncology
Contact:
Phone:
+49 6221 42 1443
Fax:
+49 6221 42 1444
Building:
INF 581/TP 4
Room:
S4.124
Project description
Myelodysplastic syndromes (MDS) are hematopoietic stem cell disorders that are associated with bone marrow failure and transformation into acute myeloid leukemia (AML). In this study, we analyzed a panel of 63 genes for mutations in 63 MDS blood or bone marrow samples using a targeted re-sequencing approach. In addition, we used CRISPR/Cas9 genome editing to knock out STAG2 in diploid, chromosomally stable HCT116-p53+/+ and HCT116-p53-/- cells and look for the signs of chromosomal instability.