Mohsen Abolfathi, M.Sc.

Mohsen Abolfathi, M.Sc.

Mohsen Abolfathi, M.Sc.

Position:

Ph.D. student

Affiliation:

Molecular Hematology/Oncology

Phone:

+49 6221 42 1443

Fax:

+49 6221 42 1444

Building:

INF 581/TP 4

Room:

S4.124

Project description

Myelodysplastic syndromes (MDS) are hematopoietic stem cell disorders that are associated with bone marrow failure and transformation into acute myeloid leukemia (AML). In this study, we analyzed a panel of 63 genes for mutations in 63 MDS blood or bone marrow samples using a targeted re-sequencing approach. In addition, we used CRISPR/Cas9 genome editing to knock out STAG2 in diploid, chromosomally stable HCT116-p53+/+ and HCT116-p53-/- cells and look for the signs of chromosomal instability.

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